Solving Scheduling Problems with Genetic Algorithms using a Priority Encoding Scheme

Scheduling problems are very hard computational tasks with several applications in multitude of domains. In this work we solve a practical problem motivated by a real industry situation, in which we apply a genetic algorithm for finding an acceptable solution in a very short time interval. The main novelty introduced in this work is the use of a priority based chromosome codification that determines the precedence of a task with respect to other ones, permitting to introduce in a very simple way all problem constraints, including setup costs and workforce availability. Results show the suitability of the approach, obtaining real time solutions for tasks with up to 50 products.Universidad de Málaga.Campus de Excelencia Internacional Andalucía Tech

Genetic analysis of microsatellites markers in two populations of Berrenda en Negro bovine breed

The Berrenda en Negro cattle breed has been used classically in the management of the fight bull and currently is found next their extinction. To contribute to the genetic conservation programs of this breed, we are characterized a sample of 32 animals with a panel of 15 microsatellites and we are provided data that permit, in a future, to compare its variability with other cattle breeds.La raza Bovina Berrenda en Negro se ha utilizado clásicamente en el manejo del toro de lidia y actualmente se encuentra próxima a su extinción. Para contribuir a los planes de recuperación genética de esta raza, se caracteriza una muestra de 32 animales con un panel de 15 microsatélites y se proporcionan datos que permitan, en un futuro, comparar su variabilidad con otras razas bovinas

Genetic characterisation of bovino criollo argentino cattle using microsatellites

It is characterized a sample of Bovino Criollo Argentino cattle with a panel of eight microsatellites. It is detected a number of alleles between 2 and 7. The values of Heterocigosity by locus are between 0.46 for HEL-1 and 0.72 for BM-1824 and the mean of Heterocigosity is 0.58.Se caracteriza una muestra de ganado Bovino Criollo Argentino con un panel de ocho microsatélites. Se detecta un número de alelos entre 2 y 7. Los valores de Heterocigosidad por locus están entre 0,46 para HEL-1 y 0,72 para BM-1824, la Heterocigosidad media es de 0,58

Origin and standing of Canary Black Pig

We summarize the historical information about origin of Canary Black Pig and standing in the Canary Islands. The presence of pig in Canary Islands is from 500 year b.C., where aborigines used its meat as food, its fat to preserve foods, its skin as clothing and its bones to produce tools and adornments. The census is constituted for 283 animals, 182 females and 101 males, with a major representation in Tenerife and Gran Canaria islands, 173 and 71 animals respectively.A través de la documentación histórica del Archipiélago Canario, se ha esbozado el origen del Cerdo Negro Canario, a la vez que se expone su estado actual en las diferentes islas del archipiélago. La presencia del cerdo data desde hace 2500 años en el Archipiélago Canario, donde los aborígenes utilizaron su carne como alimento, su manteca para conservas, su piel para vestimenta y sus huesos para fabricación de útiles y adornos. El censo lo constituyen unos 283 ejemplares, 182 hembras y 101 machos, y su mayor representación está en las islas de Tenerife y de Gran Canaria con 173 y 71 animales respectivamente

DNA polymorphisms in Merino and Churra Lebrijana sheep breeds

The Merino and Churra Lebrijana ovine breeds are two of the most important sheeps developed in Spain. In the first case, the study of its genetic characteristics is justified by the importance it has have in the origin of other wool breeds. The Churra Lebrijana sheep breed is next the extinction therefore it is necessary to begin a conservation programme of its genetic resources.Las razas ovinas Merino y Churra son dos de las más importantes ovejas explotadas en España. En el primer caso, el estudio de sus características genéticas se justifica por la importancia que ha tenido en el origen de otras razas ovinas productoras de lana. La raza Churra Lebrijana se encuentra próxima a la extinción por lo que es necesario iniciar programas para la recuperación de sus recursos genéticos

Improving lipid management in patients with acute coronary syndrome : The ACS Lipid EuroPath tool

Post-acute coronary syndrome (ACS) patients are at very high risk for recurrent events and mortality, despite the availability of effective pharmacological approaches. In 2018, the ACS EuroPath Survey, performed in collaboration with 555 European cardiologists, identified a sub-optimal LDL-C management in post-ACS patients. Based on these premises, the ACS EuroPath II project led to the development of a self-assessment tool to improve lipid management in these very high risk patients, taking into consideration the new 2019 ESC/EAS guidelines. This tool is built in 3 sections. The first is a questionnaire to assess the lipid management practice from the acute phase up to 12 months of follow-up. The main topics covered in this section relate to 1) acute phase (lipid management of ACS patients during hospitalization; 2) discharge (lipid management at discharge, with focus on follow-up plan); 3) follow-up (lipid management at the time of first and subsequent follow-ups); 4) referral pathway for definitive lipid management care of post-ACS patients; 5) evaluation of the achieved goal at 6 months to 1 year and key implications. The second section is a brief report to position the results against other European Union clinical practice and European guidelines. The last section allows the physician to evaluate and consider the implementation of one or more strategies, successfully developed in leading European centers, in order to optimize their own clinical practice

