61 research outputs found
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
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- Bakawala Rehana
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- Baker Pauline
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- Ball Margaret
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- Banaras Azra
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- Bhaskaran Biju
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- Bhatnagar Priya
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- Minks David P.
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- Mitra Dipayan
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- Mohd Nor Azlisham
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- Sandercock Peter A G
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- Sanyal Ranjan
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- Sattar Saira
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- Sudlow Cathie L M
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- Tysoe Sharon
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- van Someren Chloe
- Varquez Resti
- Vasileiadis Evangelos
- Vassallo Joseph
- Venter Marius
- Veraque Emelda
- Verrion Anna
- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
- Walker Pauli
- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
- Author
- Aawsaj Y.
- Abad Gurumeta A.
- Abad-Motos A.
- Abate E.
- Abatini C.
- Abbadessa F.
- Abbas A. M.
- Abbassi-Ghadi N.
- Abbott D.
- Abbott T.
- Abd Elazeem H. A. S.
- Abdalla M.
- Abdallah M.
- Abdel Al S.
- Abdel Jalil R.
- Abdeldayem H.
- Abdelkader Salama I.
- Abdelkarem M. M.
- Abdelkarim M.
- Abdelmajeed A.
- Abdelrahman A.
- Abdelrahman S.
- Abdelsamed A.
- Abdou M.
- Abdulkareem A.
- Abdulwahed E.
- Abdur-Rahman L.
- Abel M. K.
- Abellan M.
- Aboelkassem Ibrahim A.
- Abosamak N. E.
- Abou Chaar M. K.
- Abou-Khalil J.
- Abouassi A.
- Aboulkassem H.
- Abreu Da Silva A.
- Abu J.
- Abu Za'nouneh F. J.
- Abu-Nayla I.
- Abubakar A.
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- Adamina M.
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- Aderombi A.
- Adeyeye A.
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- Aggarwal A.
- Aghayeva A.
- Agilinko J.
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- Agostini C.
- Agoston P.
- Agrawal A.
- Agresta F.
- Aguado H.
- Aguilar Gonzalez M.
- Aguzzoli L.
- Ahad S.
- Ahmadi N.
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- Al-Ishaq Z.
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- Alnumani T.
- Alobeed O.
- Alomair A.
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- Alresaini F.
- Alriyees L.
- Alsaif A.
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- Publication venue
- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
- Author
- Aawsaj Y.
- Abad Gurumeta A.
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- Publication venue
- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
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- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
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- Adeleye O
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- Riley BJ
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- Sheikh A
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- Shurovi BN
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- Sim DPY
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
- Stewart H
- Stewart R
- Stickler E
- Stoddart MT
- Stokes E
- Stott G
- Strang S
- Stringer H
- Stringfellow TD
- Stubbing-Moore A
- Sturrock S
- Subar D
- Subratty SM
- Sukirthan N
- Sukumar S
- Sulaiman SK
- Sultan S
- Sun L
- Sundaram K
- Suresh R
- Suresh S
- Sureshkumar A
- Suri A
- Svolkinas D
- Swan A
- Swan I
- Swaray A
- Swartbol T
- Symons L
- Szczap A
- Szuman A
- Tailor S
- Tam J
- Tam JP
- Tan CY
- Tan KL
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- Tan S
- Tan TSE
- Tang A
- Tang M
- Tanna A
- Taribagil P
- Tariq A
- Tate S
- Tayeh S
- Taylor K
- Taylor O
- Taylor R
- Taylor Z
- Telfer R
- Teng T
- Tenters F
- Teo R
- Thachettu A
- Thakrar D
- Thatcher A
- Theodoropoulou K
- Thomas A
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- Tilliridou V
- Titu L
- Tod N
- Toellner H
- Toh C
- Toma T
- Tonks A
- Torrance HD
- Townsend D
- Traish M
- Trenear R
- Tresidder S
- Trevett J
- Triniman MC
- Trotter M
- Tsang JCH
- Tsang K
- Tseu B
- Tsui A
- Tullett A
- Tummon R
- Turlejski T
- Turner J
- Turner S
- Tyson N
- Ubhi HK
- Ujjal S
- Underhill R
- Vadgama N
- Vaidya A
- Vakharia A
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- Van der Laan S
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- Varatharasasingam K
- Varcada M
- Vaughan R
- Vella-Baldacchino M
- Ventre C
- Venturini S
- Verma N
- Vernet G
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- Vipond M
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- Vyas M
- Wadood Q
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- Walker NR
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- Wang H
- Wang L
- Wang X
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- Warusavitarne J
- Waterman A
- Waters S
- Watkinson G
- Watson L
- Watson N
- Waugh D
- Wayman J
- Webb E
- Webb R
- Weegenaar C
- Wei R
- Welsh K
- Whewell H
- Whitcroft I
- White C
- White F
- White P
- Whitham R
- Whyte M
- Widdison A
- Wiffen L
- Wigley C
- Wijeyaratne M
- Williams C
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- Williams H
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- Williams LM
- Williams P
- Williams S
- Wilson H
- Wilson J
- Wilson R
- Wilson V
- Wimalathasan A
- Woin E
- Wong C
- Wong E
- Wong J
- Wong MHY
- Wood CM
- Woodhams K
- Woolley A
- Wootton E
- Worley E
- Worsfold M
- Wright OW
- Wright R
- Wright S
- Wroe N
- Wynell-Mayow W
- Xu Y
- Yahaya AA
- Yalamarthi S
- Yang DD
- Yang N
- Yap J
- Yardimci E
- Yarham E
- Yasin IH
- Yasin T
- Yates J
- Ye W
- Yeo A
- Yeoh T
- Yeung J
- Yin ZD
- Yip J
- Yoganayagam N
- Yogeswara T
- York J
- Yousaf A
- Youssef H
- Yu T
- Yule A
- Zaat S
- Zanichelli D
- Zaver V
- Zeng R
- Zhang Y
- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Older People’s Adherence to Community-Based Group Exercise Programmes: A Multiple-Case Study
- Author
- A Steptoe
- AC King
- AK Bij van Der
- B Belza
- B Belza
- C Farrance
- C Naylor
- C Phoenix
- C Pope
- Carol Clark
- Clare Killingback
- DP Gill
- E Naumann
- E Orsega-Smith
- EJ Frew
- F Herzberg
- F Sun
- Fotini Tsofliou
- GD Zimet
- H Hawley-Hague
- H Hawley-Hague
- H Löllgen
- H Schröder
- HJ Bethancourt
- I Foster
- I Holloway
- J Holt-Lunstad
- J Lubben
- J Woodcock
- JB Kirby
- JF Munro
- JW Keogh
- K Fox
- KA Martin
- KC Chiang
- KM Eisenhardt
- L Cohen
- L Todres
- LR Brawley
- M Garmendia
- N Crossley
- N Mack
- NA Hernandes
- National Institute for Health and Care Excellence
- OW DeShields Jr
- R Ramsbottom
- RA Krueger
- RA Seguin
- RK Dishman
- RK Dishman
- RK Yin
- RM Ryan
- RS Barbour
- SB Merriam
- SB Reed
- SE Hartley
- SL Hughes
- SN Blair
- V Braun
- V Huta
- WEC Gillham
- WJ Chodzko-Zajko
- WL Dunlop
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Physical inactivity is a global phenomenon, with estimates of one in four adults not being active enough to achieve health benefits, thus heightening the risk of developing non-communicable diseases. In order to realise the health and wellbeing gains associated with physical activity the behaviour must be sustained. Community-based group exercise programmes (CBGEP) utilising social support have been shown to be one means of not only increasing activity levels for older people, but sustaining physical activity. A mixed-methods systematic review revealed a gap in the literature around older people’s long-term adherence to real-life CBGEP within a UK context. This study therefore sought to address this gap by understanding older people’s ongoing adherence to CBGEP with a view to gaining further insight about which factors contribute to enabling people to sustain their physical activity levels. A multiple case study research design was employed to understand older people’s (≥ 60 years, n=27) adherence (≥ 69%, for ≥ 1 year) to three current CBGEP in the South- West of England. Qualitative data (participant observation, focus groups, documents, and interviews) were collected and analysed using inductive thematic analysis followed by the analytic technique of explanation building. In order to gain deeper insights into adherence, the humanisation framework was utilised in an a priori manner to further understand adherence from a humanising perspective. Quantitative data were analysed using descriptive statistics and used to set the context of the study. This study found that older people’s adherence to CBGEP was mediated through six factors: factors relating to the individual, the instructor, programme design, social features, participant perceived benefits, and a humanised exercise environment. These all served to explain older people’s adherence to CBGEP. The humanising qualities of these CBGEP must be considered if we wish to support older people in sustaining a physically active lifestyle as they age. These findings are of interest to practitioners and policy makers in how CBGEP serve to aid older people in maintaining a physically active lifestyle with a view to preventing non-communicable diseases and in maintaining social connectivity
Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study
- Author
- Abbas Abeera
- Abbas Imran
- Abbott Nick
- Abdalla El-Rasheed
- Absar Mohammed
- Achuthan Raj
- Adwani Asha
- Agabiti Ennio
- Agrawal Amit
- Ainsworth Rachel
- Aitken Jane
- Akolekar Deepika
- Al-Ishaq Zaid
- Al-Mufti Ragheed
- AL-Zawi Abdalla Saad Abdalla
- Alder Louise
- Alkistawi Firas Eddin Bachir
- Allen Michael J.
- Allum William H.
- Amin Khalid
- Ansari Aonghus
- Asgeirsson Kristjan
- Athanasiou Irene
- Athwal Ruvinder
- Azmy Iman
- Bakri Nur Amalina Che
- Banerjee Dibyesh
- Banks Jenny
- Barkeji Musa
- Barker Sarah
- Barnes Nicola
- Barry Peter A.
- Barua Ellora
- Bathla Sonia
- Batt Jeremy
- Benson John
- Bentley James
- Betal Dibendu
- Betambeau Nadine
- Bezzaa Sabrina
- Bichoo Raouef Ahmed
- Bonomi Riccardo
- Bosch Karen
- Boundouki George
- Bramley Maria
- Brown Iain
- Bunza Ralia
- Burrah Rajaram
- Byrne Gerard
- Cain Henry
- Callaghan Maria
- Camacho Elizabeth M.
- Cariati Massimiliano
- Carmichael Amtul
- Cartlidge Christopher W. J.
- Chagla Leena
- Chalmers Ritchie
- Chambers Alice
- Chandrasekharan Sankaran
- Chandrashekar Mysore
- Charalampoudis Petros
- Chatterjee Sumohan
- Chaudhry Anushka
- Cheung Kwok-Leung
- Chong Kelvin
- Chopra Sharat
- Chouhan Ashok
- Chrysafi Ada
- Clayton Elizabeth
- Clayton Gillian
- Coles Charlotte E.
- Cook James
- Cook Lorna
- Coombs Nathan
- Copson Ellen
- Courtney Alona
- Courtney Carol-Ann
- Cox Karina
- Critchley Adam
- Cuffolo Giulio
- Cutress Ramsey I.
- Daltrey Ian
- Dani Mohsin
- Dash Isabella
- Dave Rajiv V.
- Davies Eleri
- de Silva Tania S.
- Dent Helen
- Devalia Haresh
- Dimopoulos Nikitas
- Dodwell David
- Douek Michael
- Doughty Julie
- Drew Philip
- Dua Sascha
- Dumitru Dorin
- Dunn Julie
- Egbeare Donna
- Eid Raja
- Elahi M. Bilal
- Elamass Mohamed
- Elfadl Dalia
- Elkorety Mohamed
- Elsberger Beatrix
- English Rachel Elizabeth
- Exarchos Georgios
- Fafemi Oladapo
- Fairbrother Patricia
- Fairhurst Katherine
- Fatayer Hiba
- Ferguson Douglas
- Forouhi Parto
- Franks Joanna
- Fuller Mairi
- Gahir Jasdeep
- Gallegos Nicholas
- Gandamihardja Tasha
- Gandhi Ashu
- Garreffa Emanuele
- Gathani Toral
- Gill Jasper
- Girgis Mina
- Goh Ngee-Ming
- Gopalan Vallipuran
- Govindarajulu Sasi
- Gowda Manoj
- Goyal Amit
- Goyal Sumit
- Gui Gerald
- Gvaramadze Anzors
- Hadjiminas Demetrios
- Hague Matthew
- Hamad Ahmed
- Hamed Hisham
- Harborough Kathryn E.
