127 research outputs found

    Geographic concentration of economic activities: on the validation of a distance-based mathematical index to identify optimal locations

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    The present study proposes a validation of a mathematical index Q able to identify optimal geographic places for economic activities, solely based on the location variable. This research work takes its roots in the 1970s with the statistical analysis of spatial patterns, or analysis of point processes, whose main goal is to understand if a resulting spatial distribution of points is due to chance or not. Indeed point objects are commonplace (towns in regions, plants in the landscape, galaxies in space, shops in towns) and the development of specific mathematical tools are useful to understand their own location processes. Spatial point deviations from purely random configurations may be analyzed either by quadrat or by distance methods. An interesting method of the second category – the cumulative function M – was developed recently for evaluating the relative geographic concentration and co-location of industries in a nonhomogeneous spatial framework. On this basis, and having quantified retail store interactions, The French physicist Pablo Jensen elaborated the Q-index to automatically detect promising locations. To test the relevance of this quality index, Jensen used location data from 2003 and 2005 for bakeries in the city of Lyon and discovered that between these two years, shops having closed were located on significantly lower quality sites. Here, using bankruptcy data provided by the Registrar of companies of the State of Valais in Switzerland and by the City Council of Glasgow in Scotland, we implemented a method based on univariate logistic regressions to systematically test for the relevance of the Q-index on the many commercial categories available. We show that the Q-index is reliable, although significance tests did not reach stringent levels. Access to trustable bankruptcy data remains a difficult task

    Syn-tectonic sedimentary evolution of the Miocene Çatallar Basin, southwestern Turkey

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    International audienceThe Çatallar Basin is one of the Miocene basins located in the southern part of the Bey Dağları Massif (SW Turkey). This basin has been reinvestigated and new stratigraphic and sedimentological data are now presented. The Çatallar Basin lies in paraconformity on the Bey Dağları carbonate platform of Late Cretaceous to Palaeogene age. It consists of an impersistent, shallow-marine carbonate base (Karabayır formation, Late Oligocene to Early Burdigalian) followed by an onlapping detrital sequence including the Akçay and Bağbeleni formations (Langhian to Serravallian). The Akçay formation mainly contains turbidites in which several debris-flows and olistostromes are intercalated. The lowest debris flows derive from the local carbonate platforms of Cretaceous and Palaeogene age. Higher, the debris flows and olistostromes contain large carbonate blocks deriving from nearby sources (Bey Dağları platform carbonates), whereas the accompanying pebbles originate from the allochthonous ophiolitic units located farther to the north (Lycian Nappes) or to the east (Antalya Nappes). The origin of these ophiolitic detritus is a matter of debate. The new data obtained in this study favour a northern origin

    Social contact patterns and implications for infectious disease transmission: a systematic review and meta-analysis of contact surveys

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    Background: Transmission of respiratory pathogens such as SARS-CoV-2 depends on patterns of contact and mixing across populations. Understanding this is crucial to predict pathogen spread and the effectiveness of control efforts. Most analyses of contact patterns to date have focussed on high-income settings. Methods: Here, we conduct a systematic review and individual-participant meta-analysis of surveys carried out in low- and middle-income countries and compare patterns of contact in these settings to surveys previously carried out in high-income countries. Using individual-level data from 28,503 participants and 413,069 contacts across 27 surveys we explored how contact characteristics (number, location, duration and whether physical) vary across income settings. Results: Contact rates declined with age in high- and upper-middle-income settings, but not in low-income settings, where adults aged 65+ made similar numbers of contacts as younger individuals and mixed with all age-groups. Across all settings, increasing household size was a key determinant of contact frequency and characteristics, but low-income settings were characterised by the largest, most intergenerational households. A higher proportion of contacts were made at home in low-income settings, and work/school contacts were more frequent in high-income strata. We also observed contrasting effects of gender across income-strata on the frequency, duration and type of contacts individuals made. Conclusions: These differences in contact patterns between settings have material consequences for both spread of respiratory pathogens, as well as the effectiveness of different non-pharmaceutical interventions

    Author response: Social contact patterns and implications for infectious disease transmission – a systematic review and meta-analysis of contact surveys

