79 research outputs found
Succinate Dehydrogenase (SDH) D Subunit (SDHD) Inactivation in a Growth-Hormone-Producing Pituitary Tumor: A New Association for SDH?
- Author
- Publication venue
- 'The Endocrine Society'
- Publication date
- 01/01/2012
- Field of study
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
- Author
- Abora Rial-Villavecchia
- Adriana SĂĄnchez Serrano
- AdriĂĄn Sousa
- Aina Gomila Grange
- Ainhoa Sanjuan LĂłpez
- Ainhoa Urrutia Losada
- Alberto Gato DĂez
- Alberto Romero-Palacios
- Alberto Serrano MartĂnez
- Alejandra Duarte Borges
- Alejandro Araujo
- Alexander Rombauts
- Alexandra de la Vega
- Alexandre PĂ©rez GonzĂĄlez
- Alfonso Cabello Ăbeda
- Alfonso Lluna Carrascosa
- Alicia HernĂĄndez Torres
- Almudena HernĂĄndez Milian
- Ana Alberich Conesa
- Ana Correa Ruiz
- Ana Escoresca
- Ana Ferrer Ribera
- Ana Isabel Mariño Callejo
- Ana Isabel PelĂĄez Ballesta
- Ana Such Diaz
- Andrea MartĂn Plata
- André Barbosa Ventura
- Andrés Ruiz Sancho
- Ane Andrés Eisenhofer
- Anonymous
- Antonia Alcaraz
- Antonia SepĂșlveda Berrocal
- Antonio José Ruiz Reina
- Antonio Plata Ciezar
- Araceli GonzĂĄlez-Cuevas
- Arantzazu Mera Fidalgo
- Ariadna De Genover Gil
- Aroa Villoslada Gelabert
- Aychel Elena Roura Piloto
- Beatriz Diaz Pollan
- Beatriz Dietl
- Beatriz PĂ©rez-Monte MĂnguez
- Beatriz Sobrino Diaz
- Beigel
- BelĂ©n Loeches YagĂŒe
- Berenguer
- Bhimraj
- Blanca Alonso MartĂnez
- Blanca MartĂnez Cifre
- Blanca Pinilla
- Borja Gracia-Tello
- Campochiaro
- Capra
- Carlos Bea Serrano
- Carlos Dueñas Gutiérrez
- Carlos Enrique Sabbagh Fajardo
- Carlota Gudiol
- Carmen Aguayo Jiménez
- Carmen Herrero RodrĂguez
- Carmen Infante
- Carmen Yllera
- Carolina RoldĂĄn Fontana
- Channappanavar
- Chen
- Chen
- Chiara Fanciulli
- Clara MartĂnez Montes
- Clara Muñoz Aguirre
- Claudia GonzĂĄlez Rico
- Claudia Ălvarez-Pouso
- Claudio Bueno
- ConcepciĂłn GarcĂa-GarcĂa
- ConcepciĂłn Gonzalo
- Cristina BadĂa
- Cristina Cervera Acedo
- Cristina DĂez
- Cristina Lojo Cruz
- Cristina PelĂĄez Ballesta
- Cristina PĂ©rez GarcĂa
- Daniel Molina Morant
- Daniel Podzamczer
- Daniel Roger Zapata
- David Roa Alonso
- David Vinuesa GarcĂa
- Diana Piñar Cabezos
- Efrén Sånchez Vidal
- Elena Aranda Rife
- Elena Bereciartua Bastarrica
- Elena HellĂn-Valiente
- Elena MarĂn
- Elena Morcillo RodrĂguez
- Elena Salamanca-Rivera
- Elena Trigo Esteban
- Elena Ălvaro Alonso
- Eleni Patera
- Elisa Cordero-MatĂa
- Elisa GarcĂa VĂĄzquez
- Elizabet Petkova-Saiz
- EncarnaciĂłn Moral Escudero
- Enrique Bernal Morell
- Enrique MĂguez Rey
- Ester Saez de Adana Arroniz
- Esther Aznar Muñoz
- Esther Calbo
- Esther MartĂnez Birlanga
- Eva Jiménez Gonzålez de Buitrago
- Eva León Jiménez
- Eva Pilar GarcĂa Villalba
- Eva Talavera GarcĂa
- Evangelia Anna MarĂa Zioga
- Fadel
- Fernando de la Calle Prieto
- Fernando FernĂĄndez SĂĄnchez
- Francesc Escrihuela
- Francesca Gioia
- Francisco Anguita Santos
- Francisco Arnaiz de las Revillas
- Francisco Javier De la Hera FernĂĄndez
- Francisco Javier MartĂnez Marcos
- Francisco Javier RodrĂguez GĂłmez
- Francisco Muñoz Beamud
- Francisco Tejerina
- Fåtima Brañas Baztån
- Gabriela Abelenda-Alonso
- Gabriela Escudero LĂłpez
- Galadriel Pellejero
- Gaspar Duro Ruiz
- Gemma Mut Ramon
- Gemma Muñiz Nicolås
- Guan
- Guaraldi
- Guillem Policarpo Torres
- Guillermo Cuevas Tascon
- Gurutz Orbe NarvĂĄez
- GĂłmez LucĂa
- Harris
- Helem HaydeĂ© VĂlchez Rueda
- Helena AlbendĂn Iglesias
- HoffmannâLa Roche
- Horby
- Hortensia Ălvarez DĂaz
- Ignacio Pina
- Ignacio PĂ©rez Valero
- Ignacio Ălvarez RodrĂguez
- Inmaculada GonzĂĄlez-Cuello
- Inmaculada JarrĂn
- Inmaculada LĂłpez-Montesinos
- Inés Fernåndez Jiménez
- Inés Pérez Zapata
- Irene MartĂn Rubio
- Isabel A. PĂ©rez HernĂĄndez
- Isabel Asschert AgĂŒero
- Isabel Gutiérrez
- Isabel GutiĂ©rrez MartĂn
- Isabel RĂĄbago Lorite
- Isidoro FernĂĄndez Romero
- Israel Sevilla Moreno
- Itziar Arrieta-Aldea
- IvĂĄn PelegrĂn Senent
- Ivån Piñero
- Jara Llenas-GarcĂa
- Javier De la Torre Lima
- Javier Garrido
- Javier Martin Guerra
- JerĂłnimo PachĂłn
- Jessica Souto Higueras
- JesĂșs FortĂșn Abete
- JesĂșs RodrĂguez-Baño
- JesĂșs Ruiz AragĂłn
- Joan GĂłmez-Junyent
- Joel ElĂas Chara Cervantes
- Jon Ugalde Espiñeira
- Jordi CarratalĂ
- Jordi NiubĂł
- Jorge CalderĂłn Parra
- Jorge Calvo
- Jorge Parra Ruiz
- Jorge Valencia de la Rosa
- Josefina GarcĂa GarcĂa
- Josune Goikoetxea Agirre
- José A. Oteo Revuelta
- José Antonio Iribarren Loyarte
- José Javier Castrodeza Sanz
- José Joaquin Portu Zapirain
- José Luis Sierra-Monzón
- José M. Azcona Gutiérrez
- JosĂ© M. GarcĂa de Lomas Guerrero
- José Manuel Tafalla Torres
- JosĂ© MarĂa Reguera Iglesias
- JosĂ© MarĂa Robaina BordĂłn
- José Miguel Cisneros
- José Ramón Arribas
- Juan Berenguer
- Juan Berenguer
- Juan Carlos Gainzarain Arana
- Juan Carlos LĂłpez
- Juan Carlos Ramos Ramos
- Juan Diego Ruiz Mesa
- Juan GonzĂĄlez GarcĂa
- Juan GonzĂĄlez-Moreno
- Juan Mora Delgado
- Juan Pablo Avilés Parra
- Juan RamĂłn DomĂnguez Vicent
- Juan Salillas Hernando
- Juan Torres Macho
- Judit Villar-GarcĂa
- Julen Cadiñaños Loidi
- Julio GarcĂa RodrĂguez
- Justo Lajusticia Aisa
- JĂșlia Pareja Coca
- Karim Mohamed RamĂrez
- Laia Lorenzo-Esteller
- Laia Raich Montiu
- Laura Castelo Corral
- Laura GarcĂa Escudero
- Laura GarcĂa Pereña
- Laura Guio CarriĂłn
- Laura Parra GĂłmez
- Laura RodrĂguez FernĂĄndez
- Le
- Leire PĂ©rez-Latorre
- Lluis Planas Bibiloni
- Lorea Arteche Eguizabal
- Lourdes Bladé Vidal
- Lucia Boix Palop
- Lucia SuĂĄrez
- Lucia Valiente de Santis
- LucĂa Ramos Merino
- Luisa GonzĂĄlez-Iglesias
- Luz MartĂn Carbonero
- Ma del Carmen Liébana Martos
- Ma JesĂșs del Amor EspĂn
- Ma Luisa FernĂĄndez Ăvila
- Ma Teresa PĂ©rez RodrĂguez
- Maialen Ibarguren Pinilla
- Manuel Alejandro GĂĄlvez Bobadilla
- Manuela Aguilar-Guisado
- Margarita RamĂrez
- Mario Pérez Butragueño
- Mariona Tasias Pitarch
- Marta Arsuaga Vicente
- Marta AsĂn-Corrochano
- Marta DĂaz MenĂ©ndez
- Marta FernĂĄndez Morales
- Marta Ibarrola Hierro
- Marta Jiménez Escrig
- Marta Lamata Subero
- Marta Navarro VilasarĂł
- Marta Santos Peña
- MartĂn Guillermo
- MarĂa Antonia Ribot Sanso
- MarĂa Carmen Fariñas Ălvarez
- MarĂa D. del Toro
- MarĂa Erostarbe Gallardo
- MarĂa HernĂĄndez-Bonaga
- MarĂa Isabel Guirado Torrecillas
- MarĂa JesĂșs Bustinduy Odriozola
- MarĂa JosĂ© RĂos-Villegas
- MarĂa Lorena MarĂa Valle Feijoo Begoña RodrĂguez Ferreira
- MarĂa Luisa Machado Sicilia
- MarĂa Paz GarcĂa Butenegro
- MarĂa Pilar Toledano Sierra
- MarĂa Rivas-Carmenado
- MarĂa RodrĂguez Mayo
- MarĂa RuĂz Campuzano
- MarĂa Soledad GarcĂa de Carlos
- MarĂa Victoria FernĂĄndez-Baca
- MarĂa Yllescas
- MarĂa Ăngeles Garcinuño
- Mehta
- Melchor Riera Jaume
- Mercedes Clemente Presas
- Meritxell Gavalda Manso
- Meritxell Ortega Montoliu
- Miguel GĂłrgolas HernĂĄndez-Mora
- Miguel Pedromingo Kus
- Miguel Salvert LletĂ
- Miguel Torralba GonzĂĄlez de Suso
- Miguel Ăngel MorĂĄn RodrĂguez
- Mikel Temprano Gogenola
- Miquel Hortos Alsina
- Miquel Pujol
- Mohamed Kallouchi
- Montserrat Sanmarti Vilamala
- Montserrat Viqueira GonzĂĄlez
- MĂČnica Angerri Nadal
- Mónica Liébana Gómez
- Nerea Carrasco AntĂłn
- NicolĂĄs JimĂ©nez-GarcĂa
- Nicolås Merchante Gutiérrez
- Nieves de la Cruz Felipe
- Nieves Valcarce Pardeiro
- Olga Meca Birlanga
- Olga SĂĄnchez-Pernaute
- Onofre MartĂnez Madrid
- Oscar Sanz PelĂĄez
- Pablo Ryan
- Paloma Albiol Viñals
- Patricia Gonzålez Muñiz
- Patricia GonzĂĄlez-Ruano PĂ©rez
- Patricia Jiménez Aguilar
- Patricia MartĂnez MartĂn
- Paula Mendoza Roy
- Paula Santibañez Såenz
- Pedro Gil Divasson
- Pedro MartĂnez PĂ©rez-Crespo
- Pedro Ăngel Cuadros Tito
- Pere Comas Casanova
- Pilar MartĂn DĂĄvila
- Pilar Vizcarra
- Rafae Silvariño Fernåndez
- Raquel Ălvarez Franco
- Rebeca Longueira
- Regino RodrĂguez Ălvarez
- Reinaldo EspĂndola GĂłmez
- Ricardo Gil SĂĄnchez
- Rita Godoy Lorenzo
- RocĂo Montejano SĂĄnchez
- Rojas-Marte
- Rosa de Miguel Buckley
- Rosa Oltra Sempere
- Rosana Rouco Esteves Marques
- Rosario Castilla Ortiz
- Sabela SĂĄnchez Trigo
- Saioa Domingo Echaburu
- Salvador PĂ©rez-Galera
- Santiago Moreno Guillén
- Santiago PĂ©rez Parra
- Sara Lidia Kamel Rey
- Sara Vela Bernal
- Sara Velasco Fuentes
- Sergio España Cueto
- Sergio Gilaberte ReyzĂĄbal
- Sergio Manuel Santana BĂĄez
- Sergio PĂ©rez Pinto
- Sergio RomĂĄn Soto
- Silvana Fiorante
- Silvia GarcĂa MartĂnez
- Silvia SuĂĄrez
- Sonia Calzado Isbert
- Sonia GarcĂa Prieto
- Sonsoles Salto
- Tamara CaĂnzos Romero
- Teresa AldabĂł
- Teresa AldĂĄmiz-EchevarrĂa
- Teresa Giménez
- Vanesa Alende Castro
- Vicens DĂaz de Brito FernĂĄndez
- Vicente de la Rosa
- Violeta Ramos Sesma
- Virginia Almadana
- Virginia FernĂĄndez Espinilla
- Virginia Isern FernĂĄndez
- Virginia Naranjo Velasco
- VĂctor Asensi
- Xabier Kortajarena Urkola
- Xavier Sanz Salvador
- Ye
- Yolanda Meije Castillo
- Yuan
- Zaira R. Palacios Baena
- Zhang
- Zuriñe Ortiz de Zårate Ibarra
- Ăngel DomĂnguez-Castellano
- Ăngeles GarcĂa Flores
- Ăngeles Muñoz
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/08/2020
- Field of study
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)
- Author
- Abad-DĂez JosĂ© MarĂa
- Alcaraz-Borrajo Marta
- AlcĂĄntara Ma Angelica Fajardo
- Algora Carmen Esteban
- Alonso Ana Sosa
- Alonso Ma Canto De Hoyos
- Ana BallarĂn GonzĂĄlez Null
- AntĂłn Ma ArĂĄnzazu Murciano
- Aranda ConcepciĂłn GarcĂa
- Arce Cesar SĂĄnchez
- Ariza-Cardiel Gloria
- Arteaga Beatriz Caffarena de
- Aurioles Esther MartĂn
- Aza-Pascual-Salcedo Mercedes
- Azcoaga-Lorenzo Amaya
- Bandrés-Liso Ana Cristina
- Barnestein-Fonseca M Pilar
- Barroso Margarita GĂłmez
- Beneitez Ma Elisa Viñuela
- Bernal Javier Cuartero
- Blanco Ma Eloisa Rogero
- Borda Soledad Lorenzo
- Boxó-Cifuentes José Ramón
- Bujalance-Zafra M Josefa
- Calderón-Larrañaga Amaia
- Campillo Lourdes Visedo
- Catalina SĂĄnchez Morales Null
- Cañavate Ma Dolores GarcĂa MartĂnez
- Chasco Ma del Mar Loubet
- Clerencia-Sierra Mercedes
- Coscollar-Santaliestra Carlos
- De Blas GonzĂĄlez Francisca GarcĂa
- de las Heras Esther Mateo
- de Letosa Ma Teresa MartĂn Nasarre
- De Mingo Enrique RodrĂguez
- De Rivera Eva MartĂnez Cid
- del Cura-GonzĂĄlez Isabel
- del Pozo Carmen SĂĄnchez Celaya
- Delgado Elena Mateo
- Delgado Noelia Sorinas
- DomĂnguez Susana GarcĂa
- Elena GascĂłn del Prim Null
- Escalante Nieves Muñoz
- Escortell-Mayor Esperanza
- FernĂĄndez CristĂłbal Trillo
- Fernåndez José Leiva
- FernĂĄndez Juan Carlos Moreno
- FernĂĄndez Raquel Mateo
- Fernåndez-Arquero José Manuel
- Flores Iliana Serrano
- Franco Alberto LĂłpez GarcĂa
- Galindo Jorge Olmedo
- Garach Elena BarcelĂł
- GarcĂa Eduardo DĂaz
- GarcĂa Esperanza Mora
- GarcĂa Irene GarcĂa
- GarcĂa-Agua Nuria
- GarcĂa-de Blas Francisca
- Garrido José Ignacio Torrente
- Genafo Jaime Sasporte
- Gimeno-Feliu Luis A.
- Gimeno-Miguel Antonio
- GonzĂĄlez Fernando Perales
- GonzĂĄlez Paulino Cubero
- GonzĂĄlez Rosario Iglesias
- GonzĂĄlez-GonzĂĄlez Ana Isabel
- GonzĂĄlez-Rubio Francisca
- Gorbea Carlos Bolea
- Guerra Francisco Serrano
- Gutiérrez José Fernando Tomås
- GĂĄlvez EncarnaciĂłn PelĂĄez
- Gómez Belén Muñoz
- GĂłmez Deborah Gil
- Gómez José Luis Quintana
- Hamalainen Santiago Manuel MachĂn
- HernĂĄndez-Santiago Virginia
- Isabel Ma Soledad NĂșñez
- Izquierdo Javier MartĂn
- Jiménez Ma José Fernåndez
- Lafuente Marina Pinilla
- Laguna Amaya Nuria LĂłpez
- Laguna-Berna Clara
- Laguno Lourdes Carolina PelĂĄez
- Leiva-FernĂĄndez Francisca
- Llanos Pedro SĂĄnchez
- Lorenzo Amaya Azcoaga
- Lucas Eustaquio Dendarieta
- Luz Pilar de la Mota Ybancos Null
- LĂłpez Francisco RamĂłn AbellĂĄn
- LĂłpez-LeĂłn Ana Ma
- LĂłpez-RodrĂguez Juan A.
- LĂłpez-Verde Fernando
- Ma Rosario Sanjuan Cortés Null
- Ma Teresa Delgado MarroquĂn Null
- Maqueda Rafael Ăngel
- Marcos Claudia LĂłpez
- Marengoni Alessandra
- Marta-Moreno Javier
- MartĂn Ma Victoria AsĂn
- MartĂn-FernĂĄndez JesĂșs
- Marzal Adolfo Cajal
- Mataix-San-Juan Ăngel
- Mateos-Sancho Carmina
- Medina Ricardo De Felipe
- Mellado Ma del Mar Gil
- Mendaño Ma Carmen Molina
- Mendoza Leovigildo Ginel
- Miguel Valentina MartĂn
- Molina Ma José Gracia
- Morey-Montalvo Mariel
- Muth Christiane
- MĂĄrquez-Chamizo Maria Isabel
- MĂnguez Sorio Ma del Pilar
- Naranjo Juana Morales
- Navarro Jiménez José Manuel
- Negre Antonio Luis Oto
- Ortiz Fernanda Morales
- Parrilla Ma Dolores Gallego
- Pascual Enrique Revilla
- Pascual Juan Pedro Calvo
- PelĂĄez Ma Paloma Morso
- Peña Ma José Clavijo
- Pico-Soler Victoria
- Poblador-Plou Beatriz
- Polentinos-Castro Elena
- Poncel-FalcĂł Antonio
- Pradilla Ma Victoria Muñoz
- Prados-Torres Alexandra
- Prados-Torres Daniel
- PĂ©rez Cristina Guisado
- PĂ©rez Manuel Antonio Alonso
- Quintana José Porta
- Ramiro-GonzĂĄlez MarĂa D.
