Exercise‐induced airflow changes in horses with asthma measured by electrical impedance tomography

Background: Equine asthma (EA) causes airflow impairment, which increases in severity with exercise. Electrical impedance tomography (EIT) is an imaging technique that can detect airflow changes in standing healthy horses during a histamine provocation test. Objectives: To explore EIT-calculated flow variables before and after exercise in healthy horses and horses with mild-to-moderate (MEA) and severe equine asthma (SEA). Animals: Nine healthy horses 9 horses diagnosed with MEA and 5 with SEA were prospectively included. Methods: Recordings were performed before and after 15 minutes of lunging. Absolute values from global and regional peak inspiratory (PIF, positive value) and expiratory (PEF, negative value) flows were calculated. Data were analyzed using a mixed model analysis followed by Bonferroni's multiple comparisons test to evaluate the impact of exercise and diagnosis on flow indices. Results: Control horses after exercise had significantly lower global PEF and PIF compared to horses with SEA (mean difference [95% confidence interval, CI]: 0.0859 arbitrary units [AU; 0.0339-0.1379], P < .001 and 0.0726 AU [0.0264-0.1188], P = .001, respectively) and horses with MEA (0.0561 AU [0.0129-0.0994], P = .007 and 0.0587 AU [0.0202-0.0973], P = .002, respectively). No other significant differences were detected. Conclusions and clinical importance: Electrical impedance tomography derived PIF and PEF differed significantly between healthy horses and horses with SEA or MEA after exercise, but not before exercise. Differences between MEA and SEA were not observed, but the study population was small

Magnetostratigraphy and Paleoenvironments of the Kuntila Lake Sediments, Southern Israel: Implications for Late Cenozoic Climate Variability at the Northern Fringe of the Saharo-Arabian Desert Belt

The Negev Desert in southern Israel hosts a number of late Cenozoic lacustrine and palustrine sedimentary sequences that attest for past wetter conditions in what today constitutes one of the driest deserts on Earth. These sequences are of special importance because the Negev Desert forms part of the Levantine Corridor, which was probably the only continental bridge that enabled initial out-of-Africa expansion of our genus Homo. Yet, the paleoclimatic significance of these sequences still remains unknown, mainly due to their uncertain (late Pliocene to early Pleistocene) age. Here we present a combined sedimentologic, paleontologic and magnetostratigraphic study of one of these sedimentary sequences, the so-called Kuntila Lake sediments, which was carried out at the 30 m-thick Kuntila Gate section in the Nahal Paran basin, southern Israel. Sedimentological evidence and ostracod faunas indicate that these sediments accumulated in a long-lasting lacustrine basin that underwent periodic lake-level variations. Magnetostratigraphic measurements enable the recognition of a normal (N1) and a reverse (R1) polarity zone in the lower and upper halves, respectively, of the Kuntila Gate section. Correlation of N1 to the Olduvai Subchron (1.778–1.945 Ma) appears as the most likely option in view of previously published 10Be ages derived for the uppermost part of the Kuntila Member in nearby sections. The large errors associated with these ages, however, suggest that correlation of N1 to Subchron C2An.1n (2.582–3.032 Ma) is also possible. Although our results do not resolve the age of the Arava Formation, they unequivocally relate the Kuntila Lake sediments with a long period of enhanced climatic variability because the tops of both subchrons are associated with 400 kyr eccentricity maxima. The inferred wetter conditions in the Negev Desert concurred, regardless of the age correlation, with periods of lake expansion in East Africa and clusters of short-lived expansions of the savannah throughout much of the Sahara. This would have facilitated the biogeographic connection between Africa and Eurasia, greening the path for the initial out-of-Africa dispersal of Homo. Further research on the Kuntila Lake sediments will be necessary to better determine the timing, extent and significance of such biogeographic connection

Characterization of blocks within a near seafloor Neogene MTC, Orange Basin: Constraints from a high-resolution 3D seismic data

