Infrared Galaxies in the Field of the Massive Cluster Abell S1063: Discovery of a Luminous Kiloparsec-Sized HII Region in a Gravitationally Lensed IR-Luminous Galaxy at z=0.6z=0.6

Using the Spitzer Space Telescope and Herschel Space Observatory, we have conducted a survey of infrared galaxies in the field of the galaxy cluster Abell S1063 (AS1063) at $z=0.347$, which is one of the most massive clusters known and a target of the HST CLASH and Frontier-Field surveys. The Spitzer/MIPS 24 $\mu$m and Herschel/PACS & SPIRE images revealed that the core of AS1063 is surprisingly devoid of infrared sources, showing only a few detectable sources within the central r$\sim1^{\prime}$. There is, however, one particularly bright source (2.3 mJy at 24 $\mu$m; 106 mJy at 160 $\mu$m), which corresponds to a background galaxy at $z=0.61$. The modest magnification factor (4.0$\times$) implies that this galaxy is intrinsically IR-luminous (L$_{\rm IR}=3.1\times10^{11}\ \rm L_{\odot}$). What is particularly interesting about this galaxy is that HST optical/near-infrared images show a remarkably bright and large (1 kpc) clump at one edge of the disk. Our follow-up optical/near-infrared spectroscopy shows Balmer (H$\alpha$-H8) and forbidden emission from this clump ([OII] $\lambda$3727, [OIII] $\lambda\lambda$4959,5007, [NII] $\lambda\lambda$6548,6583), indicating that it is a HII region. The HII region appears to have formed in-situ, as kinematically it is part of a rotating disk, and there is no evidence of nearby interacting galaxies. With an extinction correction of A$_{\rm V}=1.5$ mag, the star formation rate of this giant HII region is $\sim$10 M$_{\odot}$ yr$^{-1}$, which is exceptionally large, even for high redshift HII regions. Such a large and luminous HII region is often seen at $z\sim2$ but quite rare in the nearby Universe.Comment: Accepted for publication in the Astrophysical Journal. 29 pages, 15 figure

LBT and Spitzer Spectroscopy of Star-Forming Galaxies at 1 < z < 3: Extinction and Star Formation Rate Indicators

We present spectroscopic observations in the rest-frame optical and near- to mid-infrared wavelengths of four gravitationally lensed infrared (IR) luminous star-forming galaxies at redshift 1 < z < 3 from the LUCIFER instrument on the Large Binocular Telescope and the Infrared Spectrograph on Spitzer. The sample was selected to represent pure, actively star-forming systems, absent of active galactic nuclei. The large lensing magnifications result in high signal-to-noise spectra that can probe faint IR recombination lines, including Pa-alpha and Br-alpha at high redshifts. The sample was augmented by three lensed galaxies with similar suites of unpublished data and observations from the literature, resulting in the final sample of seven galaxies. We use the IR recombination lines in conjunction with H-alpha observations to probe the extinction, Av, of these systems, as well as testing star formation rate (SFR) indicators against the SFR measured by fitting spectral energy distributions to far-IR photometry. Our galaxies occupy a range of Av from ~0 to 5.9 mag, larger than previously known for a similar range of IR luminosities at these redshifts. Thus, estimates of SFR even at z ~ 2 must take careful count of extinction in the most IR luminous galaxies. We also measure extinction by comparing SFR estimates from optical emission lines with those from far-IR measurements. The comparison of results from these two independent methods indicates a large variety of dust distribution scenarios at 1 < z < 3. Without correcting for dust extinction, the H-alpha SFR indicator underestimates the SFR; the size of the necessary correction depends on the IR luminosity and dust distribution scenario. Individual SFR estimates based on the 6.2 micron PAH emission line luminosity do not show a systematic discrepancy with extinction, although a considerable, ~0.2 dex scatter is observed.Comment: Accepted for publication in The Astrophysical Journal; 14 pages, 8 figure

Large Binocular Telescope and Sptizer Spectroscopy of Star-forming Galaxies at 1 < z < 3: Extinction and Star Formation Rate Indicators

