Design and Synthesis of Heterocycles of Pharmaceutical Interest

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Influence of different transplanting date and weed management practices on yield and quality of basmati rice (Pusa Basmati-1509)

A field experiment was conducted during kharif 2014 at students’ farm of Chaudhary Charan Singh Haryana Agricultural University, college of agriculture, Kaul (Kaithal). The experiment consisted of four transplanting dates (June 15, July 5, July 25 and August 15) in main plots and six weed control treatments in sub plots treatments consisted of pre-emergence application of pretilachlor, oxadiargyl alone and sequential application of pre and post emergence herbicides viz., pretilachlor fb bispyribac, oxadiargyl fb bispyribac, weed free check and unweeded check. Based on research investigation it was observed that early transplanting dates (June 15 and July 5) produced taller plant, higher tillers/m2 and crop dry matter accumulation at all growth stages. Early transplanting produced significantly higher number of effective tillers/m2 (263) along with higher number of filled grain/ panicle (85) than delayed planting (July 25 and August 15). The 1000-grain weight was not affected by time of transplanting. The highest grain yield (4363 kg/ha) was recorded under June 15 transplanting which was statistically at par to the grain yield (4058 kg/ha) obtained under July 5 transplanting. Among the weed management practices tried, weed free check resulted in the highest values of plant height (104.2 cm), tillers/m2 (305), crop dry matter accumulation (964 g/ m2), effective tillers/m2 (271), grains length (8.5 cm), filled grains/panicle (86.3) as well as grain (4516 kg/ha) and straw yield (5506 kg/ha) which were however, comparable to pre-emergence application of oxadiargyl followed by bispyribac-sodium applied at 25 DAT and pretilachlor followed by bispribac-sodium at 25DAT

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

Essential metals, such as iron and copper, play a critical role in a plethora of cellular processes including cell growth and proliferation. However, concomitantly, excess of these metal ions in the body can have deleterious effects due to their ability to generate cytotoxic reactive oxygen species (ROS). Thus, the human body has evolved a very well-orchestrated metabolic system that keeps tight control on the levels of these metal ions. Considering their very high proliferation rate, cancer cells require a high abundance of these metals compared to their normal counterparts. Interestingly, new anti-cancer agents that take advantage of the sensitivity of cancer cells to metal sequestration and their susceptibility to ROS have been developed. These ligands can avidly bind metal ions to form redox active metal complexes, which lead to generation of cytotoxic ROS. Furthermore, these agents also act as potent metastasis suppressors due to their ability to up-regulate the metastasis suppressor gene, N-myc downstream regulated gene 1. This review discusses the importance of iron and copper in the metabolism and progression of cancer, how they can be exploited to target tumors and the clinical translation of novel anti-cancer chemotherapeutics

Biophysical interactions in tropical agroforestry systems

sequential systems, simultaneous systems Abstract. The rate and extent to which biophysical resources are captured and utilized by the components of an agroforestry system are determined by the nature and intensity of interac-tions between the components. The net effect of these interactions is often determined by the influence of the tree component on the other component(s) and/or on the overall system, and is expressed in terms of such quantifiable responses as soil fertility changes, microclimate modification, resource (water, nutrients, and light) availability and utilization, pest and disease incidence, and allelopathy. The paper reviews such manifestations of biophysical interactions in major simultaneous (e.g., hedgerow intercropping and trees on croplands) and sequential (e.g., planted tree fallows) agroforestry systems. In hedgerow intercropping (HI), the hedge/crop interactions are dominated by soil fertility improvement and competition for growth resources. Higher crop yields in HI than in sole cropping are noted mostly in inherently fertile soils in humid and subhumid tropics, and are caused by large fertility improvement relative to the effects of competition. But, yield increases are rare in semiarid tropics and infertile acid soils because fertility improvement does not offse

Efficient Organic Photovoltaics with Improved Charge Extraction and High Short-Circuit Current

Exciton generation, dissociation, free carrier transport, and charge extraction play an important role in the short-circuit current (J(sc)) and power conversion efficiency of an organic bulk heterojunction (BHJ) solar cell (SC). Here we study the impact of band offset at the interfacial layer and the morphology of active layer on the extraction of free carriers. The effects are evaluated on an inverted BHJ SC using zinc oxide (ZnO) as a buffer layer, prepared via two different methods: ZnO nanoparticle dispersed in mixed solvents (ZnO A) and sol-gel method (ZnO B). The device with ZnO A buffer layer improves the charge extraction and J(sc),. The improvement is due to the better band offset and morphology of the blend near the ZnO A/active layer interface. Further, the numerical analysis of current-voltage characteristics illustrates that the morphology at the ZnO A/active layer interface has a more dominant role in improving the performance of the organic photovoltaic than the band offset