578 research outputs found
Age at first birth in women is genetically associated with increased risk of schizophrenia
- Author
- Adolfsson R.
- Agartz I. (Ingrid)
- Agerbo E. (Esben)
- Albus M. (Margot)
- Alexander M. (Madeline)
- Amin F. (Farooq)
- Andreassen O.A. (Ole)
- Bacanu S.A. (Silviu)
- Begemann M. (Martin)
- Belliveau R.A. (Richard A.)
- Bene J. (Judit)
- Bergen S.E. (Sarah)
- Bevilacqua E. (Elizabeth)
- Bigdeli T.B. (Tim B.)
- Black D.W. (Donald)
- Blackwood D.H.R. (Douglas)
- Borglum A.D. (Anders)
- Bramon E. (Elvira)
- Bruggeman R. (Richard)
- Buccola N.G. (Nancy G)
- Buckner M.
- Bulik-Sullivan B.K. (Brendan)
- Buxbaum J.D. (Joseph D.)
- Byerley W.F. (William F)
- Cahn W. (Wiepke)
- Cai G. (Guiqing)
- Campion D. (Dominique)
- Cantor R.M.
- Carr V.J. (Vaughan J.)
- Carrera N. (Noa)
- Catts S.V. (Stanley)
- Chambert K. (Kimberly)
- Chan R.C.K. (Raymond C. K.)
- Chen E.Y.H. (Eric Y. H.)
- Chen R.Y.L. (Ronald Y.)
- Cheng W. (Wei)
- Cheung E.F.C. (Eric F. C.)
- Chong S.A. (Siow Ann)
- Cichon S. (Sven)
- Clair D.S.
- Cloninger C.R. (C Robert)
- Cohen D.J. (David J.)
- Cohen N. (Nadine)
- Collier D.A. (David)
- Cormican P. (Paul)
- Corvin A. (Aiden)
- Craddock N.J. (Nick)
- Crowley J.J. (James)
- Curtis D. (David)
- Daly M.J. (Mark J.)
- Darvasi A. (Ariel)
- Davidson M.W. (Michael )
- Davis K.L. (Kenneth)
- Degenhardt F.
- Del-Favero J. (Jurgen)
- Demontis D. (Ditte)
- Dikeos D. (Dimitris)
- Dinan T. (Timothy)
- Djurovic S. (Srdjan)
- Domenici E. (Enrico)
- Donohoe D.J. (Dennis)
- Drapeau E. (Elodie)
- Duan J. (Jubao)
- Dudbridge F. (Frank)
- Durmishi N. (Naser)
- Ehrenreich H. (Hannelore)
- Eichhammer P. (Peter)
- Escott-Price V. (Valentina)
- Esko T. (TÔnu)
- Essioux L. (Laurent)
- Fanous A.H. (Ayman H.)
- Farh K.-H. (Kai-How)
- Farrell M.S. (Martilias)
- Frank J. (Josef)
- Franke L. (Lude)
- Freedman R. (Robert)
- Freimer N.B. (Nelson)
- Friedl M.
- Friedman J.I. (Joseph)
- Fromer M. (Menachem)
- Gejman P.V. (Pablo)
- Genovese G. (Giulio)
- Georgieva I. (Irina)
- Giegling I. (Ina)
- Gill M. (Michael)
- Giusti-RodrĂguez P. (Paola)
- Godard S. (Stephanie)
- Goldstein J.I. (Jacqueline)
- Golimbet V. (Vera)
- Gopal R. (Robin)
- Gratten J. (Jacob)
- Gurling H. (Hugh)
- Haan L. (Lieuwe) de
- Hagen K. (Knut)
- Hammer C. (Christian)
- Hamshere M.L. (Marian)
- Hansen M. (Mark)
- Hansen T. (Thomas)
- Haroutunian V. (Vahram)
- Hartmann A.M. (Annette M.)
- Henskens F.A. (Frans)
- Herms S. (Stefan)
- Hirschhorn J.N. (Joel)
- Hoffmann P. (Per)
- Hofman A. (Andrea)
- Hollegaard M.V. (Mads V)
- Holmans P.A. (Peter A.)
- Hougaard D.M. (David)
- Huang H. (Hailiang)
- Hultman C.M. (Christina)
- Ikeda M. (Masashi)
- Iwata N. (Nakao)
- Jablensky A. (Assen)
- Joa I. (Inge)
- JuliĂĄ A. (Antonio)
- Jönsson E.G. (Erik)
- Kahn R. (René)
- Kalaydjieva L. (Luba)
- Karachanak-Yankova S. (Sena)
- Karjalainen J. (Juha)
- Kavanagh D. (David)
- Keller M.C. (Matthew C)
- Kendler K. (K.)
- Kennedy J.L.
- Keong J.L.C. (Jimmy Lee Chee)
- Khrunin A. (Andrey)
- Kim Y. (Yunjung)
- Kirov G. (George)
- Klovins J. (Janis)
- Knight J. (Jo)
- Knowles J.A. (James A)
- Konte B. (Bettina)
- Kucinskiene Z.A. (Zita Ausrele)
- Kuzelova-Ptackova H. (Hana)
- KuÄinskas V. (Vaidutis)
- KĂ€hler J. (Jan)
- Laurent C. (Camille)
- Lee P.H. (Phil H.)
- Lee S.H. (Sang Hong)
- Legge S.E. (Sophie)
- Lencz T. (Todd)
- Lerer B. (Bernard)
- Levinson D.F. (Douglas F.)
- Li M. (Miaoxin)
- Li Q.S. (Qingqin S.)
- Li T. (Tao)
- Liang K.-Y. (Kung-Yee)
- Lieberman A.P. (Andrew)
- Limborska S. (Svetlana)
- Liu J. (Jianjun)
- Loughland C.M. (Carmel)
- Lubinski J. (Jan)
- Lönnqvist J. (Jouko)
- Macek M. (Milan MI)
- Magnusson P.K. (Patrik)
- Maher B.S. (Brion)
- Maier W. (Wolfgang)
- Malhotra A.K. (Anil K)
- Mallet V. (Vincent)
- Marsal S. (Sara)
- Mattheisen M. (Manuel)
- Mattingsdal M. (Morten)
- McCarley R.W. (Robert)
- McCarroll S.A. (Steve)
- McDonald C. (Colm)
- McIntosh A.M. (Andrew)
- McQuillin A. (Andrew)
- Meier S.
- Meijer C. (Carin)
- Melegh B. (Bela)
- Melle I. (Ingrid)
- Mesholam-Gately R.I. (Raquelle)
- Metspalu A. (Andres)
- Michie P.T. (Patricia)
- Milani L. (Lili)
- Milanova V. (Vihra)
- Mokrab Y. (Younes)
- Moran J.L. (Jennifer L.)
- Morris D.W. (Derek W.)
- Mors O.
- Mortensen P.B.
- Mowry B.J. (Bryan J)
- Murphy K.C. (Kieran)
- Murray R. (Robin)
- Myin-Germeys I. (Inez)
- MĂŒller-Myhsok B. (B.)
- Neale B.M. (Benjamin)
- Nelis M. (Mari)
- Nenadic I. (Igor)
- Nertney D.A. (Deborah)
- Nestadt G. (Gerald)
- Ni G. (Guiyan)
- Nicodemus K.K. (Kristin)
- Nikitina-Zake L. (Liene)
- Nisenbaum L. (Laura)
- Nordin A. (Annelie)
- Nöthen M.M. (Markus)
- O'Callaghan E. (Eadbhard)
- O'donovan M.C. (Michael)
- O'Dushlaine C. (Colm)
- O'neill F.A. (F. Anthony)
- Oh S.-Y. (Sang-Yun)
- Olincy A. (Ann)
- Olsen L. (Line)
- Ophoff R.A. (Roel)
- Os J.V. (Jim Van)
- Owen M.J. (Michael)
- Palotie A. (Aarno)
- Pantelis C. (Christos)
- Papadimitriou G.N. (George)
- Papiol S. (Sergi)
- Parkhomenko E. (Elena)
- Pato C. (Carlos)
- Pato C. (Carlos)
- Paunio T. (Tiina)
- Pejovic-Milovancevic M. (Milica)
- Perkins D.O. (Diana O.)