We present spectroscopic observations in the rest-frame optical and near- to mid-infrared wavelengths of four gravitationally lensed infrared (IR) luminous star-forming galaxies at redshift 1 < z < 3 from the LUCIFER instrument on the Large Binocular Telescope and the Infrared Spectrograph on Spitzer. The sample was selected to represent pure, actively star-forming systems, absent of active galactic nuclei. The large lensing magnifications result in high signal-to-noise spectra that can probe faint IR recombination lines, including Pa and Br at high redshifts. The sample was augmented by three lensed galaxies with similar suites of unpublished data and observations from the literature, resulting in the final sample of seven galaxies. We use the IR recombination lines in conjunction with H observations to probe the extinction, Av, of these systems, as well as testing star formation rate (SFR) indicators against the SFR measured by fitting spectral energy distributions to far-IR photometry. Our galaxies occupy a range of Av from 0 to 5.9 mag, larger than previously known for a similar range of IR luminosities at these redshifts. Thus, estimates of SFR even at z 2 must take careful count of extinction in the most IR luminous galaxies.We also measure extinction by comparing SFR estimates from optical emission lines with those from far- IR measurements. The comparison of results from these two independent methods indicates a large variety of dust distribution scenarios at 1 < z < 3. Without correcting for dust extinction, the H SFR indicator underestimates the SFR; the size of the necessary correction depends on the IR luminosity and dust distribution scenario. Individual SFR estimates based on the 6.2m polycyclic aromatic hydrocarbon emission line luminosity do not show a systematic discrepancy with extinction, although a considerable, 0.2 dex, scatter is observed

Mid-Infrared Determination of Total Infrared Luminosity and Star Formation Rates of Local and High-Redshift Galaxies

We demonstrate estimating the total infrared luminosity, LIR, and star formation rates (SFRs) of star-forming galaxies at redshift 0 < z < 2.8 from single-band 24 micron observations, using local spectral energy distributions (SED) templates without introducing additional free parameters. Our method is based on characterizing the SEDs of galaxies as a function of their LIR surface density, which is motivated by the indications that the majority of IR luminous star-forming galaxies at 1 < z < 3 have extended star-forming regions, in contrast to the strongly nuclear concentrated, merger-induced starbursts in local luminous and ultraluminous IR galaxies. We validate our procedure for estimating LIR by comparing the resulting LIRs with those measured from far-IR observations at 0 < z < 2.8. AGNs were excluded using X-ray and 3.6-8.0 micron observations, which are generally available in deep cosmological survey fields. The Gaussian fits to the distribution of the discrepancies between the LIR measurements from single-band 24 micron and Herschel observations have sigma < 0.1 dex, with ~10% of objects disagreeing by more than 0.2 dex. Since the 24 micron estimates are based on SEDs for extended galaxies, this agreement suggests that ~90% of IR galaxies at high z are indeed much more physically extended than local counterparts of similar LIR, consistent with recent independent studies of the fractions of galaxies forming stars in the main-sequence and starburst modes, respectively. Because we have not introduced empirical corrections to enhance these estimates, in principle, our method should be applicable to lower luminosity galaxies. This will enable use of the 21 micron band of the Mid-Infrared Instrument (MIRI) on board the JWST to provide an extremely sensitive tracer of obscured SFR in individual star-forming galaxies across the peak of the cosmic star formation history.Comment: 17 pages, 7 figures, ApJ accepte

Variation in use of surveillance colonoscopy among colorectal cancer survivors in the United States