- Harding-Mackean Claudia
- Hardy Rob
- Hargreaves Anita
- Harries Simon
- Harvey James
- Hawkins Simon
- Heeney Anna
- Henderson Julia
- Highton Lyndsey
- Hill Arnold D. K.
- Hogan Brian
- Hogben Katy
- Holcombe Chris
- Hollywood Ciaran
- Horgan Kieran
- Horne Sarah
- Horsnell Jonathan D.
- Hurley Anna R.
- Hussien Maged
- Imran Abbas
- Irvine Tracey
- Irwin Gareth W.
- Isgar Brian
- Ives Charlotte
- Jacklin Rosamond
- Jafferbhoy Sadaf
- Jain Urvashi
- James Karen
- James Ruth
- Jenkins Stephanie C.
- Jibril Jibril
- Johnson Richard
- Jones Lucie
- Joshi Sanjay
- Kalakouti Eliana
- Kallaway Charlotte
- Kalra Loraine
- Kantola Venla
- Karagiannidis Georgios
- Kattakayam Arjun
- Kaushik Monika
- Kenny Frances
- Khalifa Eiman
- Khan Lucy R.
- Khout Hazem
- Kiernan Tamara
- Kim Baek
- King Polly
- Kirkham Jamie J.
- Kirkpatrick Katharine
- Kirwan Cliona C.
- Knight Alex
- Knowles Hannah
- Kothari Ashutosh
- Krupa Jaroslaw
- Krupa Katherine
- Krzyzanowska Catherine
- Laban Christiana
- Lafi Mohamed
- Lai Lee-Min
- Lambert Kelly
- Laurence Nicola
- Law Rebekah
- Lee Rachel Xue Ning
- Leff Daniel R.
- Liptay-Wagner Peter
- Lobo Cheryl
- Lund Jonathan
- Maalo Joseph
- Macinnes Emma
- MacLean Gael
- Macmillan Robert
- Mallidis Evangelos
- Mallon Peter
- Marla Sekhar
- Marsh Simon
- Martin Lee
- Masannat Yazan
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathers Helen
- Mazari Fayyaz
- McCulley Stephen
- McEvoy Kat
- McGoldrick Ciara
- McIntosh Jamie
- McIntosh Stuart A.
- Mckenzie Shireen
- McManus Penelope
- Mehta Disha
- Merker Louise
- Mikhael Youhana
- Mirshekar-Syahkal Bahar
- Mitchell Geraldine
- Mondani Giuseppina
- Monib Sherif
- Moody Alice
- Mortimer Caroline
- Mullan Michelle
- Mullen Russell
- Murphy John
- Mylvaganam Senthurun
- Nair Rajive
- Najeeb Erum
- Narayanan Sankaran
- Nasir Nabila
- Navin Channegowda
- Noor Lubna
- Noronha Jarin Louis
- Ntakomyti Eleni
- Odofin Olubunmi
- Olsen Sisse
- Oni Georgette
- Ooi Jane
- O’Connell Rachel
- Pain Simon
- Pakzad Farrokh
- Parmeshwar Rishikesh
- Partlett Polly
- Patani Neill
- Peck Jennifer
- Peerlink Inga
- Pereira Bernadette
- Phyu Saung Hnin
- Pieri Andrew
- Pilgrm Simon
- Podesta Carl
- Pogson Caroline
- Poonawala Shabbir
- Potter Shelley
- Potter Shelley
- Power Colm
- Prusty Lydia
- Quinn Edel
- Ralph Jane
- Ramzi Sa’ed
- Rana Dheer Singh
- Rapisarda Fabio
- Rasheed Tuabin
- Rathinaezhil Rathi
- Rattay Tim
- Ravichandran Duraisamy
- Ray Atanu
- Rayter Zenon
- Remoundos Dennis
- Rew David
- Robb Henry Douglas
- Robertson Stuart
- Roche Nicola
- Romics Laszlo
- Rowland Matthew
- Roy Pankaj
- Rusby Jennifer E.