- Rico-BlĂĄzquez Milagros
- RodrĂguez Antonia GonzĂĄlez
- RodrĂguez Ma JesĂșs Sousa
- RodrĂguez Ma JosĂ© Alcaide
- RodrĂguez Ma Luisa Moya
- RodrĂguez-Barrientos Ricardo
- Rogero-Blanco Marisa
- Romero Virginia Castillo
- Royo Eugenio Galve
- Ruiz Sylvia Hazañas
- Ruiz-San-Basilio José Ma
- Rumayor-Zarzuelo Mercedes
- RĂos Irene MartĂnez
- Sainz Macarena Toro
- Salido Enrique Leonés
- Salvador Julio SĂĄnchez
- Santaella Miguel DomĂnguez
- Sanz-Cuesta Teresa
- Serrano Beatriz LĂłpez
- Suarez Esther GĂłmez
- SĂĄnchez JesĂșs Ma Redondo
- SĂĄnchez Teodoro Corrales
- SĂĄnchez-Perruca Luis
- Taira Ma Begoña AbadĂa
- Tapia PurificaciĂłn MagĂĄn
- Tello-Bernabé Ma Eugenia
- Torres Catalina Moreno
- Torres JosĂ© Manuel RamĂrez
- Torres Ma Antonia MĂĄximo
- Valderas-MartĂnez JosĂ© MarĂa
- Valdés Gloria Aycart
- Vargas Ana Ma FernĂĄndez
- Villalba Ma del Mar Ălvarez
- Våzquez-Alarcón Rubén
- Wiesman Elisa Ceresuela
- YĂ©pez Jeannet Dolores SĂĄnchez
- Zapata Ma Isabel Ferrer
- Ălvarez Juan Carlos GarcĂa
- ĂĄlvarez-Villalba Mar
- Ălvaro Carlos Casado
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (â„3 chronic diseases) and polypharmacy (â„5 drugs prescribed in â„3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe
Experiencias de aprendizaje
- Author
- Arévalo C. Carlos M.
- Atencio Colon Dariana
- Avilez GarcĂa Freynner Ariel
- Bedoya Carlos A.
- Benavides MesĂas Viviana
- Berrocal de la Ossa Juan C.
- Castaño Millan Jean C.
- Chamorro Carolina
- Doria Javier E
- Doval Juan D.
- Florian Gonzalez Andrés F.
- Guerrero Guerrero Alba Patricia
- Guerrero Guerrero Elizabeth Marcela
- Guevara Arrieta Jessy
- LĂłpez PĂ©rez Juliana
- LĂłpez Nora E.
- Madariaga Miguel E.
- Madera Soto Derlys Margoth
- Medina GuzmĂĄn Luis Ferney
- Moncayo Palacios Mario F.
- Mora GĂłmez Liliana
- NarvĂĄez Herrera Juan Pablo
- Ortega Perez Katerine
- Pacheco Juan David
- Pineda Juliana
- Quintana Jhon
- Rivas EstefanĂa
- Rivera Viloria Johan
- Robles Avila Danys
- Ruiz J. Aida S.
- Sierra Yenifer
- Suarez Luis ĂĄngel
- Trillo SebastiĂĄn
- VelĂĄsquez Juan David
- Villegas José Carlos
- VĂĄsquez Vergara Luz Dary
- Zapata MĂĄrquez Lina
- Publication venue
- Complejo TecnolĂłgico para la GestiĂłn Agroempresarial
- Publication date
- 01/01/2019
- Field of study
Libro de experiencias de aprendizaje del grupo de investigaciĂłn Giteca y de los semilleros de investigaciĂłn en la que se visualizan las diferentes experiencias lideradas por instructores y aprendices en las diferentes ĂĄreas y lĂneas de formaciĂłn.Book of learning experiences of the Giteca research group and the research hotbeds in which the different experiences led by instructors and apprentices in the different areas and lines of training are visualized.PropagaciĂłn in vitro como un camino de aprendizaje para la formaciĂłn profesional integral -- Experiencias significativas de aprendizaje, laboratorio de hematologĂa y parasitologĂa animal del Complejo TecnolĂłgico para la GestiĂłn Agroempresarial CTPGA-SENA -- Experiencias significativas adquiridas por aprendices en el ĂĄrea de SENNOVA, Complejo TecnolĂłgico para la GestiĂłn Agroempresarial. Regional â Antioquia -- El papel de la prensa escrita en el desarrollo de la competencia textual -- Aprendiendo a Emprender con un emprendedor -- Ven y te cuento sobre ADSI -- Observaciones fenolĂłgicas del cultivo de cacao (Theobroma cacao) en los municipios de TarazĂĄ, El Bagre y Caucasia dentro de la formaciĂłn del programa SENA emprende rural -- Tejiendo sueños desde la formaciĂłn -- Forraje verde hidropĂłnico como alternativa para disminuir la expansiĂłn de la frontera agrĂcola en el Putumayo -- La importancia del saber hacer para ser competente en el sector agrĂcola -- Experiencia significativa de aprendizaje semilleros de investigaciĂłn -- La investigaciĂłn como ente transformador de pensamientos -- PiscĂcola Paraguay; Mi Sueño, Mi Proyecto de Vida! -- Estrategia de aprendizaje a travĂ©s de la investigaciĂłn y la empresa aplicando un programa de Responsabilidad Social Empresarial âRSE -- MatemĂĄtica aplicada para procesos agroindustriales de panificaciĂłnna85 pĂĄgina
Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world
- Author
- Abad Pedro
- Abbara Suhny
- Abbasi Taimur
- Abbott Brian
- Abdel Aziz Islam Shawky
- Abdulla Jawdat
- Abikhzer Gad
- Abohashem Shady
- Abougabal Mahasen
- Abramson Sandra
- Abrihan Paz
- Acuña Arturo Romero
- Affandi Erwin
- Afzal Muhammad Shehzad
- Agolti Mariela
- Agranovich Svetlana
- Aguadé-Bruix Santiago
- Aguero Roberto Nicolas
- Ahmed Hassan Mohamed Ismail
- Ahmed Taghreed
- Akhter Afroza
- Al Dhuhli Humoud
- Al Kindi Faiza
- Al-Abboud Tarek
- Al-Bulushi Naeema
- Al-Mallah Mouaz
- Alak Maria del Carmen
- Alam Edison
- Alaoui Nadia Ismaili
- Alasnag Mirvat
- Albadr Amjed
- Albalooshi Batool
- Albano Domenico
- Alberguina Lucia Graciela
- Albernaz Siqueira Maria Helena
- Alexanderson-Rosas Erick
- Alfaro Ana
- Ali Mohamed Mandour
- Alkadhi Hatem
- Alkandari Faridah
- Allam Adel
- Allarakha Mohammad Aaftaab
- Almeida Augusto
- Almousalli Omar
- Alongi Pierpaolo
- Alonso Omar
- Alves Togni Paulo Henrique
- Alves Wilson Furlan
- Ananthasubramaniam Karthikeyan
- Anderson Jill
- Andrade Jose Henrique
- Andrade Luciana
- Angelidis George
- Anselmi Carlos
- Ansheles Alexey
- AraĂșjo Roberta
- Archontaki Aikaterini
- Arnone Gaspare
- Arnous Samer
- Arnson Yoav
- Arroñada Guillermo
- Arturo Harold
- Asano Hiroshi
- Ascani Sebastian Perez
- Asfour Ahmed
- Askew Jeffrey
- Assadi Majid
- Astesiano Alfredo
- Astesiano Andrea
- Attanasio Lea
- Atyani Said
- Ayala Sandra
- Ayetey Harold
- Ayodele Tolulope
- Azevedo Guilherme
- Bagatin Elisa
- Bailly Matthieu
- Baldari Sergio
- Balmer-Swain Mallory
- Bang Ji-In
- Banthia Nilesh
- Bar-Shalom Rachel
- Barette Rene
- Baric Ana
- Barneveld Peter
- Barragan Adriana Puente
- Barragan Erika
- Barroso Asela
- Basavaraj Ashok Gangasandra
- Batinic Tonci
- Batista Juan Felipe
- Batyrkhanov Daultai
- Bauckneht Matteo
- Baugh Dainia
- Bayer Richard R.
- Bedi Punit
- Bejai Shereen
- Ben-Rais Nozha
- Benedek Imre
- Benedek Theodora
- Benitez Luis
- Benlabgaa Rabie
- Bennie George
- Benteo Pablo
- Beretta Mario
- Berman Daniel S.
- Bernheim Adam
- Bertelli Paolo
- Bester Ria
- Bettencourt Nuno
- Better Nathan
- Better Nathan
- Beuzeville Scott
- Bezerra Sabbrina
- Bhagat Jinendra Kumar
- Bhargava Rishi
- Bhat Vivek
- Bhatia Mona
- Bhatti Sabha
- Biancardi Rodrigo
- Bianco Francesco
- Bieging Erik
- Biggans Thomas
- Bittencourt Marcio Sommer
- Blanco Isabel
- Blanco Juan
- Blankstein Ron
- Blankstein Ron
- Bloom Stephen
- Blue Sean
- Bluemke David
- Bluemke David A.
- Boktor Raef
- Bom Henry
- Bonelli Juan Manuel
- Bonfiglioli Rachele
- Boni Roberto
- Borges Andressa
- Bouyoucef Salah
- Branch Kelley
- BrandĂŁo Simone
- Bravo Paco
- Brothers Jessica
- Bruno Andrea
- Bruno Isabella
- BrÄten Anders Tjellaug
- Budoff Matthew
- Buechel Ronny Ralf
- Buga Klara
- Bularga Anda
- Bull Russell
- Bullock-Palmer Renée
- Burandt Angela
- Burg Samuel
- Burger Peter
- Burgul Rajesh
- Burke Floyd W.
- Bush Kelvin
- Busnardo Elena
- Bustos Jose Javier
- Butler Patrick
- Byrne Angela
- BĂžttcher Morten
- Cabada Manuel
- Cabeda Estevan Vieira
- Cabrejas Raul
- Cabrera Antonio
- Cachero Jorge
- Cadena Alberto
- Caicedo Carlos
- Calcott Jennifer
- Califaretti Elena
- Camarero Alicia
- Camoni Luca
- Campisi Roxana
- Canal Maria Pedrera
- Candela Candace
- Canderoli Alejandro
- Canessa Jose
- Cantinho Guilhermina
- Cao Dianbo
- Capasso Elizabeth
- Carames Silvia
- Carnevale Aldo
- Carpenter John-Paul
- Carr Loretta
- Carrascosa PatrĂcia
- Carreira Lara
- Carvajal-Juarez Isabel
- Casoni Roberta
- Castro Bruno
- Castro Gabriel
- Castro Ricardo
- CasĂĄns-Tormo Irene
- Cavalcante Joao
- Cavallo Armando Ugo
- Cavenaghi Giorgio
- Cendoya Oscar
- Cerci Rodrigo
- Cerci Rodrigo J.
- Ceriani Luca
- Chambers Duane
- Chan Virgil
- Chang Donald
- Chang Tien
- Chao Charles
- Chatterjee Saurav
- Chatziioannou Sofia
- Chatzizisis Yiannis
- Cheezum Michael
- Chen Jennifer
- Chen Marcus
- Chen Tiffany
- Cheung Stephen
- Chierichetti Franca
- Chimura Chimura Misato
- Chiocchi Marcello
- Cho Sang-Geon
- Choi Andrew
- Choi Andrew
- Choi Andrew D.
