The Journal of Global Development and Peace Spring 2009

The Journal of Global Development and Peace for the spring of 2009. This issue contains articles by Dr. Perrottet on Immanuel Kant's Perpetual Peace: The New World Order of Critical Philosophy, Jessada Salathong on Education for Sustainable Development and Human Security, Dr. Benjamin on From Collective to Human Security: Development and Peace in the 21st Century, Dr. Zhu on China's New Diplomacy Since the Mid-1990s: Rationale, Reactions, and Significance, Dr. Rubenstein On Shame, Rage, and the Middle Eastern Conflict, and Dr. Ward's review of the book "Reconciliation: Islam, Democracy, and the West"

Adaptation to antiangiogenic therapy in neurological tumors

Because tumors require a vascular supply for their survival and growth, angiogenesis is considered an important therapeutic target in most human cancers including cancer of the central nervous system. Antiangiogenic therapy has focused on inhibitors of the vascular endothelial growth factor (VEGF) signaling pathway. VEGF pathway-targeted drugs have shown therapeutic efficacy in several CNS tumors and have been tried most frequently in glioblastoma. These therapies, however, have been less effective than anticipated as some patients do not respond to therapy and some receive only modest benefit. Underlying this suboptimal response are multiple mechanisms of drug resistance involving changes in both tumor cells and their microenvironment. In this review, we discuss the multiple proposed mechanisms by which neurological tumors evolve to become resistant to antiangiogenic therapies. A better understanding of these mechanisms, their context, and their interplay will likely facilitate improvements in pharmacological strategies for the targeted treatment of neurological tumors