- Rutherford Claire Louise
- Saha Sunita
- Sahu Ajay
- Sait Mohamed Razick
- Sakellariou Vasileios
- Salem Fathi
- Salih Ali
- Salman Muhammad
- Salman Reem
- Salvador Reginald
- Sami Amtul
- Sarakbi Wail Al
- Sardar Mini V.
- Sarker Masuma
- Sasi Walid
- Satpathy Anjana
- Scally Norah
- Segaran Ashvina
- Sein Tin Aung
- Seward Joanna
- Shaheed Samy
- Sharif Mohammad Amir
- Sharma Anita
- Sharma Anup
- Sharma Nisha
- Shere Mike
- Shin Hyunjin
- Shokuhi Sheila
- Shrotri Anu
- Sibbering David Mark
- Simonca Claudiu
- Sircar Tapan
- Sloan Samantha A.
- Smith Simon
- Smyth Elizabeth
- Somasundaram Santosh
- Sotheran Wendy
- Soulsby Rachel
- Soumian Soni
- Sousa Emma de
- St John Edward R. C.
- Stallard Sheila
- Stanilov Noyko
- Suleiman Usama
- Sulieman Mona
- Sutton Richard
- Sweetland Helen M.
- Tabbakh Rami
- Tanhueco Angeline
- Tansley Anne
- Taraki Zarghuna
- Taxiarchi Vicky P.
- Taylor Amanda
- Thekkinkattil Dinesh
- Thiruchelvam Paul
- Thomas Robert
- Thomson Simon
- Thorne Amanda
- Tillett Rachel
- Touqan Nader
- Tuffaha Hussein
- Turner Jane
- Turton Philip
- Urquhart Gordon
- Valassiadou Kalliope
- Vashisht Rajiv
- Vatish Jamie
- Verroiotou Maria
- Vidya Raghavan
- Vinayagam Raman
- Wahedna Yasmin
- Waheed Shamaela
- Wallace Sharon
- Walsh Adam
- Wardle Stacy
- Whisker Lisa
- Whitehead Ian
- Wignarajah Primeera
- Williams Chloe
- Williams Kate E.
- Williams Samantha K.
- Williams-Jones Susan
- Wilson Christopher
- Young Ian
- Youssef Mina M. G.
- Zammit Charles
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- British Journal of Cancer
- Publication date
- 10/12/2020
- Field of study
Abstract: Background: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. Methods: This was a national cohort study of patients with early BC undergoing multidisciplinary team (MDT)-guided treatment recommendations during the pandemic, designated ‘standard’ or ‘COVID-altered’, in the preoperative, operative and post-operative setting. Findings: Of 3776 patients (from 64 UK units) in the study, 2246 (59%) had ‘COVID-altered’ management. ‘Bridging’ endocrine therapy was used (n = 951) where theatre capacity was reduced. There was increasing access to COVID-19 low-risk theatres during the study period (59%). In line with national guidance, immediate breast reconstruction was avoided (n = 299). Where adjuvant chemotherapy was omitted (n = 81), the median benefit was only 3% (IQR 2–9%) using ‘NHS Predict’. There was the rapid adoption of new evidence-based hypofractionated radiotherapy (n = 781, from 46 units). Only 14 patients (1%) tested positive for SARS-CoV-2 during their treatment journey. Conclusions: The majority of ‘COVID-altered’ management decisions were largely in line with pre-COVID evidence-based guidelines, implying that breast cancer survival outcomes are unlikely to be negatively impacted by the pandemic. However, in this study, the potential impact of delays to BC presentation or diagnosis remains unknown
Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.
- Author
- Ahmed Munaza
- Aitken Stuart
- Aitman Timothy
- Akawi Nadia
- Al Turki Saeed
- Alachkar Hana
- Ali Sonia
- Allen Hana Lango
- Allen Louise
- Allsup David
- Alvi Mohsan
- Ambegaonkar Gautum
- Ambridge Kirsty
- Anderson Carl
- Anderson Julie
- Anjum Uruj
- Anney Richard
- Antony Dinu
- Antrobus Richard
- Archer Hayley
- Armstrong Ruth
- Armstrong Ruth
- Arno Gavin
- Artigas Maria Soler
- Arumugakani Gururaj
- Ashford Sofie
- Astle William
- Attwood Antony
- Austin Steve
- Awada Jana
- Ayub Muhammad
- Bacchelli Chiara
- Bakchoul Tamam
- Balasubramaniam Senduran
- Balasubramanian Meena
- Banka Siddharth
- Baralle Diana
- Bariana Tadbir K.
- Barnicoat Angela
- Barrett Daniel M.
- Barrett Jeffrey C.
- Barrett Jeffrey C.
- Barroso Inês
- Batstone Paul
- Baty David
- Baxendale Helen
- Bayzetinova Tanya
- Beales Phil
- Bennett Chris
- Bennett David
- Bentham Jamie
- Berg Jonathan
- Bernhard Birgitta
- Bethune Claire
- Bevan A. Paul
- Bhattacharya Shoumo
- Bibi Shahnaz
- Birney Ewan
- Bitner-Glindzicz Maria
- Bitner-Glindzicz Maria
- Blackwood Douglas
- Blair Edward
- Bleda Marta
- Blyth Moira
- Bobrow Martin
- Bochukova Elena
- Boggard Harm
- Bohanna David
- Bolton Patrick
- Bolton-Maggs Paula
- Booth Claire
- Bounds Rebecca
- Bourdon Louise
- Bourn David
- Boustred Chris
- Bradley John R.
- Bradley Lisa
- Brady Angela
- Brady Angie
- Breen Gerome
- Brent Simon
- Brewer Carole
- Brown Matthew
- Browning Michael
- Brunstrom Kate
- Bryant Emily
- Bryson Christine
- Bunyan David J.
- Burn John
- Burns Siobhan
- Calissano Mattia
- Calleja Paul
- Canham Natalie
- Canham Natalie
- Carmichael Jenny
- Carss Keren
- Carss Keren
- Carss Keren J.
- Carvill Gemma L.
- Castle Bruce
- Caulfield Mark
- Chalmers Elizabeth
- Chandler Kate
- Chandra Anita
- Chatterjee Krishna
- Chatzimichali Elena
- Chen Lu
- Chinnery Patrick
- Chitre Manali
- Church Colin
- Ciampi Antonio
- Cilliers Deirdre
- Cirak Sebhattin
- Clapham Peter
- Clarke Angus
- Clasper Susan
- Clayton Stephen
- Clayton-Smith Jill
- Clayton-Smith Jill
- Clement Emma
- Clement Gail
- Clements-Brod Naomi
- Clowes Virginia
- Clowes Virginia
- Coates Andrea
- Coates Guy
- Coghlan Gerry
- Cole Trevor
- Colgiu Irina
- Collier David
- Collins Amanda
- Collins Peter
- Collinson Morag N.
- Connell Fiona
- Cooper Nichola
- Cooper Nicola
- Cosgrove Catherine
- Cox Helen
- Cox Tony
- Craddock Nick
- Creaser-Myers Amanda
- Cresswell Lara
- Crooks Lucy
- Cross Gareth
- Cross J. Helen
- Crow Yanick
- Curran Sarah
- Curtis David
- D?Alessandro Mariella
- Dabir Tabib
- DaCosta Rosa
- Daly Allan
- Daugherty Louise
- Davidson Rosemarie
- Davies Sally
- Davies Sophie
- Davis John
- Day Ian N.M.
- Day-Williams Aaron
- de Vries Dylan
- De Vries Minka
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- Deevi Sri V.V.
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- Deshpande Charu
- Devlin Gemma
- Devlin Lisa
- Dewhurst Eleanor
- Dixit Abhijit
- Dobbie Angus
- Doffinger Rainer
- Donaldson Alan
- Donnai Dian
- Donnelly Carina
- Donnelly Deirdre
- Dormand Natalie
- Douglas Angela
- Douzgou Sofia
- Down Thomas
- Drewe Elizabeth
- Du Yuanping
- Duncan Alexis
- Dunham Ian
- Eason Jacqueline
- Edgar David
- Edkins Sarah
- Egner William
- Ellard Sian
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- Elmslie Frances
- Erber Wendy N.
- Erwood Marie
- Evans David
- Evans Karenza
- Everest Sarah
- Everington Tamara
- Faroogi Sadaf
- Fatemifar Ghazaleh
- Favier Remi
- Fendick Tina
- Firth Helen
- Firth Helen V.
- Fisher Richard
- Fitzgerald Tomas W.