- Pers T.H. (Tune)
- Petryshen T.L. (Tracey L.)
- PietilÀinen O.P.H. (Olli)
- Pimm J. (Jonathan)
- Pocklington A.J. (Andrew)
- Posthuma D. (Danielle)
- Powell J. (John)
- Price A. (Alkes)
- Pulver A.E. (Ann)
- Purcell S.M. (Shaun M.)
- Quested D.J. (Digby J)
- Rasmussen H.B. (Henrik B)
- Reichenberg A. (Abraham)
- Reimers B. (Bernhard)
- Richards A. (Alex)
- Rietschel M. (Marcella)
- Riley B.P. (Brien P.)
- Ripke S. (Stephan)
- Roffman J.L. (Joshua)
- Roussos A. (Alexandra)
- Ruderfer D. (Douglas)
- Rujescu D. (Dan)
- Salomaa V. (Veikko)
- Sanders A.R. (Alan)
- Schall J.D. (Jeffrey)
- Schubert C.R. (Christian R.)
- Schulze T.G. (Thomas)
- Schwab S.G. (Sibylle G.)
- Scolnick E. (Edward)
- Scott R.J. (Rodney J.)
- Seidman L.J. (Larry)
- Sham P.C. (Pak C.)
- Shi J. (Jianxin)
- Sigurdsson E. (Engilbert)
- Silagadze T. (Teimuraz)
- Silverman J.M. (Jeremy M.)
- Sim K. (Kang)
- Sklar P. (Pamela)
- Slominsky P. (Petr)
- Smoller J.W.
- So H.-C. (Hon-Cheong)
- Spencer C.C.A. (Chris C.)
- Stahl E.A. (Eli A.)
- Stefansson H. (Hreinn)
- Steinberg S. (Stacy)
- Stogmann E. (Elisabeth)
- Straub R.E. (Richard)
- Strengman E. (Eric)
- Strohmaier J. (Jana)
- Stroup T.S. (T. Scott)
- Subramaniam V. (Venkat)
- Sullivan P.F. (Patrick)
- Suvisaari J. (Jaana)
- Svrakic D.M. (Dragan)
- Szatkiewicz J.P. (Jin P.)
- Söderman E. (Erik)
- Thirumalai S. (Srinivasa)
- Toncheva D. (Draga)
- Tosato S. (Sarah)
- Veijola J. (Juha)
- Visscher P.M. (Peter)
- Waddington J. (John)
- Walsh D. (Dermot)
- Walters J.T. (James)
- Wang D. (Dai)
- Wang Q. (Qiang)
- Webb B.T. (Bradley T.)
- Weinberger D.R. (Daniel)
- Weiser M. (Mark)
- Wendland A. (Annika)
- Werge T.M. (Thomas)
- Wildenauer D.B. (Dieter)
- Williams N.M. (Nigel M.)
- Williams S. (Stephanie)
- Witt S.H. (Stephanie H)
- Wolen A.R. (Aaron)
- Wong E.H.M. (Emily H.M.)
- Wormley B.K. (Brandon K.)
- Wray N.R. (Naomi R.)
- Xi H.S. (Hualin Simon)
- Zai C.C. (Clement C.)
- Zheng X. (Xuebin)
- Zimprich F. (Fritz)
- Zwart J-A. (John-Anker)
- Publication venue
- Publication date
- 01/01/2018
- Field of study
Prof. Paunio on PGC:n jÀsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study
- Author
- Abdellaoui Abdel
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Amin Farooq
- Andreassen Ole A.
- Anthony O'Neill
- Bacanu Silviu A.
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Bjelland Douglas W.
- Black Donald W.
- Blackwood Douglas H. R.
- Borglum Anders
- Bramon Elvira
- Breen Gerome
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Byerley William
- BĂžrglum Anders D.
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley V.
- Chambert Kimberly D.
- Chan Raymond C.K.
- Chee Keong Jimmy Lee
- Chen Eric Y.H.
- Chen Ronald Y.L.
- Cheng Wei
- Cheung Eric F.C.
- Chong Siow Ann
- Cichon Sven
- Clair David S.
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Craddock Nick
- Crowley James J.
- Curtis David
- Daly Mark J.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko TÔnu
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Forstner Andreas J.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph I.
- Fromer Menachem
- Gejman Pablo V.
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Giusti-RodrĂguez Paola
- Godard Stephanie
- Goldstein Jacqueline I.
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Gurling Hugh
- Hammer Christian
- Hamshere Marian L.
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M.
- Heilmann-Heimbach Stefanie
- Henskens Frans A.
- Herms Stefan
- Hirschhorn Joel N.
- Hoffman Per
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads V.
- Holmans Peter A.
- Hong Lee
- Hougaard David M.
- Howrigan Daniel P.
- Huang Hailiang
- Hultman Christina M.
- Ikeda Masashi
- Iwata Nakao
- Jablensky Assen V.
- Joa Inge
- Johnson Emma C.
- JuliĂ Antonio
- Jönsson Erik G.
- Kahn René S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Keller Matthew C.
- Kendler Kenneth S.
- Kennedy James L.
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- KĂ€hler Anna K.
- Laurent Claudine
- Lee Phil
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Liu Jianjun
- Loughland Carmel M.
- Lubinski Jan
- Lönnqvist Jouko
- Macek Milan
- Magnusson Patrik K.E.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mortensen Preben B.
- Mowry Bryan
- Mowry Bryan J.
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- MĂŒller-Mhysok Betram
- MĂŒller-Myhsok Bertram
- Neale Benjamin
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordin Annelie
- Nöthen Markus M.
- Nöthen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Dushlaine Colm
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- OâDushlaine Colm
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Petryshen Tracey L.
- PietilÀinen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun M.
- Quested Digby
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Robert Cloninger
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schall Ulrich
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Stroup
- Scott Rodney J.
- Seidman Larry J.
- Sham Pak C.
- Shi Jianxin
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Simonson Matthew A.
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Spencer Chris C.A.
- Stahl Eli
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Subramaniam Mythily
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Söderman Erik
- Thirumalai Srinivas
- Toncheva Draga
- Tosato Sarah
- Van Os Jim
- Veijola Juha
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T.R.
- Wang Dai
- Wang Qiang
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin Simon
- Zai Clement C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Publication date
- 01/01/2016
- Field of study
It is well known that inbreeding increases the risk of recessive monogenic diseases, but it is less certain whether it contributes to the etiology of complex diseases such as schizophrenia. One way to estimate the effects of inbreeding is to examine the association between disease diagnosis and genome-wide autozygosity estimated using runs of homozygosity (ROH) in genome-wide single nucleotide polymorphism arrays. Using data for schizophrenia from the Psychiatric Genomics Consortium (n = 21,868), Keller et al. (2012) estimated that the odds of developing schizophrenia increased by approximately 17% for every additional percent of the genome that is autozygous (ÎČ = 16.1, CI(ÎČ) = [6.93, 25.7], Z = 3.44, p = 0.0006). Here we describe replication results from 22 independent schizophrenia case-control datasets from the Psychiatric Genomics Consortium (n = 39,830). Using the same ROH calling thresholds and procedures as Keller et al. (2012), we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data, although the effect was in the predicted direction, and the combined (original + replication) dataset yielded an attenuated but significant relationship between Froh and schizophrenia (ÎČ = 4.86,CI(ÎČ) = [0.90,8.83],Z = 2.40,p = 0.02). Since Keller et al. (2012), several studies reported inconsistent association of ROH burden with complex traits, particularly in case-control data. These conflicting results might suggest that the effects of autozygosity are confounded by various factors, such as socioeconomic status, education, urbanicity, and religiosity, which may be associated with both real inbreeding and the outcome measures of interest
Gene expression imputation across multiple brain regions provides insights into schizophrenia risk
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Albus Margot
- Alexander Madeline
- Als Thomas D.