- Chong Woon
- Choudhury Partha
- Chow Benjamin
- Chowdekar Vijay Sai
- Christensen Mette
- Cittanti Corrado
- Clarcq James
- Cognigni Luciano Martin
- Cohen Yosef
- Cohen Yosef A.
- Coie Tchoyoson Lim
- Coles Duncan
- Collaud Carlos
- Collaud Carlos
- Colletta Mauro
- Concha Carmen
- Conti Umberto
- Cordero Ayreen
- Cortes Claudia
- Cortés Filiberto
- Cortés Violeta
- Cossu Alberto
- Courtis Javier
- Cragnolino Daniel
- Crim Matthew
- Cruz Eric
- Cuadra Teresa
- Cuellar-Calabria Hug
- Cunali Fernando
- Cuocolo Alberto
- Cury Roberto
- Cusack David
- Cuzzocrea Marco
- Dabreo Dominique
- Dai Xu
- Daicz Mariana
- Danciu Sorin
- Dantas Roberto
- Dariy Olga
- Datseris Ioannis
- Dautov Tairkhan
- de Amorim Fernandes Fernando
- De Boeck Bart
- De Carvalho Filipe Penna
- De La Peña Erasmo
- De La Vega Alejandro
- De Lorenzo Andrea
- De Macedo Filho Robson
- De Maria Silvia Teresa
- De Rimini Maria Luisa
- De Souza Thiago Ferreira
- De Vincentis Giuseppe
- Decter Bruce
- Del Giudice Eleonora
- Del Riego Horacio
- Del Torto Alberico
- Della Tommasina Veronica
- Deshpande Aparna
- Dettori Fernando
- Deux Jean-François
- Deviggiano Alejandro
- Dhruva Nimish
- Diaz Javier Lopez
- Djuraev Omoa
- Dobson Mark
- Doherty Neil
- Dondi Maurizio
- Dondi Maurizio
- Dorbala Sharmila
- Dorbala Sharmila
- Dougan John
- Doukky Rami
- Downie D'Arne
- Dragonetti Laura
- Drozdova Olga
- Dunbar Anjori
- Durmo Rexhep
- Duvall William
- Dwivedi Girish
- Edmond John
- Edwards Rachael
- Efros-Monsen Elen
- Einstein Andrew J.
- Einstein Andrew J.
- Elison Barry
- Ellis Chris
- Emami Farshad
- Embon Mario
- Engela Jean
- Engelbrecht Gerrit
- Engelmann Vaclav
- Enriquez Ruben Emilio
- Ensinas Jorge
- Erba Paola Anna
- Erthal Fernanda
- Escobar Manuel Valencia
- Escorza Velez Giovanni Alejandro
- Espeche Maria del Huerto Velazquez
- Esquitin Kerry
- Evangelista Laura
- Evbuomwan Osayande
- Faccio Fernando
- Facello Adolfo
- Fairbairn Timothy
- Faletti Riccardo
- Faragasso Evelina
- Faraggi Marc
- Farah Husam
- Farrugia Alexia
- Farsad Mohsen
- Fatima Shazia
- Fentanes Emilio
- Ferencik Maros
- Ferencik Maros
- Fernandes Fabio
- Fernandes Fabio
- Fernandes Juliano
- Ferrando Rodolfo
- Ferreira Antonio
- Ferro Paola
- Feuchtner Gudrun
- Fisher Daniel
- Fitzpatrick Daniel
- Flores Ana Camila
- Florimonte Luigia
- Flotats Albert
- Forsdahl Signe Helene
- Foster Cameron
- Fragkaki Christina
- Franceschi Maja
- Francis Roslyn
- Frantellizzi Viviana
- Frenkel Alex
- Friedrich Matthias
- Fringuelli Fabio Massimo
- Fuentes Cañamero Maria Eugenia
- Fuisz Tony
- Fujimoto Shinichiro
- Fujisue Koichiro
- Fukunaga Tomohisa
- Fukushima Yoshimitsu
- Fukuyama Kae
- Gagarina Nina
- Gaikwad Anand
- Gama-Moreno Manlio
- Gamboa Isabel Berrocal
- Gannon Michael
- Garai Ildiko
- Garashi Masoud
- Garcheva-Tsacheva Marina
- GarcĂa MarĂa Elia
- Garg Ria
- Garofalo Diego
- Gastner Lori
- Gatti Marco
- Gaudiano Angela
- Georgoulias Panagiotis
- Geronazzo Ricardo
- Gerson Myron
- Gheysens Olivier
- Ghimire Ram Kumar
- Ghini Bruno
- Ghoshhajra Brian
- Gimelli Alessia
- Girijanandan Mahapatra Prof Dr
- Giubbini Raffaele
- Giuffrida Francesca
- Glaudemans Andor
- Gleeson Tadhg
- Goda Artan
- Goebel Benjamin
- Goebel Benjamin
- Goldberg Alan
- Goldner Brian
- Gomez Marie Rhiamar
- Gomez Sharon
- Goncalves Luiz
- Gong Lianggeng
- Gongxeka Harlem
- Gonza Natalia
- Gonzalez Carla
- Gonzalez Jorge
- GonzĂĄlez Luis
- GonzĂĄlez Ulises
- GonzĂĄlez-Montecinos Alejandro Becerril
- Goodwin Bruce
- Gopalan Deepa
- Gore Rosco
- Gormsen Lars Christian
- Gottlieb Ilan
- Gracia-LĂłpez Sandra
- Greenough Robert
- Grossman Gabriel Blacher
- GrÀni Christoph
- Gulyaev Vsevolod Milyevich
- Gummow Alistair
- Gunawan Gani
- Gutierrez Villamil Claudia T.
- Gutierrez Goleat
- Gutierrez Lucas
- Gutierrez Yamile Marcos
- Gutierrez Yamile Marcos
- Guzzo Miguel Angel
- Guzzo Miguel Angel
- GĂłmez Lauchy Juan Manuel
- Habets Jesse
- Habouzit Vincent
- Hadlich Marcelo
- Hafez Mohammed Nassoh
- Hage Fadi
- Haidar Mohamad
- Haider Agha
- Haider Sofia
- Hamilton Mark
- Hamilton-Craig Christian
- Hamirani Yasmin
- Han Dan
- Hapkido Habusari
- Harbinson Mark
- Hartley Thomas
- Hasbak Philip
- Hasbani Victor
- Hashimoto Jun
- Hassan Alia
- Hassan Mona
- Hassen Karen
- Hatfield Mallory
- Hawkins Carolyn
- Hawthorne Katie
- Heath Nicholas
- Hendel Robert
- Hernandez Phillip
- HernĂĄndez Gertrudis Sabatel
- Herrera Yariela
- Hess SĂžren
- Hidalgo Pablo
- Hidayat Basuki
- Hildre Dimmen Jenni-Mari
- Hill Gregory
- Hinterleitner Gerd
- Hirschfeld Cole B.
- Hirschfeld Cole B.
- Holdgaard Paw
- Homans Filip
- Hong Chae Moon
- Horgan Stephen
- Hou Yang
- Houshmand Golnaz
- Hsieh Victar
- Hua Shaw
- Huda Aulia
- Hudson Benjamin
- Huerin Melina
- Huffman Jeff
- Hurwitz Lynne
- Hyafil Fabien
- Ialuna Salvatore
- Ibrahim Ahmed
- Ichikawa Yasutaka
- Iguchi Nobuo
- Iii George Kinzfogl
- Ilic Srdja
- Imai Masamichi
- Inaki Anri
- Irodi Aparna
- Ishimura Hayato
- Iskandrian Ami
- Isobe Satoshi
- Issoufou Djibrillou Moussa
- Itskovich Irina
- Jaimes Claudia
- Jain Shashank
- Janardhanan Rajesh
- Jang Su Jin
- Jason See Jia Hao
- Jawa Zabah
- Jellis Christine
- Jeong Yong Hyu
- Jerome Scott
- Jimenez-Heffernan Amelia
- Jiménez-Santos Moisés
- Johansen Allan
- Johnson Chris
- Johnson Kerryanne
- Joseph Elizabeth
- Joshi Nikhil
- Joshi Subodh
- Juillet de Saint Lager Lucas Alix
- Jukic Mladen
- Junior José Soares
- JĂ€ger Victor
- JĂžrgensen Arve
- Kadokami Toshiaki
- Kaffas Sameh
- Kalinin Artem
- Kalnina Marika
- Kalra Dinesh
- Kamani Christel H.
- Kameoka VinĂcius
- Kaminek Milan
- Kandeel Ahmed
- Kang Won Jun
- Kapitan Miguel
- Kaplan Mitchell
- Karalkin Anatoly
- Karim Noor Khairiah A.
- Kato Takao
- Kaviratne Summanther
- Kawel-Boehm Nadine
- Kay Fernando
- Kay Michael
- Keenan Ross
- Kelion Andrew
- Kelly Faith
- Keng Felix
- Kerins David
- Khalique Omar
- Khiewvan Benjapa
- Khokhar Azhar
- Khushica Purbhoo
- Kiess Marla
- Kim Ji-Young
- Kincl VladimĂr
- Kinkhabwala Mona
- Kir Kemal Metin
- Kircher Jacqueline
- Kirkbride Rachael
- Kitt Jamie
- Kmetyuk Yaroslav
- Knafo Galit
- Knuuti Juhani
- Kokkonen Velipekka
- Kokov Alexander
- Komiagiene Renata
- Kontos Michael
- Koopmans Klaas Pieter
- Korol Pavlo
- Kostadinova Irena
- Kostkiewicz Magdalena
- Kottam Anupama
- Koukouraki Sophia
- Koutelou Maria
- Krepp Joseph
- Krohn Isabel
- Kudo Takashi
- Kudo Takashi
- Kumar Mohan Ashok
- Kumar Sukriti
- Kumita Shinichiro
- Kunikowska Jolanta
- Kviecinskiene Giedre
- Kyhl Kasper
- Kyrozi Eleni
- Lahey Ryan
- Lairez Olivier
- Lakhi Hoosen
- Lang Otto
- Larikka Martti
- Laudicella Riccardo
- Layer Jay
- Le Ngoc Ha
- Leccisotti Lucia
- Lederer Karin
- Lee Jaetae
- Lee Joseph
- Lee Ken
- Lee Kenneth
- Lee Steven H.
