1,637 research outputs found
Motivation and the gift relationship
This thesis proposes a theory of Motivation to Work, as a particular condition of general motivation, using the Maussian concept of the Gift to explain the operation of Lacanian Desire. Specifically, it argues that de-motivation stems from Gift rejection. However, as the arguments are not paradigmatically commensurable with managerialist theories, it has been necessary to establish the epistemological tradition of which this work is representative, namely, Critical Theory and Post-Structuralism/Post- Modernism. In distinction to the managerialist explanations of motivation, management and work, behaviourist theories of motivation are characterised as more properly a concern with psychological incentives, management in its current socio-historic institutionalised form as a process of social domination and work as a social experience of domination, but also as a forum for social life generally. However, as such a view receives little theoretical or empirical confirmation from managerialist literature, it is argued that it is necessary to broaden the catchment area of relevant writing, and that the literary arts have more insight than orthodox science. This is supported by reference to modern literary theory in terms of the Form/Content distinction. Central to this argument is the ontological concept of Difference and its `political' use in maintaining social domination by privileging certain forms over others. Having established the basis on which to articulate this theory of motivation, the Lacanian concept of Desire is explored, together with its relevance to motivation and management/organisation theory. The theory of the Gift Relationship is then explicated and developed, together with some of its popular sociological conceptualisations, and an argument made for an understanding in terms of its psychological signficance in explaining the operationalisation of Lacanian Desire. This is related to the work situation and to its relevance for organisational management. In conclusion, its utility is considered, as are some potential criticisms of the arguments put forward
Sheath parameters for non-Debye plasmas: simulations and arc damage
This paper describes the surface environment of the dense plasma arcs that
damage rf accelerators, tokamaks and other high gradient structures. We
simulate the dense, non-ideal plasma sheath near a metallic surface using
Molecular Dynamics (MD) to evaluate sheaths in the non-Debye region for high
density, low temperature plasmas. We use direct two-component MD simulations
where the interactions between all electrons and ions are computed explicitly.
We find that the non-Debye sheath can be extrapolated from the Debye sheath
parameters with small corrections. We find that these parameters are roughly
consistent with previous PIC code estimates, pointing to densities in the range
. The high surface fields implied by these
results could produce field emission that would short the sheath and cause an
instability in the time evolution of the arc, and this mechanism could limit
the maximum density and surface field in the arc. These results also provide a
way of understanding how the "burn voltage" of an arc is generated, and the
relation between self sputtering and the burn voltage, while not well
understood, seems to be closely correlated. Using these results, and equating
surface tension and plasma pressure, it is possible to infer a range of plasma
densities and sheath potentials from SEM images of arc damage. We find that the
high density plasma these results imply and the level of plasma pressure they
would produce is consistent with arc damage on a scale 100 nm or less, in
examples where the liquid metal would cool before this structure would be lost.
We find that the sub-micron component of arc damage, the burn voltage, and
fluctuations in the visible light production of arcs may be the most direct
indicators of the parameters of the dense plasma arc, and the most useful
diagnostics of the mechanisms limiting gradients in accelerators.Comment: 8 pages, 16 figure
Quantitative fibronectin to help decision-making in women with symptoms of preterm labour (QUIDS) part 1: Individual participant data meta-analysis and health economic analysis.
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (qfFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts) which quantifies fFN in a vaginal swab. In part 1 of the study, we will develop and internally validate a prognostic model using an individual participant data (IPD) meta-analysis of existing studies containing women with symptoms of preterm labour alongside fFN measurements and pregnancy outcome. An economic analysis will be undertaken to assess potential cost-effectiveness of the qfFN prognostic model. The primary endpoint will be the ability of the prognostic model to rule out spontaneous preterm birth within 7 days. Six eligible studies were identified by systematic review of the literature and five agreed to provide their IPD (n=5 studies, 1783 women and 139 events of preterm delivery within 7 days of testing). ETHICS AND DISSEMINATION: The study is funded by the National Institute of Healthcare Research Health Technology Assessment (HTA 14/32/01). It has been approved by the West of Scotland Research Ethics Committee (16/WS/0068). PROSPERO REGISTRATION NUMBER: CRD42015027590. VERSION: Protocol version 2, date 1 November 2016
Study protocol: quantitative fibronectin to help decision-making in women with symptoms of preterm labour (QUIDS) part 2, UK Prospective Cohort Study.