- Amin Farooq
- Andreassen Ole A.
- Bacanu Silviu A.
- Baekvad-Hansen Marie
- Begemann Martin
- Belliveau Richard A.
- Bene Judit
- Bergen Sarah E.
- Bevilacqua Elizabeth
- Bigdeli Tim B.
- Black Donald W.
- Blackwood Douglas H. R.
- Boocock James
- Borglum Anders D.
- Borglum Anders D.
- Bramon Elvira
- Bruggeman Richard
- Buccola Nancy G.
- Buckner Randy L.
- Bulik-Sullivan Brendan
- Buxbaum Joseph D.
- Buxbaum Joseph D.
- Bybjerg-Grauholm Jonas
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Campion Dominique
- Cantor Rita M.
- Carr Vaughan J.
- Carrera Noa
- Catts Stanley
- Chambert Kimberly D.
- Chan Raymond C. K.
- Chen Eric Y. H.
- Chen Ronald Y. L.
- Cheng Wei
- Cheung Eric F. C.
- Chong Siow Ann
- Cichon Sven
- Cloninger C. Robert
- Cohen David
- Cohen Nadine
- Collier David A.
- Cormican Paul
- Corvin Aiden
- Cox Nancy J.
- Craddock Nick
- Crowley James J.
- Curtis David
- Daly Mark J.
- Dang Kristen K.
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L.
- de Haan Lieuwe
- Degenhardt Franziska
- Del Favero Jurgen
- Demontis Ditte
- Devlin Bernie
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Dobbyn Amanda
- Domenici Enrico
- Domenici Enrico
- Donohoe Gary
- Drapeau Elodie
- Duan Jubao
- Dudbridge Frank
- Durmishi Naser
- Ehrenreich Hannelore
- Eichhammer Peter
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Essioux Laurent
- Fanous Ayman H.
- Farh Kai-How
- Farrell Martilias S.
- Frank Josef
- Franke Lude
- Freedman Robert
- Freimer Nelson B.
- Friedl Marion
- Friedman Joseph
- Fromer Menachem
- Fromer Menachem
- Gamazon Eric R.
- Gejman Pablo
- Genovese Giulio
- Georgieva Lyudmila
- Giegling Ina
- Gill Michael
- Girdhar Kiran
- Giusti-Rodriguez Paola
- Godard Stephanie
- Goldstein Jacqueline
- Golimbet Vera
- Gopal Srihari
- Gratten Jacob
- Grove Jakob
- Gur Raquel E.
- Gurling Hugh
- Hahn Chang-Gyu
- Hammer Christian
- Hamshere Marian L.
- Hansen Christine Soholm
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Haroutunian Vahram
- Hartmann Annette M.
- Henskens Frans A.
- Herms Stefan
- Hirai Keisuke
- Hirschhorn Joel N.
- Hoffman Gabriel
- Hoffmann Per
- Hofman Andrea
- Hollegaard Mads
- Holmans Peter A.
- Hougaard David M.
- Huang Hailiang
- Huckins Laura M.
- Hultman Christina M.
- Ikeda Masashi
- Im Hae Kyung
- Iwata Nakao
- Jablensky Assen
- Joa Inge
- Johnson Jessica S.
- Jonsson Erik G.
- Julia Antonio
- Kahler Anna K.
- Kahn Rene S.
- Kalaydjieva Luba
- Karachanak-Yankova Sena
- Karjalainen Juha
- Kavanagh David
- Keller Matthew C.
- Kendler Kenneth S.
- Kennedy James L.
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Klein Lambertus L.
- Klovins Janis
- Knight Jo
- Knowles James A.
- Konte Bettina
- Kramer Robin
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kuzelova-Ptackova Hana
- Laurent Claudine
- Lee Phil
- Lee S. Hong
- Legge Sophie E.
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F.
- Lewis David A.
- Li Miaoxin
- Li Qingqin S.
- Li Tao
- Liang Kung-Yee
- Lieberman Jeffrey
- Limborska Svetlana
- Lipska Barbara K.
- Liu Jianjun
- Logsdon Benjamin A.
- Lonnqvist Jouko
- Loughland Carmel M.
- Lubinski Jan
- Macek Milan
- Magnusson Patrik K. E.
- Mahajan Milind C.
- Maher Brion S.
- Maier Wolfgang
- Malhotra Anil K.
- Mallet Jacques
- Mangravite Lara M.
- Marsal Sara
- Mattheisen Manuel
- Mattingsdal Morten
- McCarley Robert W.
- McCarroll Steven A.
- McDonald Colm
- McIntosh Andrew M.
- McQuillin Andrew
- Meier Sandra
- Meijer Carin J.
- Melegh Bela
- Melle Ingrid
- Mesholam-Gately Raquelle I.
- Metspalu Andres
- Michie Patricia T.
- Milani Lili
- Milanova Vihra
- Mokrab Younes
- Moran Jennifer L.
- Morris Derek W.
- Mors Ole
- Mors Ole
- Mortensen Preben B.
- Mortensen Preben Bo
- Mowry Bryan J.
- Muller-Myhsok Bertram
- Murphy Kieran C.
- Murray Robin M.
- Myin-Germeys Inez
- Neale Benjamin M.
- Nelis Mari
- Nenadic Igor
- Nertney Deborah A.
- Nestadt Gerald
- Nguyen Hoang T.
- Nicodemus Kristin K.
- Nikitina-Zake Liene
- Nisenbaum Laura
- Nordentoft Merete
- Nordin Annelie
- Nothen Markus M.
- O'Callaghan Eadbhard
- O'Donovan Michael C.
- O'Dushlaine Colm
- O'Neill F. Anthony
- Oh Sang-Yun
- Olincy Ann
- Olsen Line
- Ophoff Roel A.
- Owen Michael J.
- Owen Michael J.
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N.
- Papiol Sergi
- Pardinas Antonio F.
- Parkhomenko Elena
- Pato Carlos N.
- Pato Michele T.
- Paunio Tiina
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Pejovic-Milovancevic Milica
- Perkins Diana O.
- Pers Tune H.
- Perumal Thanneer M.
- Peters Mette A.
- Petryshen Tracey L.
- Pietilainen Olli
- Pimm Jonathan
- Pocklington Andrew J.
- Posthuma Danielle
- Powell John
- Price Alkes
- Pulver Ann E.
- Purcell Shaun
- Purcell Shaun M.
- Quested Digby
- Rajagopal Veera M.
- Rajagopal Veera Manikandan
- Rasmussen Henrik B.
- Reichenberg Abraham
- Reimers Mark A.
- Richards Alexander L.
- Rietschel Marcella
- Riley Brien P.
- Ripke Stephan
- Roffman Joshua L.
- Roussos Panos
- Ruderfer Douglas M.
- Ruderfer Douglas M.
- Rujescu Dan
- Salomaa Veikko
- Sanders Alan R.
- Schadt Eric
- Schall Ulrich
- Schubert Christian R.
- Schulze Thomas G.
- Schwab Sibylle G.
- Scolnick Edward M.
- Scott Rodney J.
- Seidman Larry J.