- Leipsic Jonathon
- Lenturut-Katal Dora
- Leppo Jeffrey
- Lesser John
- Leta Rubén
- Leung Eugene
- Leung Steve
- Leva Lucia
- Lewin Howard
- Lewkowicz Julio Manuel
- Li Caiying
- Li Dong
- Li Sijin
- Li Tao
- Liga Riccardo
- Liguori Carlo
- Lima Adna
- Lima Ronaldo
- Litmanovich Diana
- Liu Hui
- Liu Jinkang
- Liu Yiyan
- Londoño Blair Juan Luis
- Londoño Juan
- Longo Giampiero
- Lopes Rafael Willain
- Lopez-Mattei Juan
- Lopez-Mattei Juan
- Lopez-Mattei Juan
- Lotti Jose Maria
- Louw Lizette
- Lovera Cesar
- Low Chen
- Lu Bin
- Lu Bin
- Lu Yao
- Lugassi Rachel
- Luis Rodrigues Jonathan Carl
- Lumbreras Luis
- Luna Hiram Rivera
- LĂžvhaugen PĂ„l
- Machado e Silva Ricardo
- Madu Chibuzo
- Madu Ernest
- Maffione Margherita
- MagalhĂŁes Tiago
- Magboo Vincent Peter
- Magnussen John
- Magurany Kathleen
- Mai Nghi
- Mai Son Hong
- Majstorov Venjamin
- Mak Sze Mun
- Makhdomi Khalid
- Malan Nico
- Maldonado Alejandro
- Maleki Majid
- Malkovskiy Eli
- Malkovskiy Eli
- Mancini Maria Elisabetta
- Mander Gordon
- Manders Jeroen
- Manka Robert
- Mansy Ahmad
- Maor Moalem Israel Shlomo
- Marcassa Claudio
- Markowitz Jeremy
- Marn Amanda
- Marousa Ntouskou
- Maroz-Vadalazhskaya Natallia
- Marquez Alejandra
- Marquez-Cabeza Juan Javier
- Martin Francisco
- Martin Jon
- Martinez de Alegria Anxo
- Maruno Hirotaka
- Masoli Osvaldo
- Masoli Osvaldo Horacio
- Massardo Teresa
- Mastrocola Luiz Eduardo
- Mastrovito Edgardo
- Mataciunas Mindaugas
- Mataki Hiroyuki
- Matis Stephen E.
- Matos Luis
- Matushita Cristina SebastiĂŁo
- Maurice Hany
- Maurovich-Horvat PĂĄl
- Maurovich-Horvat PĂĄl
- Mayoraz Matias
- Mcalindon Elisa
- Mckenna Michael
- Mcrae Tony
- Medakovic Petar
- Medeiros FĂĄbio
- Medina Francisco
- Medina John Michael
- Medjahedi Abdelkader
- Meehan Conor
- Melado Graciela Eva
- Mele Anibal
- Mendoza Fernando
- Meneghetti José Claudio
- Menezes de Siqueira Maria Eduarda
- Menezes Leon
- Menéndez Rayner
- Merani Maria Fernanda
- Meretta Alejandro Horacio
- Merhige Michael
- Mesquita ClĂĄudio Tinoco
- Migunova Ekaterina
- Milan Elisa
- Miller Robert
- Milos Katarina
- Min David
- Mirzaei Siroos
- Mititelu Raluca
- Mitra Deepanjan
- Mittal Bhagwant Rai
- Miyagawa Masao
- Modiselle Moshe
- Moffitt Chanan
- Molteni Susana
- Moncayo Antonio CalderĂłn
- Moncayo Antonio CalderĂłn
- Moncher Karen
- Monroy Edgar
- Monte Guilherme Urpia
- Montecinos Marcos
- Moore Warren
- Mor Maya
- Morayati Shamil
- More Stuart
- Morelos Martha
- Moreno-Reyes Rodrigo
- Morgan-Hughes Gareth
- Morimoto Ryota
- Moroi Masao
- Morozova Olga
- Morris Michael
- Moss Alastair
- Mossa-Basha Mahmud
- Mrsic Zorana
- Mukti Anggoro Praja
- Murphy David
- Murphy Mark
- Murray Anthony
- Murray John
- Murthy Venkatesh
- Murton Fiona
- Muskal Noam
- Mut Fernando
- Muyinda Zerida
- Muñoz Gabriel Castro
- Mykhalchenko Olena
- Myo Khin Pa
- Nabil Sherif
- Nagamachi Shigeki
- Nagpal Prashant
- Naidoo Mathava
- Nailli Qais
- Nakajima Kenichi
- Nakata Tomoaki
- Nakazato Ryo
- Namgung Chang Kyeong
- Nanasato Mamoru
- Nanayakkara Damayanthi
- Nandurkar Dee
- Naojee Ambedhkar Shantaram
- Napier Kyle
- Nardi Barbara
- Narula Jagat
- Narula Jagat
- Naseer Hamid
- Nasery Mohammad Nawaz
- Naue Vania
- Naves Danilo
- Naya Masanao
- Neill Johanne
- Nelson Katarina
- Ng Ming Yen
- Nguyen Xuan Canh
- Nicol Edward
- Nieves A LĂłpez De MunaĂn Maria
- Nijjar Prabhjot
- Nogueira Ramos Rodrigo Rizzo
- Noguera Eduardo
- Nolasco Roberto
- Nomura Cesar
- Norgaard Bjarne Linde
- Norikane Takashi
- Norton Carolina Bas
- Novoa Carlos
- Nunura Felix
- NĂžrgaard Bjarne Linde
- O'Brien Julie
- O'Rourke Edward
- O'Sullivan Patricia
- Obaldo Jerry
- Occleshaw Christopher
- Ohta Yasutoshi
- Oikonomou Anastasia
- Okarvi Subhani
- Okayama Satoshi
- Okizaki Atsutaka
- Oliveira Joao Bruno
- Ombati Kevin
- Onimode Yetunde
- Ornelas Mario
- Ortellado José
- Ortga Ramirez Jose Alberto
- Osman Medhat
- Otomi Yoichi
- Otsuka Hideki
- Ozair Ahmad
- Paar Maja Hrabak
- Pabon Luz
- Pacella Sara
- Padma Savenadia
- Paez Diana
- Paez Diana
- Paixao Eduardo
- Panagidis Christoforos
- Pandos George
- Parwani Purvi
- Parwani Purvi
- Parwani Purvi
- Pascual Thomas N. B.
- Pascual Thomas N. B.
- Pasquet AgnĂšs
- Passen Edward
- Pastrana Davidson
- Patel Amit
- Patel Chetan
- Patel Dilip
- Patel Ravi
- Patel Shivani
- Patel Tapan
- Pathmaraj Kunthi
- Patil Pravin
- Paul Ryan
- Pawhay Christian Michael
- Pedras Felipe Villela
- Peebles Charles
- Peiro Virginia
- Peix Amalia
- Pepe Giovanna
- Perez Alfredo
- Perez Ricardo Ruano
- Persic Viktor
- Petrou Ioannis
- Phillips Lawrence
- Pianta Diego Bromfman
- Picard Christian
- Pineda Mauricio
- Pinto Ibraim
- Pitman Alexander
- Pliatsek Volodymyr
- Poksi Anne
- Pollono Pablo
- Polsani Venkateshwar
- Poludasu Rajaram
- Pomerantz Brian
- Pontone Gianluca
- Pool Stefan
- Porter Thomas
- Pospelov Viktor
- Possetti Priscila
- Poulter Rohan
- Prawiro Djoko
- Preciado-Anaya Andrés
- Preciado-GutiĂ©rrez Ăscar Ulises
- Premaratne Manuja
- Premprabha Teerapon
- Prentice Ryan
- Prior David
- Prior John O.
- Probst Stephan
- Proffit Franck
- Prpic Marina
- Pubul-Nuñez Virginia
- Pugliese Francesca
- Pujol Maria Paula
- Pulizzi Sabina
- Punda Ante
- Pursnani Amit
- Pynda Yaroslav
- Pynda Yaroslav
- Quartuccio Natale
- Quinon Alvin
- Quinta Mayra
- Rabbat Mark
- Radzinschi Alejandro
- Raggi Paolo
- Raggi Paolo
- Raimondi Gustavo
- Rajbanshi Bijoy
- Rajvong Sonexay
- Ramamurti Suresh
- Ramkumar Prasad Guntur
- Rampin Lucia
- RamĂrez Nelsy Gonzalez
- Randazzo Michael
- Randazzo Michael J.
- Ranser Sara
- Rawashdeh Mohammad
- Rayo Madrid Juan Ignacio
- Redruello Marcela
- Regaieg Hamza
- Reichmuth Luise
- Repasos Evangelos
- Rey Cristina RodrĂguez
- Riaz Musab
- Ricci Fabrizio
- Rich Florence
- Ridley Lloyd
- Robinson Austin
- Robles Kim
- Rocha Ricardo
- Rochela Luis
- Rodrigues Alfredo
- Rodrigues Carlos
- Rodriguez Daniel Calderon
- RodrĂguez Cesar
- RodrĂguez Marina
- RodrĂguez MatĂas
- Roelants Veronique
- Rofe Christopher
- Roifman Idan
- Rojas Juan Carlos
- Romantini Leila
- Romero Romina Lorena
- Rominger Axel
- Roque Vanegas Hector Bladimir
- Rorie Mark
- Rosales Uvera Sandra Graciela
- Rossini Pierluigi
- Rostami Maryam Tajik
- Rovaletti Federico
- Rozikhodjaeva Gulnora
- Rubini Giuseppe
- Ruiz Diego
- Ruiz JoaquĂn
- Rumberger John
- Russell Raymond
- Russo Vincenzo
- Rutherford Natalie
- Ryzhkova Daria
- RĂos RaĂșl Araujo
- RĂžnnow Sand Niels Peter
- Saadullah Mohammad
- Sabharwal Nikant
- Sabra Philip
- Sacchetti Gian Mauro
- Sadler Diego
- Saifullina Guzaliya
- Saito Masaki
- Sakanyan Mari
- Sakata Sakata Yasushi
- Salehi Hamid
- Salobir Barbara GuĆŸic
- Sambuceti Gianmario
- Samuel Anthony
- San Miguel Lucas
- Sanches Adelina
- Sandoval Sigelinda
- Santana Sara
- Sara da Silva Leonardo
- Sarai Masayoshi
- Saranovic Dragana Sobic
- Sarda-Mantel Laure
- Sasse Alexander
- Sato Daisuke
- Satyr Maryna
- Saunders Connor
- Saxena Sudhir
- Sayman Haluk
- Sazonova Svetlana
- Scarano Massimo
- Scarlett Luke
- Schemmer Mary
- Schmidt Erzsébet
- Schneider Roman P.
