Ventricular Extrasystole Ablation: electrophysiological characterization according to its origin

Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2020-2021. Tutor: Paz Garre Anguera de SojoIntroduction. Premature Ventricular Complexes (PVCs) are a frequent nonsevere cardiac condition that in some cases can be malignant, as they may result in structural cardiomyopathies or even sudden death, and need treatment. For pharmacoresistant PVCs, catheter ablation is used with a success rate between 50-90% for PVC burden reduction. The catheter used has a set of electrodes used to measure intracavitary signals. Hypothesis and objectives. Electrophysiological characteristics of the PVCs could be used to characterize the signals expected at different ventricular structures and assess the outcome of the ablation in real-time. Material and methods. Using CARTO3 (Remote Magnetic Navigation) we studied 29 PVCs (24 patients), from the Arrhythmia Unit of the Hospital Clinic of Barcelona. We characterized unipolar and bipolar electrograms by measuring amplitudes, precocities and unipolar negative deflections, and the most precocious isochrone at different cardiac points: Left ventricle (LV), Right ventricle (RV), Pulmonary artery (AP), Summit(S) and cusps (C). Results. Bipolar signals: the most precocious locations were RV and S, differences between RV-S (24.2 ms vs 43.3 p=0.0017) and C-S (26.6 vs 43.3 p=0.0104). LV showed the largest bipolar amplitude (5.65 mV), S the lowest (0.26). Areas showing largest number of unipolar negative deflections were RV (n=1.43), C (n=1.53) and AP (n=1.65), being significantly different form S (n=0.95, p= 0.0445, 0.0092, 0.00119, respectively). The steepest slope at LV (0.3 mV/ms), flattest at S (0.0297), finding significant differences LV-RV (p=0.0493). Unipolar precocities were significantly different between RV (26.9 ms) and LV (16.2, p=0.0002). Conclusion. Relations can be found between intracavitary ablation signals and ventricular structures. Differences in precocities between ventricles could be used as a marker to assess the state of intervention. More studies are needed to characterize ventricular substructures and to assess the long-term outcome of the procedure

Design and usability study of 3D printed objects for neurorehabilitation of the upper limb

After suffering an injury that affects the motor and sensory functions of the upper limb, a rehabilitation process begins with the aim of recovering, as much as possible, the lost functions and allow the patients to have the maximum degree of independence once they leave the hospital. In the context of rehabilitation, frequently patients do exercises simulating daily activities, but materials are unsuitable because the texture, weight or size are not equal as common daily objects, losing specificity for this task. As a consequence, the user may come to consider these activities as non-stimulating, not immersive or even repetitive. Decreasing their long-term interest in doing them, affecting, above all, the chronic rehabilitation process. Consequently, from the Rehabilitation department of the Guttmann Institute, we want to carry out a project with the aim of designing and obtaining, through processes of additive manufacturing, also known as 3D printing, objects made specifically for motor learning, sensory training and the practice of activities that the patients will have to face once they leave the hospital, in their daily life. The main purpose is to evaluate if the use of these objects can present advantages of usability and improvement in the functional rehabilitation of neurological patients with motor and sensory conditions in the upper limb, with respect to the use of rehabilitation objects used conventionall

Propuesta de un modelo de gestión de conocimiento enfocado en el proceso del grupo de servicios administrativos del Ministerio de Minas y Energía

107 páginasEsta propuesta de modelo de gestión de conocimiento está enfocada a una de las áreas de apoyo del Ministerio de Minas y Energía de Colombia y tiene como finalidad mostrar a la entidad el estado de madurez de gestión del conocimiento y medición de la cultura organizacional; para este caso se tomó corno área de muestra el Grupo de Servicios Administrativos. en el cual se aplicarán los instrumentos propuestos en este trabajo de grado y con base en los resultados se realizó el análisis y posteriormente se planteó la propuesta del modelo de gestión del conocimiento más apropiada para el grupo de trabajo, para así generar nuevas culturas organizacionales en las que se refleje colaboración entre servidores públicos y compartimiento de sus conocimientos, haciendo uso de herramientas tecnológicas que facilitan la conservación, almacenamiento y distribución del conocimiento, para que de esta manera se fortalezca el talento humano y de igual forma se creen nuevas y mejores estrategias de planeación, alineadas con los objetivos de la entidad, fomentando las buenas prácticas y transformación de los procesos internos, optimizando recursos para la entidad y a su vez agilizando las actividades y unificando criterios para mejorar en las respuestas a los ciudadanos.This proposed knowledge rnanagement model is focused on one of the support areas of the Ministry of Mines and Energy of Colombia and it is goal to show the entity the state of maturity of knowledge management and measurement of organizational culture; in this case, the Administrative Services Group was taken as a sample area which the instruments proposed in this grade work were applied and based on the results, the analysis was carried out and subsequently the proposal of the knowledge management model more appropriate for the work group was proposed, in order to generate new organizational cultures in which collaboration between public servants and sharing of their knowledge is reflected, making use of technological tools that facilitate the conservation, storage and distribution of knowledge, so that in this way human talent is strengthened and similarly new and better planning strategies are created, aligned with the objectives of the entity, promoting good practices and transformation of internal processes, optimizing resources for the entity and at the same time speeding up activities and unifying criteria to improve responses to citizens.Magíster en Gerencia Estratégica de Tecnologías de InformaciónMaestrí

