5,729 research outputs found
Kinematics and H_2 morphology of the multipolar Post-AGB star IRAS 16594-4656
context: The spectrum of IRAS 16594-4656 shows shock excited H_2 emission and
collisionally excited emission lines such as[O I],[C I],and [Fe II]. aim: The
goal is to determine the location of the H_2 and [Fe II] shock emission, to
determine the shock velocities,and constrain the physical properties in the
shock. methods: High resolution spectra of the H_2 1-0 S(1),H_2 2-1 S(1), [Fe
II], and Pa emission lines were obtained with the near infrared
spectrograph Phoenix on Gemini South. results: The position-velocity diagrams
of H_2 1-0 S(1), H_2 2-1 S(1), and [Fe II] are presented. The H_2 and [Fe II]
emission is spatially extended. The collisionally excited [O I] and [C I]
optical emission lines have a similar double peaked profile compared to the
extracted H_2 profile and appear to be produced in the same shock. They all
indicate an expansion velocity of ~8 km/s and the presence of a neutral, very
high density region with about 3 x 10^6 to 5 x10^7 cm. The
[Fe II] emission however is single peaked. It has a gaussian FWHM of 30 km/s
and a total width of 62 km/s at 1% of the peak. The Pa profile is even
wider with a gaussian FWHM of 48 km/s and a total width of 75 km/s at 1% of the
peak. conclusions: The H emission is excited in a slow 5 to 20 km/s shock
into dense material at the edge of the lobes, caused by the interaction of the
AGB ejecta and the post-AGB wind. The 3D representation of the H_2 data shows a
hollow structure with less H_2 emission in the equatorial region. The [Fe II]
emission is not present in the lobes, but originates close to the central star
in fast shocks in the post-AGB wind or in a disk. The Pa emission also
appears to originate close to the star.Comment: 11 pages and 8 figures; A&A in press; the paper includig high
resolution figures can be downloaded from
http://homepage.oma.be/gsteene/publications.htm
Shock emission in the bipolar post-AGB star IRAS 16594-4656
In this paper we study the near-infrared emission spectrum of IRAS
16594-4656, a bipolar post-AGB star with spectral type B7 and no observed
ionization. Using optical and near-infrared photometry we determined the total
extinction towards this object to be A_V=7.5 +/- 0.4 mag and derived a distance
of 2.2 +/- 0.4 kpc, assuming a luminosity of 10^4 L_sol. The near-infrared
spectrum shows strong H_2 emission lines and some typical metastable shock
excited lines such as [Fe II] 1.257 & 1.644 micron. We determined the
rotational and vibrational excitation temperatures, as well as the
ortho-to-para ratio of the molecular hydrogen. Based on these we argue that the
H_2 emission is mainly collisionally excited. Line ratios indicate that the H_2
emission originates in a +/- 25 km/s C-type shock. On the other hand, the
metastable lines, and especially the [Fe II] emission lines, indicate the
presence of a +/- 75 km/s J-type shock. Hence we postulate that the H_2
emission originates where the stellar wind (with an observed terminal velocity
of +/- 126 km/s) is funneled through an equatorial density enhancement,
impinging almost tangentially upon the circumstellar material. The [Fe II]
emission either occurs along the walls of the bipolar lobes where the
transverse shock velocity would be higher, or could originate much closer to
the central star in shocks in the post-AGB wind itself, or possibly even an
accretion disk. Further high resolution near-infrared spectra are currently
being obtained to confirm the proposed geometry and kinematics.Comment: 10 pages (Latex), 8 figures, accepted for publication by A&A, the ps
file is available at http://homepage.oma.be/gsteene/publications.htm
Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI
To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such parameter is vascular leakage, which is a response to tumour-derived vascular endothelial growth factor-A and can be measured by Gadolinium-DTPA (Gd-DTPA)-enhanced magnetic resonance imaging (MRI). However, as vascular permeability and angiogenesis are not strictly coupled, tumour blood volume may be another potentially important parameter. In this study, contrast-enhanced MR imaging was performed in three orthotopic mouse models for human brain tumours (angiogenic melanoma metastases and E34 and U87 human glioma xenografts) using both Gd-DTPA to detect vascular leakage and ultrasmall iron oxide particles (USPIO) to measure blood volume. Pixel-by-pixel maps of the enhancement in the transverse relaxation rates (ΔR2 and ΔR2*) after injection of USPIO provided an index proportional to the blood volume of the microvasculature and macrovasculature, respectively, for each tumour. The melanoma metastases were characterised by a blood volume and vessel leakage higher than both glioma xenografts. The U87 glioblastoma xenografts displayed higher permeability and blood volume in the rim than in the core. The E34 glioma xenografts were characterised by a relatively high blood volume, accompanied by only a moderate blood–brain barrier disruption. Delineation of the tumour was best assessed on post-USPIO gradient-echo images. These findings suggest that contrast-enhanced MR imaging using USPIOs and, in particular, ΔR2 and ΔR2* quantitation, provides important additional information about tumour vasculature
Tests of the Equivalence Principle with Neutral Kaons
We test the Principle of Equivalence for particles and antiparticles, using
CPLEAR data on tagged K0 and K0bar decays into pi^+ pi^-. For the first time,
we search for possible annual, monthly and diurnal modulations of the
observables |eta_{+-}| and phi_{+-}, that could be correlated with variations
in astrophysical potentials. Within the accuracy of CPLEAR, the measured values
of |eta_{+-}| and phi_{+-} are found not to be correlated with changes of the
gravitational potential. We analyze data assuming effective scalar, vector and
tensor interactions, and we conclude that the Principle of Equivalence between
particles and antiparticles holds to a level of 6.5, 4.3 and 1.8 x 10^{-9},
respectively, for scalar, vector and tensor potentials originating from the Sun
with a range much greater than the distance Earth-Sun. We also study
energy-dependent effects that might arise from vector or tensor interactions.
