23 research outputs found
A Spitzer Transmission Spectrum for the Exoplanet GJ 436b, Evidence for Stellar Variability, and Constraints on Dayside Flux Variations
In this paper we describe a uniform analysis of eight transits and eleven
secondary eclipses of the extrasolar planet GJ 436b obtained in the 3.6, 4.5,
and 8.0 micron bands using the IRAC instrument on the Spitzer Space Telescope
between UT 2007 June 29 and UT 2009 Feb 4. We find that the best-fit transit
depths for visits in the same bandpass can vary by as much as 8% of the total
(4.7 sigma significance) from one epoch to the next. Although we cannot
entirely rule out residual detector effects or a time-varying, high-altitude
cloud layer in the planet's atmosphere as the cause of these variations, we
consider the occultation of active regions on the star in a subset of the
transit observations to be the most likely explanation. We reconcile the
presence of magnetically active regions with the lack of significant visible or
infrared flux variations from the star by proposing that the star's spin axis
is tilted with respect to our line of sight, and that the planet's orbit is
therefore likely to be misaligned. These observations serve to illustrate the
challenges associated with transmission spectroscopy of planets orbiting
late-type stars; we expect that other systems, such as GJ 1214, may display
comparably variable transit depths. Our measured 8 micron secondary eclipse
depths are consistent with a constant value, and we place a 1 sigma upper limit
of 17% on changes in the planet's dayside flux in this band. Averaging over the
eleven visits gives us an improved estimate of 0.0452% +/- 0.0027% for the
secondary eclipse depth. We combine timing information from our observations
with previously published data to produce a refined orbital ephemeris, and
determine that the best-fit transit and eclipse times are consistent with a
constant orbital period. [ABRIDGED]Comment: 26 pages, 18 figures, 7 tables in emulateapj format. Accepted for
publication in Ap
Altered Development of NKT Cells, γδ T Cells, CD8 T Cells and NK Cells in a PLZF Deficient Patient
In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cells. Furthermore, PLZF was also found to be expressed in all γδ T cells and in all NK cells. Importantly, we show that in a donor lacking functional PLZF, all of these various lymphocyte populations were altered. Therefore, in contrast to mice, PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs. Interestingly, the PLZF-expressing CD8+ T cell population was found to be expanded in the peripheral blood of patients with metastatic melanoma but was greatly diminished in patients with autoimmune disease
White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD
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Wide-Orbit Exoplanet Demographics
The Kepler, K2 and TESS transit surveys are revolutionizing our understanding of planets orbiting close to their host stars and our understanding of exoplanet systems in general, but there remains a gap in our understanding of wide-orbit planets. This gap in our understanding must be filled if we are to understand planet formation and how it affects exoplanet habitability. We summarize current and planned exoplanet detection programs using a variety of methods: microlensing (including WFIRST), radial velocities, Gaia astrometry, and direct imaging. Finally, we discuss the prospects for joint analyses using results from multiple methods and obstacles that could hinder such analyses. We endorse the findings and recommendations published in the 2018 National Academy report on Exoplanet Science Strategy. This white paper extends and complements the material presented therein