SOSIALISASI DIABETES DAN CEK KESEHATAN DI DUSUN TELUKEMUR DESA KEPUH TELUK KECAMATAN TAMBAK BAWEAN

The Real Work Lecture was held in Telukemur Hamlet, Bawean, Gresik district. Implementation of the Diabetes Socialization work program and Health Checks for Blood Pressure, Blood Sugar and Uric Acid are free examination activities and are followed by Diabetes education. Diabetes is a chronic disease characterized by blood sugar levels that are higher than normal. The aim of the Diabetes education program is to make the people of Telukemur Hamlet aware of the dangers of Diabetes and to be able to maintain a healthy lifestyle. Citizen health is one of the main objectives of implementing KKN to improve the quality of health for individuals and increase knowledge related to normal limits for blood pressure and blood sugar, etiology, symptoms and complications as well as prevention. Nursing work program method for diabetes socialization and health checks. The results achieved from health checks and counseling include developing public health and increasing knowledge through information about blood pressure and blood glucose, especially for the elderly in order to increase public awareness that health is important

Harnessing single amino acid catalysis : development of the enantioselective intramolecular Morita-Baylis-Hillman and Rauhut-Currier reactions and studies toward the synthesis of (+)-SCH 642305

Thesis advisor: J. Scott MillerThe development of two catalytic asymmetric synthetic methods is presented and culminates with studies of their application to the synthesis of a natural product. The intramolecular variant of the Morita-Baylis-Hillman (MBH) reaction has remained almost untouched by asymmetric catalysis. A significant advance in the field is demonstrated with the development of a highly enantioselective intramolecular MBH reaction employing a co-catalytic system of N-methylimidazole (NMI) and pipecolinic acid (Pip). The optimization of various reaction parameters and the use of protic conditions (THF-H2O, 3:1) afforded the desired products in up to 82% yield and 80% ee. The extension of this methodology to include the use of vinylogous reaction partners in the Rauhut-Currier (RC) reaction has been achieved, establishing the first highly enantioselective RC reaction. A single amino acid derivative of cysteine, in the presence of potassium tert-butoxide and a critical concentration of water in acetonitrile, was demonstrated to function as a highly selective catalyst providing products in up to 95% ee. Finally, the application of the MBH and RC reactions to the synthesis of complex molecules presents highly useful methodology for the formation of a new C–C bond in the generation of densely functionalized enantiopure products. Preliminary studies toward the application of this methodology to the stereoselective synthesis of (+)-Sch 642305 are described. Examination of the catalyst’s ability to dictate the stereoselectivity of the key step (catalyst control) and allow the synthesis of both the natural product, and difficult-to-obtain unnatural stereoisomeric analogs, will be the subject of on-going studies.Thesis (PhD) — Boston College, 2008.Submitted to: Boston College. Graduate School of Arts and Sciences.Discipline: Chemistry

Range-dependent flexibility in the acoustic field of view of echolocating porpoises (Phocoena phocoena)

Funding: Det Frie Forskningsrad (MJ)Toothed whales use sonar to detect, locate, and track prey. They adjust emitted sound intensity, auditory sensitivity and click rate to target range, and terminate prey pursuits with high-repetition-rate, low-intensity buzzes. However, their narrow acoustic field of view (FOV) is considered stable throughout target approach, which could facilitate prey escape at close-range. Here we show that, like some bats, harbour porpoises can broaden their biosonar beam during the terminal phase of attack but, unlike bats, maintain the ability to change beamwidth within this phase. Based on video, MRI, and acoustic-tag recordings, we propose this flexibility is modulated by the melon and implemented to accommodate dynamic spatial relationships with prey and acoustic complexity of surroundings. Despite independent evolution and different means of sound generation and transmission, whales and bats adaptively change their FOV, suggesting that beamwidth flexibility has been an important driver in the evolution of echolocation for prey tracking.Publisher PDFPeer reviewe

May Measurement Month 2017: an analysis of blood pressure screening results in Armenia-Europe

