76 research outputs found
Failure Mechanisms and Local Scour at Coastal Structures induced by Tsunamis
On March 11 2011, an exceptionally large tsunami event was triggered by a massive earthquake offshore, the northeast coast of Japan, which affected coastal infrastructure such as seawalls, coastal dikes and breakwaters in the Tohoku region. Such infrastructure was built to protect against the Level 1 tsunamis that previously hit the region, but not for events as significant as the 2011 Tohoku tsunami, which was categorized as a Level 2 tsunami [Shibayama et al. 2013]. The failure mechanisms of concrete-armoured dikes, breakwaters and seawalls due to Level 2 tsunamis are still not fully understood by researchers and engineers. This paper investigates the failure modes and mechanisms of damaged coastal structures in Miyagi and Fukushima Prefectures, following the authors' post-disaster field surveys carried out between 2011 and 2013. Six significant failure mechanisms were identified for the coastal dikes and seawalls affected by this tsunami: 1) Leeward toe scour failure, 2) Crown armour failure, 3) Leeward slope armour failure, 4) Seaward toe and armour failure, 5) Overturning failure, and 6) Parapet wall failure, in which leeward toe scour being recognized as the major failure mechanism in most surveyed locations. The authors also propose a simple practical mathematical model for predicting the scour depth at the leeward toe of the coastal dikes, by considering the effects of the tsunami hydrodynamics, the soil properties and the type of structure. The key advantage of this model is that it depends entirely on quantities that are measurable in the field. Furthermore this model was further refined by conducting a series of hydraulic model experiments aimed to understand the governing factors of the leeward toe scour failure. Finally, based on the results obtained, key recommendations are given for the design of resilient coastal defence structures that can survive a level 2 tsunami event
Molecular Biomarkers of Vascular Dysfunction in Obstructive Sleep Apnea
Untreated and long-lasting obstructive sleep apnea (OSA) may lead to important vascular abnormalities, including endothelial cell (EC) dysfunction, hypertension, and atherosclerosis. We observed a correlation between microcirculatory reactivity and endothelium-dependent release of nitric oxide in OSA patients. Therefore, we hypothesized that OSA affects (micro)vasculature and we aimed to identify vascular gene targets of OSA that could possibly serve as reliable biomarkers of severity of the disease and possibly of vascular risk. Using quantitative RT-PCR, we evaluated gene expression in skin biopsies of OSA patients, mouse aortas from animals exposed to 4-week intermittent hypoxia (IH; rapid oscillations in oxygen desaturation and reoxygenation), and human dermal microvascular (HMVEC) and coronary artery endothelial cells (HCAEC) cultured under IH. We demonstrate a significant upregulation of endothelial nitric oxide synthase (eNOS), tumor necrosis factor-alpha-induced protein 3 (TNFAIP3; A20), hypoxia-inducible factor 1 alpha (HIF-1α?? and vascular endothelial growth factor (VEGF) expression in skin biopsies obtained from OSA patients with severe nocturnal hypoxemia (nadir saturated oxygen levels [SaO2]<75%) compared to mildly hypoxemic OSA patients (SaO2 75%â90%) and a significant upregulation of vascular cell adhesion molecule 1 (VCAM-1) expression compared to control subjects. Gene expression profile in aortas of mice exposed to IH demonstrated a significant upregulation of eNOS and VEGF. In an in vitro model of OSA, IH increased expression of A20 and decreased eNOS and HIF-1α expression in HMVEC, while increased A20, VCAM-1 and HIF-1αexpression in HCAEC, indicating that EC in culture originating from distinct vascular beds respond differently to IH stress. We conclude that gene expression profiles in skin of OSA patients may correlate with disease severity and, if validated by further studies, could possibly predict vascular risk in OSA patients
Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors
Obstructive sleep apnea syndrome: complaints and housing characteristics in a population in the United States
Chronic hepatitis B: whom to treat and for how long? Propositions, challenges, and future directions
Recent guidelines of the American Association for the Study of Liver Diseases, the European Association for the Study of the Liver, and the Asian Pacific Association for the Study of the Liver 2008 update of the âAsian-Pacific consensus statement on the management of chronic hepatitis Bâ offer comprehensive recommendations for the general management of chronic hepatitis B (CHB). These recommendations highlight preferred approaches to the prevention, diagnosis, and treatment of CHB. Nonetheless, the results of recent studies have led to an improved understanding of the disease and a belief that current recommendations on specific therapeutic considerations, including CHB treatment initiation and cessation criteria, particularly in patient populations with special circumstances, can be improved. Twelve experts from the Asia-Pacific region formed the Asia-Pacific Panel Recommendations for the Optimal Management of Chronic Hepatitis B (APPROACH) Working Group to review, challenge, and assess relevant new data and inform future updates of CHB treatment guidelines. The significance of and controversy about reported findings were discussed and debated in an expert meeting of the Working Group in Beijing, China, in November 2008. This review paper attempts to identify areas requiring improved CHB management and provide suggestions for future guideline updates, with special emphasis on treatment initiation and duration
Measurement of the Bs Lifetime in Fully and Partially Reconstructed Bs -> Ds- (phi pi-)X Decays in pbar-p Collisions at sqrt(s) = 1.96 TeV
We present a measurement of the Bs lifetime in fully and partially
reconstructed Bs -> Ds(phi pi)X decays in 1.3 fb-1 of pbar-p collisions at
sqrt(s) = 1.96 TeV collected by the CDF II detector at the Fermilab Tevatron.
