Astrometric results of observations of mutual occultations and eclipses of the Uranian satellites in 2007

Context. The photometry of mutual occultations and eclipses of natural planetary satellites can be used to infer very accurate astrometric data. This can be achieved by processing the light curves of the satellites observed during international campaigns of photometric observations of these mutual events. Aims. This work focuses on processing the complete database of photometric observations of the mutual occultations and eclipses of the Uranian satellites made during the international campaign in 2007. The final goal is to derive new accurate astrometric data. Methods. We used an accurate photometric model of mutual events that explicitly depends on parameters that these accurate observations should be sensitive to, including the albedos of the satellites. Our original method is applied to derive astrometric data in relative positions from photometric observations of mutual occultations and eclipses of the Uranian satellites. Results. We process the 41 light-curves obtained during the international campaign of photometric observations of the Uranian satellites in 2007. The root-mean-square (rms) of the residuals "observations minus calculations" (O-C) with respect to theory for the best 34 observations are equal to 10.3 and 17.7 mas in right ascension and declination, respectively. For five observations only the position angle was derived. Topocentric or heliocentric angular differences for satellites pairs were obtained from 25 central instant offsets between observation and theory during the time period from May 4, 2007 to January 4, 2008. Conclusions. The rms of the residuals is from 10 to 20 mas that corresponds in situ to 10 to 20 km. These mutual event observations appear to be the most accurate astrometric ground-based observations of the major Uranian satellites to-date and should be used for dynamical purposes. © 2013 ESO

Common variations in estrogen-related genes are associated with severe large-joint osteoarthritis: a multicenter genetic and functional study

OBJECTIVE: Several lines of evidence suggest that estrogens influence the development of osteoarthritis (OA). The aim of this study was to explore the association of two common polymorphisms within the aromatase (CYP19A1) and estrogen receptor (ER) alpha (ESR1) genes with severe OA of the lower limbs. METHODS: The rs1062033 (CYP19A1) and rs2234693 (ESR1) single nucleotide polymorphisms were genotyped in 5528 individuals (3147 patients with severe hip or knee OA, and 2381 controls) from four centres in Spain and the United Kingdom. Gene expression was measured in femoral bone samples from a group of patients. RESULTS: In the global analysis, both polymorphisms were associated with OA, but there was a significant sex interaction. The GG genotype at rs1062033 was associated with an increased risk of knee OA in women [odds ratio (OR) 1.23; P=0.04]. The CC genotype at rs2234693 tended to be associated with reduced OA risk in women (OR 0.76, P=0.028, for knee OA; OR=0.84, P=0.076 for hip OA), but with increased risk of hip OA in men (OR 1.28; P=0.029). Women with unfavourable genotypes at both loci had an OR of 1.61 for knee OA (P=0.006). The rs1062033 genotype associated with higher OA risk was also associated with reduced expression of the aromatase gene in bone. CONCLUSIONS: Common genetic variations of the aromatase and ER genes are associated with the risk of severe OA of the large joints of the lower limb in a sex-specific manner. These results are consistent with the hypothesis that estrogen activity may influence the development of large-joint OA

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis

Hypothalamic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and body weight. Here, we show that Steroid Receptor Coactivator-1 (SRC-1) interacts with a target of leptin receptor activation, phosphorylated STAT3, to potentiate Pomc transcription. Deletion of SRC-1 in Pomc neurons in mice attenuates their depolarization by leptin, decreases Pomc expression and increases food intake leading to high-fat diet-induced obesity. In humans, fifteen rare heterozygous variants in SRC-1 found in severely obese individuals impair leptin-mediated Pomc reporter activity in cells, whilst four variants found in non-obese controls do not. In a knock-in mouse model of a loss of function human variant (SRC-1L1376P), leptin-induced depolarization of Pomc neurons and Pomc expression are significantly reduced, and food intake and body weight are increased. In summary, we demonstrate that SRC-1 modulates the function of hypothalamic Pomc neurons, and suggest that targeting SRC-1 may represent a useful therapeutic strategy for weight loss.Peer reviewe

Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel

Imputing genotypes from reference panels created by whole-genome sequencing (WGS) provides a cost-effective strategy for augmenting the single-nucleotide polymorphism (SNP) content of genome-wide arrays. The UK10K Cohorts project has generated a data set of 3,781 whole genomes sequenced at low depth (average 7x), aiming to exhaustively characterize genetic variation down to 0.1% minor allele frequency in the British population. Here we demonstrate the value of this resource for improving imputation accuracy at rare and low-frequency variants in both a UK and an Italian population. We show that large increases in imputation accuracy can be achieved by re-phasing WGS reference panels after initial genotype calling. We also present a method for combining WGS panels to improve variant coverage and downstream imputation accuracy, which we illustrate by integrating 7,562 WGS haplotypes from the UK10K project with 2,184 haplotypes from the 1000 Genomes Project. Finally, we introduce a novel approximation that maintains speed without sacrificing imputation accuracy for rare variants