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    BACKGROUND: Transmission of respiratory pathogens such as SARS-CoV-2 depends on patterns of contact and mixing across populations. Understanding this is crucial to predict pathogen spread and the effectiveness of control efforts. Most analyses of contact patterns to date have focused on high-income settings. METHODS: Here, we conduct a systematic review and individual-participant meta-analysis of surveys carried out in low- and middle-income countries and compare patterns of contact in these settings to surveys previously carried out in high-income countries. Using individual-level data from 28,503 participants and 413,069 contacts across 27 surveys, we explored how contact characteristics (number, location, duration, and whether physical) vary across income settings. RESULTS: Contact rates declined with age in high- and upper-middle-income settings, but not in low-income settings, where adults aged 65+ made similar numbers of contacts as younger individuals and mixed with all age groups. Across all settings, increasing household size was a key determinant of contact frequency and characteristics, with low-income settings characterised by the largest, most intergenerational households. A higher proportion of contacts were made at home in low-income settings, and work/school contacts were more frequent in high-income strata. We also observed contrasting effects of gender across income strata on the frequency, duration, and type of contacts individuals made. CONCLUSIONS: These differences in contact patterns between settings have material consequences for both spread of respiratory pathogens and the effectiveness of different non-pharmaceutical interventions. FUNDING: This work is primarily being funded by joint Centre funding from the UK Medical Research Council and DFID (MR/R015600/1)

    Formulation, construction and analysis of kinetic models of metabolism: A review of modelling frameworks

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    Spin Exchange Monitoring of the Strong Positive Homotropic Allosteric Binding of a Tetraradical by a Synthetic Receptor in Water

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    Next step: on the validation of the Q index to identify optimal locations for economic activities

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    The present study proposes a validation of a mathematical index Q able to identify optimal geographic places for economic activities, solely based on the location variable. This research work takes its roots in the 1970s with the statistical analysis of spatial patterns, or analysis of point processes, whose main goal is to understand if a resulting spatial distribution of points is due to chance or not. Indeed point objects are commonplace (towns in regions, plants in the landscape, galaxies in space, shops in towns) and the development of specific mathematical tools are useful to understand their own location processes. Spatial point deviations from purely random configurations may be analyzed either by quadrat or by distance methods. An interesting method of the second category – the cumulative function M – was developed recently for evaluating the relative geographic concentration and co-location of industries in a nonhomogeneous spatial framework. On this basis, and having quantified retail store interactions, the French physicist Pablo Jensen elaborated the Q-index to automatically detect promising locations. To test the relevance of this quality index, Jensen used location data from 2003 and 2005 for bakeries in the city of Lyon and discovered that between these two years, shops having closed were located on significantly lower quality sites. Here, using bankruptcy data provided by the Registrar of companies of the State of Valais in Switzerland and by the City Council of Glasgow in Scotland, we implemented a method based on univariate logistic regressions to systematically test for the relevance of the Q-index on the many commercial categories available. We show that the Q-index is reliable, although significance tests did not reach stringent levels. Access to trustable bankruptcy data remains a difficult task

    A Fossil Morphology: The Miocene Fluvial Network of the Western Taurus (Turkey)

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    International audienceIn Southern Turkey, east of Antalya, the Taurus chain contains traces of several fossil valleys incised into the most karstic areas of a high surface (1500–2200 m). These streamless valleys exhibit meanders and dry tributaries that are fragments of a former network directed NE-SW, at right angles to the structures of the Taurus chain. All these disconnected landforms are older than the Quaternary tectonic uplift of the chain. This older age is pointed out not only by a difference in orientation between the fossil network and the present drainage (which is not yet fully organised), but also by morphological contrasts between the fossil (wide valleys remnants) and recent (deeply incised rivers in narrow gorges) networks. At lower altitudes in the same area, Miocene conglomerates in the Manavgat Basin contain pebbles that can be confidently traced back to their source areas, owing to their distinctive lithologies. The study of the distribution and content of these conglomerates indicate a detrital origin located inland towards Central Anatolia where specific outcrops are located. While the fossil river network evidenced on the uppermost surfaces of the chain answers the question of how this detrital material could have travelled about eighty kilometres through the Taurus calcareous units, the age of the conglomerates allows dating the uplifted fossil valleys back to the Early Miocene
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