<p>Abstract</p> <p>Background</p> <p>Clinical practice guidelines recommend colonoscopies at regular intervals for colorectal cancer (CRC) survivors. Using data from a large, multi-regional, population-based cohort, we describe the rate of surveillance colonoscopy and its association with geographic, sociodemographic, clinical, and health services characteristics.</p> <p>Methods</p> <p>We studied CRC survivors enrolled in the Cancer Care Outcomes Research and Surveillance (CanCORS) study. Eligible survivors were diagnosed between 2003 and 2005, had curative surgery for CRC, and were alive without recurrences 14 months after surgery with curative intent. Data came from patient interviews and medical record abstraction. We used a multivariate logit model to identify predictors of colonoscopy use.</p> <p>Results</p> <p>Despite guidelines recommending surveillance, only 49% of the 1423 eligible survivors received a colonoscopy within 14 months after surgery. We observed large regional differences (38% to 57%) across regions. Survivors who received screening colonoscopy were more likely to: have colon cancer than rectal cancer (OR = 1.41, 95% CI: 1.05-1.90); have visited a primary care physician (OR = 1.44, 95% CI: 1.14-1.82); and received adjuvant chemotherapy (OR = 1.75, 95% CI: 1.27-2.41). Compared to survivors with no comorbidities, survivors with moderate or severe comorbidities were less likely to receive surveillance colonoscopy (OR = 0.69, 95% CI: 0.49-0.98 and OR = 0.44, 95% CI: 0.29-0.66, respectively).</p> <p>Conclusions</p> <p>Despite guidelines, more than half of CRC survivors did not receive surveillance colonoscopy within 14 months of surgery, with substantial variation by site of care. The association of primary care visits and adjuvant chemotherapy use suggests that access to care following surgery affects cancer surveillance.</p

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16,000 keV (λ = 0.77 Å). Refinement carried out with anisotropic displacement parameters, removal of main-chain stereochemical restraints, inclusion of H atoms in calculated positions, and 220 water molecules, converged to a final value of R = 0.1112 and Rfree = 0.1466. The structure includes what is thought to be an ordered propanol molecule (POL) only in chain D(4) and a solvated acetate molecule (ACT) coordinated to the Zn atom only in chain B(2). Possible origins and consequences of the propanol and acetate molecules are discussed. Three types of amino acid representation in the electron density are examined in detail: (i) sharp with very clearly resolved features; (ii) well resolved but clearly divided into two conformations which are well behaved in the refinement, both having high quality geometry; (iii) poor density and difficult or impossible to model. An example of type (ii) is observed for the intra-chain disulphide bridge in chain C(3) between Sγ6–Sγ11 which has two clear conformations with relative refined occupancies of 0.8 and 0.2, respectively. In contrast the corresponding S–S bridge in chain A(1) shows one clearly defined conformation. A molecular dynamics study has provided a rational explanation of this difference between chains A and C. More generally, differences in the electron density features between corresponding residues in chains A and C and chains B and D is a common observation in the Insugen (I) structure and these effects are discussed in detail. The crystal structure, also at 0.92 Å and 100 K, of a second commercially available form of human recombinant insulin, Intergen (II), deposited in the Protein Data Bank as 3W7Y which remains otherwise unpublished is compared here with the Insugen (I) structure. In the Intergen (II) structure there is no solvated propanol or acetate molecule. The electron density of Intergen (II), however, does also exhibit the three types of amino acid representations as in Insugen (I). These effects do not necessarily correspond between chains A and C or chains B and D in Intergen (II), or between corresponding residues in Insugen (I). The results of this comparison are reported

Conciliation biology: the eco-evolutionary management of permanently invaded biotic systems

Biotic invaders and similar anthropogenic novelties such as domesticates, transgenics, and cancers can alter ecology and evolution in environmental, agricultural, natural resource, public health, and medical systems. The resulting biological changes may either hinder or serve management objectives. For example, biological control and eradication programs are often defeated by unanticipated resistance evolution and by irreversibility of invader impacts. Moreover, eradication may be ill-advised when nonnatives introduce beneficial functions. Thus, contexts that appear to call for eradication may instead demand managed coexistence of natives with nonnatives, and yet applied biologists have not generally considered the need to manage the eco-evolutionary dynamics that commonly result from interactions of natives with nonnatives. Here, I advocate a conciliatory approach to managing systems where novel organisms cannot or should not be eradicated. Conciliatory strategies incorporate benefits of nonnatives to address many practical needs including slowing rates of resistance evolution, promoting evolution of indigenous biological control, cultivating replacement services and novel functions, and managing native–nonnative coevolution. Evolutionary links across disciplines foster cohesion essential for managing the broad impacts of novel biotic systems. Rather than signaling defeat, conciliation biology thus utilizes the predictive power of evolutionary theory to offer diverse and flexible pathways to more sustainable outcomes