Formulation and evaluation of new polyherbal germicidal toothpaste containing ajwain oil

The main object of the present research is to provide a formulation useful as natural herbal tooth paste which obviates the drawbacks of the earlier tooth pastes.And its to provide a good tooth paste which can give effective protection to teeth and free them from any toxicity or toxic residue and irritation when regularly used. It should be cosmetically acceptable having pleasant odour and should not leave stain on teeth or fingers after use. Brightening the teeth by removing stains would be a prerequisite of the formulation.Still another object of the present invention is highlight the potential of extract of ajwain seed in inhibiting  the activity of Streptococcus mutans bacteria which are major cause of dental caries. The study attributed presence of naphthalene derivative responsible for such protective antibiofilm activity. Ajwain oil is proven to cure tooth pain. Along with equal parts of clove oil and water, it is used as home remedy to floss mouth and treat tooth ache, bad breath and tooth decay. Keywords: Halitosis, Gingivitis and Periodontiti

Anti-bacterial activity of inorganic nanomaterials and their antimicrobial peptide conjugates against resistant and non-resistant pathogens

This review details the antimicrobial applications of inorganic nanomaterials of mostly metallic form, and the augmentation of activity by surface conjugation of peptide ligands. The review is subdivided into three main sections, of which the first describes the antimicrobial activity of inorganic nanomaterials against gram-positive, gram-negative and multidrug-resistant bacterial strains. The second section highlights the range of antimicrobial peptides and the drug resistance strategies employed by bacterial species to counter lethality. The final part discusses the role of antimicrobial peptide-decorated inorganic nanomaterials in the fight against bacterial strains that show resistance. General strategies for the preparation of antimicrobial peptides and their conjugation to nanomaterials are discussed, emphasizing the use of elemental and metallic oxide nanomaterials. Importantly, the permeation of antimicrobial peptides through the bacterial membrane is shown to aid the delivery of nanomaterials into bacterial cells. By judicious use of targeting ligands, the nanomaterial becomes able to differentiate between bacterial and mammalian cells and, thus, reduce side effects. Moreover, peptide conjugation to the surface of a nanomaterial will alter surface chemistry in ways that lead to reduction in toxicity and improvements in biocompatibility

Simple and efficient filters for performance improvement in joint transform correlator

220-222<span style="font-size:14.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" color:black;mso-ansi-language:en-in;mso-fareast-language:en-in;mso-bidi-language:="" hi"="" lang="EN-IN">Joint transform correlator is most suited to find correspondence between two opticals signals. If they are identical correlation peaks are seen in the output. However there is noise and extraction of peaks becomes difficult. Present paper proposes simple and efficient filters for improving the performance of joint transform correlator. Correlation peaks between target and reference are extracted by using simple directional and positional filters. These filters can be used with prior knowledge of the target and reference positions in the input and hence most suitable for finger print identification.</span

Laboratory analysis of patients with SARS-CoV-2 Infection in a semi-urban COVID-19 center of Lucknow, India

Timely analysis of the laboratory characteristics associated with 2019 novel coronavirus infection (COVID-19) can assist with clinical diagnosis and prognosis. This study is a collection of clinical data from 100 hospitalized patients diagnosed with COVID-19 in a dedicated COVID- 19 health center located in a semi-urban area from July to September, 2020. The average age of the patients was 50 years. The proportion of patients with comorbidities was 59%. Lymphocyte counts were reduced in the routine blood-work for all patients, but significantly lower in L2-type patients. Elevation of D-Dimer with near normal PT and APTT were detected in coagulation function tests, and more significant changes were observed in L2-type patients compared to L1-type patients. Serum ferritin levels were sensitive to SARS-CoV (severe acute respiratory syndrome coronavirus-2) infection and found to rise in L2-type patients more than L1-type patients. Inflammatory markers, CRP and Interleukin-6 (IL-6) were significantly increased in all patients, but higher in L2-type patients compared to L1-type patients. Coming to organ damage, kidney injury was the most common organ affected by COVID-19 followed by heart and liver.&nbsp

Laboratory Analysis of Patients with SARS-CoV-2 Infection in A Semi-urban COVID-19 CENTER of Lucknow, India

Timely analysis of the laboratory characteristics associated with 2019 novel coronavirus infection (COVID-19) can assist with clinical diagnosis and prognosis. This study is a collection of clinical data from 100 hospitalized patients diagnosed with COVID-19 in a dedicated COVID- 19 health center located in a semi-urban area from July to September, 2020. The average age of the patients was 50 years. The proportion of patients with comorbidities was 59%. Lymphocyte counts were reduced in the routine blood-work for all patients, but significantly lower in L2-type patients. Elevation of D-Dimer with near normal PT and APTT were detected in coagulation function tests, and more significant changes were observed in L2-type patients compared to L1-type patients. Serum ferritin levels were sensitive to SARS-CoV (severe acute respiratory syndrome coronavirus-2) infection and found to rise in L2-type patients more than L1-type patients. Inflammatory markers, CRP and Interleukin-6 (IL-6) were significantly increased in all patients, but higher in L2-type patients compared to L1-type patients. Coming to organ damage, kidney injury was the most common organ affected by COVID-19 followed by heart and liver.&nbsp

CoSP approach for the synthesis of blue MoO3 nanoparticles for application as hole transport layer (HTL) in organic solar cells

The synthesis of MoO3 nanoparticles is reported using a Continuous Spray. Pyrolysis (CoSP) reactor and the influence of zone temperature, precursor concentration on the structural and morphological properties is investigated. The collected nanoparticles are utilized to prepare thin films by spin coating and further annealing at various temperatures. The improvement in morphology, crystallinity and the band gap shift shows the effectiveness of the annealing treatment in creating a proper hole transport layer for device applications. The technique thus allows the film formation using a non-vacuum method well suited for organic solar cells. The CoSP based MoO3 (CoSP_MoO3) films are demonstrated to have equal performance to hole-injection layers composed of thermally evaporated MoO3 (eMoO(3))