1,518 research outputs found
Fermionic coherent states for pseudo-Hermitian two-level systems
We introduce creation and annihilation operators of pseudo-Hermitian fermions
for two-level systems described by pseudo-Hermitian Hamiltonian with real
eigenvalues. This allows the generalization of the fermionic coherent states
approach to such systems. Pseudo-fermionic coherent states are constructed as
eigenstates of two pseudo-fermion annihilation operators. These coherent states
form a bi-normal and bi-overcomplete system, and their evolution governed by
the pseudo-Hermitian Hamiltonian is temporally stable. In terms of the
introduced pseudo-fermion operators the two-level system' Hamiltonian takes a
factorized form similar to that of a harmonic oscillator.Comment: 13 pages (Latex, article class), no figures; v2: some amendments in
section 2, seven new refs adde
Lepton Flavor Violation in the SUSY-GUT Models with Lopsided Mass Matrix
The tiny neutrino masses measured in the neutrino oscillation experiments can
be naturally explained by the supersymmetric see-saw mechanism. If the
supersymmetry breaking is mediated by gravity, the see-saw models may predict
observable lepton flavor violating effects. In this work, we investigate the
lepton flavor violating process in the kind of neutrino mass
models based on the idea of the ``lopsided'' form of the charged lepton mass
matrix. The constraints set by the muon anomalous magnetic moment are taken
into account. We find the present models generally predict a much larger
branching ratio of than the experimental limit. Conversely,
this process may give strong constraint on the lepton flavor structure.
Following this constraint we then find a new kind of the charged lepton mass
matrix. The feature of the structure is that both the elements between the 2-3
and 1-3 generations are ``lopsided''. This structure produces a very small 1-3
mixing and a large 1-2 mixing in the charged lepton sector, which naturally
leads to small and the LMA solution for the solar neutrino
problem.Comment: 24 pages, 8 figure
Introductory programming: a systematic literature review
As computing becomes a mainstream discipline embedded in the school curriculum and acts as an enabler for an increasing range of academic disciplines in higher education, the literature on introductory programming is growing. Although there have been several reviews that focus on specific aspects of introductory programming, there has been no broad overview of the literature exploring recent trends across the breadth of introductory programming.
This paper is the report of an ITiCSE working group that conducted a systematic review in order to gain an overview of the introductory programming literature. Partitioning the literature into papers addressing the student, teaching, the curriculum, and assessment, we explore trends, highlight advances in knowledge over the past 15 years, and indicate possible directions for future research
Study of CP violation in Dalitz-plot analyses of B0 --> K+K-KS, B+ --> K+K-K+, and B+ --> KSKSK+
We perform amplitude analyses of the decays , , and , and measure CP-violating
parameters and partial branching fractions. The results are based on a data
sample of approximately decays, collected with the
BABAR detector at the PEP-II asymmetric-energy factory at the SLAC National
Accelerator Laboratory. For , we find a direct CP asymmetry
in of , which differs
from zero by . For , we measure the
CP-violating phase .
For , we measure an overall direct CP asymmetry of
. We also perform an angular-moment analysis of
the three channels, and determine that the state can be described
well by the sum of the resonances , , and
.Comment: 35 pages, 68 postscript figures. v3 - minor modifications to agree
with published versio
First Molecular Epidemiological Study of Cutaneous Leishmaniasis in Libya
Cutaneous leishmaniasis (CL) is caused by protozoan parasites of the genus Leishmania. The disease is characterized by the formation of chronic skin lesions followed by permanent scars and deformation of the infected area. It is distributed in many tropical and subtropical countries with more than 2 million cases every year. During the past few years CL has emerged as a major public health problem in Libya. So far, diagnosis was based on clinical symptoms and microscopic observation of parasites. Disease outbreaks were not investigated and the causative leishmanial species of CL were not identified so far. Our study indicates the presence of two coexisting species: Leishmania major and Leishmania tropica. These results are crucial in order to provide accurate treatment, precise prognosis and appropriate public health control measures. The recent armed conflict in Libya that ended with the Gadhafi regime collapse on October 2011 has affected all aspects of the life in the country. In this study we discussed multiple risk factors that could be associated with this conflict and present major challenges that should be considered by local and national health authorities for evaluating the CL burden and highlighting priority actions for disease control
First Observation of CP Violation in B0->D(*)CP h0 Decays by a Combined Time-Dependent Analysis of BaBar and Belle Data
We report a measurement of the time-dependent CP asymmetry of B0->D(*)CP h0
decays, where the light neutral hadron h0 is a pi0, eta or omega meson, and the
neutral D meson is reconstructed in the CP eigenstates K+ K-, K0S pi0 or K0S
omega. The measurement is performed combining the final data samples collected
at the Y(4S) resonance by the BaBar and Belle experiments at the
asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The
data samples contain ( 471 +/- 3 ) x 10^6 BB pairs recorded by the BaBar
detector and ( 772 +/- 11 ) x 10^6, BB pairs recorded by the Belle detector. We
measure the CP asymmetry parameters -eta_f S = +0.66 +/- 0.10 (stat.) +/- 0.06
(syst.) and C = -0.02 +/- 0.07 (stat.) +/- 0.03 (syst.). These results
correspond to the first observation of CP violation in B0->D(*)CP h0 decays.
