1,246 research outputs found
Evaluation of renal Kt/V as a marker of renal function in predialysis patients
Evaluation of renal Kt/V as a marker of renal function in predialysis patients.BackgroundThe use of renal Kt/V (r-Kt/V) as an indicator for the need of dialysis initiation has been recommended in the NKF-DOQI guidelines. In analogy to clinical practice in peritoneal dialysis, a fall of r-Kt/V below a threshold of 2.0 per week may indicate inadequate renal toxin elimination. However, there are no studies linking r-Kt/V with other parameters of glomerular filtration rate (GFR) in predialysis patients, and the validity of r-Kt/V as parameter for timing of dialysis initiation is unknown.MethodsRenal function was assessed repeatedly in 125 patients (N = 465 measurements). In predialysis patients (r-Kt/V <2.5 per week) r-Kt/V was compared with creatinine [CCr], urea [CUr], averaged creatinine/urea clearance [CCr/Ur], Cockcroft-Gault formula [CCG], and MDRD prediction equation 6 (MDRD6-GFR). The diagnostic performance of r-Kt/V as a parameter for timing the initiation of dialysis was evaluated.ResultsRenal Kt/V <2.5 was prevalent in 24.9% of cases (N = 116, mean 1.92 ± 0.34). In this group mean CCr was 13.8 ± 4.9, mean CUr 6.7 ± 1.3, and CCr/Ur 10.2 ± 2.9mL/min/1.73m2. There was no correlation of r-Kt/V with serum creatinine and MDRD6-GFR, but a significantly positive correlation with CCr/Ur (r2 = 0.3382, P < 0.001). Sensitivity of r-Kt/V to detect CCr/Ur < 10.5mL/min/1.73m2, defined as the threshold for dialysis initiation, was 73.6% with a specificity of 91.9%.ConclusionsThese results suggest that r-Kt/V is a parameter of acceptable specificity but poor sensitivity for the timing of dialysis initiation. Additional measures of renal function, such as the average of measured creatinine and urea clearance, also should be taken into consideration when deciding on the timing of dialysis initiation prior to the development of clinical signs of uremia and malnutrition
Self-reported medication in community-dwelling older adults in Germany: results from the Berlin Initiative Study
Background: Older adults have the highest drug utilization due to multimorbidity. Although the number of people over age 70 is expected to double within the next decades, population-based data on their medication patterns are scarce especially in combination with polypharmacy and potentially inappropriate medication (PIM). Our objective was to analyse the frequency of polypharmacy, pattern of prescription (PD) and over-the-counter (OTC) drug usage, and PIMs according to age and gender in a population-based cohort of very old adults in Germany.
Methods: Cross-sectional baseline data of the Berlin Initiative Study, a prospective cohort study of community-dwelling adults aged ≥70 years with a standardized interview including demographics, lifestyle variables, co-morbidities, and medication assessment were analysed. Medication data were coded using the Anatomical Therapeutic Chemical (ATC) classification. Age- and sex-standardized descriptive analysis of polypharmacy (≥5 drugs, PD and OTC vs. PD only and regular and on demand drugs vs regular only), medication frequency and distribution, including PIMs, was performed by age (</≥80) and gender.
Results: Of 2069 participants with an average age of 79.5 years, 97% (95%CI [96%;98%]) took at least one drug and on average 6.2 drugs (SD = 3.5) with about 40 to 66% fulfilling the criteria of polypharmacy depending on the definition. Regarding drug type more female participants took a combination of PD and OTC (male: 68%, 95%CI [65%;72%]); female: 78%, 95%CI [76%;80%]). Most frequently used were drugs for cardiovascular diseases (85%, 95%CI [83%;86%]). Medication frequency increased among participants aged ≥80 years, especially for cardiovascular drugs, antithrombotics, psychoanaleptics and dietary supplements. Among the top ten prescription drugs were mainly cardiovascular drugs including lipid-lowering agents (simvastatin), beta-blockers (metoprolol, bisoprolol) and ACE inhibitors (ramipril). The most common OTC drug was acetylsalicylic acid (35%; 95%CI [33%;37%])). Dose-independent PIM were identified for 15% of the participants.