- Shah Hardik R.
- Sham Pak C.
- Shi Jianxin
- Sieberts Solveig K.
- Sigurdsson Engilbert
- Silagadze Teimuraz
- Silverman Jeremy M.
- Sim Kang
- Sklar Pamela
- Slominsky Petr
- Smoller Jordan W.
- So Hon-Cheong
- Soderman Erik
- Spencer Chris C. A.
- St Clair David
- Stahl Eli A.
- Stefansson Hreinn
- Stefansson Kari
- Steinberg Stacy
- Stogmann Elisabeth
- Straub Richard E.
- Strengman Eric
- Strohmaier Jana
- Stroup T. Scott
- Subramaniam Mythily
- Sullivan Patrick
- Sullivan Patrick F.
- Suvisaari Jaana
- Svrakic Dragan M.
- Szatkiewicz Jin P.
- Thirumalai Srinivas
- Toncheva Draga
- Tosato Sarah
- Toyoshiba Hiroyoshi
- Van Os Jim
- Veijola Juha
- Visscher Peter M.
- Waddington John
- Walsh Dermot
- Walters James T. R.
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Webb Bradley T.
- Weinberger Daniel R.
- Weiser Mark
- Wendland Jens R.
- Werge Thomas
- Werge Thomas
- Wildenauer Dieter B.
- Williams Nigel M.
- Williams Stephanie
- Witt Stephanie H.
- Wolen Aaron R.
- Wong Emily H. M.
- Wormley Brandon K.
- Wray Naomi R.
- Xi Hualin Simon
- Zai Clement C.
- Zheng Xuebin
- Zimprich Fritz
- Publication venue
- Ludwig-Maximilians-UniversitĂ€t MĂŒnchen
- Publication date
- 01/04/2019
- Field of study
Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
- Author
- Aarno Palotie
- Aaron R. Wolen
- Abraham Reichenberg
- Adriano Chio
- Aiden Corvin
- Alan Pittman
- Alan R. Sanders
- Albert C. Ludolph
- Albert Hofman
- Aleksey Shatunov
- Alessandro Padovani
- Alexander L. Richards
- Alexandra DĂŒrr
- Alexis Brice
- Alkes Price
- Ammar Al-Chalabi
- An Goris
- Anders D. BĂžrglum
- Andre Franke
- Andre G. Uitterlinden
- Andrea Calvo
- Andrea Hofman
- Andrea Malaspina
- Andres Metspalu
- Andrew J. Pocklington
- Andrew M. McIntosh
- Andrew McQuillin
- Andrey Khrunin
- Anil K. Malhotra
- Ann E. Pulver
- Ann Olincy
- Anna K. KĂ€hler
- Anneke J. van der Kooi
- Annelie Nordin
- Annelot M. Dekker
- Annette M. Hartmann
- Antonia Ratti
- Antonio JuliĂ
- Ariel Darvasi
- Ashley R. Jones
- Assen V. Jablensky
- Ayman H. Fanous
- Bela Melegh
- Benjamin M. Neale
- Bernard Lerer
- Bernhard Landwehrmeyer
- Bertram MĂŒller-Myhsok
- Bettina Konte
- Bradley N. Smith
- Bradley T. Webb
- Brandon K. Wormley
- Brendan Bulik-Sullivan
- Brien P. Riley
- Brion S. Maher
- Bryan J. Mowry
- C Robert Cloninger
- Carin J. Meijer
- Carlos N. Pato
- Carmel M. Loughland
- Carsten Drepper
- Catherine Lomen-Hoerth
- Cathryn M. Lewis
- Charles Curtis
- Chiara Zecca
- Chris C. A. Spencer
- Christian Hammer
- Christian Lunetta
- Christian R. Andres
- Christian R. Schubert
- Christina M. Hultman
- Christine A. M. Payan
- Christophe Tzourio
- Christopher E. Shaw
- Christos Pantelis
- Cindy Maurel
- Cinzia Bertolin
- Cinzia Gellera
- Cinzia Tiloca
- Claudine Laurent
- Clement C. Zai
- Colm McDonald
- Colm OâDushlaine
- Cristina Cereda
- Cristina Moglia
- Dai Wang
- Dan Rujescu
- Daniel G. Bradley
- Daniel R. Weinberger
- Danielle Posthuma
- David A. Collier
- David Cohen
- David Curtis
- David Kavanagh
- David M. Hougaard
- David St Clair
- Deborah A. Nertney
- Denis Bauer
- Derek W. Morris
- Dermot Walsh
- Diana O. Perkins
- Dick Schijven
- Dieter B. Wildenauer
- Digby Quested
- Dimitris Dikeos
- Ditte Demontis
- Dominic B. Rowe
- Dominique Campion
- Donald W. Black
- Douglas F. Levinson
- Douglas H. R. Blackwood
- Douglas M. Ruderfer
- Draga Toncheva
- Dragan M. Svrakic
- Eadbhard OâCallaghan
- Edward M. Scolnick
- Elena Parkhomenko
- Eli A. Stahl
- Elisabeth Stogmann
- Elisabetta Pupillo
- Elizabeth Bevilacqua
- Elodie Drapeau
- Elvira Bramon
- Emily H. M. Wong
- Engilbert Sigurdsson
- Enrico Domenici
- Eric F. C. Cheung
- Eric Strengman
- Eric Y. H. Chen
- Erik G. Jönsson
- Erik Söderman
- Esben Agerbo
- Ettore Beghi
- F Anthony OâNeill
- Farooq Amin
- Federico Casale
- Fernando Rivadeneira
- Filip Eftimov
- Frank Dudbridge
- Frank P. Diekstra
- Frans A. Henskens
- Franziska Degenhardt
- François Salachas
- Fritz Zimprich
- Garth A. Nicholson
- Gary Donohoe
- George Kirov
- George N. Papadimitriou
- Gerald Nestadt
- Gerome Breen
- Giacomo P. Comi
- Giancarlo Logroscino
- Gianni SorarĂč
- Gilbert Bensimon
- Giulio Genovese
- Guiqing Cai
- Hailiang Huang
- Hana Kuzelova-Ptackova
- Hannelore Ehrenreich
- Henrik B. Rasmussen
- Hon-Cheong So
- Hreinn Stefansson
- Hualin Simon Xi
- Hugh Gurling
- Ian Blair
- Igor Nenadic
- Ina Giegling
- Inez Myin-Germeys
- Inge Joa
- Ingrid Agartz
- Ingrid Melle
- Isabella Fogh
- Jaana Suvisaari
- Jacob Gratten
- Jacqueline I. Goldstein
- Jacques Mallet
- James A. Knowles
- James J. Crowley
- James L. Kennedy
- James T. R. Walters
- Jan H. Veldink
- Jan Lubinski
- Jana Strohmaier
- Janis Klovins
- Jean- François Dartigues
- Jeffrey Lieberman
- Jennifer L. Moran
- Jens R. Wendland
- Jeremy M. Silverman
- Jesus S. Mora
- Jianjun Liu
- Jianxin Shi
- Jim Van Os
- Jimmy Lee
- Jin P. Szatkiewicz
- Jo Knight
- Jochen H. Weishaupt
- Joel N. Hirschhorn
- Johan Eriksson
- John E. Landers
- John Hardy
- John Powell
- John Q. Trojanowski
- John Waddington
- Jonathan Glass
- Jonathan Pimm
- Jordan W. Smoller
- Josef Frank
- Joseph D. Buxbaum
- Joseph I. Friedman
- Joshua L. Roffman
- Jouko Lönnqvist
- Jubao Duan
- Judit Bene
- Juha Karjalainen
- Juha Veijola
- Jurgen Del Favero
- Jurjen J. Luykx
- Kai-How Farh
- Kang Sim
- Karen E. Morrison
- Kari Stefansson
- Karol Estrada
- Katie Sidle
- Kelly Williams
- Kenneth L. Davis
- Kenneth S. Kendler
- Kieran C. Murphy
- Kimberley D. Chambert
- Kristel R. van Eijk
- Kristin K. Nicodemus
- Kuang Lin
- Kung-Yee Liang
- Larry J. Seidman
- Laura Nisenbaum
- Lauren Elman
- Laurent Essioux
- Leo McCluskey
- Leonard H. van den Berg
- Letizia Mazzini
- Liene Nikitina-Zake
- Lieuwe de Haan
- Lili Milani
- Line Olsen
- Luba Kalaydjieva
- Lude Franke
- Lukas Tittmann
- Lyudmila Georgieva
- Madeline Alexander
- Mads V. Hollegaard
- Mamede de Carvalho
- Manuel Mattheisen
- Marcella Rietschel
- Margaret OâBrien
- Margot Albus
- Mari Nelis
- Marian L. Hamshere
- Marianne de Visser
- Marion Friedl
- Mark A. Reimers
- Mark Hansen
- Mark J. Daly
- Mark Weiser
- Markus M. Nöuthen
- Markus Weber
- Martilias S. Farrell
- Martin Begemann
- Martina Wiedau-Pazos
- Masashi Ikeda
- Massimiliano Filosto
- Matthew C. Keller
- Matthew C. Kiernan
- Maura Brunetti
- Menachem Fromer
- Meraida Polak
- Miaoxin Li
- Michael A. van Es
- Michael C. OâDonovan
- Michael Davidson
- Michael Gill
- Michael J. Owen
- Michael Sendtner
- Michele T. Pato
- Milan Macek
- Milena Blagojevic-Radivojkov
- Milica Pejovic-Milovancevic
- Morten Mattingsdal
- Mythily Subramaniam
- Nadine Cohen
- Nakao Iwata
- Nancy G. Buccola
- Naomi R. Wray
- Naser Durmishi
- Nazli Basak
- Nelson B. Freimer
- Nicholas Wood
- Nick Craddock
- Nicola Ticozzi
- Nigel M. Williams
- Nilo Riva
- Noa Carrera
- null null
- null null
- Ole A. Andreassen
- Ole Mors
- Olli PietilÀinen
- Orietta Pansarasa
- Orla Hardiman
- P Nigel Leigh
- Pablo V. Gejman
- Pak C. Sham
- Pamela J. Shaw
- Pamela Sklar
- Panos Roussos
- Paola Giusti-RodrĂguez
- Patricia T. Michie
- Patrick F. Sullivan
- Patrick Vourc'h
- Patrik K. E. Magnusson
- Paul Cormican
- Per Hoffmann
- Perry T. C. van Doormaal
- Peter A Holmans
- Peter Eichhammer
- Peter Lichtner
- Peter M. Andersen
- Peter M. Visscher
- Petr Slominsky
- Phil Lee
- Philip Van Damme
- Philippe Amouyel
- Philippe Corcia
- Pietro Fratta
- Preben B. Mortensen
- Qiang Wang
- Qingqin S. Li
- R Jeroen Pasterkamp
- Randy L. Buckner
- Raquelle I. Mesholam-Gately
- Raymond C. K. Chan
- René S. Kahn
- Ricardo Rojas-GarcĂa
- Richard A. Belliveau
- Richard Bruggeman
- Richard E. Straub
- Richard W. Orrell
- Rick A. A. van der Spek
- Rita M. Cantor
- Robert Freedman
- Robert H. Brown
- Robert Swingler
- Robert W. McCarley
- Roberto Del Bo
- Robin M. Murray
- Rodney J. Scott
- Roel A. Ophoff
- Roger Pamphlett
- Rolf Adolfsson
- Ronald Y. L. Chan
- Rosa Capozzo
- Rosanna Tortelli
- Russell L. McLaughlin
- S Hong Lee
- Safa Saker-Delye
- Sandra DâAlfonso
- Sandra Meier
- Sang-Yun Oh
- Sara L. Pulit
- Sara Marsal
- Sarah E. Bergen
- Sarah Tosato
- Sena Karachanak-Yankova
- Sergi Papiol
- Shaun M. Purcell
- Shuna Colville
- Sibylle G. Schwab
- Siddharthan Chandran
- Silvana Penco
- Silviu A. Bacanu
- Simon Arcuti
- Siow Ann Chong
- Sophie E. Legge
- Srdjan Djurovic
- Srihari Gopal
- Srinivas Thirumalai
- Stacy Steinberg
- Stanley V. Catts
- Stefan Herms
- Stephan Ripke
- Stephanie Godard
- Stephanie H. Witt
- Stephanie Williams
- Steven A. McCarroll
- Stéphanie Millecamps
- Susana Pinto
- Susanna Abdulla
- Susanne Petri
- Sven Cichon
- Svetlana Limborska
- T Scott Stroup
- Tao Li
- Teimuraz Silagadze
- Thomas G. Schulze
- Thomas Hansen
- Thomas Meitinger
- Thomas Meyer
- Thomas Werge
- Tiina Paunio
- Tim B. Bigdeli
- Tim Kahlke
- Timothy Dinan
- Todd Lencz
- Tracey L. Petryshen
- Tune H. Pers
- TÔnu Esko
- Ulrich Schall
- Vahram Haroutunian
- Vaidutis Kucinskas
- Valentina Escott-Price
- Vaughan J. Carr
- Veikko Salomaa
- Vera Golimbet
- Vihra Milanova
- Vincent Meininger
- Vincenzo Silani
- Viviana Pensato
- Vivianna M. Van Deerlin
- Wei Cheng
- Wiepke Cahn
- William Byerley
- William Sproviero
- Wim Robberecht
- Wolfgang Lieb
- Wolfgang Maier
- Wouter van Rheenen
- Xuebin Zheng
- Younes Mokrab
- Yunjung Kim
- Zita Ausrele Kucinskiene
- Publication venue
- Publication date
- 01/01/2017
- Field of study
A. Palotie on työryhmÀn Schizophrenia Working Grp Psychiat jÀsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe
AI is a viable alternative to high throughput screening: a 318-target study
- Author
- Abaffy Tatjana
- Abraham Elena Theres
- AbrahaÌo JoÌnatas Santos
- Abramyan Tigran M.
- Agianian Bogos
- Agogo-Mawuli Percy
- Agoulnik Alexander I.
- Agrawal Rajendra K.
- Aguilera Elena
- Ahmed Mostafa
- Akk Gustav
- Akopian Tatos
- Al-Yozbaki Minnatallah
- Aldhamen Yasser Ali
- Alkan Cigdem
- Alramadhani Dina
- Alteen Matthew G.
- Alvarez GuzmaÌn
- Ammendola Serena
- Anastasio Noelle C.
- Anderson Brandon M.
- Anderson Deborah H.
- Andricopulo Adriano D.
- Angell Richard M.
- Anthis Nicholas J.
- Antonelli Lorenzo
- Apfel Athena Marie
- Arias Juan Antonio Sanchez
- Arozarena Imanol
- Arrigoni Cristina
- ArtiÌa Zoraima
- Ashkar Shireen R.
- Ashton Mark R.
- Austin Richard C.
- Ayachi Aicha Gharbi
- Azeem Syeda Maryam
- Bailey-Elkin Ben A.
- Balakrishnan Bijina
- BalanÌa-Fouce Rafael
- Ballatore Carlo
- Banerjee Sourav
- Banerji Versha
- Banjo Toshihiro
- Barghash Marim M.
- Batey Robert A.
- Battistoni Andrea
- Baumann Ulrich
- Bdira Fredj Ben
- Bedi Mel
- Ben-Johny Manu
- Bergman Bastiaan
- Bernard Denzil
- Berti Andrew
- Bharambe Nikhil
- Bishop Ozlem Tastan
- Blanchet Xavier
- Blelloch Robert
- Blumenthal Robert M.
- BognaÌr Gabriella
- Bogomolovas Julijus
- Bon Carlotta
- Boorman Jacob
- Borowska Anna
- Borriello Francesco
- Bowman Gregory R.
- Bradley Robert K.
- Bradshaw William J.
- Brady-Kalnay Susann M.
- Breton Hairol E.
- Bruning John B.
- Bruning John Burt
- Bryant-Friedrich Amanda
- Buckner Frederick S.
- Buroni Silvia
- Butler Brittany
- Byrne Lee J.
- Byun Soo Young
- Caflisch Amedeo
- Cakir Isin
- Caliandro Ileana
- Caljon Guy
- Cann Andrew B.
- Caporali Andrea
- Capuzzi Stephen J.
- Caroleo Maria Cristina
- Cathcart Ann M.
- Celano Stephanie L.
- Cerna Mark Vincent C. dela
- Chadni Somaia Haque
- Champion Matthew M.
- Chan Nei-Li
- Chapman Carly J.
- Chaton Catherine T.
- Chatterjee Arnab K.
- Chaudhuri Dipayan
- Chauhan Shefali
- Chaytow Helena
- Chen Daniel
- Chen Lifeng
- Chen Yicheng
- Chern Ting-Rong
- Chini Andrea
- Chou Tristan
- Chou Tsui-Fen
- Christensen Emily M.
- Christodoulides Myron
- Chu Shaoyou
- Chua Benjamin Soon Kai
- Chuah Janelle
- Chung Zara
- Chuong Patrick
- Ciccia Alberto
- Cildir GoÌkhan
- Cione Erika
- Clayton W. Brent
- Coles John G.
- Colomba Audrey
- Colotti Gianni
- Conn Graeme L.
- Conticello Silvestro G.
- Contreras Stephanie
- Cools Julie
- Coombe Deirdre R.
- Corson Timothy W.
- Cortopassi Gino
- Corvo Ileana
- Costoya Jose A.
- Cowen Leah E.
- Cox Bryan D.
- Cuddihy Andrew R.
- Cullinane Ryan T.
- Cunningham Kathryn A.
- Dahal Gopal
- Dallman Sydney
- Dame Remus T.
- Davtyan Aram
- De Keulenaer Gilles
- De Luise Monica
- de Oliveira Aldo Sena
- de Oliveira Saulo
- de Sousa Alessandra Mara
- de Souza Guilherme Eduardo
- Debonsi Hosana Maria
- Degterev Alexei
- DeHaan Nicholas
- Del Rio Flores Antonio
- Dempsey Garrett
- Desai Umesh R.
- Diallo Bakary Nâtji
- Dickhout Jeffrey
- Dickinson Bryan C.
- Dieck Chelsea L.
- Dirksen Dorian
- do Monte-Neto Rubens Lima
- Dolce Vincenza
- Donaldson William A.
- Douville ReneÌe N.
- Dowling David J.
- Drewry David H.
- Duggan Brendan M.
- Duncan Dustin
- Dymock Brian W.
- Dzhumaev Sergei
- DâAntuono Anna
- Ebright Richard H.
- Eckert Sam
- Edelman Benjamin L.
- Eitzen Gary
- ElSheikh Assmaa
- Englinger Bernhard
- Escaffre Olivier
- Espinoza Stefano
- Evans Jay D.
- Faller Kiterie M. E.
- Fan Erkang
- Fan Hua-Ying
- Fathallah M. Dahmani
- Feng Hui
- Ferrando Adolfo A.
- Ferraris Davide Maria
- Ferreira Jacob
- Ferreira Rafaela Salgado
- Fiermonte Giuseppe
- Finkelstein Joshua M.
- Fiorillo Annarita
- Fish Paul V.
- Foong Wuen Ee
- Foote Andrea Talbot
- Francisco Karol R.
- Frangos Zachary J.
- Fraser Cameron
- Freiberg Alexander N.
- Freywald Andrew
- Friedland Greg
- Fries Jacob
- Gadar Kavita
- Gandhi Neha S.
- Garaeva Alisa A.
- Garavaglia Silvia
- Garcia George A.
- GarciÌa-Cuesta Eva M.
- Garmendia Antonio E.
- Gasparre Giuseppe
- Gavathiotis Evripidis
- Gebauer Jan M.
- Geden Sandra E.
- Geisbrecht Brian V.
- Gelardi Edoardo Luigi Maria
- Gerwick William H.
- Ghilarducci Kim
- Ghosh Agnidipta
- Giardini Miriam A.
- Gierse Robin Matthias
- Giesler Kyle
- Gillingwater Thomas H.
- Gingras Alexandre R.
- Giorgis Marta
- Girolimetti Giulia
- Glubb Dylan M.
- Glukhov Evgenia
- Gniewek Pawel
- Goldenberg Joshua M.
- Gong Bin
- Gorgoglione Ruggiero
- Granneman James G.
- Greene Geoffrey L.
- Greig Iain R.
- Gruber Joshua J.
- Guido Rafael V. C.
- Gumede Njabulo Joyfull
- Gunasekharan Vignesh
- Gupta Tushita
- Gupta Yogesh K.
- Gustincich Stefano
- Haas Arthur L.
- Hahn William C.
- Haikarainen Teemu
- Hammock Bruce D.
- Hannink Mark
- Hansen Kasper B.
- Hare Stephanie
- Harijan Rajesh K.
- Haupt Larisa M.
- He Yuan
- Hedstrom Lizbeth
- Hedstrom Lizbeth
- Heifets Abraham
- Henriksen Niel
- Herdendorf Timothy J.
- Hermle Tobias
- Herr Andrew B.
- Hickey Robert J.
- Hildeman David A.
- Hirsch Anna K. H.
- Ho Gregory
- Hopkins Kevin M.
- Hoppe Heinrich
- Horstmann Nicola
- Hosfield David J.
- Hossain Sakib
- Houry Walid A.
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- Zelinskaya Natalia
- Zhang Dingqiang
- Zhang Gang
- Zhang Wenjun
- Zhang Xu
- Zhang Yan Jessie
- Zhang Zhiguo
- Zhao Jinshi
- Zhou Han
- Zhou Hui
- Zhou Jia
- Zhou Pei
- Zhou Shan
- Zhu Jiaqi
- Zhu Siran
- Zhu Yini
- Zhuo Ling
- Zochodne Douglas William
- Publication venue
- Publication date
- 01/01/2024
- Field of study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNetÂź convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNetÂź model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors
- Author
- Abdellaoui Abdel
- Abramova Liliya
- Adams Mark
- Adams Mark J.
- Adan Roger A. H.
- Adolfsson Rolf
- Adolfsson Rolf
- Adorjan Kristina
- Agartz Ingrid
- Agartz Ingrid
- Agerbo Esben
- Agerbo Esben
- Agerbo Esben
- Aguayo Samuel
- Ahuja Sunil
- Air Tracy M.
- Air Tracy M.
- Al Eissa Mariam
- Albani Diego
- Alda Martin
- Alda Martin
- Alfredsson Lars
- Alfredsson Lars
- Alfredsson Lars
- Alliey-Rodriguez Ney
- Als Thomas D.
- Andlauer Till F. M.
- Ando Tetsuya
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Anjorin Adebayo
- Anjorin Adebayo
- Antilla Verneri
- Antoniou Anastasia
- Appadurai Vivek
- Argyres Dean P.
- Arolt Volker
- Artigas Maria Soler
- Aschauer Harald
- Ashley-Koch Allison E.
- Aslan Mihaela
- Awasthi Swapnil
- Awasthi Swapnil
- Awasthi Swapnil
- Azevedo M. Helena
- Babadjanova Gulja
- Bacanu Silviu-Alin
- Backlund Lena
- Baek Ji Hyun
- Baker Jessica H.
- Ballas Zuhair
- Bass Nicholas
- Bass Nicholas
- Bau Claiton H. D.
- Bauer Michael
- Baune Bernhard T.
- Baune Bernhard T.
- Baune Bernhard T.
- Beckham Jean
- Beckham Jean
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- Berger Klaus
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- Zwart John-Anker
- ĆwiÄ tkowska Beata
- ĆwiÄ tkowska Beata
- ĆwiÄ tkowska Beata
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Zoghbi J
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- Zuchelkowski A
- Zulauf N
- à gÄrdh A
- Ăner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
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- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
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- Antier Sarah
- Antonio Font Roda Jose
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- Zweizig John
- Ălvarez-LĂłpez S.
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- æčćšéź
- éœäžž éèĄ
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 Mâ) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<eâ€0.3 at 0.33 Gpcâ3 yrâ1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5â4.5 Mâ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
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- Aronson Scott
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- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weizmann Kiendrebeogo R.
- Wellmann F.
- Wen L.
- Wette Karl
- WeĂels P.
- Whelan John
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Wilkin A. T.
- Willadsen D. J.
- Willetts K.
- Williams Daniel
- Williams Michael
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Winterflood J.
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wuchner E.
- Wysocki Daniel
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- ZadroĆŒny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- ĂrpĂĄd Gergely LĂĄszlĂł
- ć ćæŹœ
- éœäžž éèĄ
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- AntĂŽnio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
- Carolyn Droste
- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- CĂĄssio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
- Dan Scharfstein
- Dana Cosma
- Daniel Coyne
- Daniel Hiser
- Daniel Kolansky
- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
- Debbie Cohen-Stein
- Debbie Mascaro
- Deepak Koppolu
- Dennis Levinson
- Derek Lewis
- Detian Li
- Devasmita Dev
- Devesh Patel
- Dewan Deepak
- Dick de Zeeuw
- Diego Aizenberg
- Dinesh Jain
- Dinesh Khullar
- Diogo Belo
- Dmitry Zateyshshikov
- Domenico Santoro
- Domingos d'Avila
- Donald Brandon
- Donald Fraser
- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
- Egle Urbanaviciene
- Ekaterina Velichkova
- Elena Christofides
- Elena Grineva
- Elena Kolmakova
- Elena Shutemova
- Eleonora Harcsa
- Elizabeth Barranco
- Elizabeth Gelersztein
- Elizabeth Kern
- Elizete Keitel
- Eloisa Tellez Chavez
- Emanuela Orsi
- Emil Martinka
- Emyr Davies
- Enrique Gonzalez
- Eric Alamartine
- Eric Hernandez Triana
- Eric Thervet
- Erick Turcios Juarez
- Esteban Cercos
- Eugenia Galindo-Ramos
- Eva Peterfai
- Evaly Chen
- Evandro de Souza Portes
- Evgueniy Vazelov
- Fabian Otreras
- Fabiana Loss de Carvalho Contieri
- Fabio Malberti
- Fadi Saba
- Fadlo Fraige Filho
- Favio Edmundo Enriquez Sosa
- Fayzal Ahmed
- Ferdinando Carlo Sasso
- Fernanco Augusto Alves da Costa
- Fernanda Cristina Camelo Sanches
- Fernando Cereto Castro
- Fernando Flores Lozano
- Fernando Jimenez Florez
- Fernando Krynski
- Fernando M Edwin
- Fernando Thomé
- Fernando Trespalacios
- Florence Santos
- Florencia Kraft
- Fracisco Javier Gonzalez Martinez
- Fran Morren
- Franciso Jose Tinahones Madueno
- Frank Eder
- Franklin Joseph
- Franklin Paul Haase
- Frantisek Saudek
- François Dubé
- François Madore
- Freemu Varghese
- Gabriela Cecilia Coloma
- Gabriela Genova-Hristova
- Gabriele von Ingersleben
- Gaetano Serviddio
- Galina Nagibovich
- Gary Meininger
- Gema Fernandez Fresnedo
- Georg Plassmann
- George Bakris
- George Hon
- George Newman
- Gerald DaRoza
- Gerald Keightley
- Gerry Tan
- Giacomo Garibotto
- Giorgio Fuiano
- Giovanni FrascĂ
- Giovanni Gambaro
- Giuseppe Derosa
- Gizella Petro
- Glenn Chertow
- Gnyandev Patel
- Godwin Simon
- Goga Vukotic
- Gopal Krishna
- Grace Aquitania
- Grace Lin
- Graham Hillis
- Graziano Di Cianni
- Grazyna Orlowska-Kowalik
- Grazyna Popenda
- Greene T.
- Greg Fulcher
- Gregorio Obrador
- Gregorio Obrador Vera
- Grit Faulmann
- Guadalupe Morales Franco
- Guillermo Fragale
- Guixia Wang
- Gulam Latiff
- Gustavo Cristian Greloni
- Guy Chouinard
- Gyongyi Csecsei
- Gyorgy Paragh
- Halyna Tomashkevych
- Hans Prozesky
- Harpreet Bajaj
- Hasnain Khandwala
- Hector Rodriguez
- Heerspink H. J. L.
- Helena Oosthuizen
- Hendrik Nortje
- Henry Watson
- Hermann Haller
- Hernan Finkelstein
- Hernan Yupanqui
- Hiddo J L Heerspink
- Hiralal Maheshwari
- Hiroko Oishi
- Hiromi Aoki
- Hiromi Rodriguez Pattzi
- Hiroshi Kono
- Hitoshi Akiyama
- Holly Wang
- Hong Mao
- Hong Zhang
- Hongguang Zheng
- Hongli Lin
- Horacio Sessa
- Hugo Colombo
- Hugo Laviada Molina
- Hugo Roberto Kurtz Lisboa
- Humberto Pavon
- Hyuk-Sang Kwon
- Iain MacDougall
- Ian Fraser
- Idalia Acosta
- Ildiko Halmagyi
- In-Kyung Jeong
- Ines Bartolacci
- Ingrid Abrahamsen
- Ingrid Buganova
- Inna Kolesnyk
- Ioana Emilia Ferariu
- Irene Noronha
- Irina Glinkina
- Irina Osipova
- Iryna Dudar
- Isabel Erika Rucker Joerg
- Isabel Garcia
- Isam Marar
- Israel Hartman
- Iuliia Komisarenko
- Ivan Fushtey
- Ivan Ory
- Ivan Rychlik
- Ivan RychlĂk
- Ivan Smirnov
- Ivan Topchii
- Ivan Villegas
- Iveta Smatanova
- Jaco Jurgens
- Jakkidi Reddy
- Jamal Hammoud
- James Conway
- James Januzzi
- James Welker
- Jan Culak
- Jana Babikova
- Jana Belobradkova
- Jana Dzuponova
- Janos Mucsi
- Jardine M. J.
- Jason Gaglia
- Javier Narvarte
- Javier Nieto Iglesias
- Jayameena Peringat
- Jayant Kumar
- Jean Carlo Tibes Hachmann
- Jean Welsh
- Jean-Pierre Fauvel
- Jeevren Reddy
- Jeffrey Kropp
- Jeffrey Stephens
- Jeimeen Agra
- Jelena Ignjatovic
- Jesus Cuadrado
- Jesus Egido de Los Rios
- Jian Liu
- Jiao Sun
- Jinkui Yang
- Jiri Lastuvka
- Jiri Pumprla
- Joaquin Pablo Gonzalez
- Johannes Breedt
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- John Lentz
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- Jorge Hector Resk
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- Jorge Mordujovich
- Jorgelina Sala
- Jose Antonio SĂĄnchez Arenales
- Jose Chevaile Ramos
- Jose David Gomez Rangel
- Jose Esteban Jodar Gimeno
- Jose Francisco Kerr Saraiva
- Jose Hector Sanchez Mijangos
- Jose L GĂłrriz
- Jose Luis Accini Mendoza
- Jose Ma Portoles Perez
- Jose Osvaldo Fretes
- Jose Ricardo Correa Rotter
- Joseph Abdallah
- Joseph Aiello
- Joseph Feuerstein
- Joseph O'Hare
- Joseph Proietto
- Josier Nisnisan
- José Vicente Sanchez Polo
- JoĂŁo Lindolfo Cunha Borges
- JoĂŁo Soares FelĂcio
- Juan Alfredo Tamayo Y Orozco
- Juan Baas Cruz
- Juan Carlos Santos
- Juan Diego Higuera
- Juan Frias
- Juan Gonzalo Godoy Jorquera
- Juan Pablo Albisu
- Juan Pablo Moreira Diaz
- Juan Peralta Calcaneo
- Juan Rosas Guzman
- Juan Villagordoa Mesa
- JungEun Lee
- Kamal Abouglila
- Karel Peterka
- Karina Hufert
- Karlton Pettis
- Katalin Keltai
- Katalin Revesz
- Katarina Halciakova
- Katarina Lalic
- Kathy Nicholls
- Kati De Brouwer
- Kazuhiro Yanagida
- Kazunori Koyama
- Kazuyuki Mizuyama
- Kee Sing Ng
- Kenneth Cohen
- Kenneth Deck
- Kenneth Hershon
- Kenneth Liss
- Kenneth W Mahaffey
- Khalid Abdul Kadir
- Khurram Wadud
- Kim Travis
- Kiril Hristozov
- Kook-Hwan Oh
- Krisztian Kiss
- Kun Ho Yoon
- Lachezar Lozanov
- Lajos Major
- Lalaine Delos Santos
- Landman Lombard
- Larisha Pillay-Ramaya
- Larry Distiller
- Larysa Pererva
- Laszlo Deak
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- Laura Akright
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- Lawrence Distiller
- Lawrence Lehrner
- Lawrence Leiter
- Lech Lazuka
- Lee-Ming Chuang
- Lenka Dohnalova
- Leslie Spry
- Levin A.
- Li Yuan Lee
- Lidia Bermudez
- Ligia Petrica
- Lilia Beatriz Schiavi
- Liliana Monica Angelescu
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- Lin Sun
- Lincoln Chapin
- Linong Ji
- Lisa Rich
- Liudmila Kvitkova
- Lori Yost
- Luca Chiovato
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- Luiz Alberto Andreotti Turatti
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- Maria Florencia Fernandez
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- Masahiro Koizumi
- Masakiyo Wakasugi
- Masayo Yamada
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- Matthew Beacom
- Meg J Jardine
- Meg Jardine
- Meininger G.
- Melchor Alpizar Salazar
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- Mercedes Velo Plaza
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- Nadia Zalunardo
- Nadiya Tryshchuk
- Nan Chen
- Narayan Prasad
- Naresh Aggarwal
- Natalia Malaver
- Nataliia Pashkovska
- Natarajan Gopalakrishnan
- Navdeep Tangri
- Naveen Atray
- Neal B.
- Nebojsa Lalic
- Neil Kumar
- Nelson Kopyt
- Nelson Rodriguez Papini
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- Nicole Li
- Nik Nur Fatnoon Nik Ahmad
- Nina Patel
- Nizar Daboul
- Noble Gracious
- Nomangesi Ngcakani
- Nonna Kravchun
- Nora Marchetta
- Norman Muirhead
- Norsiah Ali
- Oleg Legun
- Oleg Nagibovich
- Oleg Uriasyev
- Oleksandr Golovchenko
- Oleksandr Samoylov
- Oleksii Korzh
- Olga Barbarash
- Olga Barna
- Olga Barysheva
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- Olga Gyrina
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- Olivert Gomez
- Oomman Abraham
- Osamu Tomonaga
- Oscar Tarsicio Moreno Loza
- Osvaldo Brusco
- Pablo Antonio Novoa
- Pablo Mele
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- Pablo Serrano Sanson
- Paranthaman Vengadasalam
- Patricia Del Carmen Gonzalez Colaso
- Patrick English
- Patrick Parfrey
- Paul Ainsworth
- Paul Frenk Baron
- Paul Nixon
- Paul Noonan
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- Paulina Virginia Lanchiotti
- Pavel Weiner
- Peak Mann Mah
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- Peggy Barnhill
- Peggy Lin
- Pere Alvarez Garcia
- Perkovic V.
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- Philippe Zaoui
- Phyllis August
- Piermarco Piatti
- Pierre Gourdy
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- Pietro Castellino
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- Ping Tu
- Pollock C.
- Prasanth Surampudi
- Pusadee Suchinda
- Qinkai Chen
- Rachel Bregman
- Radica Alicic
- Radu Jacob
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- Raied Abdullah
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- Rakhi Khanna
- Rallabhandi Sankaram
- Raman Purighalla
- Ramesh Chandra Vyasam
- Ramesh Thimmaiah
- Ramon Berenguer
- Ramon Moreda
- Rangel Rangelov
- Rao K Satyanarayana
- Ravendran Govender
- Ravi Sarin
- Reddy Sreedhar
- Reginald Parker
- Rehan Symonds
- Reinhold Jerwan-Keim
- Remi Rabasa-Lhoret
- Renan Montenegro Junior
- Renata Bijata-Bronisz
- Rhea Severina Comia
- Rhonda Bentley-Lewis
- Riad Darwish
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- Roberto Pecoits-Filho
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- Roberto Trevisan
- Rodica-Ioana Avram
- Rodolfo Andres Ahuad Guerrero
- Rohana Abdul Ghani
- Rohit Pankhaniya
- Rolando Zamarripa Escobedo
- Ronald Goldenberg
- Ronald Harris
- Ronald Watts
- Ronaldo Arturo Gonzalez Orellana
- Ronan Roussel
- Ronnie Aronson
- Rosa Isela Luna Ceballos
- RosĂąngela Milagres
- Ruben Dario Vargas Alonso
- Rury Holman
- Russell Scott
- Sacha De Serres
- Sahay Manisha
- Saiful Shahrizal Bin Shudim
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- Salah Abusnana
- Salvatore De Cosmo
- Sam Henein
- Sam Philip
- Samuel Cohen
- Samuel Mujica Trenche
- Samy Hadjadj
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- Sandor Vangel
- Sandra Berenice Saaveddra Sanchez
- Sanjeev Rastogi
- Sara Jaffer
- Sarah Olelewe
- Satoshi Ota
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- Scott Kasner
- Secundino Cigarran Guldris
- Senan Sultan
- Serge Cournoyer
- Sergei Nedogoda
- Sergey Vorobyev
- Sergio Saul Irizar Santana
- Shahabul Arfeen
- Shahnaz Shahinfar
- Shang-Jyh Hwang
- Shelley Williams
- Shenaz Ramtoola
- Shenglian Gan
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- Shizuo Kajiyama
- Shozo Miyauchi
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- Silvia Nicolai
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- Sini George
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- Souhila Ounadjela
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- Srikanth Bellary
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- Stanislaw Mazur
- Stefan Dimitrov
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- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
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- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- SĂ©rgio Alberto Cunha VĂȘncio
- SĂ©rgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
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- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ăngela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodiumâglucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with reninâangiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
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