Submarine mass wasting processes in deepwater settings can incorporate large blocks, which may play a key role in deepwater geological processes and geohazard assessment. However, there is a limited understanding of the deformation style arising from the interaction between submarine blocks and structural/bathymetric barriers such as ramps. The deformation and kinematic history of several submarine blocks (with a thickness of up to 150 m) within a near seafloor mass transport complex in the Orange Basin are documented using seismic geo- morphic methods. The interpreted blocks are preserved in three discrete fault-bounded morphological terrains within a Neogene mass-transport complex. These terrains vary in lengths from 2 km to 6 km; they have heights of 60 m to 150 m and are characterized by discrete and localized structural highs on the present-day seafloor. Block sizes vary across terrains suggesting differences in the block evolution process. Blocks near the ramp appear in seismic profiles comprising (a) Chaotic and transparent seismic reflections and (b) parallel to sub-parallel, continuous, low to moderate amplitude reflections. This variability in seismic facies of the blocks reflects the de- gree of their interaction and translation over a ramp at the basal shear zone of the mass transport complex, ev- idenced by the difference in the block features on the upslope portion of the ramp versus the downslope part. Notably, the deformation styles recorded in the blocks show the impact of the ramp during mass flow, which has broader implications for understanding the internal mechanisms of blocky mass transport complexes in many continental margins

Stratigraphic record reveals contrasting roles of overflows and underflows over glacial cycles in a hypersaline lake (Dead Sea)

In lakes and oceans, links between modern sediment density flow processes and deposits preserved in long-term geological records are poorly understood. Consequently, it is unclear whether, and if so how, long-term climate changes affect the magnitude/frequency of sediment density flows. One approach to answering this question is to analyze a comprehensive geological record that comprises deposits that can be reliably linked to modern sediment flow processes. To address this question, we investigated the unique ICDP Core 5017-1 from the Dead Sea (the largest and deepest hypersaline lake on the Earth) depocenter covering MIS 7-1. Based on an understanding of modern sediment density flow processes in the lake, we link homogeneous muds in the core to overflows (surface flood plumes, ρflowρwater). Our dataset reveals (1) overflows are more prominent during interglacials, while underflows are more prominent during glacials; (2) orbital-scale climate changes affected the flow magnitude/frequency via changing salinity and density profile of lake brine, lake-level, and source materials

Seismic stratigraphy of Lago Fagnano sediments (Tierra del Fuego, Argentina) - A potencial archive of paleoclimatic change and tectonic activity since the Late Glacial

Located at 54ºS in the heart of the Island of Tierra del Fuego, Lago Fagnano occupies the deepest of a chain of en-echelon tectonic depressions along the Magallanes-Fagnano Transform system (MFT). A recent geophysical campaign combining 3.5 kHz (pinger) single-channel with 1 in3 airgun multi-channel systems surveyed more than 100 m of glacio-lacustrine sediments filling two main sub-basins. These data provide a unique opportunity to visualize the most recent lacustrine sequence with high-resolution while simultaneously imaging the oldest infill. A preliminary seismic stratigraphic analysis of the high-resolution 3.5 kHz pinger data allowed the identification of three major seismostratigraphic units (A, the oldest and C, the youngest). While unit A is interpreted as glacially derived sediments, the overlying unit B is interpreted as fining upward sequences of proglacial turbidites reflecting sediment pulses released by the retreating Fagnano glacier during the last deglaciation. A major environmental change occurred during deposition of unit C when pelagic style of sedimentation is intercalated by sequences of downslope mass flow events probably triggered by relatively strong tectonic pulses along the MFT system. Gravity cores show a regular alternation of light and dark laminae occasionally interrupted by homogenous sedimentary units interpreted as turbidites. Ultra-high resolution X-ray fluorescence micro-profiles show fluctuations in major trace elements at mm scale that may indicate seasonal variations in the sedimentary influx. These core data provide a unique record of decadal changes in regional climate that can be compared with other marine and continental archives to improve our understanding of the forcing mechanisms behind climate change

Orbital- and Millennial-Scale Changes in Lake-Levels Facilitate Earthquake-Triggered Mass Failures in the Dead Sea Basin

Acknowledgments The authors appreciate the editor L. Flesch for handling our manuscript, Ed Pope and Sebastian Cardona for constructive reviews. This research was supported by the Austrian Science Fund (FWF): M 2817 to Y. Lu and P30285-N34 to J. Moernaut, the University of Liege under Special Funds for Research, IPD-STEMA Program (R.DIVE.0899-J-F-G to Y. Lu), the Israel Science Foundation (#1645/19 to S. Marco and #1093/10 to R. Bookman), and the ICDP. A.A. is indebted to the Helmholtz Virtual Institute DESERVE for support. The authors thank C. Daxer for help modeling the Kernel Density and Nadav Wetzler for discussion.Peer reviewedPublisher PD