Effectiveness of a Multi-Component Intervention for Overweight and Obese Children (Nereu Program): A Randomized Controlled Trial

Introduction: Treatment of childhood obesity is a complex challenge for primary health care professionals. Objectives: To evaluate the effectiveness of the Nereu Program in improving anthropometric parameters, physical activity and sedentary behaviours, and dietary intake. Methods: Randomized, controlled, multicentre clinical trial comparing Nereu Program and usual counselling group interventions in primary care settings. The 8-month study recruited 113 children aged 6 to 12 years with overweight/obesity. Before recruitment, eligible participants were randomly allocated to an intensive, family-based multi-component behavioural intervention (Nereu Program group) or usual advice from their paediatrician on healthy eating and physical activity. Anthropometric parameters, objectively measured sedentary and physical activity behaviours, and dietary intake were evaluated pre- and post-intervention. Results: At the end of the study period, both groups achieved a similar decrease in body mass index (BMIsd) compared to baseline. Nereu Program participants (n = 54) showed greater increases in moderate-intense physical activity (+6.27% vs. -0.61%, p<0.001) and daily fruit servings (+0.62 vs. +0.13, p<0.026), and decreased daily soft drinks consumption (-0.26 vs. -0.02, p<0.047), respectively, compared to the counselling group (n = 59). Conclusions: At the end of the 8-month intervention, participants in the Nereu Program group showed improvement in physical activity and dietary behaviours, compared to the counselling group

Evaluation of a family intervention programme for the treatment of overweight and obese children (Nereu Programme): a randomized clinical trial study protocol

Background: Obesity is mainly attributed to environmental factors. In developed countries, the time spent on physical activity tasks is decreasing, whereas sedentary behaviour patterns are increasing. The purpose of the intervention is to evaluate the effectiveness of an intensive family-based behavioural multicomponent intervention (Nereu programme) and compared it to counselling intervention such as a health centre intervention programme for the management of children"s obesity. Methods/Design: The study design is a randomized controlled multicenter clinical trial using two types of interventions: Nereu and Counselling. The Nereu programme is an 8-month intensive family-based multi-component behavioural intervention. This programme is based on a multidisciplinary intervention consisting of 4 components: physical activity sessions for children, family theoretical and practical sessions for parents, behaviour strategy sessions involving both, parents and children, and lastly, weekend extra activities for all. Counselling is offered to the family in the form of a monthly physical health and eating habits session. Participants will be recruited according the following criteria: 6 to 12 year-old-children, referred from their paediatricians due to overweight or obesity according the International Obesity Task Force criteria and with a sedentary profile (less than 2 hours per week of physical activity), they must live in or near the municipality of Lleida (Spain) and their healthcare paediatric unit must have previously accepted to cooperate with this study. The following variables will be evaluated: a) cardiovascular risk factors (anthropometric parameters, blood test and blood pressure), b) sedentary and physical activity behaviour and dietary intake, c) psychological aspects d) health related quality of life (HRQOL), e) cost-effectiveness of the intervention in relation to HRQOL. These variables will be then be evaluated 4 times longitudinally: at baseline, at the end of the intervention (8 months later), 6 and 12 months after the intervention. We have considered necessary to recruit 100 children and divide them in 2 groups of 50 to detect the differences between the groups. Discussion: This trial will provide new evidence for the long-term effects of childhood obesity management, as well as help to know the impact of the present intervention as a health intervention tool for healthcare centres. Trial registration: ClinicalTrials.gov, NCT01878994This research is partially funded by the Instituto de Salud Carlos III in Spain, from the Ministry of Economy and Competitiveness with the expedient number PI12/02220, the Diputació de Lleida, the Department of Health of the Generalitat de Catalunya and the City Council of Lleida “La Paeria - Ajuntament de Lleida”. This research was supported by the Institute of Physical Education of Catalonia (INEFC), University of Lleida, Spain, (VCP/3570/2010, de 29 d’octubre, DOGC NÚM. 5753 – 11.11.2010; VCP/28/2009, 14 of January, DOGC NÚM. 5302 – 22/01/1999)

