Alteration of Pharmacokinetic Parameters for Pentobarbital by Ischemic Stroke and Reversion to Normal by Dexamethasone Treatment

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97147/1/j.1552-4604.1980.tb02548.x.pd

n-Si/SiGe quantum cascade structures for THz emission

In this work we report on modelling the electron transport in n-Si/SiGe structures. The electronic structure is calculated within the effective-mass complex-energy framework, separately for perpendicular (Xz) and in-plane (Xxy) valleys, the degeneracy of which is lifted by strain, and additionally by size quantization. The transport is described via scattering between quantized states, using the rate equations approach and tight-binding expansion, taking the coupling with two nearest-neighbour periods. The acoustic phonon, optical phonon, alloy and interface roughness scattering are taken in the model. The calculated U/I dependence and gain profiles are presented for a couple of QC structures

Microbiological influences on fracture surfaces of intact mudstone and the implications for geological disposal of radioactive waste

The significance of the potential impacts of microbial activity on the transport properties of host rocks for geological repositories is an area of active research. Most recent work has focused on granitic environments. This paper describes pilot studies investigating changes in transport properties that are produced by microbial activity in sedimentary rock environments in northern Japan. For the first time, these short experiments (39 days maximum) have shown that the denitrifying bacteria, Pseudomonas denitrificans, can survive and thrive when injected into flow-through column experiments containing fractured diatomaceous mudstone and synthetic groundwater under pressurized conditions. Although there were few significant changes in the fluid chemistry, changes in the permeability of the biotic column, which can be explained by the observed biofilm formation, were quantitatively monitored. These same methodologies could also be adapted to obtain information from cores originating from a variety of geological environments including oil reservoirs, aquifers and toxic waste disposal sites to provide an understanding of the impact of microbial activity on the transport of a range of solutes, such as groundwater contaminants and gases (e.g. injected carbon dioxide)

Relationship between eruptions of active-region filaments and associated flares and CMEs

To better understand the dynamical process of active-region filament eruptions and associated flares and CMEs, we carried out a statistical study of 120 events observed by BBSO, TRACE, and t(SOHO/EIT) from 1998 to 2007 and combined filament observations with the NOAA's flare reports, MDI magnetograms, and LASCO data, to investigate the relationship between active-region filament eruptions and other solar activities. We found that 115 out of 120 filament eruptions are associated with flares. 56 out of 105 filament eruptions are found to be associated with CMEs except for 15 events without corresponding LASCO data. We note the limitation of coronagraphs duo to geometry or sensitivity, leading to many smaller CMEs that are Earth-directed or well out of the plane of sky not being detected by near-Earth spacecraft. Excluding those without corresponding LASCO data, the CME association rate of active-region filament eruptions clearly increases with X-ray flare class from about 32% for C-class flares to 100% for X-class flares. The eruptions of active-region filaments associated with Halo CMEs are often accompanied by large flares. About 92% events associated with X-class flare are associated with Halo CMEs. Such a result is due to that the Earth-directed CMEs detected as Halo CMEs are often the larger CMEs and many of the smaller ones are not detected because of the geometry and low intensity. The average speed of the associated CMEs of filament eruptions increases with X-ray flare size from 563.7 km/s for C-class flares to 1506.6 km/s for X-class flares. Moreover, the magnetic emergence and cancellation play an important role in triggering filament eruptions. These findings may be instructive to not only in respect to the modeling of active-region filament eruptions but also in predicting flares and CMEs.Comment: 19 Pages, 7 figures, Accepted for publication in MNRA

Design of 12.5 kA current leads for the Large Hadron Collider using high temperature superconductor material

The Large Hadron Collider will be equipped with about 8000 superconducting magnets. Some 2600 current leads will feed the currents ranging from 25 to 12500 A. CERN aims to reduce the consumption of liquid helium, using high temperature superconductors in these leads. A development of leads for 12.5 kA is being conducted in collaboration with Oxford Instruments. The design options for these leads are described. A test rig and prototype lead have been made according to one of the options. Electrical contact tests are in progress on BSCCO-2212 and YBCO-123 samples. In the first run, the prototype carried 13000 A

