Search for Λ + c → ϕ p π 0 and branching fraction measurement of Λ + c → K − π + p π 0

We have searched for the Cabibbo-suppressed decay Λ+c→ϕpπ0 in e+e− collisions using a data sample corresponding to an integrated luminosity of 915 fb−1. The data were collected by the Belle experiment at the KEKB e+e− asymmetric-energy collider running at or near the Υ(4S) and Υ(5S)resonances. No significant signal is observed, and we set an upper limit on the branching fraction of B(Λ+c→ϕpπ0)\u3c15.3×10−5 at 90% confidence level. The contribution of nonresonant Λ+c→K+K−pπ0 decays is found to be consistent with zero, and the corresponding upper limit on its branching fraction is set to be B(Λ+c→K+K−pπ0)NR\u3c6.3×10−5 at 90% confidence level. We also search for an intermediate hidden-strangeness pentaquark decay P+s→ϕp. We see no evidence for this intermediate decay and set an upper limit on the product branching fraction of B(Λ+c→P+sπ0)×B(P+s→ϕp)\u3c8.3×10−5 at 90% confidence level. Finally, we measure the branching fraction for the Cabibbo-favored decay Λ+c→K−π+pπ0; the result is B(Λ+c→K−π+pπ0)=(4.42±0.05(stat)±0.12(syst)±0.16(norm))%, which is the most precise measurement to date

Atmospheric Muon Flux at Sea Level, Underground, and Underwater

The vertical sea-level muon spectrum at energies above 1 GeV and the underground/underwater muon intensities at depths up to 18 km w.e. are calculated. The results are particularly collated with a great body of the ground-level, underground, and underwater muon data. In the hadron-cascade calculations, the growth with energy of inelastic cross sections and pion, kaon, and nucleon generation in pion-nucleus collisions are taken into account. For evaluating the prompt muon contribution to the muon flux, we apply two phenomenological approaches to the charm production problem: the recombination quark-parton model and the quark-gluon string model. To solve the muon transport equation at large depths of homogeneous medium, a semi-analytical method is used. The simple fitting formulas describing our numerical results are given. Our analysis shows that, at depths up to 6-7 km w. e., essentially all underground data on the muon intensity correlate with each other and with predicted depth-intensity relation for conventional muons to within 10%. However, the high-energy sea-level data as well as the data at large depths are contradictory and cannot be quantitatively decribed by a single nuclear-cascade model.Comment: 47 pages, REVTeX, 15 EPS figures included; recent experimental data and references added, typos correcte

The Genetic Signatures of Noncoding RNAs

The majority of the genome in animals and plants is transcribed in a developmentally regulated manner to produce large numbers of non–protein-coding RNAs (ncRNAs), whose incidence increases with developmental complexity. There is growing evidence that these transcripts are functional, particularly in the regulation of epigenetic processes, leading to the suggestion that they compose a hitherto hidden layer of genomic programming in humans and other complex organisms. However, to date, very few have been identified in genetic screens. Here I show that this is explicable by an historic emphasis, both phenotypically and technically, on mutations in protein-coding sequences, and by presumptions about the nature of regulatory mutations. Most variations in regulatory sequences produce relatively subtle phenotypic changes, in contrast to mutations in protein-coding sequences that frequently cause catastrophic component failure. Until recently, most mapping projects have focused on protein-coding sequences, and the limited number of identified regulatory mutations have been interpreted as affecting conventional cis-acting promoter and enhancer elements, although these regions are often themselves transcribed. Moreover, ncRNA-directed regulatory circuits underpin most, if not all, complex genetic phenomena in eukaryotes, including RNA interference-related processes such as transcriptional and post-transcriptional gene silencing, position effect variegation, hybrid dysgenesis, chromosome dosage compensation, parental imprinting and allelic exclusion, paramutation, and possibly transvection and transinduction. The next frontier is the identification and functional characterization of the myriad sequence variations that influence quantitative traits, disease susceptibility, and other complex characteristics, which are being shown by genome-wide association studies to lie mostly in noncoding, presumably regulatory, regions. There is every possibility that many of these variations will alter the interactions between regulatory RNAs and their targets, a prospect that should be borne in mind in future functional analyses

