Magazines as contradictory spaces for alcohol messaging: a mixed method content and thematic analysis of UK women’s magazine representations of alcohol and its consumption

BACKGROUND Women’s magazines provide a space in which gendered norms around alcohol-related practice are (re)-produced. They act as important points of reference for women to draw upon in their own understandings of alcohol use within their identity making. Studying the alcohol-related messages women’s magazines disseminate is therefore an important line of inquiry. METHODS An analysis of textual and visual alcohol depictions, including alcohol advertising, in 70 editions of 20 printed magazines targeted at and read by women, published between August 2020 and January 2021, was conducted using quantitative content and qualitative thematic analysis. RESULTS Women’s magazines have the potential to disseminate public health messages about the physical and mental health impacts of alcohol use, alcohol’s role in gender inequalities and the risk of harm from alcohol use by men. However, they do so in ways that reproduce harmful gender norms and expectations, and overlook the structural causes of alcohol-related harms. Associations between alcohol use and violence against women were simplified, in ways that ignored the root causes, produced victim-blaming narratives and deflected responsibility from the perpetrator to the effects of alcohol. Narratives around drinking and sobriety were underpinned by concerns over appearance, which reinforced social expectations of the ideal feminine body. Health narratives were in conflict with the presence of pro-alcohol messages such as consumption suggestions and alcohol advertising, which promoted alcohol use as a normalised aspect of women’s day to day lives. CONCLUSIONS Women receive a number of mixed and contradictory messages on alcohol use through their magazine readership, which places limits on magazines as educational sources of public health messaging

An exploration of the role of alcohol in relation to living situation and significant life events for the homeless population in Merseyside, UK.

Approximately 10% of the population in the UK are estimated to have been homeless ot some point in their lifetime (Crisis 2014) and there were 2,744 rough sleepers identified in England in 2014 (Department for Communities and Local Government 2015). Alcohol misuse is both a cause and effect of homelessness (Shelter 2007) and is considered to be a major health risks amongst the homeless (Crisis 2002). This research used life history interviews and calendars to explore changes in the research participants’ alcohol consumption in relation to their living situation and significant life events. Additionally, PhotoVoice activities were used to further explore their everyday lived experiences. Recovery capital, which is derived from the concept of ‘social capital’ (Bourdieu and Wacquant 1992; Teachman et al 1997), refers to the quality and quantity of resources that a person can access in order to initiate and sustain recovery from addiction (Granfield and Cloud 2001). In the context of this research, recovery capital has also been applied to the resources needed in order to overcome homelessness as well as addiction to alcohol. The findings from this research highlight the importance of social capital during significant life events. It was often a lack of social capital that led to homelessness and increased alcohol consumption. Subsequently, in order to overcome alcohol addiction and homelessness, participants need to develop recovery capital. The sample that was recruited for this project was small, and is therefore not representative of the experiences of the homeless population in general. However, the findings from this research do demonstrate how further research is needed in order to further explore the relationships between alcohol consumption, living situation and significant life events

STOP-sexual violence: evaluation of a community-based nightlife worker awareness raising bystander training programme

Background: Preventing sexual violence in nightlife environments is a pervasive issue across many countries. This study explored the associated impact of a nightlife worker sexual violence awareness raising/bystander training programme (STOP-SV) on trainees’ sexual violence myth acceptance and readiness and confidence to intervene. Methods: Pre- and post-test (n = 118), and 3-month follow-up (n = 38) trainee surveys were implemented across three countries (Czech Republic, Portugal and Spain). Paired-sample tests examined changes across time-periods in participants’ myth acceptance (e.g. unwanted sexual advances are a normal part of a night out), and readiness and confidence to intervene. Multi-nominal regression was used to examine the relationship between the change in pre-to-post-training scores and trainee characteristics. Results: Compared to pre-training, post-training participants were significantly (P < 0.01) less likely to agree with sexual violence myths, and more likely to be ready and confident to intervene. In bi-variate and multi-variate analyses, we found no significant associations between the change in pre-to-post-training scores and trainee characteristics. Analyses of the small follow-up sub-sample illustrated some positive changes at the post-training and follow-up time-periods (i.e. reduction in sexual violence myth acceptance). Conclusion: This exploratory study suggests that the STOP-SV training programme was associated with a decrease in trainees’ acceptance of sexual violence myths, and an increase in their readiness and confidence to intervene. Our findings support the case for further implementation and evaluation of awareness raising/bystander programmes for nightlife workers that aim to prevent and respond to sexual violence

