Primary productivity and its variability in the Atlantic Southern ocean

Includes bibliographical references.The two principal bottom-up drivers of the High Nutrient Low Chlorophyll (HNLC) characteristics of the Southern Ocean are light and nutrient (mainly dissolved iron) limitation ( Boyd , 2002; Mitchell et al., 1991), which have varying limiting roles over the growing season ( Boyd, 2002; Swart et al., 2014). This research commenced with an investigation of the meridional characteristics of primary productivity in the Atlantic Southern Ocean during austral summer 2008

Experimental simulation of retrodirective cross-eye jamming

Experimental measurements that accurately simulate the effect of a retrodirective cross-eye jammer on a monopulse radar are described. The accuracy of a recently published extended analysis of retrodirective cross-eye jamming and the limitations of the conventional phase-front analysis of cross-eye jamming are illustrated by the experiments.The Armaments Corporation of South Africa (Armscor) and the National Research Foundation (NRF).http://ieeexplore.ieee.org/ai201

Tolerance analysis of cross-eye jamming systems

The matching required between the two directions through a retrodirective cross-eye jammer is considered using both the traditional phase-front analysis and an extended analysis. The design parameters to achieve a specified tracking error are derived and an optimal design is proposed. The results for the extended analysis show that the tolerances required to induce large angular errors in a monopulse radar are not as strict as the traditional analysis suggests.Armaments Corporation of South Africa (Armscor) and the National Research Foundation (NRF)http://ieeexplore.ieee.org/xpl/RecentIssue.jsp?reload=true&punumber=7ai201

Non-verbal sound processing in the primary progressive aphasias

Little is known about the processing of non-verbal sounds in the primary progressive aphasias. Here, we investigated the processing of complex non-verbal sounds in detail, in a consecutive series of 20 patients with primary progressive aphasia [12 with progressive non-fluent aphasia; eight with semantic dementia]. We designed a novel experimental neuropsychological battery to probe complex sound processing at early perceptual, apperceptive and semantic levels, using within-modality response procedures that minimized other cognitive demands and matching tests in the visual modality. Patients with primary progressive aphasia had deficits of non-verbal sound analysis compared with healthy age-matched individuals. Deficits of auditory early perceptual analysis were more common in progressive non-fluent aphasia, deficits of apperceptive processing occurred in both progressive non-fluent aphasia and semantic dementia, and deficits of semantic processing also occurred in both syndromes, but were relatively modality specific in progressive non-fluent aphasia and part of a more severe generic semantic deficit in semantic dementia. Patients with progressive non-fluent aphasia were more likely to show severe auditory than visual deficits as compared to patients with semantic dementia. These findings argue for the existence of core disorders of complex non-verbal sound perception and recognition in primary progressive aphasia and specific disorders at perceptual and semantic levels of cortical auditory processing in progressive non-fluent aphasia and semantic dementia, respectively

Voice processing in dementia: a neuropsychological and neuroanatomical analysis

Voice processing in neurodegenerative disease is poorly understood. Here we undertook a systematic investigation of voice processing in a cohort of patients with clinical diagnoses representing two canonical dementia syndromes: temporal variant frontotemporal lobar degeneration (n = 14) and Alzheimer’s disease (n = 22). Patient performance was compared with a healthy matched control group (n = 35). All subjects had a comprehensive neuropsychological assessment including measures of voice perception (vocal size, gender, speaker discrimination) and voice recognition (familiarity, identification, naming and cross-modal matching) and equivalent measures of face and name processing. Neuroanatomical associations of voice processing performance were assessed using voxel-based morphometry. Both disease groups showed deficits on all aspects of voice recognition and impairment was more severe in the temporal variant frontotemporal lobar degeneration group than the Alzheimer’s disease group. Face and name recognition were also impaired in both disease groups and name recognition was significantly more impaired than other modalities in the temporal variant frontotemporal lobar degeneration group. The Alzheimer’s disease group showed additional deficits of vocal gender perception and voice discrimination. The neuroanatomical analysis across both disease groups revealed common grey matter associations of familiarity, identification and cross-modal recognition in all modalities in the right temporal pole and anterior fusiform gyrus; while in the Alzheimer’s disease group, voice discrimination was associated with grey matter in the right inferior parietal lobe. The findings suggest that impairments of voice recognition are significant in both these canonical dementia syndromes but particularly severe in temporal variant frontotemporal lobar degeneration, whereas impairments of voice perception may show relative specificity for Alzheimer’s disease. The right anterior temporal lobe is likely to have a critical role in the recognition of voices and other modalities of person knowledge

Health-related quality of life in patients with a germline BRCA mutation and metastatic pancreatic cancer receiving maintenance olaparib

Background: Patients with metastatic pancreatic cancer often have a detriment in health-related quality of life (HRQoL). In the randomized, double-blind, phase III POLO trial progression-free survival was significantly longer with maintenance olaparib, a poly(ADP-ribose) polymerase inhibitor, than placebo in patients with a germline BRCA1 and/or BRCA2 mutation (gBRCAm) and metastatic pancreatic cancer whose disease had not progressed during first-line platinum-based chemotherapy. The prespecified HRQoL evaluation is reported here. Patients and methods: Patients were randomized to receive maintenance olaparib (300 mg b.i.d.; tablets) or placebo. HRQoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item module at baseline, every 4 weeks until disease progression, at discontinuation, and 30 days after last dose. Scores ranged from 0 to 100; a ≥10-point change or difference between arms was considered clinically meaningful. Adjusted mean change from baseline was analysed using a mixed model for repeated measures. Time to sustained clinically meaningful deterioration (TSCMD) was analysed using a log-rank test. Results: Of 154 randomized patients, 89 of 92 olaparib-arm and 58 of 62 placebo-arm patients were included in HRQoL analyses. The adjusted mean change in Global Health Status (GHS) score from baseline was <10 points in both arms and there was no significant between-group difference [-2.47; 95% confidence interval (CI) -7.27, 2.33; P = 0.31]. Analysis of physical functioning scores showed a significant between-group difference (-4.45 points; 95% CI -8.75, -0.16; P = 0.04). There was no difference in TSCMD for olaparib versus placebo for GHS [P = 0.25; hazard ratio (HR) 0.72; 95% CI 0.41, 1.27] or physical functioning (P = 0.32; HR 1.38; 95% CI 0.73, 2.63). Conclusions: HRQoL was preserved with maintenance olaparib treatment with no clinically meaningful difference compared with placebo. These results support the observed efficacy benefit of maintenance olaparib in patients with a gBRCAm and metastatic pancreatic cancer. ClincalTrials.gov number: NCT02184195

Effects of an explosive polar cyclone crossing the Antarctic marginal ice zone

Antarctic sea ice shows a large degree of regional variability, which is partly driven by severe weather events. Here we bring a new perspective on synoptic sea ice changes by presenting the first in situ observations of an explosive extratropical cyclone crossing the winter Antarctic marginal ice zone (MIZ) in the South Atlantic. This is complemented by the analysis of subsequent cyclones and highlights the rapid variations that ice-landing cyclones cause on sea ice: Midlatitude warm oceanic air is advected onto the ice, and storm waves generated close to the ice edge contribute to the maintenance of an unconsolidated surface through which waves propagate far into the ice. MIZ features may thus extend further poleward in the Southern Ocean than currently estimated. A concentration-based MIZ definition is inadequate, since it fails to describe a sea ice configuration which is deeply rearranged by synoptic weather