Comportamiento de la estomatitis subprótesis en pacientes del Policlínico Hermanos Cruz

Introducción: la estomatitis subprótesis es una inflamación congestiva de la mucosa que suele aparecer en contacto con las bases protéticas. Objetivo: determinar el comportamiento de la estomatitis subprótesis grado I, II y III. Método: se realizó un estudio observacional de tipo descriptivo de corte transversal en el período comprendido entre Junio del 2012 a febrero del 2013, en pacientes portadores de prótesis dental pertenecientes al Policlínico Docente “Hermanos Cruz”.  El  universo estuvo constituido por 955 pacientes portadores de prótesis dental que acudieron a consulta de Estomatología en dicho período, y la muestra quedó constituida por los 235 pacientes portadores de estomatitis subprótesis. Para determinar el grado de lesión se realizó una  observación de la cavidad bucal durante el examen clínico según la clasificación establecida.Resultados: en la medida que avanza la edad, existe una mayor incidencia de la enfermedad, siendo el sexo masculino el más afectado con predominio del grado I. La mayoría de los pacientes mantenía un uso continuo de la prótesis y los más afectados fueron aquellos que portaban prótesis con base acrílica. La mayor cantidad de lesiones  se localizaron en la zona media. Conclusiones: A las consultas de Estomatología acuden con frecuencia pacientes portadores de estomatitis subprótesis, con un cuadro clínico en mayor o menor severidad

Variable stars in the VVV globular clusters. II. NGC6441, NGC6569, NGC6626 (M28), NGC6656 (M22), 2MASS-GC02, and Terzan10

© ESO 2021. This is the accepted manuscript version of an article which has been published in final form at https://doi.org/10.1051/0004-6361/202140546Context. The Galactic globular clusters (GGCs) located in the inner regions of the Milky Way suffer from high extinction that makes their observation challenging. High densities of field stars in their surroundings complicate their study even more. The VISTA Variables in the Via Lactea (VVV) survey provides a way to explore these GGCs in the near-infrared where extinction effects are highly diminished. Aims. We conduct a search for variable stars in several inner GGCs, taking advantage of the unique multi-epoch, wide-field, near-infrared photometry provided by the VVV survey. We are especially interested in detecting classical pulsators that will help us constrain the physical parameters of these GGCs. In this paper, the second of a series, we focus on NGC 6656 (M 22), NGC 6626 (M 28), NGC 6569, and NGC 6441; these four massive GGCs have known variable sources, but quite different metallicities. We also revisit 2MASS-GC 02 and Terzan 10, the two GGCs studied in the first paper of this series. Methods. We present an improved method and a new parameter that efficiently identify variable candidates in the GGCs. We also use the proper motions of those detected variable candidates and their positions in the sky and in the color-magnitude diagrams to assign membership to the GGCs. Results. We identify and parametrize in the near-infrared numerous variable sources in the studied GGCs, cataloging tens of previously undetected variable stars. We recover many known classical pulsators in these clusters, including the vast majority of their fundamental mode RR Lyrae. We use these pulsators to obtain distances and extinctions toward these objects. Recalibrated period-luminosity-metallicity relations for the RR Lyrae bring the distances to these GGCs to a closer agreement with those reported by Gaia, except for NGC 6441, which is an uncommon Oosterhoff III GGC. Recovered proper motions for these GGCs also agree with those reported by Gaia, except for 2MASS-GC 02, the most reddened GGC in our sample, where the VVV near-infrared measurements provide a more accurate determination of its proper motions.Peer reviewe

Three novel and the common Arg677Ter RP1 protein truncating mutations causing autosomal dominant retinitis pigmentosa in a Spanish population

BACKGROUND: Retinitis pigmentosa (RP), a clinically and genetically heterogeneous group of retinal degeneration disorders affecting the photoreceptor cells, is one of the leading causes of genetic blindness. Mutations in the photoreceptor-specific gene RP1 account for 3–10% of cases of autosomal dominant RP (adRP). Most of these mutations are clustered in a 500 bp region of exon 4 of RP1. METHODS: Denaturing gradient gel electrophoresis (DGGE) analysis and direct genomic sequencing were used to evaluate the 5' coding region of exon 4 of the RP1 gene for mutations in 150 unrelated index adRP patients. Ophthalmic and electrophysiological examination of RP patients and relatives according to pre-existing protocols were carried out. RESULTS: Three novel disease-causing mutations in RP1 were detected: Q686X, K705fsX712 and K722fsX737, predicting truncated proteins. One novel missense mutation, Thr752Met, was detected in one family but the mutation does not co-segregate in the family, thereby excluding this amino acid variation in the protein as a cause of the disease. We found the Arg677Ter mutation, previously reported in other populations, in two independent families, confirming that this mutation is also present in a Spanish population. CONCLUSION: Most of the mutations reported in the RP1 gene associated with adRP are expected to encode mutant truncated proteins that are approximately one third or half of the size of wild type protein. Patients with mutations in RP1 showed mild RP with variability in phenotype severity. We also observed several cases of non-penetrant mutations

