7th Drug hypersensitivity meeting: part two

No abstract availabl

Glucose, BMI and pre-neoplastic lesions in the cervix [Glucosa, índice de masa corporal y lesiones preneoplásicas en el cuello uterino]

Background: The obesity and abnormal blood glucose level has been associated with cervical cancer development; however, few studies have been performed about this relation. Objective: Evaluate the blood glucose levels and body mass index (BMI) in women with human papilloma virus infection (HPV-I) and cervical intraepithelial neoplasia (CIN-I). Patients and method: Transversal study of 44 women diagnosed with HPV-I and CIN-I from September to December 2010 in Dysplasia Clinic of Regional Hospital of Guzman City, Federal entity of Jalisco, Mexico. The diagnoses were carried by biopsy of cervix, glucose test results were evaluated by spectrophotometry and determinate the BMI. Results: The 18% (n=8) of women were without injury, 41% (n=18), with HPV-I and 41% (n=18) CIN-I. High blood glucose was observed in CIN-I versus without injury in the cervix (p = 0.05), the correlation was OR = 2.6 (95% CI: 1.090-6.52). The young women (19-35 years) were 17% high glucose, 28% normal glucose and 55% low glucose. In group of the medium age (35-65 years) 23% showed high glucose, 50% normal and 27% low. The BMI was not relation with diagnosis, although in the age (young versus age median p=0.001). Conclusion: These results support the proposal about the high levels of glucose in plasma and obesity could be risk cofactors in the development of preneoplasic lesion of cervix

Glucose, BMI and pre-neoplastic lesions in the cervix [Glucosa, índice de masa corporal y lesiones preneoplásicas en el cuello uterino]

Background: The obesity and abnormal blood glucose level has been associated with cervical cancer development; however, few studies have been performed about this relation. Objective: Evaluate the blood glucose levels and body mass index (BMI) in women with human papilloma virus infection (HPV-I) and cervical intraepithelial neoplasia (CIN-I). Patients and method: Transversal study of 44 women diagnosed with HPV-I and CIN-I from September to December 2010 in Dysplasia Clinic of Regional Hospital of Guzman City, Federal entity of Jalisco, Mexico. The diagnoses were carried by biopsy of cervix, glucose test results were evaluated by spectrophotometry and determinate the BMI. Results: The 18% (n=8) of women were without injury, 41% (n=18), with HPV-I and 41% (n=18) CIN-I. High blood glucose was observed in CIN-I versus without injury in the cervix (p = 0.05), the correlation was OR = 2.6 (95% CI: 1.090-6.52). The young women (19-35 years) were 17% high glucose, 28% normal glucose and 55% low glucose. In group of the medium age (35-65 years) 23% showed high glucose, 50% normal and 27% low. The BMI was not relation with diagnosis, although in the age (young versus age median p=0.001). Conclusion: These results support the proposal about the high levels of glucose in plasma and obesity could be risk cofactors in the development of preneoplasic lesion of cervix

CD28-, CD45RAnull/dim and natural killer-like CD8+ T cells are increased in peripheral blood of women with low-grade cervical lesions

Background: In response to antigen naive CD8+, T cells differentiate into effector cells, which express Natural killer (NK) receptors, lose CD28 expression, and die by apoptosis. However, in smaller quantities, the cells are retained for subsequent exposure to the same antigen. Knowledge is limited regarding whether the percentages of CD28-, Effector memory (EMRAnull/dim), and the CD16+/CD56 + CD8+ T cells of women with low-grade cervical lesions are altered at a systemic level.Methods: We enrolled in this study women controls and women with Human papilloma virus infection (HPV-I) without associated cellular neoplastic changes and with Cervical Intraepithelial Neoplastic-I (CIN-I). Flow cytometry (FC) was performed for measurement of CD28-, memory subset, and NK-like CD8 + T cells, and IL-17, IFN-gamma, Tumor necrosis factor (TNF)-alpha, Interleukin (IL)-10, IL-6, IL-4, and IL-2. Finally, we genotyped the HPV.Results: The CIN-I group increased the CD8 + CD28- and CD16+/56+ T cell percentage compared with that of HPV-I and controls (p <0.01), and CD8 + CCR7-CD45RAnull/dim (EMRAnull/dim) T cells were also increased in the CIN-I group compared with the controls (p <0.01). These two study groups were HPV- genotyped; 49% were HPV18+, and we did not observe differences in cytokine levels among all groups.Conclusions: Increased levels of CD28-, EMRAnull/dim, and CD16+/CD56 + CD8+ T cells of peripheral blood in women with CIN-I may be associated with persistent HPV infection and could exert an influence on progression to cervical cancer. Zapotitlán 2014 Pita-Lopez et al.; licensee BioMed Central Ltd.Central Ltd