Local vibration modes and nitrogen incorporation in AlGaAs: N layers

Raman scattering measurements in dilute AlGaAs:N films grown by plasma-assisted molecular beam epitaxy on (100) GaAs substrates reveal strong local vibration modes (LVM) associated to N complexes. The LVM observed frequencies between 325 and 540 cm–1 are in good agreement with density functional theory supercell calculations of AlnGa4–nN complexes (n = 1,2,3,4). We find that the observed LVMs correspond to all n values including Al4N. The LVMs spectra are resonant at energies around 1.85 eV. The values of the extended phonon frequencies of the ternary compound (GaAs and AlAs-like) reveal changes in the N distribution depending on the growth conditions: A transition from random- to nonrandom nitrogen distribution is observed upon increasing the growth temperature. Our results confirm the preferential bonding of N to Al in AlGaAs:N, due to the higher Al-N bond strength as compared to the Ga-N bond

Microbial impacts of CO2 transport in Sherwood Sandstone

Work carried out by BGS and the Japan Atomic Energy Authority (JAEA) has shown that microbial processes can have profound effects on the transport properties of host rock (i.e. the movement of fluids and contaminants through the host material) relevant to radioactive waste disposal. Recent research, performed as part of the BGS Radtran project, has examined Sherwood Sandstone samples in the context of radioactive waste disposal; this particular formation is also a potential reservoir for carbon dioxide storage in the UK. As part of the BGS opportunities fund programme, this project has, for the first time, evaluated interactions between fluids saturated with carbon dioxide/Sherwood Sandstone/microbes (Pseudomonas aeruginosa) in transport experiments, using BGS developed apparatus under pressurised subsurface conditions. This pilot study has highlighted the impacts of differences in the physical characteristics of core Sherwood Sandstone samples collected adjacent to each other in a core sample, and the ability of P. aeruginosa to survive in CO2 saturated artificial groundwater and the potential to form a biofilm in an environment suitable likely to be found at a carbon capture and storage location. These results demonstrate that in this short study, the injection of P. aeruginosa into the biotic experiment does not appear to impact on the physical transport properties of the Sherwood Sandstone, although the presence of CO2 appears to enhance the mobilisation of a number of chemical species. However, in other work which utilised the same organism and rock type but without introduction of CO2 saturated fluid, post-inoculation injection changes were observed. These included short but rapid saw-tooth like changes in the pressure profile (Wragg et al, 2012). These impacts were not observed in the current study which suggests that the CO2 saturated fluid was impacting on the ability of the microbes to alter permeability. This short study has, however, indicated the need to carry out longer term investigations to reproduce these initial findings

Molecular Dynamics Simulations of GABA Binding to the GABAC Receptor: The Role of Arg104

GABA is the major inhibitory neurotransmitter in the nervous system and acts at a variety of receptors including GABAC receptors, which are a subclass of GABAA receptors. Here we have used molecular dynamics simulations of GABA docked into the extracellular domain of the GABAC receptor to explain the molecular interactions of the neurotransmitter with the residues that contribute to the binding site; in particular, we have explored the interaction of GABA with Arg104. The simulations suggest that the amine group of GABA forms cation-π interactions with Tyr102 and Tyr198, and hydrogen-bonds with Gln83, Glu220, Ser243, and Ser168, and, most prominently, with Arg104. Substituting Arg104 with Ala, Glu, or Lys, which experimentally disrupt GABAC receptor function, and repeating the simulation revealed fewer and different bonding patterns with GABA, or the rapid exit of GABA from the binding pocket. The simulations therefore unveil interactions of GABA within the binding pocket, and explain experimental data, which indicate that Arg104 is critical for the efficient functioning of the receptor

On the radio afterglow of gamma ray bursts

We use the cannonball (CB) model of gamma ray bursts (GRBs) to predict the spectral and temporal behaviour of their radio afterglows (AGs). A single simple expression describes the AGs at all times and frequencies; its high-frequency limit reproduces the successful CB model predictions for optical and X-ray AGs. We analyze all of the observed radio AGs of GRBs with known redshifts, including those of the exceptionally close-by GRB 980425. We also study in detail the time-evolution of the AGs' spectral index. The agreement between theory and observations is excellent, even though the CB model is extremely frugal in the number of parameters required to explain the radio observations. We propose to use the scintillations in the radio AGs of GRBs to verify and measure the hyperluminal speed of their jetted CBs, whose apparent angular velocity is of the same order of magnitude as that of galactic pulsars, consistently measured directly, or via scintillations.Comment: Accepted for publication in A&