We measure tau(Bs) = 1.518 +/- 0.041 (stat.) +/- 0.027 (syst.) ps. The ratio of
this result and the world average B0 lifetime yields tau(Bs)/tau(B0) = 0.99
+/-0.03, which is in agreement with recent theoretical predictions.Comment: submitted to Phys. Rev. Let
Observation of the structure in the Mass Spectrum in cays
The observation of the structure in decays produced in collisions at \sqrt{s}=1.96~\TeV is
reported with a statistical significance greater than 5 standard deviations. A
fit to the mass spectrum is performed assuming the presence of a
Breit-Wigner resonance. The fit yields a signal of resonance
events, and resonance mass and width of
4143.4^{+2.9}_{-3.0}(\mathrm{stat})\pm0.6(\mathrm{syst})~\MeVcc and
15.3^{+10.4}_{-6.1}(\mathrm{stat})\pm2.5(\mathrm{syst})~\MeVcc respectively.
The parameters of this resonance-like structure are consistent with values
reported from an earlier CDF analysis.Comment: 7 pages, 2 figures, submited to Phys. Rev. Let
Inter-model diversity of Arctic amplification caused by global warming and its relationship with the Inter-tropical Convergence Zone in CMIP5 climate models
Surface-based Arctic amplification (AA) has experienced a remarkable increase in recent decades. Therefore, it is important to understand how Arctic warming might change in response to global warming. By analyzing the Coupled Model Intercomparison Project Phase 5 (CMIP5) multi-model dataset, we examine how AA correlates with changes in tropical Pacific precipitation in response to global warming. It is found that that the changes in the latitudinal position of the Inter-tropical Convergence Zone (ITCZ) are associated to the simulated AA strength in the CMIP5 climate models. Specifically, AA tends to be stronger (weaker) in models where the ITCZ shifts relatively more northward (southward). Further analysis indicates that the inter-model diversity of AA strength in the CMIP5 climate models is related to the changes in large-scale atmospheric circulation associated with the meridional shift of the ITCZ. These results emphasize a close relationship between AA and changes in tropical Pacific precipitation in response to global warming. ? 2016, Springer-Verlag Berlin Heidelberg.111Nsciescopu
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Role of the upper ocean structure in the response of ENSO-like SST variability to global warming
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B. Dewitte benefited from support of the CNRS (Centre National de la Recherche Scientifique) through a STAR (Science and Technology Amicable Research) program and of the ANR (Agence Nationale de la Recherche) through the PCCC (Peru Chile Climate Change) program. 4 SPRINGER NEW YORK CLIM DYNAMThe response of El Nio and Southern Oscillation (ENSO)-like variability to global warming varies comparatively between the two different climate system models, i.e., the Meteorological Research Institute (MRI) and Geophysical Fluid Dynamics Laboratory (GFDL) Coupled General Circulation Models (CGCMs). Here, we examine the role of the simulated upper ocean temperature structure in the different sensitivities of the simulated ENSO variability in the models based on the different level of CO(2) concentrations. In the MRI model, the sea surface temperature (SST) undergoes a rather drastic modification, namely a tendency toward a permanent El Nio-like state. This is associated with an enhanced stratification which results in greater ENSO amplitude for the MRI model. On the other hand, the ENSO simulated by GFDL model is hardly modified although the mean temperature in the near surface layer increases. In order to understand the associated mechanisms we carry out a vertical mode decomposition of the mean equatorial stratification and a simplified heat balance analysis using an intermediate tropical Pacific model tuned from the CGCM outputs. It is found that in the MRI model the increased stratification is associated with an enhancement of the zonal advective feedback and the non-linear advection. In the GFDL model, on the other hand, the thermocline variability and associated anomalous vertical advection are reduced in the eastern equatorial Pacific under global warming, which erodes the thermocline feedback and explains why the ENSO amplitude is reduced in a warmer climate in this model. It is suggested that change in stratification associated with global warming impacts the equatorial wave dynamics in a way that enhances the second baroclinic mode over the gravest one, which leads to the change in feedback processes in the CGCMs. Our results illustrate that the upper ocean vertical structure simulated in the CGCMs is a key parameter of the sensitivity of ENSO-like SST variability to global warming
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