Elevated blood pressure (BP) is a growing burden worldwide, leading to over 10 million deaths each year. May Measurement Month (MMM) is a global initiative aimed at raising awareness of high BP and to act as a temporary solution to the lack of screening programmes worldwide. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May 2017. Blood pressure measurement, the definition of hypertension and statistical analysis followed the standard MMM protocol. The study was conducted in public areas (14 sites in Yerevan and 18 in regions), both indoor and outdoor, as well as in 42 primary care centres. A total of 9199 individuals were screened during MMM17 of which 9186 had three BP measurements available. The mean age of screened individuals was 50 ± 16.7 years, 57.3% was female. At the time of screening 17.9% were on antihypertensive medication. After imputation, a percentage of participants with hypertension was 33.9%, and 52.9% of them were on treatment. Of those treated, 77.0% had uncontrolled BP. MMM17 was the largest BP screening campaign undertaken in Armenia. We found that in Armenia, untreated hypertension is common, as is not adequately treated hypertension

Place of isolated ancient and generalized forms of tuberculosis in children age 4-11 years in 2001-2015 in the siberian region

Despite the improvement of epidemiological indicators for tuberculosis, the reservoir of specific nosology is preserved. With the involvement of the child in the educational system, the range of his communication increases and, together with it, the probability of infection of the child with ILD and the disease with primary forms of tuberculosis increases. Objective: to characterize the structure of clinical forms of tuberculosis in children 4-11 years for the period 2001-2015 in the Omsk region. Materials and methods. The study is retrospective, with the inclusion of 609 children aged 4 to 11 years who received inpatient treatment from 2001 to 2015. The structure of clinical forms of tuberculosis was compared with the allocation of extrapulmonary forms in a temporal aspect. In the comparative periods there were no significant gender differences, the inhabitants of the village prevailed. Results and discussion. The structure of clinical forms of tuberculosis in patients aged 4-11 years is represented by tuberculosis of respiratory organs up to 92-98% of cases in preschool children and 89-92% of cases in children 7-11 years old and with time the proportion of TBL decreased, and the proportion of PTC increased, at the level of 3-7%. Isolated extrapulmonary tuberculosis was registered less frequently, mainly the urinary system suffered, children aged 4-6 years were ill with isolated forms at a frequency of 1% to 9% of cases. The generalized form of the process among children aged 4-6 years increased from 2% to 7%, and among 7-11 years - from 3% to 7% of all cases of tuberculosis, more often there was a combined lesion of organs with pulmonary tissue. Conclusions. On the territory of the region in the period from 2001 to 2015 in children 4-11 years old with tuberculosis, tuberculosis of the respiratory organs prevailed in the structure of clinical forms, and extrapulmonary tuberculosis did not lose its importance and from the moment of introduction into practice CT influenced the structure of the generalized form of the process.Несмотря на улучшение эпидемиологических показателей по туберкулезу, резервуар специфической нозологии сохраняется. При вовлечении ребенка в образовательную систему увеличивается круг его общения и вместе с этим повышается вероятность инфицирования ребенка МБТ и заболевания первичными формами туберкулеза. Цель работы: охарактеризовать структуру клинических форм туберкулеза у детей 4-11 лет за период 2001-2015 гг. в Омской области. Материалы и методы. Исследование ретроспективное, с включением 609 детей в возрасте от 4 до 11 лет, получавших стационарное лечение с 2001 по 2015 год. Сравнивалась структура клинических форм туберкулеза с выделением места внелегочных форм во временном аспекте. В сравниваемые периоды не наблюдалось значимых гендерных различий, преобладали жители села. результаты и обсуждение. Структура клинических форм туберкулеза у пациентов 4-11 лет, представлена туберкулезом органов дыхания до 92-98% случаев у дошкольников и 89-92% случаев заболевания у детей 7-11 лет и со временем доля ТВЛУ снизилась, а доля ПТК увеличилась, бактериовыделение отмечено на уровне 3-7%. Изолированный внелегочный туберкулез регистрировался реже, в основном страдала мочевая система, дети 4-6 лет болели изолированными формами с частотой от 1% до 9% случаев. Генерализованная форма процесса среди детей 4-6 лет возросла с 2% до 7%, а среди 7-11 лет – с 3% до 7% всех случаев заболевания туберкулезом, чаще встречалось сочетанное поражение органов с легочной тканью. Выводы. На территории региона в период с 2001 по 2015 гг. у детей 4-11 лет с туберкулезом в структуре клинических форм преобладал туберкулез органов дыхания, а внелегочный туберкулез не утратил своего значения и с момента внедрения в практику КТ оказал влияние на структуру генерализованной формы процесса

An analysis of blood pressure screening of 21 112 participants in Armenia: May Measurement Month 2018.

