Exploring potential 'extra-familial' child homicide assailants in the UK and estimating their homicide rate: perception of risk – the need for debate

High-profile child murders lead parents to fear for their children’s safety, but perception of risk is often at variance with reality. We explore the numbers of potential ‘Extra-familial’ child homicide assailants in the United Kingdom and estimate their actual murder rate to determine risk levels. A South of England study, equivalent to a 4 per cent sample of the UK population, of a decade of consecutive child homicides identified the characteristics of child homicide assailants, finding that the most frequent assailants--the ‘Intra-familial’--were very different from ‘Extra-familial’ assailants. ‘Extra-familial’ killers were all males, aged nineteen to forty-two, with convictions for Violent-Multi-Criminal-Child-Sex-Abuse (VMCCSA) offences and Multi-Criminal-Child-Sex-Abuse (MCCSA), whose victims were aged seven-plus years. Projecting these characteristics onto the male UK population enables us to estimate the numbers of potential UK ‘Extra-familial’ assailants, which are set against known UK child (five to fourteen) homicides (WHO, 2005). To account for any ‘hidden’ child homicides, deaths in the ‘undetermined’ violent death category, designated ‘Other External Cause’ (OEC), are calculated to provide a ‘maximum’ child homicide rate. There were potentially 912 VMCCSA and 886 MCCSA ‘Extra-familial’ offenders in the United Kingdom, who could be responsible for the WHO-reported UK three-year average of ‘Extra-family’ fifteen child homicide and seventeen OEC deaths per annum; a homicide rate of 12,061 per million (pm) for VMCCSA and 3,386 pm for MCSA, which is 1.21 and 0.34 per cent; however, the VMCCSA homicide rate was 403 times greater than the all children accident and cancer death rates. Though the vast majority of these potential assailants did not kill, comparatively, they are extremely dangerous. Practice and ethical issues are debated, which considers active outreach for the ‘treatable’ to possible ‘reviewable’ custodial sentences for the VMCCSA

Effects of a curricular model on skill development, knowledge, and game performance

Being able to play a sport has been a primary goal of any physical education program (NASPE, 1995). A tool used by physical education teachers in promoting sport has been the use of curricular models. Two models that have been of interest have been the Sport Education Curricular Model (SECM) and a multi-activity model. With little research investigating how these two models influence game play in the secondary level; the purpose of this study was to investigate how the SECM and a longer version of the multi-activity model called the Extended Multi-Activity Model (EMAM) would affect skill development, knowledge, and game performance for the sport of volleyball at the secondary level.;A 2 x 2 x 3 (group x gender x time) research design was utilized on forty-seven secondary students testing volleyball skills (i.e., serve, set, and pass), knowledge, and game performance. Participants were tested on the dependent variables pre, mid, and post of the twenty lesson intervention. Results revealed no group x time interaction but data there were improvement in skills for both models. There were also no significant differences for knowledge although there was some improvement for both curricular models. There was an interaction effect for group x time when dealing with game performance, F (2, 86) = 8.06, p \u3c .01. The SECM group overall made more correct decisions, executed skill more proficiently, and adjusted to the ball better than the EMAM group. In conclusion, if the goal of the physical education program is to promote game play, the SECM is more efficient in enhancing game play than an extended version of the multi-activity model (i.e., EMAM)

Using Photovoice in PETE Programs to Initiate Positive Change

The purpose of this presentation will be to provide teacher educators with an overview of the Photovoice methodology and its potential utility in curricular change. The National Association for Sport and Physical Education’s ([NASPE], 2008) PETE standards state educators should allow diversity to drive instructional related decision-making. Photovoice, a participatory action research methodology, is a tool teacher educators can use to be responsive to the continuously changing contexts of public schools

Using Group Model Building to Understand Factors That Influence Childhood Obesity in an Urban Environment

Background: Despite increased attention, conventional views of obesity are based upon individual behaviors, and children and parents living with obesity are assumed to be the primary problem solvers. Instead of focusing exclusively on individual reduction behaviors for childhood obesity, greater focus should be placed on better understanding existing community systems and their effects on obesity. The Milwaukee Childhood Obesity Prevention Project is a community-based coalition established to develop policy and environmental change strategies to impact childhood obesity in Milwaukee, Wisconsin. The coalition conducted a Group Model Building exercise to better understand root causes of childhood obesity in its community. Methods: Group Model Building is a process by which a group systematically engages in model construction to better understand the systems that are in place. It helps participants make their mental models explicit through a careful and consistent process to test assumptions. This process has 3 main components: (1) assembling a team of participants; (2) conducting a behavior-over-time graphs exercise; and (3) drawing the causal loop diagram exercise. Results: The behavior-over-time graph portion produced 61 graphs in 10 categories. The causal loop diagram yielded 5 major themes and 7 subthemes. Conclusions: Factors that influence childhood obesity are varied, and it is important to recognize that no single solution exists. The perspectives from this exercise provided a means to create a process for dialogue and commitment by stakeholders and partnerships to build capacity for change within the community