- Schoepf U. Joseph
- Schofield Rebecca
- Scholte Arthur
- Scholtens AsbjĂžrn
- Scholtz Leonie
- Schvartzman Paulo
- SciagrĂ Roberto
- Sebikali Mugisha Julius
- Sekar Ramkumar
- Sellem Ali
- Semple Thomas
- Seneviratne Sujith
- Sengupta Shantanu
- Senra Tiago
- Sereegotov Erdenechimeg
- Sergienko Vladimir
- Sergienko Vladimir
- Sevilla Ana
- Shaaban Mahmoud
- Shah Nishant
- Shah Nishant R.
- Shah Samir
- Shalev Aryeh
- Shanbhag Sujata
- Sharma Gaurav
- Sharma Naveen
- Shaw Leslee J.
- Shaw Leslee J.
- Shayani Steven
- Shetty Deepa
- Shiozaki Afonso
- Shiraishi Shinya
- Shirani Jamshid
- Shirka Ervina
- Shivaram Pushpa
- Shrestha Ganesh
- Shulman Jonathan
- Shurupova Irina
- Sierra-Galan Lilia M.
- Sierra-Galan Lilia M.
- Sigman Steven
- Silva FĂĄbio Martins
- Simanek Milan
- Simon Mitch
- Simonsson Magnus
- Singh Bhanupriya
- Singh Santosh
- Sinitsyn Valentin
- Siqueira Cristiano
- Siu Silvia
- Slart Riemer
- Slim Ahmad
- Small Gary
- Smanio Paola
- Smith Alexandra
- Smith David
- So Young
- Soares Carlos Eduardo
- Soeriadi Erwin Affandi
- Solanki Vijay
- Solari Lucrecia
- Soldat-Stankovic Valentina
- Soli Idrissa Adamou
- Soman Prem
- Sood Aditya
- Sood Ashwani
- Sperandio Massimiliano
- Spiro Bernardo
- Srichai-Parsia Monvadi Barbara
- Stan Claudiu Adrian
- Stankovic Sinisa
- Stanton Tony
- Stavrou Petros
- Stefanelli Antonella
- Steffensen Rolf
- Strada Bruno
- Streeter James
- Strouhal Peter
- Stuart Murch
- Stubbs Michael
- Subedi Deepak
- Sueldo Claudio Pereyra
- Sun Kai
- Suwa Yoshinobu
- Swainson Ian
- Syawaluddin Hilman
- Syed Ghulam
- Szilveszter Balint
- T Albert
- Tacher Vania
- Tag Naima
- Takanami Kentaro
- Takehana Kazuya
- Taki Junichi
- Taleb Sara
- Tamaki Nagara
- Tandon Vikas
- Tang Gongshun
- Tang Jeanelle Margareth
- Taniguchi Yasuyo
- Taubman Kim
- Tawakol Ahmed
- Taylor Andrew
- Tecson Bettina
- Teragawa Hiroki
- Theng Youdaline
- Thientunyakit Tanyaluck
- Thimister Paul
- Thomas Dustin
- Thomas Paul
- Thomassen Anders
- Thompson Randall
- Thu Phyo Si
- To Andrew
- Tomas Miguel Santaularia
- Tomizawa Nobuo
- Topping William
- Torbet Tara
- Torreao Jorge
- Torres Rafael
- Traverso Sonia
- Traverzo Sonia Simona
- Trifonova Tatjana
- Trinidad Desiree
- Trivedi Adwait
- Tsujita Kenichi
- Tweed Katharine
- Udugama Chandraguptha
- Uellendahl Marly
- Ullery Shawn
- Umeji Kyoko
- Unger Steven
- Unzek Samuel
- Upton Anthony
- Uretsky Seth
- Uson Kristine Joy
- Ussov Wladimir Yurievich
- Uusitalo Valtteri
- Uy Mila
- Vajauskas Donatas
- Vakhromeeva Margarita
- Valiullina Nailya
- Vallejo Enrique
- Valles Mario
- Vallurupalli Srikanth
- Vallée Jean-Paul
- Valsamaki Pipitsa
- Vamadevan Shankar
- Van Asperen Erik-Jan
- Van De Heyning Caroline M.
- Van Gaal William
- Van Pelt Niels
- Vangu Mboyo
- Vargas Luis Salazar
- Vasquez Andres
- Vavlukis Marija
- Velez Mayra Sanchez
- Veltman Niels
- Ventroni Guido
- Vergel Damiana
- Verjans Johan
- Verma Atul
- Verma Vikas
- Verschure Derk
- VerĂssimo OtĂĄvia
- Villines Todd C.
- Villines Todd C.
- Vitola Joao V.
- Vitola Joao V.
- Vondrak Andrej
- Voutnis Demetrius
- Vuuren Magritha Jv
- VĂĄrady Edit
- VĂĄzquez Manuel Castillo
- Wagenaar Nils
- Wakabayashi Yasushi
- Waller Alfonso
- Waltrick Roberto
- Wang Ellen
- Wang Jian
- Wang Ximing
- Wang Yifan
- Wang Yining
- Wang Zhao-Qian
- Ward Parker
- Wayne Victor
- Weihmuller Juan Sebastian
- Weir-Mccall Jonathan
- Weiss Konrad
- Weissman Gaby
- Wesbey George
- White James
- White Kelly
- Williams Michelle C.
- Williams Michelle C.
- Wilson Peter
- Winchester David
- Winchester David
- Wolcan Juan
- Wolinsky David
- Won Kyoung Sook
- Wong David
- Wong Kirby
- Wu Jiang
- Wu Zhifang
- Xia Liming
- Xiao Jiangxi
- Xu Lei
- Xu Zhuoran
- Yamada Shinichiro
- Yamazaki Shinya
- Yang Youyou
- Yew Min Sen
- Yin Wu
- Yoneyama Tatsuya
- Yost Sandra
- Young Calum
- Younger John
- Younis Muhammad Numair
- Yu Jianqun
- Yuan Li
- Zaid Eed Abu
- Zakavi Seyed Rasoul
- Zapparoli Marcello
- Zavadovsky Konstantin
- Zeffiro Susana
- ZeidĂĄn Nahla
- Zerahn Bo
- Zgaljardic Michael
- Zhang Longjiang
- Zhang Tong
- Zhang Xiaoli
- Zhang Yong-Gao
- Zhu Li
- Zhuravlev Kirill
- Zoboli Stefania
- Zukotynski Katherine
- Zuluaga Alejandro
- Ăvrehus Kristian Altern
- Ć talc Monika
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic.
Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality.
Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States.
Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis.
Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- AgnĂšs Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
- Ajitha Rajendran
- Akemi Hirao
- Akira Ohuchi
- Aktham Yaghi
- Ala Khaled
- Alan Sustic
- Alan Sustic
- Alba Riera
- Alban Greca
- Alberto de JesĂșs Ortiz
- Alberto Peratoner
- Alejandra Aucapina
- Alejandra Azahara Marguello Fernandez
- Alejandro Ibarra
- Aleksandar Ć uput
- Aleksandra Gutysz-Wojnicka
- Alessandra Negro
- Alessandro Di Risio
- Alessandro Galazzi
- Alexander Dullenkopf
- Alexander Kiselev
- Alexander Tsarev
- Alexandra Pivkina
- Alexandra Vasquez
- Alexis Tabah
- Ali KaÄnıcı
- Alida Moise
- Aline Ramalho
- Alinoy Lavy
- Alisha van Axel
- Alma Cani
- Alvaro Ortega Guerrero
- Amalia Corso
- Amber Markham
- Amelia Ferreira
- Amer Assiri
- Amilcar Garcia
- Amilcar Garcia
- Amit Gupta
- Amit Gupta
- Amy Collins
- Amy Thompson
- Amy Walsh
- Amylkar Garay Reyes
- Amylkar José Garay Reyes
- Ana Alabart Llinas
- Ana AlĂcia Velarde Pineda
- Ana Bantar
- Ana Belén Curto Polo
- Ana Belén Sånchez de la Ventana
- Ana Diaz
- Ana Diaz
- Ana Isabel Clement
- Ana Laura Gonzalez
- Ana Lucia Vitti Ronchini
- Ana Margarida Feranandes
- Ana MarĂa De Pablo
- Ana Pascual-Bielsa
- Ana Tavares
- Ana Vochin
- Ana Wensell FernĂĄndez
- Anastasia Spyropoulou
- Anastasio Espejo Cano
- Andeas StĂŒbner
- Andrea Bruni
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Cortegiani
- Andrea Giampaoletti
- Andrea Martonova
- Andrea Martonova
- Andrea McDonnell
- Andrea McLucas
- Andrej Markota
- Andrijan Kartalov
- Andréa Maria Laizner
- Andréa Maria Laizner
- Andréa Maria Laizner
- Ane Stenset
- Angela Trposak
- Angelica Olivetto de Almeida
- Anisette Hoegenhaven
- Anita Alias
- Anita Jans
- Anita VukoviÄ
- Anita-Chrysolyte Kusi-Appiah
- Anja Diers
- Anja Hansen
- Ann-Sofie Malvemyr
- Anna Alexandrou
- Anna Diaz
- Anna Efthymiou
- Anna Kyriakoudi
- Anna Leonova
- Anna Vita Bruno
- Anne Fishman
- Anne Langvad
- Anne Marie Kodal
- Anne Sofie Bomholt Pedersen
- Anne Williams
- Anne-Sophie Debue
- Annette Carey
- Annette Toellefsen
- Anthony Adenekan
- Anthony Radavidson
- Antigoni Karathanou
- Anton TurÄan
- Antonella Cotoia
- Antonella Mo
- Antoni Margarit Ribas
- Antonia Liarmakopoulou
- Antonija Petosic
- Antonino Rizzo
- Antonio Abdala
- Antonio Barone
- Antonio Landaverde
- Antonio Manzo
- Antonio Margarit Ribas
- Antony Eneas
- Apostolos Bakas
- Arena Raimondo
- Arif Moghal
- Aristeidis Vakalos
- Arlette Van Den Elst
- Armanda Bozena
- Armando Schmukler
- Armorel Salberg
- Artemis Patsalos
- Arturo Briva
- Arvind Baronia
- Asbjorn Blondal
- Ascanio Tridente
- Ashish K Khanna
- Ashish K Khanna
- Ashish Khanna
- Ashley Szabo Eltorai
- Ashok Sundai Raj
- Ashwaq Ali
- Asmah Zainudin
- Asu Ozgultekin
- Ata Mahmoodpoor
- Athena Lavrentieva
- Attilio Quaini
- Audrey Fioretti
- Audrey Massard
- Auke Reidinga
- Auli Palmu
- AvĆar Zerman
- Aya Alabuzidi
- Ayako Noguchi
- Ayça GĂŒmĂŒĆ
- Azmin Huda Abdul Rahim
- Babangida John Sankey
- Badiola Hilario
- Banu TaĆdemir
- Baoke Zhang
- Barbara Garcia
- Barbro Meland
- Bart Ramaker
- Basri Mat Nor
- Battsetseg Baasanjav
- BaĆar Erdivanli
- BaĆar Erdivanli
- Beatrice Pastore
- Begoña Zalba-Etayo
- Belen Burgos Conde
- Belinda Guadi-Gosh
- Ben Attwood
- Benjamin Bongiorno
- Benjamin Gerretsen
- BenoĂźt Chinardet
- Berenice Navarro
- Bernardo Panka
- Bernardo Panka
- Bernd Oliver Rose
- Bert Loef
- Betty Star Kampayana
- Beverley Thomas
- Beysim Ăzcan
- Beysim Ăzcan
- Bhagyesh Shah
- Biljana Kuzmanovska
- Bindu Thankamma
- Bing Song
- Binny Tuinstra
- Birgitte Fosser Johansen
- Birthe Husted
- Biyan Li