Elevated blood pressure (BP) is a growing burden worldwide and is the leading cause of mortality and disability-adjusted life years all over the world. May Measurement Month (MMM) is a global initiative aimed to raise awareness of high BP and to act as a temporary solution to the lack of screening programmes worldwide. An opportunistic cross-sectional survey of volunteers aged ≥18 was carried out in May to July 2018. Blood pressure measurement, the definition of hypertension (HTN) and statistical analysis followed the standard MMM protocol. The study was conducted in public areas (17 sites in Yerevan and 22 in regions), both indoor and outdoor, as well as in 78 primary care centres. A total of 21 112 individuals were screened during MMM18, of which 20 732 had three BP measurements available. The mean age of screened individuals was 46.2 ± 17.3 years, 57.8% were female. At the time of screening, 26.1% were on antihypertensive medication. After imputation, the percentage of participants with HTN was 38.7%, and 76.7% of them were aware of their high BP. Of participants receiving treatment, 47.1% had a controlled BP. MMM18 was the largest BP screening campaign undertaken in Armenia. We found that the proportion of HTN is substantial in Armenia, which may be a vital contributor to the growing burden of non-communicable diseases. Our results also suggest that untreated HTN is common and when treated still not adequately controlled in Armenia. The current situation, with an insufficient control rate of HTN, must be changed as soon as possible

Theoretical studies of 31P NMR spectral properties of phosphanes and related compounds in solution

Selected theoretical methods, basis sets and solvation models have been tested in their ability to predict 31P NMR chemical shifts of large phosphorous-containing molecular systems in solution. The most efficient strategy was found to involve NMR shift calculations at the GIAO-MPW1K/6-311++G(2d,2p)//MPW1K/6-31G(d) level in combination with a dual solvation model including the explicit consideration of single solvent molecules and a continuum (PCM) solvation model. For larger systems it has also been established that reliable 31P shift predictions require Boltzmann averaging over all accessible conformations in solution

ЭПИДЕМИОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ НИЗКОЭНЕРГЕТИЧЕСКИХ ПЕРЕЛОМОВ В РЕСПУБЛИКЕ АРМЕНИЯ

Until present no data was available inArmeniain respect of incidence of low energy fractures that are typical of osteoporotic locations which consequently did not allow to evaluate the scope of this problem across the country.Purpose of the study – to identify the incidence of low energy fractures in proximal femur, in distal forearm, in proximal humerus and in distal tibia across population ofArmenia aged 50 years and older.Materials and methods. An observing population study was performed in two regions of Armenia during 2011-2013 where the frequency of selected locations in cases of moderate trauma was identified. During 2011-2012 the information was collected based on traumatology service records adding in 2013 other sources including primary level of healthcare due to observed infrequent applications for medical help in cases of trauma. Results. In 2013 the incidence of proximal femur fractures in men was reported as 136 cases per 100 000 of population aged 50 years and older, in women – 201 cases per 100 000. At the same time only 57.7% of patients with proximal femur fractures were admitted to hospital. Distal forearm fractures incidence in men and women was observed correspondingly 56/100 000 and 176/100 000 cases, proximal humerus fractures – 39/100 000 and 86/100 000 cases and distal tibia fractures – 39/100 000 and 86/100 000 cases. The predicted annual number of proximal femur fracture in Armenia amounts to 2067 cases, distal forearm fractures – 1205, proximal humerus fractures – 640.Conclusion. Epidemiological data that was collected for the first time on low energy fractures incidence confirmed the acute osteoporosis issue inArmenia and revealed the problems in organization of medical care for the group of senior patients with injuries.До настоящего времени в Армении отсутствовали данные о частоте низкоэнергетических переломов, что не позволяло оценить масштабы проблемы остеопороза.Целью исследования было определение инцидентности низкоэнергетических (остеопорозных) переломов проксимального отдела бедренной кости (ППОБК), переломов дистального отдела предплечья, плечевой кости, а также дистальных отделов голени у лиц 50 лет и старше. Методы. В 2011–2013 гг. в двух регионах страны было проведено обсервационное популяционное исследование количества переломов, произошедших при небольшой травме. В 2011–2012 гг. сбор информации проводился на основе данных травматологической службы, а в2013 г. к ним добавили другие источники, включая первичное звено здравоохранения.Результаты. Инцидентность ППОБК среди лиц 50 лет и старше составила 136 и 201 на 100 тыс. у мужчин и женщин соответственно. При этом было госпитализировано только 57,7% пациентов. Инцидентность переломов дистального отдела предплечья у мужчин и женщин составила соответственно 56 и 176 на 100 тыс., переломов проксимального отдела плечевой кости – 39 и 86 на 100 тыс., костей дистального отдела голени – 39 и 86 на 100 тыс. Прогнозируемое ежегодное число ППОБК составляет 2067 случаев, переломов дистального отдела предплечья – 1205, переломов проксимального отдела плечевой кости – 640.Выводы. Проведенное исследование выявило низкий уровень оказания специализированной травматологической помощи пожилым пациентам с низкоэнергетическими переломами. Республика Армения остро нуждается в программах, направленных на профилактику, раннее выявление и лечение остеопороза

