Nanosilica-stabilised supercritical carbon dioxide foam for enhanced oil recovery application

Various enhanced oil recovery (EOR) methods have been studied intensively and proven to mobilize, and aid in improving the flow of remaining oil in the reservoirs to producing wells, thus leading to better oil recoveries. Gases have been commonly used in EOR, such as natural gas, carbon dioxide (CO2), and nitrogen while CO2 is the most commonly used gas. Foam flooding has started to gain more interests in the field for its promising gas mobility reduction. However, foam generated with surfactant suffers instability under harsh reservoir condition, such as high pressure, high temperature and high salinity. Nanoparticle has then come into play for the role to stabilise foam and several studies on the subject have shown favourable results. Nevertheless, nanoparticle-stabilised foam requires more studies and understanding. This thesis involved the study of nanoparticle-stabilised supercritical CO2 foam in the presence of surfactant. Foams with different formulations (supercritical CO2, brine, surfactant and nanoparticles) were generated using a customised glass-bead packed column (GBPC) under 1,500 psi pressure, 25 °C, and a constant flow rate of 6 ml/min. The effect of different nanoparticle concentrations (0%, 0.1%, 0.5%, 0.6% and 1%) and brine salinities (0%, 0.5%, 2% and 10%) on foam are of the key objectives of the study and were both tested. Foam stability and foam mobility tests were carried out quantitatively and qualitatively. Pressure difference valued across the GBPC were recorded. Foam structures and formations were monitored using a camera to capture the images every three minutes throughout the duration of 60 minutes. Nanoparticle-stabilised supercritical CO2 foam successfully shows significant improvement on foam stability over surfactant foam by 27% as well as slight improvement on foam mobility reduction. Nanoparticle-stabilised foam stability in the presence of oil was also tested. Sodium dodecyl sulfate surfactant foam stabilised with 1.0 wt% nanoparticle concentration shows superior foam stability in the presence of oil

ALR-GAN: Adaptive Layout Refinement for Text-to-Image Synthesis

We propose a novel Text-to-Image Generation Network, Adaptive Layout Refinement Generative Adversarial Network (ALR-GAN), to adaptively refine the layout of synthesized images without any auxiliary information. The ALR-GAN includes an Adaptive Layout Refinement (ALR) module and a Layout Visual Refinement (LVR) loss. The ALR module aligns the layout structure (which refers to locations of objects and background) of a synthesized image with that of its corresponding real image. In ALR module, we proposed an Adaptive Layout Refinement (ALR) loss to balance the matching of hard and easy features, for more efficient layout structure matching. Based on the refined layout structure, the LVR loss further refines the visual representation within the layout area. Experimental results on two widely-used datasets show that ALR-GAN performs competitively at the Text-to-Image generation task.Comment: Accepted by TM

An Optimization Scheduling Model for Wind Power and Thermal Power with Energy Storage System considering Carbon Emission Trading

Wind power has the characteristics of randomness and intermittence, which influences power system safety and stable operation. To alleviate the effect of wind power grid connection and improve power system’s wind power consumptive capability, this paper took emission trading and energy storage system into consideration and built an optimization model for thermal-wind power system and energy storage systems collaborative scheduling. A simulation based on 10 thermal units and wind farms with 2800 MW installed capacity verified the correctness of the models put forward by this paper. According to the simulation results, the introduction of carbon emission trading can improve wind power consumptive capability and cut down the average coal consumption per unit of power. The introduction of energy storage system can smooth wind power output curve and suppress power fluctuations. The optimization effects achieve the best when both of carbon emission trading and energy storage system work at the same time

C1q/TNF-related protein 3 (CTRP3) and 9 (CTRP9) concentrations are decreased in patients with heart failure and are associated with increased morbidity and mortality.

BACKGROUND: Biochemical marker has revolutionized the approach to the diagnosis of heart failure. However, it remains difficult to assess stability of the patient. As such, novel means of stratifying disease severity are needed. C1q/TNF-Related Protein 3 (CTRP3) and C1q/TNF-Related Protein 9 (CTRP9) are novel adipokines that contribute to energy homeostasis with additional anti-inflammatory and anti-ischemic properties. The aim of our study is to evaluate concentrations of CTRP3 and CTRP9 in patients with HFrEF (heart failure with reduced ejection fraction) and whether associated with mortality. METHODS: Clinical data and plasma were obtained from 176 healthy controls and 168 patients with HFrEF. CTRP3 and CTRP9 levels were evaluated by enzyme-linked immunosorbent assay. RESULTS: Both CTRP3 and CTRP9 concentrations were significantly decreased in the HFrEF group compared to the control group (p \u3c 0.001). Moreover, patients with higher New York Heart Association class had significantly lower CTRP3 or CTRP9 concentrations. Correlation analysis revealed that CTRP3 and CTRP9 levels were positively related with LVEF% (CTRP3, r = 0.556, p \u3c 0.001; CTRP9, r = 0.526, p \u3c 0.001) and negatively related with NT-proBNP levels (CTRP3, r = - 0.454, p \u3c 0.001; CTRP9, r = - 0.483, p \u3c 0.001). After a follow up for 36 months, after adjusted for age, LVEF and NT-proBNP, we observed that CTRP3 or CTRP9 levels below the 25th percentile was a predictor of total mortality (CTRP3,HR:1.93,95%CI1.03~3.62,P = 0.042;CTRP9,HR:1.98,95%CI:1.02~3.85,P = 0.044) and hospitalizations (CTRP3,HR:2.34,95% CI:1.43~3.82,P = 0.001;CTRP9,HR:2.67,95%CI:1.58~4.50,P \u3c 0.001). CONCLUSIONS: CTRP3 and CTRP9 are decreased in patients with HFrEF, proportionate to disease severity, and each is associated with increased morbidity and mortality. TRIAL REGISTRATION: NCT01372800 . Registered May 2011

A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells

Imaging active PPIases in live cells with a small molecular probe.</p

Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)

Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence. Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions, etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM.Improving the Ability of Diagnosis and Treatment of Difficult Disease

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

A multimodal cell census and atlas of the mammalian primary motor cortex

ABSTRACT We report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex (MOp or M1) as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties, and cellular resolution input-output mapping, integrated through cross-modal computational analysis. Together, our results advance the collective knowledge and understanding of brain cell type organization: First, our study reveals a unified molecular genetic landscape of cortical cell types that congruently integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a unified taxonomy of transcriptomic types and their hierarchical organization that are conserved from mouse to marmoset and human. Third, cross-modal analysis provides compelling evidence for the epigenomic, transcriptomic, and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types and subtypes. Fourth, in situ single-cell transcriptomics provides a spatially-resolved cell type atlas of the motor cortex. Fifth, integrated transcriptomic, epigenomic and anatomical analyses reveal the correspondence between neural circuits and transcriptomic cell types. We further present an extensive genetic toolset for targeting and fate mapping glutamatergic projection neuron types toward linking their developmental trajectory to their circuit function. Together, our results establish a unified and mechanistic framework of neuronal cell type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties