Factors associated with self-perceived state of health in adolescents with congenital cardiac disease attending paediatric cardiologic clinics

The purpose of our study was to determine the ways in which adolescents with congenital cardiac disease believed that the condition had affected their life, and how these views were related to their perceived health. Interviews were conducted with a series of 37 adolescents, 17 girls and 20 boys, aged from 11 to 18, as they attended the clinics of 4 paediatric cardiologists in a teaching hospital in the United Kingdom. Transcripts of the interviews were analysed for recurring themes. A questionnaire was formed consisting of a set of questions for each theme, and additional items eliciting “perceived health”, and administered to a second series of 74 adolescents, 40 boys and 34 girls, who were again aged from 11 to 18 years. Slightly less than half (46%) perceived their health as either “good” or “very good”, and one-third (33%) rated it as “average”. The majority (66%) felt themselves to be “the same” as, or only very slightly “different” from, their peers. The assessment of the seriousness of their condition by the adolescents, the degree to which they saw themselves as different from others, and their perceived health, were not related to the “complexity of the underlying medical condition” as rated by their physician. It was the psychosocial themes, such as exclusion from activities or the effect of the condition on relationships, that were most strongly related to the perception of their health by the adolescents. Improved education of parents, teachers and peers, and attendance at classes for cardiac rehabilitation, might help to ameliorate some of these problems

On-the-fly memory compression for multibody algorithms.

Memory and bandwidth demands challenge developers of particle-based codes that have to scale on new architectures, as the growth of concurrency outperforms improvements in memory access facilities, as the memory per core tends to stagnate, and as communication networks cannot increase bandwidth arbitrary. We propose to analyse each particle of such a code to find out whether a hierarchical data representation storing data with reduced precision caps the memory demands without exceeding given error bounds. For admissible candidates, we perform this compression and thus reduce the pressure on the memory subsystem, lower the total memory footprint and reduce the data to be exchanged via MPI. Notably, our analysis and transformation changes the data compression dynamically, i.e. the choice of data format follows the solution characteristics, and it does not require us to alter the core simulation code

Uncovering the chemical structure of the pulsating low-mass white dwarf SDSS J115219.99+024814.4

Pulsating low-mass white dwarf stars are white dwarfs with stellar masses between 0.30 M⊙ and 0.45 M⊙ that show photometric variability due to gravity-mode pulsations. Within this mass range, they can harbour both a helium- and hybrid-core, depending if the progenitor experienced helium-core burning during the pre-white dwarf evolution. SDSS J115219.99+024814.4 is an eclipsing binary system where both components are low-mass white dwarfs, with stellar masses of 0.362±0.014 M⊙ and 0.325±0.013 M⊙. In particular, the less massive component is a pulsating star, showing at least three pulsation periods of ∼1314 s, ∼1069 s and ∼582.9 s. This opens the way to use asteroseismology as a tool to uncover its inner chemical structure, in combination with the information obtained using the light-curve modelling of the eclipses. To this end, using binary evolutionary models leading to helium- and hybrid-core white dwarfs, we compute adiabatic pulsations for ℓ = 1 and ℓ = 2 gravity modes with Gyre. We found that the pulsating component of the SDSS J115219.99+024814.4 system must have a hydrogen envelope thinner that the value obtained from binary evolution computations, independently of the inner composition. Finally, from our asteroseismological study, we find a best fit model characterised by Teff = 10 917 K, M=0.338 M⊙, MH = 10−6 M⊙ with the inner composition of a hybrid WD

On-the-fly memory compression for multibody algorithms

Memory and bandwidth demands challenge developers of particle-based codes that have to scale on new architectures, as the growth of concurrency outperforms improvements in memory access facilities, as the memory per core tends to stagnate, and as communication networks cannot increase bandwidth arbitrary. We propose to analyse each particle of such a code to find out whether a hierarchical data representation storing data with reduced precision caps the memory demands without exceeding given error bounds. For admissible candidates, we perform this compression and thus reduce the pressure on the memory subsystem, lower the total memory footprint and reduce the data to be exchanged via MPI. Notably, our analysis and transformation changes the data compression dynamically, i.e. the choice of data format follows the solution characteristics, and it does not require us to alter the core simulation code