Relation of IL28B Gene Polymorphism with Biochemical and Histological Features in Hepatitis C Virus-Induced Liver Disease

BACKGROUND/AIMS: Polymorphism at the IL28B gene may modify the course of hepatitis C virus (HCV) chronic infection. Our aim was to study the influence of IL28B rs12979860 gene polymorphism on the biochemistry and pathology of HCV-induced disease in the clinical course from mild chronic hepatitis C to hepatocellular carcinoma. METHODS: We have determined the rs12979860 single nucleotide polymorphism (SNP) upstream IL28B gene in two groups of patients with HCV-induced chronic liver disease: 1) 268 patients (159 men) with biopsy-proven chronic hepatitis C, to analyse its relation with biochemical, virological and histological features; and 2) 134 patients (97 men) with HCV-related hepatocellular carcinoma. The distribution of the analysed SNP in hepatocellular carcinoma patients was compared with that found in untreated chronic hepatitis C patients. All patients were white and most were Spaniards. RESULTS: In multivariate analysis ALT values were higher (P = 0.001) and GGT values were lower (P<0.001) in chronic hepatitis C patients homozygotes for the major rs12979860C allele as compared with carriers of the mutated rs12979860T allele. Steatosis was more frequent (Odds ratio = 1.764, 95% C.I. 1.053-2.955) and severe (P = 0.026) in carriers of the rs12979860T allele. No relation was found between the analysed SNP and METAVIR scores for necroinflammation and fibrosis, and there were no differences in the distribution of the analysed SNP between hepatocellular carcinoma and untreated chronic hepatitis C patients. CONCLUSION: The IL28B rs12979860 polymorphism correlates with the biochemical activity and the presence and severity of liver steatosis in chronic hepatitis C

Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care

<p>Abstract</p> <p>Background</p> <p>Vaginitis is a common complaint in primary care. In uncomplicated candidal vaginitis, there are no differences in effectiveness between oral or vaginal treatment. Some studies describe that the preferred treatment is the oral one, but a Cochrane's review points out inconsistencies associated with the report of the preferred way that limit the use of such data. Risk factors associated with recurrent vulvovaginal candidiasis still remain controversial.</p> <p>Methods/Design</p> <p>This work describes a protocol of a multicentric prospective observational study with one year follow up, to describe the women's reasons and preferences to choose the way of administration (oral vs topical) in the treatment of not complicated candidal vaginitis. The number of women required is 765, they are chosen by consecutive sampling. All of whom are aged 16 and over with vaginal discharge and/or vaginal pruritus, diagnosed with not complicated vulvovaginitis in Primary Care in Madrid.</p> <p>The main outcome variable is the preferences of the patients in treatment choice; secondary outcome variables are time to symptoms relief and adverse reactions and the frequency of recurrent vulvovaginitis and the risk factors. In the statistical analysis, for the main objective will be descriptive for each of the variables, bivariant analysis and multivariate analysis (logistic regression).. The dependent variable being the type of treatment chosen (oral or topical) and the independent, the variables that after bivariant analysis, have been associated to the treatment preference.</p> <p>Discussion</p> <p>Clinical decisions, recommendations, and practice guidelines must not only attend to the best available evidence, but also to the values and preferences of the informed patient.</p

The First Post-Kepler Brightness Dips of KIC 8462852

We present a photometric detection of the first brightness dips of the unique variable star KIC 8462852 since the end of the Kepler space mission in 2013 May. Our regular photometric surveillance started in October 2015, and a sequence of dipping began in 2017 May continuing on through the end of 2017, when the star was no longer visible from Earth. We distinguish four main 1-2.5% dips, named "Elsie," "Celeste," "Skara Brae," and "Angkor", which persist on timescales from several days to weeks. Our main results so far are: (i) there are no apparent changes of the stellar spectrum or polarization during the dips; (ii) the multiband photometry of the dips shows differential reddening favoring non-grey extinction. Therefore, our data are inconsistent with dip models that invoke optically thick material, but rather they are in-line with predictions for an occulter consisting primarily of ordinary dust, where much of the material must be optically thin with a size scale <<1um, and may also be consistent with models invoking variations intrinsic to the stellar photosphere. Notably, our data do not place constraints on the color of the longer-term "secular" dimming, which may be caused by independent processes, or probe different regimes of a single process

EDUCACIÓN AMBIENTAL Y SOCIEDAD. SABERES LOCALES PARA EL DESARROLLO Y LA SUSTENTABILIDAD

Este texto contribuye al análisis científico de varias áreas del conocimiento como la filosofía social, la patología, la educación para el cuidado del medio ambiente y la sustentabilidad que inciden en diversas unidades de aprendizaje de la Licenciatura en Educación para la Salud y de la Maestría en Sociología de la SaludLas comunidades indígenas de la sierra norte de Oaxaca México, habitan un territorio extenso de biodiversidad. Sin que sea una área protegida y sustentable, la propia naturaleza de la región ofrece a sus visitantes la riqueza de la vegetación caracterizada por sus especies endémicas que componen un paisaje de suma belleza

A survey for variable young stars with small telescopes – VIII. Properties of 1687 Gaia selected members in 21 nearby clusters

The Hunting Outbursting Young Stars (HOYS) project performs long-term, optical, multi-filter, high cadence monitoring of 25 nearby young clusters and star forming regions. Utilising Gaia DR3 data we have identified about 17000 potential young stellar members in 45 coherent astrometric groups in these fields. Twenty one of them are clear young groups or clusters of stars within one kiloparsec and they contain 9143 Gaia selected potential members. The cluster distances, proper motions and membership numbers are determined. We analyse long term (≈ 7 yr) V, R, and I-band light curves from HOYS for 1687 of the potential cluster members. One quarter of the stars are variable in all three optical filters, and two thirds of these have light curves that are symmetric around the mean. Light curves affected by obscuration from circumstellar materials are more common than those affected by accretion bursts, by a factor of 2 – 4. The variability fraction in the clusters ranges from 10 to almost 100 percent, and correlates positively with the fraction of stars with detectable inner disks, indicating that a lot of variability is driven by the disk. About one in six variables shows detectable periodicity, mostly caused by magnetic spots. Two thirds of the periodic variables with disk excess emission are slow rotators, and amongst the stars without disk excess two thirds are fast rotators – in agreement with rotation being slowed down by the presence of a disk

Recuperación de los Problemas de Juego Patológico con y sin Tratamiento.

Research shows that only a very small percentage of pathological gam- blers seek professional treatment at any time, and that the commonest form of escape from pathological gambling is natural recovery. In gene- ral, gamblers who follow treatment programmes present greater severity of the problem than those who do not follow such programmes. There do not appear to be excessive differences in the factors related to change between those who seek treatment and those who recover by themselves. Behavioural and cognitive-motivational strategies, as well as cognitive processes of change, are the factors that best explain change and main- tained abstinence in pathological gambling. In any case, further research is necessary on the factors involved in recovery from pathological gam- bling, with a view to improving the therapeutic resources available for treating this type of problem

Influence of the inclusion of chestnut (Castanea sativa Miller) in the finishing diet and cooking technique on the physicochemical parameters and volatile profile of biceps femoris muscle

The aim of this study was to evaluate the influence of the diet (chestnut vs. commercial feed) and cooking techniques (roasting, grilling, frying and microwaving) on the quality of the Biceps femoris muscle of the Celta pig breed. Chemical composition, physicochemical parameters, oxidative stability and volatile profile were analysed. Overall, the inclusion of chestnuts did not affect the chemical composition, except for intramuscular fat content, which was higher in chestnut-fed pigs. The colour and shear force of cooked Biceps femoris were not affected by the finishing diet. However, a significant increase in cooking losses and thiobarbituric acid reactive substances (TBARS) value was found with the chestnuts included in the diet. In addition, the inclusion of chestnuts also modified some volatile compound that could be associated with the diet, such as furan, 2-pentyl. On the other hand, the cooking method significantly affected chemical composition (moisture, fat, protein and ash content), colour parameters, cooking loss, TBARS and volatile profile, whereas the shear force was not affected. Concretely, fried and microwave were the techniques that led to a greater presence of intramuscular fat. In addition, the frying method also showed the highest a* value, whereas the microwaved technique displayed the highest cooking loss. Regarding lipid oxidation, the fried method displayed the lower TBARS and hexanal content. On the other hand, the major volatile compounds were aldehydes in all cooking methods except for the frying technique in chestnut samples. Finally, method-frying displayed the lowest amount of total volatiles compounds, unlike grilling.Axencia Galega de Innovación | Ref. IN607A2019/0