In how many ways can one age successfully? Patterns of wellbeing in the Lothian Birth Cohort 1936

This thesis explored cognitive, psychosocial, and physical domains of wellbeing to find out their contribution to successful ageing in 70-year old individuals. Discovering groups with different patterns of wellbeing and their correlates may be informative about what constitutes success in old age. The objectives were to find out whether distinct groups within and across domains of wellbeing existed, and to find out the variables associated with the resulting groups. Using a cross-sectional design on the Lothian Birth Cohort 1936 (LBC1936, maximum n = 1091), which is a group of community-dwelling 70 year-olds, latent class analysis (LCA) was used to explore possible patterns of ageing in domains of cognitive, psychosocial, and physical function. Demographic, personality, and lifestyle variables that were not used in the LCA were used to characterise the resulting groups. The first study investigated cognitive ability. Individuals were grouped according to their scores on general cognitive ability (g), memory, and speed. I accepted a 3-group solution, including High- (n = 749, 69%), Average- (n = 303, 28%), and Low- (n = 39, 4%) cognition groups. Results indicated the presence of a strong dimension: people who did well on one component also did well on others, and failed to show any indication of uneven patterns of scores. In the second study on psychosocial wellbeing individuals were grouped according to their scores on physical function, quality of life, and emotional wellbeing. A 5-group solution was accepted. High (n =515, 42.7%), Average (n = 417, 38.3%), and Poor (n = 37, 3.4%) Wellbeing groups were identified; however, contrasting patterns of wellbeing across components were noticed in the two other groups: one group scored relatively highly on physical function, but low on emotional wellbeing (High Function/ Low Spirits, n = 60, 5.5%), while another group showed low physical function but relatively high emotional wellbeing (Low Function/High Spirits, n = 62, 5.7%). The next study investigated the physical fitness domain: groups were determined on physical fitness, lack of inflammation, and lack of morbidity. Two groups, High Physical Fitness (n = 757, 73.3%) and Low Physical Fitness (n = 291, 26.7%) were identified, which, like the cognitive domain, also indicated a continuous pattern of wellbeing. In the final study individuals were grouped according to their scores on all variables reflecting cognitive, psychosocial, and physical function. I identified 3 groups showing high or uneven patterns of wellbeing. The majority of individuals fell in the High Wellbeing group (n = 712, 65.3%). The two other groups contained either individuals scoring high on cognitive measures but poorly on psychosocial and physical measures (the Low Bio-Psychosocial group, n = 158, 14.5%), or individuals scoring low on cognitive measures but highly on psychosocial and physical measures (the Low Cognition group, n = 221, 20.3%). Intelligence, personality and health behaviours showed salient differences amongst the groups in all studies. Overall, high childhood cognitive ability, low scores on Neuroticism, and avoiding smoking were associated with high wellbeing. Overall, results demonstrated that although wellbeing in old age is primarily dimensional, there is evidence of groups showing uneven patterns of function, indicating that individuals could show relatively successful patterns in some areas of wellbeing despite relatively poor functioning in other areas. Awareness of the importance of lifelong intelligence and personality traits and health practices to later-life wellbeing amongst health-care professionals and policymakers may help address risk-prevention, and improve compliance and patient-practitioner relationships to reduce health inequalities

Developing Web-based Search Portals on Birds for Different Target Groups

This paper presents the experiences and interim results from the ongoing iterative development and testing of four distinctive search portals on birds. The search portals are developed within the EU STERNA project and address different target user groups. Based upon specific use case scenarios the search portals are tested and validated in four specific phases, applying three different testing methods: WAMMI online evaluation, focus group evaluation and task-based usability tests. The paper introduces the four search portals, depicts the testing methodology and presents the first results from the ongoing user validation process

Rapporto Attività di Progetto Attività scientifiche per i radar di Mars Express e di Mars Reconnaissance Orbiter Fase E2 Continuazione Riunione di Avanzamento n.1

Rapporto presentato alla Riunione di Avanzamento n.1, relativo alle attività tecnico/scientifiche svolte nel periodo 14/11/2019-31/01/2020 nell'ambito del contratto ASI-INAF 2019-21-HH.0, riguardante i radar di Mars Express e di Mars Reconnaissance Orbiter Fase E2 Continuazion

Rapporto Attività di Progetto Attività scientifiche per i radar di Mars Express e di Mars Reconnaissance Orbiter Fase E2 Continuazione Riunione di Avanzamento n.3

Rapporto presentato alla Riunione di Avanzamento n.3, relativo alle attività tecnico/scientifiche svolte nel periodo 16/11/2020-28/02/2021 nell'ambito del contratto ASI-INAF 2019-21-HH.0 riguardante i radar di Mars Express e di Mars Reconnaissance Orbiter Fase E2 Continuazion

