The Role Of The Nurse Practitioner In Health Promotion During Pregnancy

Health promotion is fundamental to nurse practitioner practice. To be effective in health promotion, the nurse practitioner must have a clear understanding of the nature of behavioral change, the individual issues each client brings to a particular behavior, and have expertise in health promotion. The nurse practitioner must possess specific skills to facilitate the client’s movement along the continuum of health behavior change. Health promotion that enhances prenatal care has been described and established by evidence-based research and professional practice guidelines. The purpose of this evidence-based research project was to develop a current nurse practitioner knowledgebase regarding the role of the nurse practitioner in health promotion during pregnancy. Literature indicated that health promotion during pregnancy is crucial, yet the current level of health care knowledge regarding the role of the nurse practitioner is limited. Further research into the role of the nurse practitioner is critically needed to better serve nurse practitioners and their clients. Nola Pender’s Health Promotion Model (HPM) was used to guide this project. The HPM has served as a framework for research aimed at predicting overall healthpromoting lifestyles and specific behaviors and using wellness orientation to clarify health-promoting behaviors

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer\u27s Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study

With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer’s disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recruiting 270 adults with DS over the age of 25. The study is designed to characterize trajectories of change in DS-associated AD (DS-AD). The current study reports its cross-sectional analysis of the first 90 subjects enrolled. Plasma biomarkers phosphorylated tau protein (p-tau), neurofilament light chain (NfL), amyloid β peptides (Aβ1-40, Aβ1-42), and glial fibrillary acidic protein (GFAP) were undertaken with previously published methods. The clinical data from the baseline visit include demographics as well as the cognitive measures under the Severe Impairment Battery (SIB) and Down Syndrome Mental Status Examination (DS-MSE). Biomarker distributions are described with strong statistical associations observed with participant age. The biomarker data contributes to understanding DS-AD across the spectrum of disease. Collectively, the biomarker data show evidence of DS-AD progression beginning at approximately 40 years of age. Exploring these data across the full LIFE-DSR longitudinal study population will be an important resource in understanding the onset, progression, and clinical profiles of DS-AD pathophysiology

Cluster K Mycobacteriophages: Insights into the Evolutionary Origins of Mycobacteriophage TM4

Five newly isolated mycobacteriophages –Angelica, CrimD, Adephagia, Anaya, and Pixie – have similar genomic architectures to mycobacteriophage TM4, a previously characterized phage that is widely used in mycobacterial genetics. The nucleotide sequence similarities warrant grouping these into Cluster K, with subdivision into three subclusters: K1, K2, and K3. Although the overall genome architectures of these phages are similar, TM4 appears to have lost at least two segments of its genome, a central region containing the integration apparatus, and a segment at the right end. This suggests that TM4 is a recent derivative of a temperate parent, resolving a long-standing conundrum about its biology, in that it was reportedly recovered from a lysogenic strain of Mycobacterium avium, but it is not capable of forming lysogens in any mycobacterial host. Like TM4, all of the Cluster K phages infect both fast- and slow-growing mycobacteria, and all of them – with the exception of TM4 – form stable lysogens in both Mycobacterium smegmatis and Mycobacterium tuberculosis; immunity assays show that all five of these phages share the same immune specificity. TM4 infects these lysogens suggesting that it was either derived from a heteroimmune temperate parent or that it has acquired a virulent phenotype. We have also characterized a widely-used conditionally replicating derivative of TM4 and identified mutations conferring the temperature-sensitive phenotype. All of the Cluster K phages contain a series of well conserved 13 bp repeats associated with the translation initiation sites of a subset of the genes; approximately one half of these contain an additional sequence feature composed of imperfectly conserved 17 bp inverted repeats separated by a variable spacer. The K1 phages integrate into the host tmRNA and the Cluster K phages represent potential new tools for the genetics of M. tuberculosis and related species

Cross-Sectional Exploration of Plasma Biomarkers of Alzheimer's Disease in Down Syndrome: Early Data from the Longitudinal Investigation for Enhancing Down Syndrome Research (LIFE-DSR) Study

With improved healthcare, the Down syndrome (DS) population is both growing and aging rapidly. However, with longevity comes a very high risk of Alzheimer's disease (AD). The LIFE-DSR study (NCT04149197) is a longitudinal natural history study recruiting 270 adults with DS over the age of 25. The study is designed to characterize trajectories of change in DS-associated AD (DS-AD). The current study reports its cross-sectional analysis of the first 90 subjects enrolled. Plasma biomarkers phosphorylated tau protein (p-tau), neurofilament light chain (NfL), amyloid β peptides (Aβ1-40, Aβ1-42), and glial fibrillary acidic protein (GFAP) were undertaken with previously published methods. The clinical data from the baseline visit include demographics as well as the cognitive measures under the Severe Impairment Battery (SIB) and Down Syndrome Mental Status Examination (DS-MSE). Biomarker distributions are described with strong statistical associations observed with participant age. The biomarker data contributes to understanding DS-AD across the spectrum of disease. Collectively, the biomarker data show evidence of DS-AD progression beginning at approximately 40 years of age. Exploring these data across the full LIFE-DSR longitudinal study population will be an important resource in understanding the onset, progression, and clinical profiles of DS-AD pathophysiology

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Calibration of the CMS hadron calorimeters using proton-proton collision data at root s=13 TeV

Methods are presented for calibrating the hadron calorimeter system of theCMSetector at the LHC. The hadron calorimeters of the CMS experiment are sampling calorimeters of brass and scintillator, and are in the form of one central detector and two endcaps. These calorimeters cover pseudorapidities vertical bar eta vertical bar ee data. The energy scale of the outer calorimeters has been determined with test beam data and is confirmed through data with high transverse momentum jets. In this paper, we present the details of the calibration methods and accuracy.Peer reviewe

Drivers of conflict and resilience in shifting transboundary fisheries

Climate change is causing fish stocks to shift, upending the social-ecological systems that rely on the historic distributions of these stocks and creating or exacerbating fisheries conflicts. The movements of internationally shared stocks between Exclusive Economic Zones (EEZs) or between EEZs and the high seas are especially concerning because they bring into play a variety of geopolitical factors and equity issues surrounding missing or conflicting regulations of jurisdictional boundary zones. Though many studies have explored the responses to and repercussions of shifting stocks on fisheries management, there is a dearth of interdisciplinary case studies that provide insight into the complexity of conflict formation in shifting transboundary fisheries, and that highlight the initial response stages where inclusion of proactive and cooperative measures can greatly improve a system's resilience to conflict. Our study helps to fill this gap by drawing on the knowledge of a diverse group of experts to analyze four case studies where transboundary stock shifts, geopolitical or governance tensions, and uncertainty regarding the future of the marine environment collide. Through synthesis of case study findings, we create a causal model of fishery conflict, within which we highlight factors that may heighten or mitigate the risk of conflict over shifting resources such as complex histories of power imbalance, unequal access to resources, or a lack of consistent and transparent data collection. Cooperation and equitable decision-making processes are recognized as vital components of internationally shared stock management which can promote lasting, effective, and conflict-resilient fisheries

Drivers of conflict and resilience in shifting transboundary fisheries

Climate change is causing fish stocks to shift, upending the social-ecological systems that rely on the historic distributions of these stocks and creating or exacerbating fisheries conflicts. The movements of internationally shared stocks between Exclusive Economic Zones (EEZs) or between EEZs and the high seas are especially concerning because they bring into play a variety of geopolitical factors and equity issues surrounding missing or conflicting regulations of jurisdictional boundary zones. Though many studies have explored the responses to and repercussions of shifting stocks on fisheries management, there is a dearth of interdisciplinary case studies that provide insight into the complexity of conflict formation in shifting transboundary fisheries, and that highlight the initial response stages where inclusion of proactive and cooperative measures can greatly improve a system's resilience to conflict. Our study helps to fill this gap by drawing on the knowledge of a diverse group of experts to analyze four case studies where transboundary stock shifts, geopolitical or governance tensions, and uncertainty regarding the future of the marine environment collide. Through synthesis of case study findings, we create a causal model of fishery conflict, within which we highlight factors that may heighten or mitigate the risk of conflict over shifting resources such as complex histories of power imbalance, unequal access to resources, or a lack of consistent and transparent data collection. Cooperation and equitable decision-making processes are recognized as vital components of internationally shared stock management which can promote lasting, effective, and conflict-resilient fisheries