Conclusions: Polypharmacy was excessive in older adults, with not only PD but also OTC drugs contributing to the high point prevalence. The medication patterns reflected the treatment of chronic diseases in this age group. There was even an increase in medication frequency between below and above 80 years especially for drugs of cardiovascular diseases, antithrombotic medication, psychoanaleptics, and dietary supplements
Parton Distributions Working Group
The main focus of this working group was to investigate the different issues
associated with the development of quantitative tools to estimate parton
distribution functions uncertainties. In the conclusion, we introduce a
"Manifesto" that describes an optimal method for reporting data.Comment: Report of the Parton Distributions Working Group of the 'QCD and Weak
Boson Physics workshop in preparation for Run II at the Fermilab Tevatron'.
Co-Conveners: L. de Barbaro, S.A. Keller, S. Kuhlmann, H. Schellman, and
W.-K. Tun
A GLOBAL QCD STUDY OF DIRECT PHOTON PRODUCTION
A global QCD analysis of the direct photon production process from both fixed
target and collider experiments is presented. These data sets now completely
cover the parton range from 0.01 to 0.6, thereby providing a stringent test
of perturbative QCD and parton distributions. Previous detailed studies of
direct photons emphasized fixed target data. We find most data sets have a
steeper distribution than the QCD prediction. Neither global fits with
new parton distributions nor improved photon fragmentation functions can
resolve this problem since the deviation occurs at different values for
experiments at different energies. A more likely explanation is the need for
additional broadening of the of the initial state partons. The magnitude
and the possible physical origin of this effect are investigated and discussed.Comment: 8 page Latex file using epsf.sty for figures. 6 eps figures submitted
separately in uuencoded file
Pattern selection in the absolutely unstable regime as a nonlinear eigenvalue problem: Taylor vortices in axial flow
A unique pattern selection in the absolutely unstable regime of a driven,
nonlinear, open-flow system is analyzed: The spatiotemporal structures of
rotationally symmetric vortices that propagate downstream in the annulus of the
rotating Taylor-Couette system due to an externally imposed axial through-flow
are investigated for two different axial boundary conditions at the in- and
outlet. Unlike the stationary patterns in systems without through-flow the
spatiotemporal structures of propagating vortices are independent of parameter
history, initial conditions, and system's length. They do, however, depend on
the axial boundary conditions, the driving rate of the inner cylinder and the
through-flow rate. Our analysis of the amplitude equation shows that the
pattern selection can be described by a nonlinear eigenvalue problem with the
frequency being the eigenvalue. Approaching the border between absolute and
convective instability the eigenvalue problem becomes effectively linear and
the selection mechanism approaches that one of linear front propagation.
PACS:47.54.+r,47.20.Ky,47.32.-y,47.20.FtComment: 15 pages (LateX-file), 8 figures (Postscript
kt Effects in Direct-Photon Production
We discuss the phenomenology of initial-state parton-kt broadening in
direct-photon production and related processes in hadron collisions. After a
brief summary of the theoretical basis for a Gaussian-smearing approach, we
present a systematic study of recent results on fixed-target and collider
direct-photon production, using complementary data on diphoton and pion
production to provide empirical guidance on the required amount of kt
broadening. This approach provides a consistent description of the observed
pattern of deviation of next-to-leading order QCD calculations relative to the
direct-photon data, and accounts for the shape and normalization difference
between fixed-order perturbative calculations and the data. We also discuss the
uncertainties in this phenomenological approach, the implications of these
results on the extraction of the gluon distribution of the nucleon, and the
comparison of our findings to recent related work.Comment: LaTeX, uses revtex and epsf, 37 pages, 15 figure
Temperature calibration of Mg/Ca ratios in the intermediate water benthic foraminifer Hyalinea balthica
