Neutron Energy Spectrum Measurements with a Compact Liquid Scintillation Detector on EAST

A neutron detector based on EJ301 liquid scintillator has been employed at EAST to measure the neutron energy spectrum for D-D fusion plasma. The detector was carefully characterized in different quasi-monoenergetic neutron fields generated by a 4.5 MV Van de Graaff accelerator. In recent experimental campaigns, due to the low neutron yield at EAST, a new shielding device was designed and located as close as possible to the tokamak to enhance the count rate of the spectrometer. The fluence of neutrons and gamma-rays was measured with the liquid neutron spectrometer and was consistent with 3He proportional counter and NaI (Tl) gamma-ray spectrometer measurements. Plasma ion temperature values were deduced from the neutron spectrum in discharges with lower hybrid wave injection and ion cyclotron resonance heating. Scattered neutron spectra were simulated by the Monte Carlo transport Code, and they were well verified by the pulse height measurements at low energies.Comment: 19 pages,10 figures, 1 tabl

Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion

AbstractThousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p. In addition, lncRNA-KRTAP5-AS1 and lncRNA-TUBB2A could act as competing endogenous RNAs to affect the function of Claudin-4. Our results suggest that non-coding RNAs play important roles in the regulatory network of Claudin-4. As such, non-coding RNAs should be considered as potential biomarkers and therapeutic targets against gastric cancer.</jats:p

Which is better for gastric cancer patients, perioperative or adjuvant chemotherapy: a meta-analysis

meta-analysis of chemotherapy adverse effects. (A) Nausea and vomit, (B) gastrointestinal problem, (C) liver toxicity, (D) neurologic effects, (E) leukopenia, (F) thrombocytopenia, (G) neutropenia. (TIF 507 kb

Challenges and Countermeasures of Teachers’ Professional Development from the Perspective of Globalization

Under the influence of globalization, the intensification of international competition is in the final analysis the competition of education and talents. Teachers are the main body of teaching activities. Teachers’ professionalization is an important symbol to measure a country’s educational level. At present, the professional development of teachers in China is facing enormous challenges. In terms of concept, system and the allocation and utilization of educational resources, there are great problems. In order to meet the needs of teachers’ professional development in the perspective of globalization, the new era should promote the upgrading of teachers’ professional level from the aspects of renewal of ideas, improvement of system guarantee system, diversified development and integration and distribution of resources

Efficient Enzymatic Synthesis of Guanosine 5′-Diphosphate-Sugars and Derivatives

An N-acetylhexosamine 1-kinase from Bifidobacterium infantis (NahK_15697), a guanosine 5'-diphosphate (GDP)-mannose pyrophosphorylase from Pyrococcus furiosus (PFManC), and an Escherichia coli inorganic pyrophosphatase (EcPpA) were used efficiently for a one-pot three-enzyme synthesis of GDP-mannose, GDP-glucose, their derivatives, and GDP-talose. This study represents the first facile and efficient enzymatic synthesis of GDP-sugars and derivatives starting from monosaccharides and derivatives

The association of family functioning and suicide in children and adolescents: positive behavior recognition and non-suicidal self-injury as sequential mediators

BackgroundSuicide is a major behavioral issue among children and adolescents, and family functioning potentially influencing its occurrence. Furthermore, positive behavior recognition, as a key component of positive youth development, may act as a mediating factor in the relationship between family functioning and suicide. Non-suicidal self-injury (NSSI) often co-occurs with suicide and may also mediate the impact of family functioning on suicide. Therefore, the aim of this study is to examine the role of family functioning in child and adolescent suicide, with positive behavior recognition and NSSI serving as sequential mediating factors.MethodsThe participants in this study were recruited from the Chengdu Positive Child Development (CPCD) cohort study. The analysis was based on the second round of cross-sectional data from the CPCD cohort. They were required to complete questionnaires that included measures of family functioning, suicide, positive behavior recognition, and NSSI. SPSS 26.0 and Mplus 8.3 were used for descriptive statistical analysis, correlation analysis and mediation effect analysis.ResultsA total of 8,124 participants completed the questionnaires, with an average age of 11.00 ± 2.18 years. The sample comprised 4,195 male and 3,929 female participants. The findings indicate that 17.93% of children and adolescents reported suicide thoughts, 10.06% had formulated suicide plans, and 8.64% had attempted suicide. Poor family functioning shows a significant positive correlation with suicide (r = 0.322, p &lt; 0.01). The multiple mediation effect of positive behavior recognition and NSSI in the association between family functioning and suicide was statistically significant (β = 0.034, 95% CI = 0.027, 0.042).ConclusionThis study found that poor family functioning is a risk factor for suicide in children and adolescents, with positive behavior recognition and non-suicidal self-injury acting as sequential mediating factors

Properties and customization of sensor materials for biomedical applications.

Low-power chemo- and biosensing devices capable of monitoring clinically important parameters in real time represent a great challenge in the analytical field as the issue of sensor calibration pertaining to keeping the response within an accurate calibration domain is particularly significant (1–4). Diagnostics, personal health, and related costs will also benefit from the introduction of sensors technology (5–7). In addition, with the introduction of Registration, Evaluation, Authorization, and Restriction of Chemical Substances (REACH) regulation, unraveling the cause–effect relationships in epidemiology studies will be of outmost importance to help establish reliable environmental policies aimed at protecting the health of individuals and communities (8–10). For instance, the effect of low concentration of toxic elements is seldom investigated as physicians do not have means to access the data (11)