Identification of Cancer Cell-Line Origins Using Fluorescence Image-Based Phenomic Screening

Universal phenotyping techniques that can discriminate among various states of biological systems have great potential. We applied 557 fluorescent library compounds to NCI's 60 human cancer cell-lines (NCI-60) to generate a systematic fluorescence phenotypic profiling data. By the kinetic fluorescence intensity analysis, we successfully discriminated the organ origin of all the 60 cell-lines

Genetic and maternal effects on tail spine and body length in the invasive spiny water flea (Bythotrephes longimanus)

Interest in the evolution of invasive species has grown in recent years, yet few studies have investigated sources of variation in invasive species traits experiencing natural selection. The spiny water flea, Bythotrephes longimanus, is an invasive zooplankton in the Great Lakes that exhibits seasonal changes in tail spine and body length consistent with natural selection. Evolution of Bythotrephes traits, however, depends on the presence and magnitude of quantitative genetic variation, which could change within or across years. Clonal analysis of wild-captured Bythotrephes indicated that variance components for distal spine length were variable among but not within years. Spine length was always heritable but was not always influenced by maternal effects. In contrast, variance components for body length varied both within and among years, but likewise body length was always heritable and not always influenced by maternal effects. Results indicate that important Bythotrephes traits have heritable variation comparable to native species and other invasive species that would enable an evolutionary response to natural selection. This evolutionary capacity could contribute to the widespread success and dramatic effects of Bythotrephes invasion in systems with diverse biotic and abiotic conditions

Evolutionary origins of invasive populations

What factors shape the evolution of invasive populations? Recent theoretical and empirical studies suggest that an evolutionary history of disturbance might be an important factor. This perspective presents hypotheses regarding the impact of disturbance on the evolution of invasive populations, based on a synthesis of the existing literature. Disturbance might select for life-history traits that are favorable for colonizing novel habitats, such as rapid population growth and persistence. Theoretical results suggest that disturbance in the form of fluctuating environments might select for organismal flexibility, or alternatively, the evolution of evolvability. Rapidly fluctuating environments might favor organismal flexibility, such as broad tolerance or plasticity. Alternatively, longer fluctuations or environmental stress might lead to the evolution of evolvability by acting on features of the mutation matrix. Once genetic variance is generated via mutations, temporally fluctuating selection across generations might promote the accumulation and maintenance of genetic variation. Deeper insights into how disturbance in native habitats affects evolutionary and physiological responses of populations would give us greater capacity to predict the populations that are most likely to tolerate or adapt to novel environments during habitat invasions. Moreover, we would gain fundamental insights into the evolutionary origins of invasive populations

Induction of cell cycle changes and modulation of apoptogenic/anti-apoptotic and extracellular signaling regulatory protein expression by water extracts of I'm-Yunity™ (PSP)

