Dominique Chateau. Epistémologie de l’esthétique ; Dominique Chateau. La Philosophie de l’art ; Dominique Chateau. Qu’est-ce que l’art ?

La parution simultanée de ces trois ouvrages de Dominique Chateau chez L’Harmattan constitue un véritable triptyque. La considération sur l’esthétique, comme “branche” de la philosophie, paraît donc au centre de deux réflexions qui, pour l’une, examine ses racines et, pour l’autre (selon une métaphore romantique) questionne sa fleur. Mais, en son centre même, l’articulation de ce triptyque n’échappe pas au travail de sape épistémologique auquel procède l’auteur : « L’épistémologie d’une disci..

Enhance quality care performance: Determination of the variables for establishing a common database in French paediatric critical care units

Abstract Selected variables for the French Paediatric Intensive Care registry. Rationale, aims, and objectives Providing quality care requires follow-up in regard to clinical and economic activities. Over the past decade, medical databases and patient registries have expanded considerably, particularly in paediatric critical care medicine (eg, the Paediatric Intensive Care Audit Network (PICANet) in the UK, the Australian and New Zealand Paediatric Intensive Care (ANZPIC) Registry in Australia and New Zealand, and the Virtual Paediatric Intensive Care Unit Performance System (VPS) in the USA). Such a registry is not yet available in France. The aim of this study was to determine variables that ought to be included in a French paediatric critical care registry. Methods Variables, items, and subitems from 3 foreign registries and 2 French local databases were used. Items described each variable, and subitems described items. The Delphi method was used to evaluate and rate 65 variables, 90 items, and 17 subitems taking into account importance or relevance based on input from 28 French physicians affiliated with the French Paediatric Critical Care Group. Two ratings were used between January and May 2013. Results Fifteen files from 10 paediatric intensive care units were included. Out of 65 potential variables, 48 (74%) were considered to be indispensable, 16 (25%) were considered to be optional, and 1 (2%) was considered to be irrelevant. Out of 90 potential items, 62 (69%) were considered to be relevant, 23 (26%) were considered to be of little relevance, and 5 (6%) were considered to be irrelevant. Out of 17 potential subitems, 9 (53%) were considered to be relevant, 6 (35%) were considered to be of little relevance, and 2 (12%) were considered to be irrelevant. Conclusions The necessary variables that ought to be included in a French paediatric critical care registry were identified. The challenge now is to develop the French registry for paediatric intensive care units

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

PEINDRE L'IMPOSSIBLE (BARNETT NEWMAN, FRANCIS BACON, WILLEM DE KOONING)

PARIS1-BU Pierre Mendès-France (751132102) / SudocPARIS-INHA (751025206) / SudocSudocFranceF

Validation d'un système de déport de lumière à fibres optiques hautement birefringentes pour application à la polarimétrie de Mueller endoscopique

National audienc

Mind Control

Ce volume intitulé Mind Control est consacré aux relations entre les expérimentations artistiques et les techniques de conditionnement psychologique au cours de la période contemporaine (XIXe-XXIe siècles). Il analyse la culture visuelle d'œuvres d’art qui jouent sur la reprise, le contre-pied, le déplacement voire l’instrumentalisation de divers protocoles mis en place dans les laboratoires de psychologie. Entre suggestion et hypnose, test comportemental et images subliminales, parasitage et lavage de cerveau, ce numéro croise des objets, des discours et des dispositifs d’influence très variés, de l’art de la publicité au cinéma expérimental, du « design pédagogique » à la vidéo, de la « musique d’ameublement » à la performance, jusqu’aux réseaux sociaux les plus récents, pour interroger les stratégies de persuasion et de contrôle dans nos sociétés contemporaines et le rôle des pratiques artistiques dans leur mise à distance ou leur détournement critique. Cet ouvrage, préparé sous la direction de Pascal Rousseau, est le onzième volume de la collection Histo.Art, présentant les travaux de l’École doctorale Histoire de l’art de l’université Paris 1 Panthéon-Sorbonne