Author Posting. © American Geophysical Union, 2011. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry Geophysics Geosystems 12 (2011): Q04003, doi:10.1029/2010GC003333.Core top samples from Indonesian and northeast Atlantic depth transects were used to calibrate Mg/Ca and δ18O in tests of the calcitic benthic foraminifer Hyalinea balthica to bottom water temperature between 4°C and 13°C. This shallow infaunal species is primarily abundant in neritic to upper bathyal sediments (<600 m). Both linear and exponential calibrations suggest a temperature sensitivity of ~12% per °C that is ~4 times higher than observed in other species of deep-sea benthic foraminifera. Culture experiments support the core top calibration. We find no discernible effect of salinity and saturation on Mg/Ca. Comparison between the measured benthic foraminiferal δ18O and predicted equilibrium values suggests that on average H. balthica δ18O is 0.64‰ ± 0.13‰ lower than predicted from the equilibrium composition. To test the reliability of using paired H. balthica Mg/Ca and δ18O measurements for reconstructing seawater δ18Osw and salinity, we apply this calibration to another depth transect from Cape Ghir off NW Africa, which was not included in the calibration. Based on error analysis of the calibration data and this validation test, we show that the uncertainty of reconstructing bottom water temperature and salinity from paired Mg/Ca and δ18O measurements of H. balthica is better than ±0.7°C and ±0.69 practical salinity scale, respectively. The small uncertainties allow for the reconstruction of seawater density to better than 0.3σθ units, which is precise enough for the identification of specific water masses and reconstruction of changes in their properties. We propose that the relatively high Mg content and temperature sensitivity of H. balthica might be due to minor, biologically mediated contribution of high-Mg calcite to the primarily low Mg calcite test, which is influenced by the ambient temperature. This hypothesis, if correct, suggests that benthic species with relatively high Mg/Ca may be better suited for deepwater temperature reconstructions than species that have thus far been more commonly used.This project
was funded by NSF Awards OCE 02‐20922 and 09‐02977 to
YR, OCE 09‐28607 to MK, OCE02‐20776 to DWO, and DFG
priority program INTERDYNAMIK to AM
Spin-photon interface and spin-controlled photon switching in a nanobeam waveguide
Access to the electron spin is at the heart of many protocols for integrated
and distributed quantum-information processing [1-4]. For instance, interfacing
the spin-state of an electron and a photon can be utilized to perform quantum
gates between photons [2,5] or to entangle remote spin states [6-9].
Ultimately, a quantum network of entangled spins constitutes a new paradigm in
quantum optics [1]. Towards this goal, an integrated spin-photon interface
would be a major leap forward. Here we demonstrate an efficient and optically
programmable interface between the spin of an electron in a quantum dot and
photons in a nanophotonic waveguide. The spin can be deterministically prepared
with a fidelity of 96\%. Subsequently the system is used to implement a
"single-spin photonic switch", where the spin state of the electron directs the
flow of photons through the waveguide. The spin-photon interface may enable
on-chip photon-photon gates [2], single-photon transistors [10], and efficient
photonic cluster state generation [11]
Measurement of the lepton charge asymmetry in W-boson decays produced in p-pbar collisions
We describe a measurement of the charge asymmetry of leptons from W boson
decays in the rapidity range 0 enu, munu events from
110+/-7 pb^{-1}of data collected by the CDF detector during 1992-95. The
asymmetry data constrain the ratio of d and u quark momentum distributions in
the proton over the x range of 0.006 to 0.34 at Q2 \approx M_W^2. The asymmetry
predictions that use parton distribution functions obtained from previously
published CDF data in the central rapidity region (0.0<|y_l|<1.1) do not agree
with the new data in the large rapidity region (|y_l|>1.1).Comment: 13 pages, 3 tables, 1 figur
Measurement of the Lifetime Difference Between B_s Mass Eigenstates
We present measurements of the lifetimes and polarization amplitudes for B_s
--> J/psi phi and B_d --> J/psi K*0 decays. Lifetimes of the heavy (H) and
light (L) mass eigenstates in the B_s system are separately measured for the
first time by determining the relative contributions of amplitudes with
definite CP as a function of the decay time. Using 203 +/- 15 B_s decays, we
obtain tau_L = (1.05 +{0.16}/-{0.13} +/- 0.02) ps and tau_H = (2.07
+{0.58}/-{0.46} +/- 0.03) ps. Expressed in terms of the difference DeltaGamma_s
and average Gamma_s, of the decay rates of the two eigenstates, the results are
DeltaGamma_s/Gamma_s = (65 +{25}/-{33} +/- 1)%, and DeltaGamma_s = (0.47
+{0.19}/-{0.24} +/- 0.01) inverse ps.Comment: 8 pages, 3 figures, 2 tables; as published in Physical Review Letters
on 16 March 2005; revisions are for length and typesetting only, no changes
in results or conclusion
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