Rapporto Attività di Progetto Attività scientifiche per i radar di Mars Express e di Mars Reconnaissance Orbiter Fase E2 Continuazione Riunione di Avanzamento n.2

Rapporto presentato alla Riunione di Avanzamento n.2, relativo alle attività tecnico/scientifiche svolte nel periodo 01/02/2020-15/11/2020 nell'ambito del contratto ASI-INAF 2019-21-HH.0 riguardante i radar di Mars Express e di Mars Reconnaissance Orbiter Fase E2 Continuazion

Prelamin A mediates myocardial inflammation in dilated and HIV-Associated cardiomyopathies

Cardiomyopathies are complex heart muscle diseases that can be inherited or acquired. Dilated cardiomyopathy can result from mutations in LMNA, encoding the nuclear intermediate filament proteins lamin A/C. Some LMNA mutations lead to accumulation of the lamin A precursor, prelamin A, which is disease causing in a number of tissues, yet its impact upon the heart is unknown. Here, we discovered myocardial prelamin A accumulation occurred in a case of dilated cardiomyopathy, and we show that a potentially novel mouse model of cardiac-specific prelamin A accumulation exhibited a phenotype consistent with inflammatory cardiomyopathy, which we observed to be similar to HIV-associated cardiomyopathy, an acquired disease state. Numerous HIV protease therapies are known to inhibit ZMPSTE24, the enzyme responsible for prelamin A processing, and we confirmed that accumulation of prelamin A occurred in HIV' patient cardiac biopsies. These findings (a) confirm a unifying pathological role for prelamin A common to genetic and acquired cardiomyopathies; (b) have implications for the management of HIV patients with cardiac disease, suggesting protease inhibitors should be replaced with alternative therapies (i.e., nonnucleoside reverse transcriptase inhibitors); and (c) suggest that targeting inflammation may be a useful treatment strategy for certain forms of inherited cardiomyopathy

Profiles of physical, emotional and psychosocial wellbeing in the Lothian birth cohort 1936

<p>Abstract</p> <p>Background</p> <p>Physical, emotional, and psychosocial wellbeing are important domains of function. The aims of this study were to explore the existence of separable groups among 70-year olds with scores representing physical function, perceived quality of life, and emotional wellbeing, and to characterise any resulting groups using demographic, personality, cognition, health and lifestyle variables.</p> <p>Methods</p> <p>We used latent class analysis (LCA) to identify possible groups.</p> <p>Results</p> <p>Results suggested there were 5 groups. These included High (n = 515, 47.2% of the sample), Average (n = 417, 38.3%), and Poor Wellbeing (n = 37, 3.4%) groups. The two other groups had contrasting patterns of wellbeing: one group scored relatively well on physical function, but low on emotional wellbeing (Good Fitness/ Low Spirits,n = 60, 5.5%), whereas the other group showed low physical function but relatively well emotional wellbeing (Low Fitness/Good Spirits, n = 62, 5.7%). Salient characteristics that distinguished all the groups included smoking and drinking behaviours, personality, and illness.</p> <p>Conclusions</p> <p>Despite there being some evidence of these groups, the results also support a largely one-dimensional construct of wellbeing in old age—for the domains assessed here—though with some evidence that some individuals have uneven profiles.</p

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Patterns and associates of cognitive function, psychosocial wellbeing and health in the Lothian Birth Cohort 1936

BACKGROUND: Cognitive function, psychosocial wellbeing and health are important domains of function. Consistencies and inconsistencies in patterns of wellbeing across these domains may be informative about wellbeing in old age and the ways it is manifested amongst individuals. In this study we investigated whether there were groups of individuals with different profiles of scores across these domains. We also aimed to identify characteristics of any evident groups by comparing them on variables that were not used in identifying the groups. METHODS: The sample was the Lothian Birth Cohort 1936, which included 1091 participants born in 1936. They are a community-dwelling, narrow-age-range sample of 70-year-olds. Most had taken part in the Scottish Mental Survey 1947 at an average age of 11, making available a measure of childhood intelligence. We used latent class analysis (LCA) to explore possible profiles using 9 variables indicating cognitive functioning, psychosocial wellbeing and health status. Demographic, personality, and lifestyle variables – none of which were used in the LCA – were used to characterize the resulting profile groups. RESULTS: We accepted a 3-group solution, which we labeled High Wellbeing (65.3%), Low Cognition (20.3%), and Low Bio-Psychosocial (14.5%). Notably, the High Wellbeing group had significantly higher childhood IQ, lower Neuroticism scores, and a lower percentage of current smokers than the other 2 groups. CONCLUSION: The majority of individuals were functioning generally well; however, there was evidence of the presence of groups with different profiles, which may be explained in part in terms of cognitive ability differences. Results suggested that higher life-long intelligence, personality traits associated with less mental distress, and basic health practices such as avoiding smoking are important associates of wellbeing in old age