Finally, we compile upper limits on the gravitational coupling difference
between K0 and K0bar as a function of the scalar, vector and tensor interaction
range.Comment: 15 pages latex 2e, five figures, one style file (cernart.csl)
incorporate
Improving mental health and psychosocial wellbeing in humanitarian settings: reflections on research funded through R2HC
The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits <i>Porphyromonas gingivalis</i>-induced expression of interleukin-8 by oral keratinocytes
Objective:
The alpha 7 nicotinic receptor (α7nAChR) is expressed by oral keratinocytes. α7nAChR activation mediates anti-inflammatory responses. The objective of this study was to determine if α7nAChR activation inhibited pathogen-induced interleukin-8 (IL-8) expression by oral keratinocytes.<p></p>
Materials and methods:
Periodontal tissue expression of α7nAChR was determined by real-time PCR. OKF6/TERT-2 oral keratinocytes were exposed to <i>Porphyromonas gingivalis</i> in the presence and absence of a α7nAChR agonist (PHA-543613 hydrochloride) alone or after pre-exposure to a specific α7nAChR antagonist (α-bungarotoxin). Interleukin-8 (IL-8) expression was measured by ELISA and real-time PCR. Phosphorylation of the NF-κB p65 subunit was determined using an NF-κB p65 profiler assay and STAT-3 activation by STAT-3 in-cell ELISA. The release of ACh from oral keratinocytes in response to <i>P. gingivalis</i> lipopolysaccharide was determined using a GeneBLAzer M3 CHO-K1-blacell reporter assay.<p></p>
Results:
Expression of α7nAChR mRNA was elevated in diseased periodontal tissue. PHA-543613 hydrochloride inhibited <i>P. Gingivalis</i>-induced expression of IL-8 at the transcriptional level. This effect was abolished when cells were pre-exposed to a specific α7nAChR antagonist, α-bungarotoxin. PHA-543613 hydrochloride downregulated NF-κB signalling through reduced phosphorylation of the NF-κB p65-subunit. In addition, PHA-543613 hydrochloride promoted STAT-3 signalling by maintenance of phosphorylation. Furthermore, oral keratinocytes upregulated ACh release in response to <i>P. Gingivalis</i> lipopolysaccharide.<p></p>
Conclusion:
These data suggest that α7nAChR plays a role in regulating the innate immune responses of oral keratinocytes.<p></p>
IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection
Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC). IS was supported by The University of Queensland Centennial and IPRS Scholarships. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Electric current circuits in astrophysics
Cosmic magnetic structures have in common that they are anchored
in a dynamo, that an external driver converts kinetic energy into internal
magnetic energy, that this magnetic energy is transported as Poynting fl ux across the magnetically dominated structure, and that the magnetic energy
is released in the form of particle acceleration, heating, bulk motion,
MHD waves, and radiation. The investigation of the electric current system is
particularly illuminating as to the course of events and the physics involved.
We demonstrate this for the radio pulsar wind, the solar flare, and terrestrial
magnetic storms
Co-channel interference cancellation using precoding for bi-direction multiple hops MIMO relay systems
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.
Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1981 and diagnosed with schizophrenia as well as controls from the same birth cohort. Furthermore, we present the first genome-wide interaction survey of single nucleotide polymorphisms (SNPs) and maternal cytomegalovirus (CMV) infection. The GWA analysis included 888 cases and 882 controls, and the follow-up investigation of the top GWA results was performed in independent Danish (1396 cases and 1803 controls) and German-Dutch (1169 cases, 3714 controls) samples. The SNPs most strongly associated in the single-marker analysis of the combined Danish samples were rs4757144 in ARNTL (P=3.78 × 10(-6)) and rs8057927 in CDH13 (P=1.39 × 10(-5)). Both genes have previously been linked to schizophrenia or other psychiatric disorders. The strongest associated SNP in the combined analysis, including Danish and German-Dutch samples, was rs12922317 in RUNDC2A (P=9.04 × 10(-7)). A region-based analysis summarizing independent signals in segments of 100 kb identified a new region-based genome-wide significant locus overlapping the gene ZEB1 (P=7.0 × 10(-7)). This signal was replicated in the follow-up analysis (P=2.3 × 10(-2)). Significant interaction with maternal CMV infection was found for rs7902091 (P(SNP × CMV)=7.3 × 10(-7)) in CTNNA3, a gene not previously implicated in schizophrenia, stressing the importance of including environmental factors in genetic studies
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