Thermoelectric effects in superconducting proximity structures

Attaching a superconductor in good contact with a normal metal makes rise to a proximity effect where the superconducting correlations leak into the normal metal. An additional contact close to the first one makes it possible to carry a supercurrent through the metal. Forcing this supercurrent flow along with an additional quasiparticle current from one or many normal-metal reservoirs makes rise to many interesting effects. The supercurrent can be used to tune the local energy distribution function of the electrons. This mechanism also leads to finite thermoelectric effects even in the presence of electron-hole symmetry. Here we review these effects and discuss to which extent the existing observations of thermoelectric effects in metallic samples can be explained through the use of the dirty-limit quasiclassical theory.Comment: 14 pages, 10 figures. 374th WE-Heraus seminar: Spin physics of superconducting heterostructures, Bad Honnef, 200

Quantification of muco-obstructive lung disease variability in mice via laboratory X-ray velocimetry

To effectively diagnose, monitor and treat respiratory disease clinicians should be able to accurately assess the spatial distribution of airflow across the fine structure of lung. This capability would enable any decline or improvement in health to be located and measured, allowing improved treatment options to be designed. Current lung function assessment methods have many limitations, including the inability to accurately localise the origin of global changes within the lung. However, X-ray velocimetry (XV) has recently been demonstrated to be a sophisticated and non-invasive lung function measurement tool that is able to display the full dynamics of airflow throughout the lung over the natural breathing cycle. In this study we present two developments in XV analysis. Firstly, we show the ability of laboratory-based XV to detect the patchy nature of cystic fibrosis (CF)-like disease in β-ENaC mice. Secondly, we present a technique for numerical quantification of CF-like disease in mice that can delineate between two major modes of disease symptoms. We propose this analytical model as a simple, easy-to-interpret approach, and one capable of being readily applied to large quantities of data generated in XV imaging. Together these advances show the power of XV for assessing local airflow changes. We propose that XV should be considered as a novel lung function measurement tool for lung therapeutics development in small animal models, for CF and for other muco-obstructive diseases.Freda Werdiger, Martin Donnelley, Stephen Dubsky, Rhiannon P. Murrie, Richard P. Carnibella, Chaminda R. Samarage ... et al

Search for Higgs bosons decaying to tautau pairs in ppbar collisions at sqrt(s) = 1.96 TeV

We present a search for the production of neutral Higgs bosons decaying into tautau pairs in ppbar collisions at a center-of-mass energy of 1.96 TeV. The data, corresponding to an integrated luminosity of 5.4 fb-1, were collected by the D0 experiment at the Fermilab Tevatron Collider. We set upper limits at the 95% C.L. on the product of production cross section and branching ratio for a scalar resonance decaying into tautau pairs, and we then interpret these limits as limits on the production of Higgs bosons in the minimal supersymmetric standard model (MSSM) and as constraints in the MSSM parameter space.Comment: 7 pages, 5 figures, submitted to PL

Measurement of three-jet differential cross sections d sigma-3jet / d M-3jet in p anti-p collisions at sqrt(s)=1.96 TeV

We present the first measurement of the inclusive three-jet differential cross section as a function of the invariant mass of the three jets with the largest transverse momenta in an event in p anti-p collisions at sqrt(s) = 1.96 TeV. The measurement is made in different rapidity regions and for different jet transverse momentum requirements and is based on a data set corresponding to an integrated luminosity of 0.7 fb^{-1} collected with the D0 detector at the Fermilab Tevatron Collider. The results are used to test the three-jet matrix elements in perturbative QCD calculations at next-to-leading order in the strong coupling constant. The data allow discrimination between parametrizations of the parton distribution functions of the proton.Comment: 10 pages, 4 figures, 2 tables, submitted to Phys. Lett. B, corrected chi2 values for NNPD

Measurements of inclusive W+jets production rates as a function of jet transverse momentum in ppbar collisions at sqrt{s}=1.96 TeV

This Letter describes measurements of inclusive W (--> e nu) + n jet cross sections (n = 1-4), presented as total inclusive cross sections and differentially in the nth jet transverse momentum. The measurements are made using data corresponding to an integrated luminosity of 4.2 fb-1 collected by the D0 detector at the Fermilab Tevatron Collider, and achieve considerably smaller uncertainties on W +jets production cross sections than previous measurements. The measurements are compared to next-to-leading order perturbative QCD (pQCD) calculations in the n =1-3 jet multiplicity bins and to leading order pQCD calculations in the 4-jet bin. The measurements are generally in agreement with pQCD predictions, although certain regions of phase space are identified where the calculations could be improved