The Economics of Reproduction-Related Health Care

This paper presents the first systematic estimates of the direct money costs of reproduction-related health services. In 1982 Americans spent approximately $17.7 billion for contraception, abortion, treatment of infertility, obstetrical care, and infant care. This represented 5.5 percent of total health care spending and was equal to$327 per woman of reproductive age (15?44). Obstetrical care accounted for almost half of the reproduction-related expenditures and infant care accounted for morethan one-third. The paper discusses the demographic, technologic, economic,and sociopolitical factors that determine these expenditures. It also considers related public policy issues regarding legal status, sources of funding, and allocation of resources.

How Journalists Think About the First Amendment Vis-à-Vis Their Coverage of Hate Groups

This study, based on in-depth interviews with U.S.-based journalists (n = 18), explores the increasingly fraught circumstances of reporting on hate groups. We examine how journalists think about the First Amendment vis-à-vis their coverage of such groups. Through the lens of media ecology and First Amendment principles and theories, we argue ultimately that journalists who cover hate groups use the First Amendment to identify their place in the journalistic environment

Le Forum, Vol. 42 No. 2

https://digitalcommons.library.umaine.edu/francoamericain_forum/1095/thumbnail.jp

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression

The PTEN phosphatase acts on phosphatidylinositol 3,4,5-triphosphates resulting from phosphatidylinositol 3-kinase (PI3K) activation. PTEN expression has been shown to be decreased in colorectal cancer. Little is known however as to the specific cellular role of PTEN in human intestinal epithelial cells. The aim of this study was to investigate the role of PTEN in human colorectal cancer cells.Caco-2/15, HCT116 and CT26 cells were infected with recombinant lentiviruses expressing a shRNA specifically designed to knock-down PTEN. The impact of PTEN downregulation was analyzed on cell polarization and differentiation, intercellular junction integrity (expression of cell-cell adhesion proteins, barrier function), migration (wound assay), invasion (matrigel-coated transwells) and on tumor and metastasis formation in mice. Electron microscopy analysis showed that lentiviral infection of PTEN shRNA significantly inhibited Caco-2/15 cell polarization, functional differentiation and brush border development. A strong reduction in claudin 1, 3, 4 and 8 was also observed as well as a decrease in transepithelial resistance. Loss of PTEN expression increased the spreading, migration and invasion capacities of colorectal cancer cells in vitro. PTEN downregulation also increased tumor size following subcutaneous injection of colorectal cancer cells in nude mice. Finally, loss of PTEN expression in HCT116 and CT26, but not in Caco-2/15, led to an increase in their metastatic potential following tail-vein injections in mice.Altogether, these results indicate that PTEN controls cellular polarity, establishment of cell-cell junctions, paracellular permeability, migration and tumorigenic/metastatic potential of human colorectal cancer cells

The Yeast Nuclear Pore Complex and Transport Through It

Exchange of macromolecules between the nucleus and cytoplasm is a key regulatory event in the expression of a cell’s genome. This exchange requires a dedicated transport system: (1) nuclear pore complexes (NPCs), embedded in the nuclear envelope and composed of proteins termed nucleoporins (or “Nups”), and (2) nuclear transport factors that recognize the cargoes to be transported and ferry them across the NPCs. This transport is regulated at multiple levels, and the NPC itself also plays a key regulatory role in gene expression by influencing nuclear architecture and acting as a point of control for various nuclear processes. Here we summarize how the yeast Saccharomyces has been used extensively as a model system to understand the fundamental and highly conserved features of this transport system, revealing the structure and function of the NPC; the NPC’s role in the regulation of gene expression; and the interactions of transport factors with their cargoes, regulatory factors, and specific nucleoporins

Medical informatics : computer applications in health care and biomedicine

New Yorkxxvii, 854 p.; 25 cm

Covering Hate: Field Theory and Journalistic Role Conception in Reporting on White Nationalist Rallies

In the United States, journalists covering white nationalist groups find themselves in an impossible situation: how do you cover the newsworthy rallies—and the concerns raised by the local community—without providing a platform for hate speech? The present study conducts in-depth, semi-structured interviews with 18 journalists who have covered white nationalist rallies. Through the lens of field theory, this study seeks to understand how journalists conceive of their role in such coverage, how they situate themselves within the field, and how they articulate the best practices for this challenging form of reporting. This study finds that white nationalist rallies presented a challenge to journalistic habitus, and journalists responded by drawing from the well of experience and professional socialization

How Journalists Think About the First Amendment Vis-à-Vis Their Coverage of Hate Groups

This study, based on in-depth interviews with U.S.-based journalists (n = 18), explores the increasingly fraught circumstances of reporting on hate groups. We examine how journalists think about the First Amendment vis-à-vis their coverage of such groups. Through the lens of media ecology and First Amendment principles and theories, we argue ultimately that journalists who cover hate groups use the First Amendment to identify their place in the journalistic environment

How Journalists Think About The First Amendment Vis-à-vis Their Coverage of Hate Groups

This study, based on in-depth interviews with U.S.-based journalists (n = 18), explores the increasingly fraught circumstances of reporting on hate groups. We examine how journalists think about the First Amendment vis-à-vis their coverage of such groups. Through the lens of media ecology and First Amendment principles and theories, we argue ultimately that journalists who cover hate groups use the First Amendment to identify their place in the journalistic environment