The Lake CHAd Deep DRILLing project (CHADRILL) – targeting ~10 million years of environmental and climate change in Africa

At present, Lake Chad ( ∼ 13◦0 N, ∼ 14◦ E) is a shallow freshwater lake located in the Sahel/Sahara region of central northern Africa. The lake is primarily fed by the Chari–Logone river system draining a ∼ 600 000 km2 watershed in tropical Africa. Discharge is strongly controlled by the annual passage of the intertropical convergence zone (ITCZ) and monsoon circulation leading to a peak in rainfall during boreal summer. During recent decades, a large number of studies have been carried out in the Lake Chad Basin (LCB). They have mostly focused on a patchwork of exposed lake sediments and outcrops once inhabited by early hominids. A dataset generated from a 673 m long geotechnical borehole drilled in 1973, along with outcrop and seismic reflection studies, reveal several hundred metres of Miocene–Pleistocene lacustrine deposits. CHADRILL aims to recover a sedimentary core spanning the Miocene–Pleistocene sediment succession of Lake Chad through deep drilling. This record will provide significant insights into the modulation of orbitally forced changes in northern African hydroclimate under different climate boundary conditions such as high CO2 and absence of Northern Hemisphere ice sheets. These investigations will also help unravel both the age and the origin of the lake and its current desert surrounding. The LCB is very rich in early hominid fossils (Australopithecus bahrelghazali; Sahelanthropus tchadensis) of Late Miocene age. Thus, retrieving a sediment core from this basin will provide the most continuous climatic and environmental record with which to compare hominid migrations across northern Africa and has major implications for understanding human evolution. Furthermore, due to its dramatic and episodically changing water levels and associated depositional modes, Lake Chad’s sediments resemble maybe an analogue for lake systems that were once present on Mars. Consequently, the study of the subsurface biosphere contained in these sediments has the potential to shed light on microbial biodiversity present in this type of depositional environment. We propose to drill a total of ∼ 1800 m of poorly to semi-consolidated lacustrine, fluvial, and eolian sediments down to bedrock at a single on-shore site close to the shoreline of present-day Lake Chad. We propose to locate our drilling operations on-shore close to the site where the geotechnical Bol borehole (13◦280 N, 14◦440 E) was drilled in 1973. This is for two main reasons: (1) nowhere else in the Chad Basin do we have such detailed information about the lithologies to be drilled; and (2) the Bol site is close to the depocentre of the Chad Basin and therefore likely to provide the stratigraphically most continuous sequence

A New Approach to Constrain the Seismic Origin for Prehistoric Turbidites as Applied to the Dead Sea Basin

Acknowledgments The authors appreciate the editor Lucy Flesch for handling our manuscript, Stefano Vitale and Alina Polonia for constructive reviews. This research was supported by the University of Liege under Special Funds for Research, IPD‐STEMA Program (R.DIVE.0899‐J‐F‐G to Y. Lu), Austrian Science Fund (FWF: M 2817 to Y. Lu), the DESERVE Virtual Institute of the Helmholtz Association (to A. Agnon), the Israel Science Foundation (#1093/10 to R.Bookman and #1645/19 to S.Marco), and the ICDP.Peer reviewedPublisher PD

Two-step closure of the Miocene Indian Ocean Gateway to the Mediterranean

The Tethys Ocean was compartmentalized into the Mediterranean Sea and Indian Ocean during the early Miocene, yet the exact nature and timing of this disconnection are not well understood. Here we present two new neodymium isotope records from isolated carbonate platforms on both sides of the closing seaway, Malta (outcrop sampling) and the Maldives (IODP Site U1468), to constrain the evolution of past water mass exchange between the present day Mediterranean Sea and Indian Ocean via the Mesopotamian Seaway. Combining these data with box modeling results indicates that water mass exchange was reduced by similar to 90% in a first step at ca. 20 Ma. The terminal closure of the seaway then coincided with the sea level drop caused by the onset of permanent glaciation of Antarctica at ca. 13.8 Ma. The termination of meridional water mass exchange through the Tethyan Seaway resulted in a global reorganization of currents, paved the way to the development of upwelling in the Arabian Sea and possibly led to a strengthening of South Asian Monsoon