BACKGROUND: I'm-Yunity™ (PSP) is a mushroom extract derived from deep-layer cultivated mycelia of the patented Cov-1 strain of Coriolus versicolor (CV), which contains as its main bioactive ingredient a family of polysaccharo-peptide with heterogeneous charge properties and molecular sizes. I'm-Yunity™ (PSP) is used as a dietary supplement by cancer patients and by individuals diagnosed with various chronic diseases. Laboratory studies have shown that I'm-Yunity™ (PSP) enhances immune functions and also modulates cellular responses to external challenges. Recently, I'm-Yunity™ (PSP) was also reported to exert potent anti-tumorigenic effects, evident by suppression of cell proliferation and induction of apoptosis in malignant cells. We investigate the mechanisms by which I'm-Yunity™ (PSP) elicits these effects. METHODS: Human leukemia HL-60 and U-937 cells were incubated with increasing doses of aqueous extracts of I'm-Yunity™ (PSP). Control and treated cells were harvested at various times and analyzed for changes in: (1) cell proliferation and viability, (2) cell cycle phase transition, (3) induction of apoptosis, (4) expression of cell cycle, apoptogenic/anti-apoptotic, and extracellular regulatory proteins. RESULTS: Aqueous extracts of I'm-Yunity™ (PSP) inhibited cell proliferation and induced apoptosis in HL-60 and U-937 cells, accompanied by a cell type-dependent disruption of the G(1)/S and G(2)/M phases of cell cycle progression. A more pronounced growth suppression was observed in treated HL-60 cells, which was correlated with time- and dose-dependent down regulation of the retinoblastoma protein Rb, diminution in the expression of anti-apoptotic proteins bcl-2 and survivin, increase in apoptogenic proteins bax and cytochrome c, and cleavage of poly(ADP-ribose) polymerase (PARP) from its native 112-kDa form to the 89-kDa truncated product. Moreover, I'm-Yunity™ (PSP)-treated HL-60 cells also showed a substantial decrease in p65 and to a lesser degree p50 forms of transcription factor NF-κB, which was accompanied by a reduction in the expression of cyclooxygenase 2 (COX2). I'm-Yunity™ (PSP) also elicited an increase in STAT1 (signal transducer and activator of transcription) and correspondingly, decrease in the expression of activated form of ERK (extracellular signal-regulated kinase). CONCLUSION: Aqueous extracts of I'm-Yunity™ (PSP) induces cell cycle arrest and alterations in the expression of apoptogenic/anti-apoptotic and extracellular signaling regulatory proteins in human leukemia cells, the net result being suppression of proliferation and increase in apoptosis. These findings may contribute to the reported clinical and overall health effects of I'm-Yunity™ (PSP)

Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial

Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke. Methods: We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515. Findings: Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p&lt;0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (&lt;1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (&lt;1%) deaths in the albiglutide group. Interpretation: In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes. Funding: GlaxoSmithKline

Recovery capital in the context of homelessness, high levels of alcohol consumption, and adverse significant life events

From Crossref journal articles via Jisc Publications RouterHistory: epub 2021-12-16, issued 2021-12-16Publication status: PublishedFunder: Alcohol Research UK; FundRef: 10.13039/50110000028

Evaluation of the good night out campaign: a sexual violence bystander training programme for nightlife workers in England

From Springer Nature via Jisc Publications RouterHistory: received 2021-10-11, accepted 2022-07-06, registration 2022-07-07, epub 2022-08-16, online 2022-08-16, ppub 2023-10Acknowledgements: Bryony Parry and the GNOC CIC team (www.goodnightoutcampaign.org/) developed the intervention and trained local stakeholders to deliver the programme. The GNOC, Liverpool City Council, Rape and Sexual Abuse Merseyside and Birmingham and Solihull Women’s Aid supported data collection.Publication status: PublishedAim: Sexual violence is global public health, human rights and gender equality issue. Sexual violence bystander programmes for nightlife workers are emerging across a few countries and further examination of such programmes is required. This exploratory study evaluates the potential effectiveness of the Good Night Out Campaign, a sexual violence bystander programme for nightlife workers. Subject and methods: Two hundred and seven trainees attending the 1.5 hour training programme across two cities in England were recruited opportunistically, immediately prior to training delivery. Sexual violence myth acceptance and readiness and confidence to intervene in sexual violence were measured at baseline and post-intervention. Analyses used paired-sample tests to examine differences in the three measurements pre to post-training and effect sizes were quantified using Cohen’s d. Results: Compared to pre-training, post-training participants were significantly (p < 0.001) less likely to agree with sexual violence myths, and more likely to be confident and ready to intervene in sexual violence or incidents of vulnerability. Effect sizes were small–medium. Conclusions: The study adds to emergent evidence suggesting that sexual violence bystander programmes may be promising in decreasing sexual violence myths and barriers to bystander intervention, and increasing willingness to intervene amongst nightlife workers. Findings can support the emergence of sexual violence prevention activities implemented in nightlife spaces. Further programme implementation and evaluation using experimental designs is needed to explore outcomes in greater depth, considering the complexity of the nightlife environment