Place of isolated ancient and generalized forms of tuberculosis in children age 4-11 years in 2001-2015 in the siberian region

Despite the improvement of epidemiological indicators for tuberculosis, the reservoir of specific nosology is preserved. With the involvement of the child in the educational system, the range of his communication increases and, together with it, the probability of infection of the child with ILD and the disease with primary forms of tuberculosis increases. Objective: to characterize the structure of clinical forms of tuberculosis in children 4-11 years for the period 2001-2015 in the Omsk region. Materials and methods. The study is retrospective, with the inclusion of 609 children aged 4 to 11 years who received inpatient treatment from 2001 to 2015. The structure of clinical forms of tuberculosis was compared with the allocation of extrapulmonary forms in a temporal aspect. In the comparative periods there were no significant gender differences, the inhabitants of the village prevailed. Results and discussion. The structure of clinical forms of tuberculosis in patients aged 4-11 years is represented by tuberculosis of respiratory organs up to 92-98% of cases in preschool children and 89-92% of cases in children 7-11 years old and with time the proportion of TBL decreased, and the proportion of PTC increased, at the level of 3-7%. Isolated extrapulmonary tuberculosis was registered less frequently, mainly the urinary system suffered, children aged 4-6 years were ill with isolated forms at a frequency of 1% to 9% of cases. The generalized form of the process among children aged 4-6 years increased from 2% to 7%, and among 7-11 years - from 3% to 7% of all cases of tuberculosis, more often there was a combined lesion of organs with pulmonary tissue. Conclusions. On the territory of the region in the period from 2001 to 2015 in children 4-11 years old with tuberculosis, tuberculosis of the respiratory organs prevailed in the structure of clinical forms, and extrapulmonary tuberculosis did not lose its importance and from the moment of introduction into practice CT influenced the structure of the generalized form of the process.Несмотря на улучшение эпидемиологических показателей по туберкулезу, резервуар специфической нозологии сохраняется. При вовлечении ребенка в образовательную систему увеличивается круг его общения и вместе с этим повышается вероятность инфицирования ребенка МБт и заболевания первичными формами туберкулеза. Цель работы: охарактеризовать структуру клинических форм туберкулеза у детей 4-11 лет за период 2001-2015 гг. в омской области. Материалы и методы. Исследование ретроспективное, с включением 609 детей в возрасте от 4 до 11 лет, получавших стационарное лечение с 2001 по 2015 год. Сравнивалась структура клинических форм туберкулеза с выделением места внелегочных форм во временном аспекте. В сравниваемые периоды не наблюдалось значимых гендерных различий, преобладали жители села. результаты и обсуждение. Структура клинических форм туберкулеза у пациентов 4-11 лет, представлена туберкулезом органов дыхания до 92-98% случаев у дошкольников и 89-92% случаев заболевания у детей 7-11 лет и со временем доля тВЛУ снизилась, а доля Птк увеличилась, бактериовыделение отмечено на уровне 3-7%. Изолированный внелегочный туберкулез регистрировался реже, в основном страдала мочевая система, дети 4-6 лет болели изолированными формами с частотой от 1% до 9% случаев. Генерализованная форма процесса среди детей 4-6 лет возросла с 2% до 7%, а среди 7-11 лет – с 3% до 7% всех случаев заболевания туберкулезом, чаще встречалось сочетанное поражение органов с легочной тканью. Выводы. На территории региона в период с 2001 по 2015 гг. у детей 4-11 лет с туберкулезом в структуре клинических форм преобладал туберкулез органов дыхания, а внелегочный туберкулез не утратил своего значения и с момента внедрения в практику кт оказал влияние на структуру генерализованной формы процесса