- Bjoern Monsen
- Bjorn Bratsberg
- Bodin Khwannimit
- Bogdan Raitsiou
- Bojan Jovanovic
- Bonnie Bowes
- BoÄaç Ăzserezli
- Bram Kilapong
- Bram Kilapong
- Branislava Stefanovic
- Brian Marsh
- Brigitte Tejeda-Huezo
- Brita Fosser Olsen
- Britt Galaaen
- Britt Sjobo
- Britta Jepsen
- Bronagh Blackwood
- Bruno Miguel Bispo
- Bruno Sousa
- Bruno Sousa
- Brynja Rygvadottir
- Burhan Hadri
- Burhan Hadri
- Byung Ju Kang
- Caihong Hui
- Caiju Song
- Caitriona Cody
- Can Turan
- Carita Löfqvist
- Carlo Alberto Volta
- Carlos Alejandro Bascary
- Carlos Castro Delgado
- Carmel Chapman
- Carmel Georgiev
- Carmen Partera Luque
- Carmen Velasco Guillén
- Carole Boulanger
- Carole Boulanger
- Carole Brett
- Carolina GarzĂłn-Tovar
- Carolina Palaez
- Caroline LagerhÀll
- Caroline O'Donnell
- Caroline Paillet
- Carrie Sona
- Casiano Barrera Groba
- Catalin Traian Guran
- Catarina Nunes
- Catarina Tingsvik
- Catherine Motherway
- Catherine O'Brien
- Catherine Smith
- Cathy Becker
- Catia Quagliotto
- Cecilia Inés Loudet
- Cecilia Loudet
- Celia Tirado
- Ceri Lynch
- Cesar Aponte
- Cesar Rodriguez Nuñez
- Chaiwut Sawawiboon
- Chaoqun Ma
- Charalampos Martinos
- Charalice Ramiro
- Charikleia Nikolaou
- Charlotte Carter
- Charlotte Young
- Charlotte Young
- Chen Yumei
- Cheng
- Chenghau Mu
- Chengxia Sun
- Cheryl Bealer
- Cheryl Davidson
- Chiara Gatti
- Chiara Megna
- Chiara Megna
- Cho Young-Jae
- Chris Gerome Ellazar
- Chris Smith
- Chrisi Diakaki
- Christian Ferretti
- Christian Frey
- Christian Theisen
- Christiana Chime
- Christine Fiedler
- Christine Sheehan
- Christophe Borin
- Christophe Giacardi
- Christopher Barnes
- Christopher Barnes
- Christopher Palfreeman
- Christopher Potestio
- Christos Christofis
- Christos Dragoumanis
- Chrysanthos Markoulias
- Chrysostomos Katsenos
- Chun Jie Xia
- Chunxia Li
- Cindy Barefield
- Cindy Pillard
- Cintia Valencia Hurtado
- Cinzia Borgognoni
- Claire Derbyshire
- Claire Randell
- Claire Reynolds
- Clara Hurtado
- Clara Santa Rita
- Clare Fielding
- Clare Howcroft
- Claude Sertznig
- Claudia Lizbeth Lopez Nava
- Claudia Martins
- Congcong Liu
- Constantina Constantinou
- Cristal April Jane Aperocho
- Cristian Quiroga
- Cristiana Mota Pinheiro
- Cristina Paños Espinosa
- Cristina Petrisor
- Cui Yuan
- Cynthia Xing
- Cyril Thix
- Cyril Thix
- CĂ©dric Bruel
- CĂ©dric Daubin
- Dagmar Holmquist
- Daira Gonzalez
- Daisy Mehay
- Dale Ventour
- Damei Wang
- Damien O'Connell Rosemary Finn
- Dana Tomescu
- Dana Tomescu
- Danca LanÄariÄovĂĄ
- Daniel Blanco
- Daniel Horner
- Daniel Owens
- Daniel Sancho Muriel
- Daniela Alampi
- Daniela Carmen Filipescu
- Danielle Hacking
- Danil Baskakov
- Daria Rabarova
- Dassy Levy
- David De Bels
- David Higgins
- David Perez-Torres
- David Shaw
- Davide Massimo Ghioldi
- Dea Mahanes
- Debbie Noblezada-Uy
- Deborah Jibrin
- DeHong Lei
- Deirdre Doyle
- Dejan VeliÄkoviÄ
- Delmiro Becker
- Delphine Ngo
- Demet Tok Aydin
- Detlef Kindgen-Milles
- Devrim AkdaÄ
- Deyan Cao
- Diana Alvarez
- Diane Barkas
- Dianne Figaro-Barclay
- Dick Nahar
- Diego Rolando Morocho Tutillo
- Dimitra Lepida
- Dimitrios Papadopoulos
- Dinko Tonkovic
- Dirk von Lewinski
- Dmitriy Galishevskiy
- Dmitry Sergeev
- Dolly Mabel Bordon Cabral
- Dominic Carney
- Donaldo S Arteta Arteta
- Dongfang Wei
- Dongliang Lin
- Dongmei Bai
- Dongshu Ni
- Donna Cummings
- Dorel Sandesc
- Dorothee Mueller
- Dorothy Terry
- Drammen Sykehus
- Dritan Muzha
- Dritan Muzha
- Duygu Kayar Calili
- Dylan De Lange
- Dylan De Lange
- Edda Johansen
- Edwin Chapeta
- Egide Buregeya
- Egidija Bielskute
- Eileen Gilder
- Eirini Pantiora
- Eirini Papageorgiou
- Eirini-Chysovalanto Patsiou
- Ekaterina Tokareva
- Elaine Barros
- Elaine Thorpe
- Eleanor Santiago
- Elena Molinos
- Eleni Achilleos
- Eliane Mazocoli
- Elie Gharios
- Elif Erdogan
- Elif Erdogan
- Elin Kristoffersen
- Elin Mari Skorstad
- Elin Steffenak
- Elina Karjula
- Elisabet Gallart
- Elisabeth Wiborg
- Elisabetta Brizio
- Elizabeth Campbell
- Elizabeth Maidana
- Elizabeth Stones
- Ella Rokosh
- Elsa Afonso
- Elsa Afonso
- Emanuel Valgolio
- Emiliano Dean
- Emilio Maseda
- Emma Aves
- Emma Moreno Barreiro
- Emma Parkin
- Enas Soula
- Eneli Anvelt
- Enora Atchade
- Epaminontas Farmakis
- Erik Roman-Pognuz
- Erika Backlund Jansson
- Eryun Tian
- Esben Straede
- Esteban Milioto
- Estefania Orozco
- EstefanĂa Prol-Silva
- EstevĂŁo Lafuente
- Etienne De Montmollin
- Eugenio Garofalo
- Eugenio Martinez-Hurtado
- Eugeniya Larina
- EulĂĄlia Luis
- Eumorfia Kondili
- Eunice Tole
- Eva Joelsson-Alm
- Eva Joelsson-Alm
- Eva Ă kerman
- Eva Ă kerman
- Evangelia Michailidou
- Evdokia Sourla
- Evellyn Oliveira
- Evgeniy Zuev
- Evren ĆentĂŒrk
- Ewa Wahlbom
- Ewa Wallin
- Fabienne Etourneau
- Fabio Capuzzi
- Fabio Guarracino
- Fan Yang
- Fanglan Wang
- Farid Zand
- Farshad Heidari
- Fatema Salman
- Fateme Jafaraghaee
- Fatemeh Zarei
- Fatiha Essardy
- Fatima Fernandes
- Fatima Ferreira
- Fatima Kasem El Ahmad
- Fatime Hawchar
- Faustina Excel Adipa
- Fausto Guerrero
- Faye Morren
- Fayez François Abillama
- Fayez François Abillama
- Federica Dellafiore
- Federica Mancini
- Federica Piergentili
- Federico Gordo
- Federico Iglesias
- Fei Ouyang
- Feifei Chen
- Feifei Luo
- Feifei Zhang
- Fekri Abroug
- Fengling Yang
- Ferdinand Aganon
- Fernando Avalos
- Fernando Baccaro
- Fernando Lipovestky
- Fernando Lipovesty
- Fernando Molinar
- Fernando Pablo Bertoletti
- Fernando Tapia
- Fethi GĂŒl
- Fidelina Canete
- Filip Naumovski
- Filipo Binda
- Filippo Boroli
- Filpe Pires
- Fiona Coyer
- Fiona Coyer
- Fiona Coyer
- Fiona O'Shea
- Firas Ashour
- Flavia Ranalli
- Frances Dawn
- Frances Lin
- Frances Lin
- Frances Lin
- Frances Lin
- Francesca De Sanctis
- Francesca Paola Tranello
- Francesca Rubulotta
- Francesca Rubulotta
- Francesca Rubulotta
- Francesco D'Ambrosio
- Francesco Uccelli
- Francis Hannes
- Francisco Javier Saenz Abos
- Frank Bloos
- Frank Bloos
- Franklin Dean Cerezo
- François Philippart
- FrÀnk Gils
- Fumiya Kanda
- Fuqun Pan
- Fuying Ma
- Gabor Nardai
- Gabriel Enrique Rodriguez
- Gabriel Preda
- Gabriel Suen
- Gabriela Mendez
- Gao Chunhua
- Gari Slobodianiuk
- Garri Slobodianiuk
- Gavin D Leslie
- Gaëtan PlantefÚve
- Ged Williams
- Gen Meng
- Genci Hyska
- Georgios Gkiokas
- Georgios Papathanakos
- Geraldine Craig
- Gerry Fitzpatrick
- Ghaleb Almekhlafi
- Giacomo Castiglione
- Gian Domenico Giusti
- Giancarlo Abregal
- Giannoula Thoma
- Gilberto Felipe Vazquez de Anda
- Gilles Martin
- Gillian Berry
- Giorgia Rubulotta
- Giovanni Scire
- Glenda Rooney
- Gloria Alvarenga
- Gloria Montaldi
- Gonzalo MartĂn Alvarez
- Gonzalo Pagella
- Gordana Pavlisa
- Gordana Zivanovic-Posilovic
- Grace Lacaden
- Graciela Del Valle Gimenez
- Graciela Zakalik
- Grit Henning
- Gro Anne Lunde
- Gro Ringstad Akselsen
- Guangyan Liu
- Guangyuan Gao
- Guanxiu Shi
- Guifang Du
- Guijun Bao
- Guillaume Besch
- Guillermo Muñiz Albaiceta
- Guiping Zhang
- Gulbahar Caliskan
- Gulsah Karaoren
- Gun Löf
- Gunilla Mattsson
- GuoXian Wang
- Guoxue He
- Guoyan Zhu
- Gustavo Andres Alvarez
- Gustavo Badariotti
- Guy François
- GĂŒlseren Elay
- Hai Yin
- Hai Yun Wang
- Hailing Guo
- Haiyan Chen
- Haiyan Wang
- Hajer Ben Zahra
- Hakan Yilmaz
- Hanne Andresen
- Hanne Haugom
- Hanne Irene Jensen
- Hanne Irene Jensen
- Hansjoerg Waibel
- Harriet Judd
- Hasan Nabi Undar
- Hayriye Cankar Dal
- Hazem Ahmed
- Heather Byers
- Hege Bjorgen
- Hege Ostenjo
- Helen Baker
- Helen Derrick
- Helen Jaundoo
- Helen Williams
- Helena Behan
- Helena Cesar
- Helena Fernandez Alonso
- Hemena Äuljak
- Hernan Aguirre-Bermeo
- Hernan Aguirre-Bermeo
- Hervé Mentec
- Hervé Quintard
- Heung Bum Lee
- Hideaki Sakuramoto
- Hilary Twiggs
- Hilaryano Ferreira
- Hong Zhang
- Hong Zheng
- Hongjuan Chen
- Hongmei Liu
- Hongmei Qiao
- Hongsu Zhang
- Hongyan Shao
- Howe Yan
- Hrönn Birgisdottir
- Hrönn Birgisdóttir
- Hua Ji
- Huai Yang
- Huan Duan
- Hugo Perez
- Hui Min Zhao
- Hui Zhang
- Humberto Costa
- Humberto Gallegos-Perez
- Huseyin Arikan
- Hyacinth Harding-Goldson
- Hyun Keun Chee
- Ian Kerslake
- IdĂĄlia Valerio
- Ifigenia Ravani