Glory Oscillations in the Index of Refraction for Matter-Waves

We have measured the index of refraction for sodium de Broglie waves in gases of Ar, Kr, Xe, and nitrogen over a wide range of sodium velocities. We observe glory oscillations -- a velocity-dependent oscillation in the forward scattering amplitude. An atom interferometer was used to observe glory oscillations in the phase shift caused by the collision, which are larger than glory oscillations observed in the cross section. The glory oscillations depend sensitively on the shape of the interatomic potential, allowing us to discriminate among various predictions for these potentials, none of which completely agrees with our measurements

DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation

Summary: Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG island methylator (CIMP) phenotype. To protect from cancer, normal intestinal epithelial cells respond to oncogenic BRAFV600E by activation of intrinsic p53 and p16-dependent tumor suppressor mechanisms, such as cellular senescence. Conversely, CIMP is thought to contribute to bypass of these tumor suppressor mechanisms, e.g. via epigenetic silencing of tumor suppressor genes, such as p16. It has been repeatedly proposed that DNMT3B is responsible for BRAFV600E-induced CIMP in human CRC. Here we set out to test this by in silico, in vitro, and in vivo approaches. We conclude that although both BRAFV600E and DNMT3B harbor oncogenic potential in vitro and in vivo and show some evidence of cooperation in tumor promotion, they do not frequently cooperate to promote CIMP and human intestinal cancer

An economic evaluation of the healthcare cost of tinnitus management in the UK

Background: There is no standard treatment pathway for tinnitus patients in the UK. Possible therapies include education and reassurance, cognitive behavioural therapies, modified tinnitus retraining therapy (education and sound enrichment), or amplification of external sound using hearing aids. However, the effectiveness of most therapies is somewhat controversial. As health services come under economic pressure to deploy resources more effectively there is an increasing need to demonstrate the value of tinnitus therapies, and how value may be continuously enhanced. The objective of this project was to map out existing clinical practice, estimate the NHS costs associated with the management approaches used, and obtain initial indicative estimates of cost-effectiveness.Methods: Current treatment pathways, costs and health outcomes were determined from the tinnitus literature, national statistics, a patient survey, and expert opinion. These were used to create an Excel-based economic model of therapy options for tinnitus patients. The probabilities associated with the likelihood of an individual patient receiving a particular combination of therapies was used to calculate the average cost of treatment per patient, average health outcome per patient measured in QALYs gained, and cost-effectiveness, measured by the average cost per QALY gained.Results: The average cost of tinnitus treatment per patient per year is GB£717, equating to an NHS healthcare bill of GB£750 million per year. Across all pathways, tinnitus therapy costs £10,600 per QALY gained. Results were relatively insensitive to restrictions on access to cognitive behaviour therapy, and a subsequent reliance on other therapies.Conclusions: NHS provisions for tinnitus are cost-effective against the National Institute for Health and Care Excellence cost-effective threshold. Most interventions help, but education alone offers very small QALY gains. The most cost-effective therapies in the model were delivered within audiology

Continuous Deployment Transitions at Scale

Predictable, rapid, and data-driven feature rollout; lightning-fast; and automated fix deployment are some of the benefits most large software organizations worldwide are striving for. In the process, they are transitioning toward the use of continuous deployment practices. Continuous deployment enables companies to make hundreds or thousands of software changes to live computing infrastructure every day while maintaining service to millions of customers. Such ultra-fast changes create a new reality in software development. Over the past four years, the Continuous Deployment Summit, hosted at Facebook, Netflix, Google, and Twitter has been held. Representatives from companies like Cisco, Facebook, Google, IBM, Microsoft, Netflix, and Twitter have shared the triumphs and struggles of their transition to continuous deployment practices—each year the companies press on, getting ever faster. In this chapter, the authors share the common strategies and practices used by continuous deployment pioneers and adopted by newcomers as they transition and use continuous deployment practices at scale

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

Basic Atomic Physics

Contains reports on five research projects.National Science Foundation Grant PHY 96-024740National Science Foundation Grant PHY 92-21489U.S. Navy - Office of Naval Research Contract N00014-96-1-0484Joint Services Electronics Program Grant DAAHO4-95-1-0038National Science Foundation Grant PHY95-14795U.S. Army Research Office Contract DAAHO4-94-G-0170U.S. Army Research Office Contract DAAG55-97-1-0236U.S. Army Research Office Contract DAAH04-95-1-0533U.S. Navy - Office of Naval Research Contract N00014-96-1-0432National Science Foundation Contract PHY92-22768David and Lucile Packard Foundation Grant 96-5158National Science Foundation Grant PHY 95-01984U.S. Army Research OfficeU.S. Navy - Office of Naval Research Contract N00014-96-1-0485AASERT N00014-94-1-080