27 research outputs found
Balance de las exposiciones del centenario de Felipe II (Lisboa, primavera 1998 y Valladolid, invierno 1998-99)
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Las provincias italianas y la defensa de la Monarquía
El articulo de Luis A. Ribot es un intento de análisis de conjunto de la defensa de los territorios italianos pertenecientes a la Monarquía Hispánica, teniendo en cuenta el papel jugado por cada uno de ellos en el sistema defensivo conjunto elaborado por la Monarquía.Though this article Luis A. Ribot attempts to analyze the defensive works in the Italian lands that belonged to the Spanish Monarchy, taking into account the role played by each territory in, the defensive system elaborated by that Monarchy
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Las revueltas italianas del siglo XVII
[ES] Tras plantear una panorámica general de las revueltas que tuvieron lugar en la Italia española, centradas especialmente en el siglo XVII, el artículo profundiza en las que se produjeron, de forma casi simultánea, en los reinos de Napóles y Sicilia, en 1647-1648. Basándose en las aportaciones bibliográficas publicadas a partir de los años sesenta del siglo XX, analiza las causas de cada una de ellas, así como su desarrollo y sus diversas fases. Se fija también en las similitudes y diferencias entre ambas y en las repercusiones que tuvieron sobre el poder español en el sur de Italia. En última instancia, las dos grandes revueltas fueron el resultado de la fuerte presión financiera y humana a la que fueron sometidos los dos reinos para financiar la política bélica del conde-duque de Olivares y las múltiples repercusiones que dicha presión tuvo sobre ellos.[EN] Here we have a brief panorama of southern Italian revolutions from XVIIth Century, especially the simultaneous riots that took place in Naples and Sicily on 1647-48. Using his own research and the recent bibliography about this, the Author gave us an analysis of the causes, wealth and conclusion of these events. Both have very similar consequences for the decadence of Spanish dominion in Italy
Carlos II: el centenario olvidado
[ES] A partir de una reflexión inicial sobre el fenómeno de las conmemoraciones, el autor se plantea las causas por las que el tercer centenario de la muerte de Carlos II no dará lugar a ninguna conmemoración. Con independencia de las valoraciones de todo tipo que puedan hacerse de dichas celebraciones, lo cierto es que, en este caso, tal vez hubieran permitido acercar al gran público a uno de los monarcas peor conocidos y menos valorados de la historia de España. Lo más grave, sin embargo, es que la sombra del desconocimiento y el juicio peyorativo se extienden también sobre todo su reinado. Las investigaciones sobre aquel periodo, sin embargo, a pesar de que no abundan, muestran una realidad bastante distinta, en la que la decadencia y la pérdida de la hegemonía internacional convivieron con importantes iniciativas y realizaciones políticas, tanto en el ámbito interno de la Monarquía, como en las relaciones internacionales.[EN] Parting from an initial reflection about the phenomenon of commemorations, the author ponders the causes for which the third centenary of Charles IFs death will not be the subjet of any celebrations. Besides any evaluations which might be made of these events, the truth is that, perhaps, in this case, a commemoration would have brought the general public closer to one of the least known and worst valued monarchs in the history of Spain. What is more serious, however, is the fact that the shadow of ignorance and pejorative judgement extend also over the entirety of his reign. Though scarce, research about this period shows a very different reality, in wich decadence and the loss of international hegemony cohabitated with important political initiatives and achievements, both in the monarchy's internal domain and in the international arena