Anticoagulation in patients with atrial fibrillation and active cancer: an international survey on patient management

Background: In patients with active cancer and atrial fibrillation (AF) anticoagulation, thrombotic and bleeding risk still entail uncertainty.Aim: We explored the results of an international survey examining the knowledge and behaviours of a large group of physicians.Methods and results: A web-based survey was completed by 960 physicians (82.4% cardiologists, 75.5% from Europe). Among the currently available anticoagulants for stroke prevention in patients with active cancer, direct oral anticoagulants (DOACs) were preferred by 62.6%, with lower values for low molecular weight heparin (LMWH) (24.1%) and for warfarin (only 7.3%). About 46% of respondents considered that DOACs should be used in all types of cancers except in non-operable gastrointestinal cancers. The lack of controlled studies on bleeding risk (33.5% of respondents) and the risk of drug interactions (31.5%) were perceived as problematic issues associated with use of anticoagulants in cancer. The decision on anticoagulation involved a cardiologist in 27.8% of cases, a cardiologist and an oncologist in 41.1%, and a team approach in 21.6%. The patient also was involved in decision-making, according to similar to 60% of the respondents. For risk stratification, use of CHA2DS2-VASc and HAS-BLED scores was considered appropriate, although not specifically validated in cancer patients, by 66.7% and 56.4%, respectively.Conclusion: This survey highlights that management of anticoagulation in patients with AF and active cancer is challenging, with substantial heterogeneity in therapeutic choices. Direct oral anticoagulants seems having an emerging role but still the use of LMWH remains substantial, despite the absence of long-term data on thromboprophylaxis in AF.Cardiolog

Intranasal administration of mesenchymal stem cell secretome reduces hippocampal oxidative stress, neuroinflammation and cell death, improving the behavioral outcome following perinatal asphyxia

Indexación: Scopus.PerinatalAsphyxia (PA) is a leading cause ofmotor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global PA, we investigated the neuroprotective effect of intranasally administered secretome, derived from human adipose mesenchymal stem cells (MSC-S), preconditioned with either deferoxamine (an hypoxia-mimetic) or TNF-ff+IFN- (pro-inflammatory cytokines). PA was generated by immersing fetus-containing uterine horns in a water bath at 37 ffC for 21 min. Thereafter, 16 ffL of MSC-S (containing 6 ffg of protein derived from 2 ff 105 preconditioned-MSC), or vehicle, were intranasally administered 2 h after birth to asphyxia-exposed and control rats, evaluated at postnatal day (P) 7. Alternatively, pups received a dose of either preconditioned MSC-S or vehicle, both at 2 h and P7, and were evaluated at P14, P30, and P60. The preconditioned MSC-S treatment (i) reversed asphyxia-induced oxidative stress in the hippocampus (oxidized/reduced glutathione); (ii) increased antioxidative Nuclear Erythroid 2-Related Factor 2 (NRF2) translocation; (iii) increased NQO1 antioxidant protein; (iv) reduced neuroinflammation (decreasing nuclearNF-ffB/p65 levels and microglial reactivity); (v) decreased cleaved-caspase-3 cell-death; (vi) improved righting reflex, negative geotaxis, cliff aversion, locomotor activity, anxiety, motor coordination, and recognition memory. Overall, the study demonstrates that intranasal administration of preconditioned MSC-S is a novel therapeutic strategy that prevents the long-term effects of perinatal asphyxia. © 2020 by the authors.https://www.mdpi.com/1422-0067/21/20/780

The exposure of the hybrid detector of the Pierre Auger Observatory

The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays. It consists of a surface array to measure secondary particles at ground level and a fluorescence detector to measure the development of air showers in the atmosphere above the array. The "hybrid" detection mode combines the information from the two subsystems. We describe the determination of the hybrid exposure for events observed by the fluorescence telescopes in coincidence with at least one water-Cherenkov detector of the surface array. A detailed knowledge of the time dependence of the detection operations is crucial for an accurate evaluation of the exposure. We discuss the relevance of monitoring data collected during operations, such as the status of the fluorescence detector, background light and atmospheric conditions, that are used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic