Evaluation der Experimentierklausel nach § 6c SGB II - Vergleichende Evaluation des arbeitsmarktpolitischen Erfolgs der Modelle der Aufgabenwahrnehmung "Optierende Kommune" und "Arbeitsgemeinschaft"; Untersuchungsfeld 2: Implementations- und Governanceanalyse; Zwischenbericht Mai 2007 an das BMAS

Zwischenbericht 2007 der FH Frankfurt, Institut für Stadt- und Regionalentwicklung, und des Instituts für angewandte Sozialwissenschaft (infas) zur Implementations- und Governanceanalyse im Rahmen der Evalouation der Experimentierklausel nach § 6c SGB II. Die Implementations- und Governanceanalyse untersucht die Umsetzung der durch das SGB II definierten Leistungsprozesse anhand einer Stichprobe von 154 regionalen Einheiten aus allen Arbeitsgemeinschaften (ARGEn), zugelassenen kommunalen Trägern und Fällen getrennter Aufgabenwahrnehmung. Der Bericht analysiert im ersten Teil überregionale Governance-Strukturen (z. B. rechtliche und finanzielle Vorgaben, Zielvereinbarungen), die Auswirkungen auf die Leistungserbringung der SGB II-Einheiten haben. Im zweiten Teil werden die lokalen Steuerungs- und Organisationsstrukturen in den Formen der Aufgabenwahrnehmung untersucht und wird eine Typologie der Organisation des Leistungsprozesses entwickelt. Der dritte Teil beschäftigt sich mit der Ausgestaltung der Schnittstellen zwischen SGB II, SGB III und SGB VIII, insbesondere im Hinblick auf Eingliederungsleistungen für Jugendliche und junge Erwachsene sowie die Organisation der Arbeitsvermittlung

Sozialbetriebe - Arbeitsfoerderbetriebe ein innovatives Arbeitsmarktpolitisches Instrument

IAB-90-0BE0-309900 BA 056 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEDEGerman

Squamous Cell Carcinoma Masquerading as Rhinophyma

A rhinophyma lesion can mask the existence of coexisting occult skin cancers, and many types of tumors can mimic a rhinophyma. Although several coexistent malignant tumors have been reported in patients with rhinophyma, few reports have described the coexistence of rhinophyma and cutaneous squamous cell carcinoma (SCC). Herein, we report on a case of SCC in a 45-year-old man who presented with 2-month-history of a painful, erythematous, globular plaque on the tip of his nose and this lesion mimicked a rhinophyma lesion. The histopathologic examination showed a proliferation of atypical squamous cells that extended into the dermis, which was consistent with SCC. He was treated with surgical excision, and there has been no evidence of recurrence during the follow-up period of 1 year

Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans

Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and failure. To determine how strain influences the transcriptional response to pressure overload-induced heart failure (HF) and which of these changes accurately reflect the human disease, we analyzed the myocardial transcriptional profile of mouse strains with high (C57BL/6J) and low (129S1/SvImJ) susceptibility for HF development, which we compared to that of human failing hearts. Following transverse aortic constriction (TAC), C57BL/6J mice developed overt HF while 129S1/SvImJ did not. Despite a milder aortic constriction, impairment of ejection fraction and ventricular remodeling (dilation, fibrosis) was more pronounced in C57BL/6J mice. Similarly, changes in myocardial gene expression were more robust in C57BL/6J (461 genes) compared to 129S1/SvImJ mice (71 genes). When comparing these patterns to human dilated cardiomyopathy (1344 genes), C57BL/6J mice tightly grouped to human hearts. Overlay and bioinformatic analysis of the transcriptional profiles of C57BL/6J mice and human failing hearts identified six co-regulated genes (POSTN, CTGF, FN1, LOX, NOX4, TGFB2) with established link to HF development. Pathway enrichment analysis identified angiotensin and IGF-1 signaling as most enriched putative upstream regulator and pathway, respectively, shared between TAC-induced HF in C57BL/6J mice and in human failing hearts. TAC-induced heart failure in C57BL/6J mice more closely reflects the gene expression pattern of human dilated cardiomyopathy compared to 129S1/SvImJ mice. Unbiased as well as targeted gene expression and pathway analyses identified periostin, angiotensin signaling, and IGF-1 signaling as potential causes of increased HF susceptibility in C57BL/6J mice and as potentially useful drug targets for HF treatment

Community-associated Staphylococcus aureus from sub-saharan Africa and Germany : a cross-sectional geographic correlation study

Clonal clusters and gene repertoires of Staphylococcus aureus are essential to understand disease and are well characterized in industrialized countries but poorly analysed in developing regions. The objective of this study was to compare the molecular-epidemiologic profiles of S. aureus isolates from Sub-Saharan Africa and Germany. S. aureus isolates from 600 staphylococcal carriers and 600 patients with community-associated staphylococcal disease were characterized by DNA hybridization, clonal complex (CC) attribution, and principal component (PCA)-based gene repertoire analysis. 73% of all CCs identified representing 77% of the isolates contained in these CCs were predominant in either African or German region. Significant differences between African versus German isolates were found for alleles encoding the accessory gene regulator type, enterotoxins, the Panton-Valentine leukocidin, immune evasion gene cluster, and adhesins. PCA in conjunction with silhouette analysis distinguished nine separable PCA clusters, with five clusters primarily comprising of African and two clusters of German isolates. Significant differences between S. aureus lineages in Africa and Germany may be a clue to explain the apparent difference in disease between tropical/(so-called) developing and temperate/industrialized regions. In low-resource countries further clinical-epidemiologic research is warranted not only for neglected tropical diseases but also for major bacterial infections