Gains from diversification: a regret theory approach

In this paper we analyze a regret-averse individual best choice in a two risky assets portfolio. We extend previous literature and contribute new results by considering a model with two assets. We get the conditions for the regret-averse investor to diversify the portfolio. We additionally compare the behavior of the regret-averse investor with the behavior of its risk-averse counterpart. We characterize the conditions under which both types of agents behavior coincide.optimization; diversification; regret theory; quadrant dependent.

The Sunyaev-Zeldovich effect in superclusters of galaxies using gasdynamical simulations: the case of Corona Borealis

[Abridged] We study the thermal and kinetic Sunyaev-Zel'dovich (SZ) effect associated with superclusters of galaxies using the MareNostrum Universe SPH simulation. We consider superclusters similar to the Corona Borealis Supercluster (CrB-SC). This paper is motivated by the detection at 33GHz of a strong temperature decrement in the CMB towards the core of this supercluster. Multifrequency observations with VSA and MITO suggest the existence of a thermal SZ effect component in the spectrum of this cold spot, which would account for roughly 25% of the total observed decrement. We identify nine regions containing superclusters similar to CrB-SC, obtain the associated SZ maps and calculate the probability of finding such SZ signals arising from hot gas within the supercluster. Our results show that WHIM produces a thermal SZ effect much smaller than the observed value. Neither can summing the contribution of small clusters and galaxy groups in the region explain the amplitude of the SZ signal. When we take into account the actual posterior distribution from the observations, the probability that WHIM can cause a thermal SZ signal like the one observed is <1%, rising up to a 3.2% when the contribution of small clusters and galaxy groups is included. If the simulations provide a suitable description of the gas physics, then we conclude that the thermal SZ component of the CrB spot most probably arises from an unknown galaxy cluster along the line of sight. The simulations also show that the kinetic SZ signal associated with the supercluster cannot provide an explanation for the remaining 75% of the observed cold spot in CrB.Comment: Accepted for publication in MNRAS. 14 pages, 9 figure

Editorial on Cerebral endothelial and glial cells are more than bricks in the Great Wall of the brain: insights into the way the blood-brain barrier actually works (celebrating the centenary of Goldman's experiments)

Carta editorial a la revista Frontiers in cellular neuroscience sobre las células endoteliales cerebrales y gliales. Se analiza la manera en que la barrera sangre-cerebro realmente funciona.Editorial letter to Frontiers in cellular neuroscience on cerebral endothelial and glial cells. It looks at how the blood-brain barrier actually works.peerReviewe

Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue

Drug biotransformation is a crucial mechanism for facilitating the elimination of chemicals from the organism and for decreasing their pharmacological activity. Published evidence suggests that brain drug metabolism may play a role in the development of adverse drug reactions and in the clinical response to drugs and xenobiotics. The blood–brain barrier (BBB) has been regarded mainly as a physical barrier for drugs and xenobiotics, and little attention has been paid to the BBB as a drug-metabolizing barrier. The presence of drug-metabolizing enzymes in the BBB is likely to have functional implications because local metabolism may inactivate drugs or may modify the drug’s ability to cross the BBB, thus modifying drug response and the risk of developing adverse drug reactions. In this perspective paper, we discuss the expression of relevant xenobiotic metabolizing enzymes in the brain and in the BBB, and we cover current advances and future directions on the potential role of these BBB drug-metabolizing enzymes as modifiers of drug response

Chandra unveils a binary Active Galactic Nucleus in Mrk463

We analyse Chandra, XMM-Newton and HST data of the double-nucleus Ultraluminous Infrared Galaxy (ULIRG), Mrk463. The Chandra detection of two luminous ($\mathrm{L}_\mathrm{2-10 keV}=1.5\times10^{43}$ and $3.8\times10^{42}$ erg cm$^{-2}$ s$^{-1}$), unresolved nuclei in Mrk~463 indicates that this galaxy hosts a binary AGN, with a projected separation of $\simeq3.8$ kpc ($3.83\pm0.01$ arcsec). While the East nucleus was already known to be a Seyfert 2 (and this is further confirmed by our Chandra detection of a neutral iron line), this is the first unambiguous evidence in favour of the AGN nature of the West nucleus. Mrk463 is therefore the clearest case so far for a binary AGN, after NGC6240.Comment: 7 pages, 7 figures, accepted for publication in MNRA