Levels of oxidative stress in serum and dietary behavior in adults in a rural area of Jalisco, Mexico [Indicadores de estr�s oxidativo en suero y comportamiento alimentario en adultos de una zona rural de Jalisco, M�xico]

Introduction: The feeding behavior establishes a relation of humans with food, includes food habits that could be involved with oxidative stress. Objective: To evaluate the relation of indicators of oxidative stress (lipid peroxides) and antioxidant (ascorbic acid, catalase, superoxide dismutase) with feeding behavior in adults of Teocuhitatlan Corona, Jalisco, Mexico. Method: Study observational, descriptive, cross-sectional of 44 adults with 43 to 88 years, was used a instrument of feeding behavior. The questionnaire were related to indicators of oxidative stress. Were used descriptive statistics, frequency distribution and analysis of covariance with adjustment variables, was considered significant p <0.05. Results: The values of serum lipid peroxides were related to behaviors: consider the nutritional content as most important when choosing food (p = 0.042), dislike milk (p = 0.027), intake of sweets between meals (p = 0.001), habitual inclusion of vegetables and salads in main meal (p = 0.018). We do not found association in to values of ascorbic acid, cholesterol in low density lipoproteins and enzymatic activities of catalase and superoxide dismutase with food behaviors. Discussion: The feeding behaviors analyzed in this study may be involved with development of oxidative stress and could be have protective or harmful effect in development to complications of chronic non-com-municable diseases and aging in this population. This suggests to analyze demographic and socio-cultural aspects of region and besides analyzing the consumption and metabolic markers related to food. � 2015, Grupo Aula Medica S.A. All rights reserved

Immunological study of a chitosan prosthesis in the sciatic nerve regeneration of the axotomized dog

This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response

Sensitivity of the Cherenkov Telescope Array for probing cosmology and fundamental physics with gamma-ray propagation

The Cherenkov Telescope Array (CTA), the new-generation ground-based observatory for γ astronomy, provides unique capabilities to address significant open questions in astrophysics, cosmology, and fundamental physics. We study some of the salient areas of γ cosmology that can be explored as part of the Key Science Projects of CTA, through simulated observations of active galactic nuclei (AGN) and of their relativistic jets. Observations of AGN with CTA will enable a measurement of γ absorption on the extragalactic background light with a statistical uncertainty below 15% up to a redshift z=2 and to constrain or detect γ halos up to intergalactic-magnetic-field strengths of at least 0.3 pG . Extragalactic observations with CTA also show promising potential to probe physics beyond the Standard Model. The best limits on Lorentz invariance violation from γ astronomy will be improved by a factor of at least two to three. CTA will also probe the parameter space in which axion-like particles could constitute a significant fraction, if not all, of dark matter. We conclude on the synergies between CTA and other upcoming facilities that will foster the growth of γ cosmology

Multi-messenger Observations of a Binary Neutron Star Merger

International audienceOn 2017 August 17 a binary neutron star coalescence candidate (later designated GW170817) with merger time 12:41:04 UTC was observed through gravitational waves by the Advanced LIGO and Advanced Virgo detectors. The Fermi Gamma-ray Burst Monitor independently detected a gamma-ray burst (GRB 170817A) with a time delay of $\sim 1.7\,{\rm{s}}$ with respect to the merger time. From the gravitational-wave signal, the source was initially localized to a sky region of 31 deg(2) at a luminosity distance of ${40}_{-8}^{+8}$ Mpc and with component masses consistent with neutron stars. The component masses were later measured to be in the range 0.86 to 2.26 $\,{M}_{\odot }$. An extensive observing campaign was launched across the electromagnetic spectrum leading to the discovery of a bright optical transient (SSS17a, now with the IAU identification of AT 2017gfo) in NGC 4993 (at $\sim 40\,{\rm{Mpc}}$) less than 11 hours after the merger by the One-Meter, Two Hemisphere (1M2H) team using the 1 m Swope Telescope. The optical transient was independently detected by multiple teams within an hour. Subsequent observations targeted the object and its environment. Early ultraviolet observations revealed a blue transient that faded within 48 hours. Optical and infrared observations showed a redward evolution over ∼10 days. Following early non-detections, X-ray and radio emission were discovered at the transient’s position $\sim 9$ and $\sim 16$ days, respectively, after the merger. Both the X-ray and radio emission likely arise from a physical process that is distinct from the one that generates the UV/optical/near-infrared emission. No ultra-high-energy gamma-rays and no neutrino candidates consistent with the source were found in follow-up searches. These observations support the hypothesis that GW170817 was produced by the merger of two neutron stars in NGC 4993 followed by a short gamma-ray burst (GRB 170817A) and a kilonova/macronova powered by the radioactive decay of r-process nuclei synthesized in the ejecta