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (fFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts, USA) which quantifies fFN in a vaginal swab. In QUIDS part 2, we will perform a prospective cohort study in at least eight UK consultant-led maternity units, in women with symptoms of preterm labour at 22+0 to 34+6 weeks gestation to externally validate a prognostic model developed in QUIDS part 1. The effects of quantitative fFN on anxiety will be assessed, and acceptability of the test and prognostic model will be evaluated in a subgroup of women and clinicians (n=30). The sample size is 1600 women (with estimated 96-192 events of preterm delivery within 7 days of testing). Clinicians will be informed of the qualitative fFN result (positive/negative) but be blinded to quantitative fFN result. Research midwives will collect outcome data from the maternal and neonatal clinical records. The final validated prognostic model will be presented as a mobile or web-based application. ETHICS AND DISSEMINATION: The study is funded by the National Institute of Healthcare Research Health Technology Assessment (HTA 14/32/01). It has been approved by the West of Scotland Research Ethics Committee (16/WS/0068). VERSION: Protocol V.2, Date 1 November 2016. TRIAL REGISTRATION NUMBER: ISRCTN 41598423andCPMS: 31277
Half the story: Thermal effects on within-host infectious disease progression in a warming climate
Immune defense is temperature dependent in cold-blooded vertebrates (CBVs) and thus directly impacted by global warming. We examined whether immunity and within-host infectious disease progression are altered in CBVs under realistic climate warming in a seasonal mid-latitude setting. Going further, we also examined how large thermal effects are in relation to the effects of other environmental variation in such a setting (critical to our ability to project infectious disease dynamics from thermal relationships alone). We employed the three-spined stickleback and three ecologically relevant parasite infections as a “wild” model. To generate a realistic climatic warming scenario we used naturalistic outdoors mesocosms with precise temperature control. We also conducted laboratory experiments to estimate thermal effects on immunity and within-host infectious disease progression under controlled conditions. As experimental readouts we measured disease progression for the parasites and expression in 14 immune-associated genes (providing insight into immunophenotypic responses). Our mesocosm experiment demonstrated significant perturbation due to modest warming (+2°C), altering the magnitude and phenology of disease. Our laboratory experiments demonstrated substantial thermal effects. Prevailing thermal effects were more important than lagged thermal effects and disease progression increased or decreased in severity with increasing temperature in an infection-specific way. Combining laboratory-determined thermal effects with our mesocosm data, we used inverse modeling to partition seasonal variation in Saprolegnia disease progression into a thermal effect and a latent immunocompetence effect (driven by nonthermal environmental variation and correlating with immune gene expression). The immunocompetence effect was large, accounting for at least as much variation in Saprolegnia disease as the thermal effect. This suggests that managers of CBV populations in variable environments may not be able to reliably project infectious disease risk from thermal data alone. Nevertheless, such projections would be improved by primarily considering prevailing thermal effects in the case of within-host disease and by incorporating validated measures of immunocompetence
Momentum of an electromagnetic wave in dielectric media
Almost a hundred years ago, two different expressions were proposed for the
energy--momentum tensor of an electromagnetic wave in a dielectric. Minkowski's
tensor predicted an increase in the linear momentum of the wave on entering a
dielectric medium, whereas Abraham's tensor predicted its decrease. Theoretical
arguments were advanced in favour of both sides, and experiments proved
incapable of distinguishing between the two. Yet more forms were proposed, each
with their advocates who considered the form that they were proposing to be the
one true tensor. This paper reviews the debate and its eventual conclusion:
that no electromagnetic wave energy--momentum tensor is complete on its own.
When the appropriate accompanying energy--momentum tensor for the material
medium is also considered, experimental predictions of all the various proposed
tensors will always be the same, and the preferred form is therefore
effectively a matter of personal choice.Comment: 23 pages, 3 figures, RevTeX 4. Removed erroneous factor of mu/mu_0
from Eq.(44
The Correlation of Narrow Line Emission and X-ray Luminosity in Active Galactic Nuclei
We combine emission line and X-ray luminosities for 45 sources from the
Chandra Deep Field South (CDF-S), and seven HELLAS sources, to obtain a new
sample of 52 X-ray selected type-II active galactic nuclei (AGNs). Eighteen of
our sources are very luminous with a typical, absorption-corrected 2-10 keV
luminosity of few 10^{44} erg/sec (type-II QSOs). We compare the emission line
properties of the new sources with emission line and X-ray luminosities of
known low redshift, mostly lower luminosity AGNs by using a composite spectrum.
We find that / and / decrease with L(2-10 keV) such that . The trend was already evident, yet neglected
in past low redshift samples. This lead to erroneous calibration of the
line-to-X-ray luminosity in earlier AGN samples. The analysis of several type-I
samples shows the same trend with a similar slope but a median / which is larger by a factor of about two compared
with optically selected type-II samples. We interpret this shift as due to
additional reddening in type-II sources and comment in general on the very
large extinction in many type-II objects and the significantly smaller average
reddening of the SDSS type-II AGNs. The decrease of / with L(2--10 keV) is large enough to suggest that a significant
fraction of high luminosity high redshift type-II AGNs have very weak emission
lines that may have escaped detection in large samples. A related decrease of
EW([OIII]) with optical continuum luminosity is demonstrated by an analysis of
12,000 type-I SDSS AGNs.Comment: 10 pages, 3 diagrams, accepted by A&
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
in the CMS endcaps. Their performance has been evaluated using data taken
during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Chromosome Tips Damaged in Anaphase Inhibit Cytokinesis
Genome maintenance is ensured by a variety of biochemical sensors and pathways that repair accumulated damage. During mitosis, the mechanisms that sense and resolve DNA damage remain elusive. Studies have demonstrated that damage accumulated on lagging chromosomes can activate the spindle assembly checkpoint. However, there is little known regarding damage to DNA after anaphase onset. In this study, we demonstrate that laser-induced damage to chromosome tips (presumptive telomeres) in anaphase of Potorous tridactylis cells (PtK2) inhibits cytokinesis. In contrast, equivalent irradiation of non-telomeric chromosome regions or control irradiations in either the adjacent cytoplasm or adjacent to chromosome tips near the spindle midzone during anaphase caused no change in the eventual completion of cytokinesis. Damage to only one chromosome tip caused either complete absence of furrow formation, a prolonged delay in furrow formation, or furrow regression. When multiple chromosome tips were irradiated in the same cell, the cytokinesis defects increased, suggesting a potential dose-dependent mechanism. These results suggest a mechanism in which dysfunctional telomeres inhibit mitotic exit
- …