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and has a profound effect on the quality of life of older people. The potential role of age-dependent mitochondrial dysfunction and cumulative oxidative stress as the underlying cause of muscle aging remains a controversial topic. Here we show that the pharmacological attenuation of age-related mitochondrial redox changes in muscle with SS31 is associated with some improvements in oxidative damage and mitophagy in muscles of old mice. However, this treatment failed to rescue the age-related muscle fiber atrophy associated with muscle atrophy and weakness. Collectively, these data imply that the muscle mitochondrial redox environment is not a key regulator of muscle fiber atrophy during sarcopenia but may play a key role in the decline of mitochondrial organelle integrity that occurs with muscle aging

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Observation of the Decay B0s→K0¯K0

We measure the decay B0s→K0¯K0 using data collected at the Υ(5S) resonance with the Belle detector at the KEKB e+e− collider. The data sample used corresponds to an integrated luminosity of 121.4  fb−1. We measure a branching fraction B(B0s→K0¯K0)=[19.6+5.8−5.1(stat)±1.0(syst)±2.0(NB0s¯B0s)]×10−6 with a significance of 5.1 standard deviations. This measurement constitutes the first observation of this deca

A Nd6 molecular butterfly: a unique all-in-one material for SMM, MCE and maiden photosensitized opto-electronic device fabrication

Besides iron, ironically neodymium (Nd) is the most ubiquitously used metal for magnetic purposes, even among the lanthanides, when it comes to the field of molecular magnetism, yet it ranks among the least studied metals. However, strong apathy towards this magnetic lanthanide means that vital information will be missed, which is required for the advancement of the subject. Herein, we have successfully demonstrated the usefulness of a hexanuclear neodymium complex as a magnetic material, and also in electronic device fabrication. A {NdIII6} cage with an aesthetically pleasing butterfly topology was synthesized using a rather non-conventional N-rich pyridyl-pyrazolyl-based ligand. The cage shows single-molecule magnet (SMM) properties, with an effective energy barrier, Ueff, the value of 3.4 K, and relaxation time, τ0, of 3.1 × 10−4 s, originating from an unusual occurrence of metal centers with different coordination environments. Furthermore, magnetic studies reveal significant cryogenic magnetic cooling, with a magnetic entropy change of 8.28 J kg−1 K−1 at 5 T and 3 K. To the best of our knowledge, the titular compound is the only example of an Nd-complex that exhibits concomitant magnetocaloric effect (MCE) and SMM properties. Complete active space self-consistent field (CASSCF) calculations were carried out to shed light on the origin of the magnetic anisotropy and magnetic relaxation of the compound. The same uniqueness is also true for the first electronic investigation carried out on the Nd complex. The maiden electronic device fabricated using the Nd complex shows an interesting intertwining of electronic and optical features, which contribute towards its improved photosensitized optoelectronic data. This journal is © The Royal Society of Chemistr

Analytic considerations and design basis for the IEEE distribution test feeders

For nearly 20 years, the Test Feeder Working Group of the Distribution System Analysis Subcommittee has been developing openly available distribution test feeders for use by researchers. The purpose of these test feeders is to provide models of distribution systems that reflect the wide diversity in design and their various analytic challenges. Because of their utility and accessibility, the test feeders have been used for a wide range of research, some of which has been outside the original scope of intended uses. This paper provides an overview of the existing distribution feeder models and clarifies the specific analytic challenges that they were originally designed to examine. Additionally, this paper will provide guidance on which feeders are best suited for various types of analysis. The purpose of this paper is to provide the original intent of the Working Group and to provide the information necessary so that researchers may make an informed decision on which of the test feeders are most appropriate for their work