The hypothesis of no mixing-induced CP violation is excluded in these decays at
the level of 5.4 standard deviations.Comment: 9 pages, 2 figures, submitted to Physical Review Letter
Salmonella Type III Effector AvrA Stabilizes Cell Tight Junctions to Inhibit Inflammation in Intestinal Epithelial Cells
Salmonella Typhimurium is a major cause of human gastroenteritis. The Salmonella type III secretory system secretes virulence proteins, called effectors. Effectors are responsible for the alteration of tight junction (TJ) structure and function in intestinal epithelial cells. AvrA is a newly described bacterial effector found in Salmonella. We report here that AvrA expression stabilizes cell permeability and tight junctions in intestinal epithelial cells. Cells colonized with an AvrA-deficient bacterial strain (AvrA−) displayed decreased cell permeability, disruption of TJs, and an increased inflammatory response. Western blot data showed that TJ proteins, such as ZO-1, claudin-1, decreased after AvrA- colonization for only 1 hour. In contrast, cells colonized with AvrA-sufficient bacteria maintained cell permeability with stabilized TJ structure. This difference was confirmed in vivo. Fluorescent tracer studies showed increased fluorescence in the blood of mice infected with AvrA- compared to those infected with the AvrA-sufficient strains. AvrA- disrupted TJ structure and function and increased inflammation in vivo, compared to the AvrA- sufficient strain. Additionally, AvrA overexpression increased TJ protein expression when transfected into colonic epithelial cells. An intriguing aspect of this study is that AvrA stabilized TJs, even though the other TTSS proteins, SopB, SopE, and SopE2, are known to disrupt TJs. AvrA may play a role in stabilizing TJs and balancing the opposing action of other bacterial effectors. Our findings indicate an important role for the bacterial effector AvrA in regulation of intestinal epithelial cell TJs during inflammation. The role of AvrA represents a highly refined bacterial strategy that helps the bacteria survive in the host and dampen the inflammatory response
Improved Limits on decays to invisible final states
We establish improved upper limits on branching fractions for B0 decays to
final States 10 where the decay products are purely invisible (i.e., no
observable final state particles) and for final states where the only visible
product is a photon. Within the Standard Model, these decays have branching
fractions that are below the current experimental sensitivity, but various
models of physics beyond the Standard Model predict significant contributions
for these channels. Using 471 million BB pairs collected at the Y(4S) resonance
by the BABAR experiment at the PEP-II e+e- storage ring at the SLAC National
Accelerator Laboratory, we establish upper limits at the 90% confidence level
of 2.4x10^-5 for the branching fraction of B0-->Invisible and 1.7x10^-5 for the
branching fraction of B0-->Invisible+gammaComment: 8 pages, 3 postscript figures, submitted to Phys. Rev. D (Rapid
Communications
Resveratrol Suppresses Constitutive Activation of AKT via Generation of ROS and Induces Apoptosis in Diffuse Large B Cell Lymphoma Cell Lines
BACKGROUND: We have recently shown that deregulation PI3-kinase/AKT survival pathway plays an important role in pathogenesis of diffuse large B cell lymphoma (DLBCL). In an attempt to identify newer therapeutic agents, we investigated the role of Resveratrol (trans-3,4', 5-trihydroxystilbene), a naturally occurring polyphenolic compound on a panel of diffuse large B-cell lymphoma (DLBCL) cells in causing inhibition of cell viability and inducing apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the action of Resveratrol on DLBCL cells and found that Resveratrol inhibited cell viability and induced apoptosis by inhibition of constitutively activated AKT and its downstream targets via generation of reactive oxygen species (ROS). Simultaneously, Resveratrol treatment of DLBCL cell lines also caused ROS dependent upregulation of DR5; and interestingly, co-treatment of DLBCL with sub-toxic doses of TRAIL and Resveratrol synergistically induced apoptosis via utilizing DR5, on the other hand, gene silencing of DR5 abolished this effect. CONCLUSION/SIGNIFICANCE: Altogether, these data suggest that Resveratrol acts as a suppressor of AKT/PKB pathway leading to apoptosis via generation of ROS and at the same time primes DLBCL cells via up-regulation of DR5 to TRAIL-mediated apoptosis. These data raise the possibility that Resveratrol may have a future therapeutic role in DLBCL and possibly other malignancies with constitutive activation of the AKT/PKB pathway
- …