Miradas colectivas de los departamentos del Huila y Tolima municipios de Garzón, Yaguará, Nàtaga, Ibagué

Desde la perspectiva de una mirada colectiva, evidenciamos la importancia de la Planificación Participativa, qué busca a través de un proceso de trasformación social y urbana favorecer el diálogo entre los estudiantes participantes, la ciudadanía y el ámbito social. De igual manera se hace evidente que un proyecto social resulta exitoso en la medida en que haya una participación ciudadana, que construya su propia visión sobre el problema que está viviendo en pro de una buena convivencia y bienestar integral. El presente trabajo expone el valor y necesidad de llevar a cabo acciones de responsabilidad social a través de la metodología de una intervención de la Psicología Comunitaria, tomando a la comunidad intervenida como el sujeto y objeto de dicha intervención y los efectos que dichas acciones generaran en la comunidad y en nosotros como profesionales responsables de cambio sociaFrom the perspective of a collective view, we highlight the importance of Participatory Planning, which seeks through a process of social and urban transformation to foster dialogue between participating students, citizenship and social environment. Likewise, it becomes evident that a social project is successful to the extent that there is citizen participation that builds its own vision on the problem that is living in favor of a good coexistence and integral well-being. The present work exposes the value and necessity of carrying out social responsibility actions through the methodology of an intervention of Community Psychology, taking the intervened community as the subject and object of said intervention and the effects that these actions generate in the community and in us as professionals responsible for social change

A phylogenetic and proteomic reconstruction of eukaryotic chromatin evolution

Histones and associated chromatin proteins have essential functions in eukaryotic genome organization and regulation. Despite this fundamental role in eukaryotic cell biology, we lack a phylogenetically comprehensive understanding of chromatin evolution. Here, we combine comparative proteomics and genomics analysis of chromatin in eukaryotes and archaea. Proteomics uncovers the existence of histone post-translational modifications in archaea. However, archaeal histone modifications are scarce, in contrast with the highly conserved and abundant marks we identify across eukaryotes. Phylogenetic analysis reveals that chromatin-associated catalytic functions (for example, methyltransferases) have pre-eukaryotic origins, whereas histone mark readers and chaperones are eukaryotic innovations. We show that further chromatin evolution is characterized by expansion of readers, including capture by transposable elements and viruses. Overall, our study infers detailed evolutionary history of eukaryotic chromatin: from its archaeal roots, through the emergence of nucleosome-based regulation in the eukaryotic ancestor, to the diversification of chromatin regulators and their hijacking by genomic parasites.Research in the A.S.-P. group was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 851647) and the Spanish Ministry of Science and Innovation (PGC2018-098210-A-I00). We also acknowledge support of the Spanish Ministry of Science and Innovation to the EMBL partnership, the Centro de Excelencia Severo Ochoa and the CERCA Programme (Generalitat de Catalunya). C.N. is supported by an FPI PhD fellowship from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC). X.G.-B. is supported by a Juan de la Cierva fellowship (FJC2018-036282-I) from MEIC. I.R.-T. was supported by a European Research Council (grant no. 616960). B.F.L. was supported by the Natural Sciences and Engineering Research Council of Canada (NSERC; RGPIN-2017-05411) and by the ‘Fonds de Recherche Nature et Technologie’, Quebec. P.L.-G. and D.M. were supported by a Moore and Simons foundations grant (GBMF9739) and by European Research Council advanced grants (322669, 787904). Research in the C.S. group was supported by the ERC through project TACKLE (advanced grant no. 695192)

Los repositorios institucionales de las universidades públicas valencianas: situación actual y retos para el futuro

