86 research outputs found
Chern-Simons Correlations on (2+1)D Lattice
We have computed the contribution of zero modes to the value of the number of
particles in the model of discrete (2+1)-dimensional nonlinear Schr\"odinger
equation. It is shown for the first time that in the region of small values of
the Chern-Simons coefficient k there exists a universal attraction between
field configurations. For k=2 this phenomenon may be a dynamic origin of the
semion pairing in high temperature superconducting state of planar systems.Comment: 9 pages, 2 figures Sabj-class: Strongly Correlated Electron
Energy Bounds of Linked Vortex States
Energy bounds of knotted and linked vortex states in a charged two-component
system are considered. It is shown that a set of local minima of free energy
contains new classes of universality. When the mutual linking number of vector
order parameter vortex lines is less than the Hopf invariant, these states have
lower-lying energies.Comment: 4 pages, Latex2
Quantum vortices in systems obeying a generalized exclusion principle
The paper deals with a planar particle system obeying a generalized exclusion
principle (EP) and governed, in the mean field approximation, by a nonlinear
Schroedinger equation. We show that the EP involves a mathematically simple and
physically transparent mechanism, which allows the genesis of quantum vortices
in the system. We obtain in a closed form the shape of the vortices and
investigate its main physical properties.
PACS numbers: 03.65.-w, 03.65.Ge, 05.45.YvComment: 7 pages, 4 figure
Vortex solitons - Mass, Energy and Angular momentum bunching in relativistic electron-positron plasmas
It is shown that the interaction of large amplitude electromagnetic waves
with a hot electron-positron (e-p) plasma (a principal constituent of the
universe in the MeV epoch) leads to a bunching of mass, energy, and angular
momentum in stable, long-lived structures. Electromagnetism in the MeV epoch,
then, could provide a possible route for seeding the observed large-scale
structure of the universe.Comment: 17 pages with 2 figure
Photon- and meson-induced reactions on the nucleon
In an unitary effective Lagrangian model we develop a unified description of
both meson scattering and photon-induced reactions on the nucleon. Adding the
photon to an already existing model for meson-nucleon scattering yields both
Compton and meson photoproduction amplitudes. In a simultaneous fit to all
available data involving the final states , , ,
and the parameters of the nucleon resonances are
extracted.Comment: 57 pages, 14 figures, LaTex (uses Revtex and graphicx). Submitted to
Phys. Rev. C. References updated, Fig. 14 change
Transverse momentum spectra of charged particles in proton-proton collisions at GeV with ALICE at the LHC
The inclusive charged particle transverse momentum distribution is measured
in proton-proton collisions at GeV at the LHC using the ALICE
detector. The measurement is performed in the central pseudorapidity region
over the transverse momentum range GeV/.
The correlation between transverse momentum and particle multiplicity is also
studied. Results are presented for inelastic (INEL) and non-single-diffractive
(NSD) events. The average transverse momentum for is (stat.) (syst.) GeV/ and
\left_{\rm NSD}=0.489\pm0.001 (stat.) (syst.)
GeV/, respectively. The data exhibit a slightly larger than measurements in wider pseudorapidity intervals. The results are
compared to simulations with the Monte Carlo event generators PYTHIA and
PHOJET.Comment: 20 pages, 8 figures, 2 tables, published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/390
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial
More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University Münster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369
AI is a viable alternative to high throughput screening: a 318-target study
: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery
The western painted turtle genome, a model for the evolution of extreme physiological adaptations in a slowly evolving lineage
Background: We describe the genome of the western painted turtle, Chrysemys picta bellii, one of the most widespread, abundant, and well-studied turtles. We place the genome into a comparative evolutionary context, and focus on genomic features associated with tooth loss, immune function, longevity, sex differentiation and determination, and the species' physiological capacities to withstand extreme anoxia and tissue freezing.Results: Our phylogenetic analyses confirm that turtles are the sister group to living archosaurs, and demonstrate an extraordinarily slow rate of sequence evolution in the painted turtle. The ability of the painted turtle to withstand complete anoxia and partial freezing appears to be associated with common vertebrate gene networks, and we identify candidate genes for future functional analyses. Tooth loss shares a common pattern of pseudogenization and degradation of tooth-specific genes with birds, although the rate of accumulation of mutations is much slower in the painted turtle. Genes associated with sex differentiation generally reflect phylogeny rather than convergence in sex determination functionality. Among gene families that demonstrate exceptional expansions or show signatures of strong natural selection, immune function and musculoskeletal patterning genes are consistently over-represented.Conclusions: Our comparative genomic analyses indicate that common vertebrate regulatory networks, some of which have analogs in human diseases, are often involved in the western painted turtle's extraordinary physiological capacities. As these regulatory pathways are analyzed at the functional level, the painted turtle may offer important insights into the management of a number of human health disorders
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