Overview of the instrumentation for the Dark Energy Spectroscopic Instrument

The Dark Energy Spectroscopic Instrument (DESI) embarked on an ambitious 5 yr survey in 2021 May to explore the nature of dark energy with spectroscopic measurements of 40 million galaxies and quasars. DESI will determine precise redshifts and employ the baryon acoustic oscillation method to measure distances from the nearby universe to beyond redshift z > 3.5, and employ redshift space distortions to measure the growth of structure and probe potential modifications to general relativity. We describe the significant instrumentation we developed to conduct the DESI survey. This includes: a wide-field, 3.°2 diameter prime-focus corrector; a focal plane system with 5020 fiber positioners on the 0.812 m diameter, aspheric focal surface; 10 continuous, high-efficiency fiber cable bundles that connect the focal plane to the spectrographs; and 10 identical spectrographs. Each spectrograph employs a pair of dichroics to split the light into three channels that together record the light from 360–980 nm with a spectral resolution that ranges from 2000–5000. We describe the science requirements, their connection to the technical requirements, the management of the project, and interfaces between subsystems. DESI was installed at the 4 m Mayall Telescope at Kitt Peak National Observatory and has achieved all of its performance goals. Some performance highlights include an rms positioner accuracy of better than 0.″1 and a median signal-to-noise ratio of 7 of the [O ii] doublet at 8 × 10−17 erg s−1 cm−2 in 1000 s for galaxies at z = 1.4–1.6. We conclude with additional highlights from the on-sky validation and commissioning, key successes, and lessons learned

Overview of the DESI Legacy Imaging Surveys

The DESI Legacy Imaging Surveys (http://legacysurvey.org/) are a combination of three public projects (the Dark Energy Camera Legacy Survey, the Beijing–Arizona Sky Survey, and the Mayall z-band Legacy Survey) that will jointly image ≈14,000 deg2 of the extragalactic sky visible from the northern hemisphere in three optical bands (g, r, and z) using telescopes at the Kitt Peak National Observatory and the Cerro Tololo Inter-American Observatory. The combined survey footprint is split into two contiguous areas by the Galactic plane. The optical imaging is conducted using a unique strategy of dynamically adjusting the exposure times and pointing selection during observing that results in a survey of nearly uniform depth. In addition to calibrated images, the project is delivering a catalog, constructed by using a probabilistic inference-based approach to estimate source shapes and brightnesses. The catalog includes photometry from the grz optical bands and from four mid-infrared bands (at 3.4, 4.6, 12, and 22 μm) observed by the Wide-field Infrared Survey Explorer satellite during its full operational lifetime. The project plans two public data releases each year. All the software used to generate the catalogs is also released with the data. This paper provides an overview of the Legacy Surveys project

The UK10K project identifies rare variants in health and disease

M. Kivimäki työryhmäjäsen.The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7x) or exomes (high read depth, 80x) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with levels of triglycerides (APOB), adiponectin (ADIPOQ) and low-density lipoprotein cholesterol (LDLR and RGAG1) from single-marker and rare variant aggregation tests. We describe population structure and functional annotation of rare and low-frequency variants, use the data to estimate the benefits of sequencing for association studies, and summarize lessons from disease-specific collections. Finally, we make available an extensive resource, including individual-level genetic and phenotypic data and web-based tools to facilitate the exploration of association results.Peer reviewe

Astrometric results of observations of mutual occultations and eclipses of the Uranian satellites in 2007

Context. The photometry of mutual occultations and eclipses of natural planetary satellites can be used to infer very accurate astrometric data. This can be achieved by processing the light curves of the satellites observed during international campaigns of photometric observations of these mutual events. Aims. This work focuses on processing the complete database of photometric observations of the mutual occultations and eclipses of the Uranian satellites made during the international campaign in 2007. The final goal is to derive new accurate astrometric data. Methods. We used an accurate photometric model of mutual events that explicitly depends on parameters that these accurate observations should be sensitive to, including the albedos of the satellites. Our original method is applied to derive astrometric data in relative positions from photometric observations of mutual occultations and eclipses of the Uranian satellites. Results. We process the 41 light-curves obtained during the international campaign of photometric observations of the Uranian satellites in 2007. The root-mean-square (rms) of the residuals "observations minus calculations" (O-C) with respect to theory for the best 34 observations are equal to 10.3 and 17.7 mas in right ascension and declination, respectively. For five observations only the position angle was derived. Topocentric or heliocentric angular differences for satellites pairs were obtained from 25 central instant offsets between observation and theory during the time period from May 4, 2007 to January 4, 2008. Conclusions. The rms of the residuals is from 10 to 20 mas that corresponds in situ to 10 to 20 km. These mutual event observations appear to be the most accurate astrometric ground-based observations of the major Uranian satellites to-date and should be used for dynamical purposes. © 2013 ESO

Astrometric results of observations of mutual occultations and eclipses of the Uranian satellites in 2007

Context. The photometry of mutual occultations and eclipses of natural planetary satellites can be used to infer very accurate astrometric data. This can be achieved by processing the light curves of the satellites observed during international campaigns of photometric observations of these mutual events. Aims. This work focuses on processing the complete database of photometric observations of the mutual occultations and eclipses of the Uranian satellites made during the international campaign in 2007. The final goal is to derive new accurate astrometric data. Methods. We used an accurate photometric model of mutual events that explicitly depends on parameters that these accurate observations should be sensitive to, including the albedos of the satellites. Our original method is applied to derive astrometric data in relative positions from photometric observations of mutual occultations and eclipses of the Uranian satellites. Results. We process the 41 light-curves obtained during the international campaign of photometric observations of the Uranian satellites in 2007. The root-mean-square (rms) of the residuals "observations minus calculations" (O-C) with respect to theory for the best 34 observations are equal to 10.3 and 17.7 mas in right ascension and declination, respectively. For five observations only the position angle was derived. Topocentric or heliocentric angular differences for satellites pairs were obtained from 25 central instant offsets between observation and theory during the time period from May 4, 2007 to January 4, 2008. Conclusions. The rms of the residuals is from 10 to 20 mas that corresponds in situ to 10 to 20 km. These mutual event observations appear to be the most accurate astrometric ground-based observations of the major Uranian satellites to-date and should be used for dynamical purposes. © 2013 ESO