El objetivo de la presente comunicación es realizar un análisis sobre la situación actual de los repositorios institucionales en las universidades públicas valencianas y reflexionar sobre los retos que se platean en los próximos años, con la finalidad de impulsar el conocimiento abierto en el ámbito valenciano. Esta reflexión, además de novedosa en nuestro ámbito geográfico-político, es necesaria y oportuna en este momento, puesto que recientemente se ha creado el grupo de trabajo de repositorios institucionales de las universidades públicas valencianas, formado por la Universitat de València, la Universitat Politècnica de València, la Universitat d?Alacant, la Universidad Miguel Hernández de Elche y la Universitat Jaume I de Castellón. Este grupo se enmarca en el proyecto Campus Habitat 5U , en el que las bibliotecas de las universidades públicas valencianas han creado diferentes grupos de trabajo para impulsar proyectos en común, entre ellos, el que trata sobre los repositorios. El punto de partida es el siguiente: las cinco universidades cuentan con sus respectivos repositorios institucionales, creados en diferentes años y con lógicas diferencias, pero con características comunes: mismo software, Dspace, contenidos similares, y con intereses comunes: hacer del repositorio institucional el archivo de la producción científica, docente y académica de la universidad, impulsando la difusión en acceso abierto del conocimiento universitario. Para llevar a cabo el análisis de la situación actual de cada repositorio, se ha elaborado una encuesta con diferentes indicadores, unos cualitativos y otros cuantitativos, sobre los propios repositorios y sobre el acceso abierto en general. A partir de estos datos se ha elaborado un informe sobre la situación actual de los repositorios universitarios valencianos y el acceso abierto. Estos mismos datos nos han permitido, por una parte, entrever los retos que se nos plantean en un futuro inmediato a los repositorios valencianos, y, por otra parte, destacar aquellos aspectos en los que el trabajo cooperativo puede ser útil para alcanzar el objetivo inicial, de impulso del acceso abierto en el ámbito valenciano. El siguiente paso ha sido establecer las prioridades de trabajo. Como resultado, se presenta en esta comunicación un resumen de dicho informe y las conclusiones sobre los retos planteados en cuanto a difusión, interoperabilidad y eficiencia en la gestión de los repositorios. Para alcanzar con éxito dichos retos resulta imprescindible el trabajo cooperativo. Se trata, en definitiva, de una reflexión general sobre los horizontes de los repositorios valencianos, que bien se podría extrapolar a otros ámbitos.Gómez Castaño, J.; Barrueco Cruz, JM.; París-Folch, M.; Aguilar-Lorente, E.; Martínez-Galindo, FJ. (2015). Los repositorios institucionales de las universidades públicas valencianas: situación actual y retos para el futuro. http://hdl.handle.net/10251/4807

Multicenter prospective clinical study to evaluate children short-term neurodevelopmental outcome in congenital heart disease (children NEURO-HEART) : study protocol

Altres ajuts: RETICS funded by the PN 2018-2021 (Spain).Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances in early diagnosis and postnatal management have increased survival in CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, have emerged as a key prognostic factor in the counseling of these pregnancies. Eligible participants are women presenting at 20 to < 37 weeks of gestation carrying a fetus with CHD. Maternal/neonatal recordings are performed at regular intervals, from the fetal period to 24 months of age, and include: placental and fetal hemodynamics, fetal brain magnetic resonance imaging (MRI), functional echocardiography, cerebral oxymetry, electroencephalography and serum neurological and cardiac biomarkers. Neurodevelopmental assessment is planned at 12 months of age using the ages and stages questionnaire (ASQ) and at 24 months of age with the Bayley-III test. Target recruitment is at least 150 cases classified in three groups according to three main severe CHD groups: transposition of great arteries (TGA), Tetralogy of Fallot (TOF) and Left Ventricular Outflow Tract Obstruction (LVOTO). The results of NEURO-HEART study will provide the most comprehensive knowledge until date of children's neurologic prognosis in CHD and will have the potential for developing future clinical decisive tools and improving preventive strategies in CHD. , on 4th December 2016 (retrospectively registered)

Family Matters:Rethinking the Psychology of Human Social Motivation

What motives do people prioritize in their social lives? Historically, social psychologists, especially those adopting an evolutionary perspective, have devoted a great deal of research attention to sexual attraction and romantic-partner choice (mate seeking). Research on long-term familial bonds (mate retention and kin care) has been less thoroughly connected to relevant comparative and evolutionary work on other species, and in the case of kin care, these bonds have been less well researched. Examining varied sources of data from 27 societies around the world, we found that people generally view familial motives as primary in importance and mate-seeking motives as relatively low in importance. Compared with other groups, college students, single people, and men place relatively higher emphasis on mate seeking, but even those samples rated kin-care motives as more important. Furthermore, motives linked to long-term familial bonds are positively associated with psychological well-being, but mate-seeking motives are associated with anxiety and depression. We address theoretical and empirical reasons why there has been extensive research on mate seeking and why people prioritize goals related to long-term familial bonds over mating goals. Reallocating relatively greater research effort toward long-term familial relationships would likely yield many interesting new findings relevant to everyday people’s highest social priorities