- Ignacio Martin-Loeches
- Ignacio Sabbag
- Ihor Iovenko
- Ileana Adamina
- Ilse Van Cotthem
- Imelda Perdomo Fonseca
- Imen Talik
- Ina FilipoviÄ-GrÄiÄ
- India Lye
- Ines Rosado
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- Ingeborg D Welters
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- Javier Bogarin
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- Joerg C Schefold
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- Walid Sellami
- Walter Swinnen
- Wan Nasrudin Wan Ismail
- Wang Zhijuan
- Wangari Waweru-Siika
- Wangari Waweru-Siika
- Wangyan Jin
- Wei Sun
- Wei Wang
- Wei Wei
- Wei Zhang
- Wei Zhang
- Weilian Yuan
- Weiwei Li
- Wenche Arntsen
- Wendy Brown
- Wendy Chaboyer
- Wendy Chaboyer
- Wendy Milner
- Wenjie Ju
- Wenmei Wang
- Wenmin Chen
- Wenwen Zhao
- Wenzhen Cao
- Wesal Ali Belkhair
- Willem Dieperink
- Windu Baskoro
- Won-Yeon Lee
- Wu Yuchen
- Xia Cui
- Xia Huang
- Xianhong Zheng
- Xianping Luo
- Xiao Fang Tian
- Xiao Xu
- XiaoChun Hu
- Xiaodi Liu
- Xiaofang Luo
- Xiaohan Li
- Xiaohan Li
- Xiaojun Wu
- Xiaoli Yan
- Xiaomin Wang
- Xiaoqiong Deng
- Xiaowu Bai
- Xiaoyan Chen
- Xiaoyan Chen
- Xiaoying Wu
- XiaoZhe Liu
- Ximena Villanueva
- Xingguo Li
- Xinhua Xia
- Xinhua Xia
- Xinjian Li
- Xinran Ding
- Xinxia Li
- Xinxia Li
- Xiuhua Fang
- Xiuhua Fang
- Xiujuan Xue
- XiuMei Liu
- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ăgoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ăngela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam ViĆĄnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- AkdaÄ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo MartĂn
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas MarĂa Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini MatĂas
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- Baker Helen
- Baker Nerilee
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- Balbay Abidin Oner
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- Banwarie Preveen
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- Barkas Diane
- Barnes Christopher
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- Barreiro Emma Moreno
- Barros Elaine
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- Barrueco-Francioni Jesus Emilio
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- Baruah Rosaleen
- Bascary Carlos Alejandro
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- DâAmbrosio Francesco
- DâAmbrosio Paolo
- Ebaid Maie
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- Efe Serdar
- Efthimiou Aikaterini
- Efthymiou Anna
- Egi Moritoki
- Egorova Natalya
- Ei Poe Poe
- Elatrous Souheil
- Elay GĂŒlseren
- Elgammudi Mala
- Elhadi Ahmed
- Elhadi Muhammed
- Elhechmi Youssef Zied
- Elkhayari Mina
- Ellazar Chris Gerome
- Eller Philipp
- Eltorai Ashley Szabo
- Enamorado Judy
- Enamorado Judy Enamorado
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- Eng Timothy
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- Erdogan Elif
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- von Lewinski Dirk
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- Wahab Sherliza
- Wahlbom Ewa
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- Wallin Ewa
- Walsh Amy
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- Waweru-Siika Wangari
- Wei Dongfang
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- Wei Xiyan
- Wei Ying
- Welters Ingeborg D.
- White Joanne
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- Xia Xinhua
- Xiao Lina
- Xiao Min
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- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
- Yeni Nomhle Princess
- Yeon-Joo Lee
- Yildiz Ä°smail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias JesĂșs Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman AvĆar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ăgoston Zsuzsann
- Ă kerman Eva
- Ăelik Jale Bengi
- Ăamendys-Silva Silvio A.
- Ăzcan Beysim
- Ăzserezli BoÄaç
- ĂnlĂŒ Nurdan
- Äuljak Hemena
- ĆentĂŒrk Evren
- Ć uput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9â27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6â16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2â1.8), stage II (OR 1.6; 95% CI 1.4â1.9), and stage III or worse (OR 2.8; 95% CI 2.3â3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
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- Adam ViĆĄnja Nesek
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- de Ceballos José Peral Gutierrez
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- De Schryver Nicolas
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- Dean Emiliano
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- Eng Timothy
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- Fielding Clare
- Fielding Mark
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- Finn Damien OâConnell Rosemary
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- Gerritsen Rik T.
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- Gu Yanmei
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- Honore Patrick M.
- Honoré Patrick M.
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- KĂŒtimets Martin
- Labeau Sonia O.
- Lacaden Grace
- Lafuente EstevĂŁo
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- Lepida Dimitra
- Leslie Gavin D.
- Lestari Mayang Indah
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- Llaurado-Serra M.
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- Mancini Federica
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- Maruyama Kumi
- Maseda Emilio
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- Zermeno Jorge Macias
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- Zhang Ying
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- Zhao Lijuan
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- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ăgoston Zsuzsann
- Ă kerman Eva
- Ăelik Jale Bengi
- Ăamendys-Silva Silvio A.
- Ăzcan Beysim
- Ăzserezli BoÄaç
- ĂnlĂŒ Nurdan
- Äuljak Hemena
- ĆentĂŒrk Evren
- Ć uput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Substitution of glutamic acid for alanine 1135 in the putative "catalytic loop" of the tyrosine kinase domain of the human insulin receptor. A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity.
- Publication venue
- American Society for Biochemistry and Molecular Biology:9650 Rockville Pike:Bethesda, MD 20814:(301)530-7145, EMAIL: [email protected], INTERNET: http://www.faseb.org/asbmb, Fax: (301)571-1824
- Publication date
- 01/01/1993
- Field of study
The intracellular domain of the insulin receptor possesses activity as a tyrosine-specific protein kinase which is stimulated by insulin binding to the extracellular domain of the receptor. We have identified a patient with a genetic form of insulin resistance who is heterozygous for a mutation substituting Glu for Ala1135 in the putative "catalytic loop" of the tyrosine kinase domain of the receptor. In this investigation, the Glu1135 mutant receptor was expressed by transfection of mutant cDNA into NIH-3T3 cells. Like previously described mutations in the tyrosine kinase domain, the Glu1135 mutation impairs receptor tyrosine kinase activity and inhibits the ability of insulin to stimulate thymidine incorporation and receptor endocytosis. These data support the hypothesis that the receptor tyrosine kinase activity plays a necessary role in the ability of the receptor to mediate insulin action in vitro and in vivo. However, unlike previously described mutations in the intracellular domain of the receptor, the Glu1135 mutation impairs proteolytic cleavage of the proreceptor into separate subunits and impairs the transport of the receptor to the cell surface. These latter defects provide an explanation for the decrease in the number of receptors on the cell surface observed in the patient's circulating monocytes despite the fact that the mutant receptor is resistant to endocytosis and insulin-induced down-regulation
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