A Numerical Study of Brown Dwarf Formation via Encounters of Protostellar Disks

The formation of brown dwarfs (BDs) due to the fragmentation of proto-stellar disks undergoing pairwise encounters was investigated. High resolution allowed the use of realistic initial disk models where both the vertical structure and the local Jeans mass were resolved. The results show that objects with masses ranging from giant planets to low mass stars can form during such encounters from initially stable disks. The parameter space of initial spin-orbit orientations and the azimuthal angles for each disk was explored. An upper limit on the initial Toomre Q value of ~2 was found for fragmentation to occur. Depending on the initial configuration, shocks, tidal-tail structures and mass inflows were responsible for the condensation of disk gas. Retrograde disks were generally more likely to fragment. When the interaction timescale was significantly shorter than the disks' dynamical timescales, the proto-stellar disks tended to be truncated without forming objects. The newly-formed objects had masses ranging from 0.9 to 127 Jupiter masses, with the majority in the BD regime. They often resided in star-BD multiples and in some cases also formed hierarchical orbiting systems. Most of them had large angular momenta and highly flattened, disk-like shapes. The objects had radii ranging from 0.1 to 10 AU. The disk gas was assumed to be locally isothermal, appropriate for the short cooling times in extended proto-stellar disks, but not for condensed objects. An additional case with explicit cooling that reduced to zero for optically thick gas was simulated to test the extremes of cooling effectiveness and it was still possible to form objects in this case. Detailed radiative transfer is expected to lengthen the internal evolution timescale for these objects, but not to alter our basic results.Comment: 18 pages, 12 figures and 2 tables. Accepted for publication in MNRA

IMMUNOSUPPRESIVE EFFECTS OF THE METHANOLIC EXTRACT OF CHRYSOPHYLLUM CAINITO LEAVES ON MACROPHAGE FUNCTIONS

Background: The aim of this work was to evaluate the immunomodulatory effect of the methanol extract (MeOH) from Chrysophyllum cainito leaves on the MΦs functions. Material and Methods: Peritoneal murine MΦs isolated from Balb/c mice were treated with the MeOH extract and stimulated with LPS. The effect on the phagocytosis was evaluated by flow cytometry assay. The nitric oxide (NO) and hydrogen peroxide (H2O2) production was measured by the Griess reagent and phenol red reaction, respectively. Levels of IL-6 and TNF-was measured using an ELISA kit. Viability of MΦs and Vero cells was determined by the MTT method. Results: The MeOH extract of C. cainito leaves inhibited significantly the phagocytosis, and decreased IL-6 and TNF-α production as well as NO and H2O2 released by the MΦs, in a concentration-dependent manner. In addition, MeOH extract of C. cainito showed low cytotoxicity effect against the cells. Conclusion: These results suggest that MeOH extract of C. cainito leaves has an immunosuppressive effect on murine MΦs, without effects on cell viability. GC-MS chromatogram analysis of MeOH extract showed that lupeol acetate and alpha-amyrin acetate are the principal compounds

Developmental and tumoral vascularization is regulated by G protein-coupled receptor kinase 2

Tumor vessel dysfunction is a pivotal event in cancer progression. Using an in vivo neovascularization model, we identified G protein–coupled receptor kinase 2 (GRK2) as a key angiogenesis regulator. An impaired angiogenic response involving immature vessels was observed in mice hemizygous for Grk2 or in animals with endothelium-specific Grk2 silencing. ECs isolated from these animals displayed intrinsic alterations in migration, TGF-β signaling, and formation of tubular networks. Remarkably, an altered pattern of vessel growth and maturation was detected in postnatal retinas from endothelium-specific Grk2 knockout animals. Mouse embryos with systemic or endothelium-selective Grk2 ablation had marked vascular malformations involving impaired recruitment of mural cells. Moreover, decreased endothelial Grk2 dosage accelerated tumor growth in mice, along with reduced pericyte vessel coverage and enhanced macrophage infiltration, and this transformed environment promoted decreased GRK2 in ECs and human breast cancer vessels. Our study suggests that GRK2 downregulation is a relevant event in the tumoral angiogenic switch.Our laboratory is funded by grants from Ministerio de Educación y Ciencia (SAF2011-23800), Fundación Ramón Areces, The Cardiovascular Network (RECAVA) of Ministerio Sanidad y Consumo-Instituto Carlos III (RD06-0014/0037 and RD12/0042/0012), and Comunidad de Madrid (S-2010/BMD- 2332) to F. Mayor Jr. and Instituto Carlos III (PI11/00859), Fundación Ramón Areces, and Fundación Rodríguez Pascual to P. Penela. Marta Mendiola is supported by a postdoctoral research contract from Fondo de Investigación Sanitaria (“Sara Borrell” Programme), Instituto de Salud Carlos III