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- Fletcher Debra
- Flicek Paul
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- Flyod James
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- Furnell Abigail
- Futema Marta
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- Gallagher Louise
- Gardham Alice
- Gardiner Carol
- Gattens Michael
- Gaunt Lorraine
- Geihs Matthias
- Geschwind Daniel
- Ghali Neeti
- Ghali Neeti
- Ghataorhe Pavandeep K.
- Ghurye Rohit
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- Gissen Paul
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- Gorman Kathleen M.
- Goudie David
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- Greenhalgh Alan
- Greenhalgh Lynn
- Greinacher Andreas
- Gribble Susan
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- Grigoriadou Sofia
- Grozeva Detelina
- Gräf Stefan
- Guo Xiaosen
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- Gurling Hugh
- Haack Tobias B.
- Hackett Scott
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- Hague Rosie
- Haimel Matthias
- Halmagyi Csaba
- Hammerton Tracey
- Harrison Lucy
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- Hart Deborah
- Hawkins Rose
- Hayman Grant
- He Liu
- Heemskerk Johan W.M.
- Hellens Stephen
- Henderson Alex
- Henderson Robert
- Hendricks Audrey
- Hensiek Anke
- Henskens Yvonne
- Herwadkar Archana
- Hewitt Sarah
- Hildyard Lucy
- Hobson Emma
- Holden Simon
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- Holder Muriel
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- Hollingsworth Georgina
- Holmans Peter
- Homfray Tessa
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- Huang Liren
- Hubbard Tim
- Huissoon Aarnoud
- Humbert Marc
- Humphreys Mervyn
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- Hurles Matthew E.
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- Hurst Jane
- Hurst Jane
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- Jing Tian
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- Jones Wendy D.
- Josifova Dragana
- Josifova Dragana
- Joss Shelagh
- Joyce Chris
- Kaemba Beckie
- Kaplanis Joanna
- Kaye Jane
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- Kazmi Rashid
- Keane Thomas
- Keeling David
- Kelleher Peter
- Kelly Anne M.
- Kelsell Rosemary
- Kemp John
- Kennedy Fiona
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- Kerr Bronwyn
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- Kini Usha
- Kinning Esther
- Kirby Gail
- Kirk Claire
- Kivuva Emma
- Kolb-Kokocinski Anja
- Koziell Ania
- Kraus Alison
- Krishnakumar Deepa
- Krishnappa Netravathi
- Kuijpers Taco W.
- Kumar Dhavendra
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- Kumararatne Dinakantha
- Kurian Manju
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- Langford Cordelia
- Langman Caroline
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- Lawson Daniel
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- Lees Melissa
- Lees Melissa
- Lek Monkol
- Lentaigne Claire
- Li Rui
- Li Yingrui
- Liang Jieqin
- Liesner Ri
- Lim Derek
- Lin Hong
- Linger Rachel
- Liu Ryan
- Longhurst Hilary
- Longman Cheryl
- Lopes Margarida
- Lorenzo Lorena
- Lowther Gordon
- Lynch Sally A.
- Lönnqvist Jouko
- MacArthur Daniel
- Machado Rajiv
- Mackenzie Rob
- MacLaren Robert
- Magee Alex
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- Maher Eddy
- Maimaris Jesmeen
- Male Alison
- Mangles Sarah
- Manson Ania
- Mansour Sahar
- Mapeta Rutendo
- Marchini Jonathan
- Marenne Gaëlle
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- Martin Jennifer
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- Masati Larahmie
- Maslen John
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- Massimo Mangino
- Mathias Mary
- Mathieson Iain
- Matser Vera
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- Maye Una
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- McConnell Vivienne
- McCullagh Gary
- McDermott Elizabeth
- McEntagart Meriel
- McGowan Ruth
- McGuffin Peter
- McIntosh Andrew
- McJannet Coleen
- McKay Kirsten
- McKechanie Andrew G.
- McKee Shane
- McMullan Dominic J.
- McNerlan Susan
- McQuillin Andrew
- McRae Jeremy F.
- McTague Amy
- McWilliam Catherine
- Meacham Stuart
- Meehan Sharon
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- Megy Karyn
- Mehta Sarju
- Mehta Sarju
- Metcalfe Kay
- Metrustry Sarah
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- Middleton Anna
- Miedzybrodzka Zosia
- Miles Emma
- Millar Carolyn M.
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- Moayyeri Alireza
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- Morrell Nicholas
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- Morton Jenny
- Mugalaasi Hood
- Mumford Andrew
- Muntoni Francesco
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- Murng Sai
- Murphy Elaine
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- Naik Swati
- Nejentsev Sergey
- Nellåker Chris
- Nemeth Andrea
- Nevitt Louise
- Newbury-Ecob Ruth
- Noorani Sadia
- Norman Andrew
- Northstone Kate
- Nurden Paquita
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- O'Shea Rosie
- Ogilvie Caroline
- Oksenhendler Eric
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- Oualkacha Karim
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- Paternoster Lavinia
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- Reid Evan
- Rhodes Christopher J.
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- Sanchis-Juan Alba
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- Schiffels Stephen
- Schmidts Miriam
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- Shearing Emma
- Shears Debbie
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- Stauss Hans
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- Straub Volker
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- Swaminathan Ganesh Jawahar
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- Wright Michael
- Xu ChangJiang
- Yang Jian
- Yates Laura
- Yau Michael
- Yeatman Nigel
- Yong Patrick
- Young Tim
- Yu Ping
- Zhang Fend
- Zhang Pingbo
- Publication venue
- AJHG
- Publication date
- 01/01/2019
- Field of study
The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. All affected individuals presented with epileptic encephalopathy, severe neurodevelopmental delay (often with regression), and a hyperkinetic movement disorder. Additional neurological features included postnatal microcephaly and hypotonia. Five children died in childhood or adolescence (mean age of death: 9 years), mainly as a result of secondary respiratory complications. CACNA1B encodes the pore-forming subunit of the pre-synaptic neuronal voltage-gated calcium channel Cav2.2/N-type, crucial for SNARE-mediated neurotransmission, particularly in the early postnatal period. Bi-allelic loss-of-function variants in CACNA1B are predicted to cause disruption of Ca2+ influx, leading to impaired synaptic neurotransmission. The resultant effect on neuronal function is likely to be important in the development of involuntary movements and epilepsy. Overall, our findings provide further evidence for the key role of Cav2.2 in normal human neurodevelopment.MAK is funded by an NIHR Research Professorship and receives funding from the Wellcome Trust, Great Ormond Street Children's Hospital Charity, and Rosetrees Trust. E.M. received funding from the Rosetrees Trust (CD-A53) and Great Ormond Street Hospital Children's Charity. K.G. received funding from Temple Street Foundation. A.M. is funded by Great Ormond Street Hospital, the National Institute for Health Research (NIHR), and Biomedical Research Centre. F.L.R. and D.G. are funded by Cambridge Biomedical Research Centre. K.C. and A.S.J. are funded by NIHR Bioresource for Rare Diseases. The DDD Study presents independent research commissioned by the Health Innovation Challenge Fund (grant number HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome Trust Sanger Institute (grant number WT098051). We acknowledge support from the UK Department of Health via the NIHR comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London. This research was also supported by the NIHR Great Ormond Street Hospital Biomedical Research Centre. J.H.C. is in receipt of an NIHR Senior Investigator Award. The research team acknowledges the support of the NIHR through the Comprehensive Clinical Research Network. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, Department of Health, or Wellcome Trust. E.R.M. acknowledges support from NIHR Cambridge Biomedical Research Centre, an NIHR Senior Investigator Award, and the University of Cambridge has received salary support in respect of E.R.M. from the NHS in the East of England through the Clinical Academic Reserve. I.E.S. is supported by the National Health and Medical Research Council of Australia (Program Grant and Practitioner Fellowship)
Learning From Each Other: The Special Cell and Domestic Violence Activist Responses in Different Contexts Across the World
- Author
- Publication venue
- Publication date
- 01/10/2013
- Field of study
Honour-based Violence (HBV) and Honour-based Killings in Iraqi Kurdistan and in the Kurdish Diaspora in the UK
- Publication venue
- Publication date
- 01/01/2010
- Field of study
Double Jeopardy: Disabled women’s experiences of domestic violence.
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2015
- Field of study
- …