Effect of Exercise Type and Gender on Cardiopulmonary response among Stroke Survivors in Spastic and Relative Recovery Stages

Background: Stroke is one of the most common causes of long-term disability worldwide, and stroke patients need assistance with activities of daily living. Stroke survivors in our environment are not routinely prescribed adequate exercises during stroke rehabilitation partly because of the limited amount of research that has identified optimal dosing of exercises. This study sought to evaluate cardiopulmonary responses to 8-week regimen of squatting and treadmill exercises among stroke survivors of different sexes in the spastic and relative recovery stages. Methodology: Thirty male and female stroke survivors were randomly assigned into two groups comprising of subjects in the spastic (group A) and relative recovery (group B) stages, and subjected to an 8-week regimen of squatting and/or treadmill exercise. Cardiopulmonary functions were recorded at the beginning and the end of the exercise regimen. Data were processed using SPSS version 20.0; p values ˂ 0.05 were considered significant. Results: There was a significant decrease in SBP and DBP, and an increase in HR, FVC and FEV1 at the end of all the regimens, in the spastic and relative recovery groups. At week 1, males had significantly higher values of SBP, FVC and FEV1, but at week 8, males had more reduction in SBP values and more increase in FVC and FEV1 values than the females. Conclusion: Our data show that squatting and treadmill exercise regimens improve blood pressure, forced vital capacity, forced expiratory volume and functional mobility in both male and female stroke survivors in the spastic and relative recovery stages. This improvement is more expressed in males than in females. Keywords: Cardiopulmonary response, Exercise regimen, Gender, Stroke rehabilitation, Stroke survivor

Efficacy of some bio-control agent formulations on scab of cowpea and groundnut late leaf spot in the Nigerian savanna

Field experiment on fungicidal efficacy of Trichoderma harzianum, Pseudomonas fluorescens and Bacillus cereus formulations against cowpea scab and groundnut late leaf spot was conducted. The trials were conducted in 2016 and 2017 rainy seasons on two farms of the Institute for Agricultural Research located at Samaru, Zaria (110 12′ N, 070 37′ E) in the Northern Guinea savanna and Minijbir, Kano (08031' E., l20 03' N) in the Sudan savanna. The formulations were applied as seed treatment, foliar spray and also incorporated into the soil by broadcasting the powdered formulations on the ridges. The experiment was laid in Randomized Complete Block Design replicated three times with five treatments which consisted of the three formulations, Funguforce (Mancozeb + Carbendazim) and control. Data were taken on plant emergence, pod yield, disease incidence and severity. Irrespective of the treatments, incidence of scab at both Samaru and Minjibir were at par. However, Funguforce application gave lowest mean scab severities of 10% and 8.5% at Minjibir and Samaru respectively in 2017. In 2016 at Samaru, P. fluorescens had the lowest incidence (50.57 %) while B. cereus had the lowest severity (14.40 %) of groundnut late leaf spot. At Minjibir however, T. harzianum recorded the lowest incidence (48.75 %) and severity (18.22 %). The incidence and severity of groundnut late leaf spot at Samaru in 2017 did not significantly vary while at Minjibir lowest incidence (9.77 %) and severity (9.73 %) were recorded on Funguforce. The microbial formulations recorded an average pod yield increase of 10 – 58 % which was comparable with that of Funguforce. The use of formulations of T. harzianum, P. fluorescens and B. cereus in the management of fungal diseases of cowpea and groundnut in the Nigerian savanna is therefore recommended.Keywords: Genetic-crosses, RILs, Polymorphisms, Genetic-Markers, EP

Activation of pro-apoptotic cells, reactive astrogliosis and hyperphosphorylation of tau protein in trimethyltin-induced hippocampal injury in rats

Neurodegenerative diseases cause neural cells to lose both the functional and sensory abilities as a result of genetic factors, proteopathies and mitochondrial dysfunction. Neurodegeneration forms the basis of most neurodegenerative disorders for example Alzheimer’s disease, Huntington’s diseases, and Parkinson’s diseases. The mechanism that underlines the process of neurodegeneration is not well understood. Understanding the process and mechanism involved in neurodegeneration might offer a better therapeutic approach to positively manage cases of neurodegenerative diseases. Therefore, this study’s target was to create an animal model to study neurodegeneration. Sixteen adult male Wistar rats were used in the study and divided into two groups. Control (0.2 mL of normal saline (NS)), and trimethyltin-treated (TMT, 8 mg/kg stat dose only). These animals underwent perfusion with 4% paraformaldehyde, brain excision and analysis of p53 antigen, GFAP and Bielshowsky on these tissues. The results showed that animals in the control group showed presence of activated p53 antigen, reactive astrogliosis, neurofibrillary tangles, and amyloid plaques within the cytoplasm of the hippocampal cells. Cornus Ammonis (CA2) and (CA3) showed more of the trimethylrtin injury than CA1 and CA4. This study thus revealed that, intra-peritoneal administration of single dose of 8mg/kg of trimethyltin can offer an attractive disease model to study some neurodegenerative diseases. Keywords: p53 antigen, Bielshowsky, Glia fibrillary acidic protein, Trimethyltin, Hippocampus

Kriteria awalan pembangunan persisir air di sekitar kawasan bangunan tinggi

Kajian ini untuk mengenalpasti kriteria pembangunan persisir air di kawasan bangunan tinggi yang menyumbang kepada aktiviti sekeliling. Kajian ini juga akan mencerakinkan kriteria persisir air di kawasan bangunan tinggi serta mengkaji pembangunan persisir air berdasarkan dari aktiviti yang wujud di kawasan kajian. Kajian kes yang dipilih adalah di sekitar Sungai Singapura dan Marina Bay, Sungai Klang dan Putrajaya. Kajian dijalankan dengan melakukan kajian lapang serta temubual dengan pihak berkuasa tempatan serta kajian pustaka yang memperlihatkan pembangunan kawasan persisiran air dan rekabentuk bandar dan tumpuan kepada ruang awam sebagai elemen utama. Malaysia kini mula mewujudkan kawasan ruangan awam untuk rekreasi di sekitar persisir air. Kesimpulan daripada kajian ini akan menganalisis elemen dan kriteria persisir air yang dirancang dengan mencerminkan keadaan setempat serta menyediakan ruang awam untuk menghidupkan kawasan persisir air sekaligus meningkatkan imej bandar. Kriteria tersebut dapat digunakan sebagai panduan kepada pereka-pereka dalam merekabentuk bangunan tinggi di kawasan persisir air serta kajian ini juga dapat membantu projek rekabentuk senibina studio 2 bagi bangunan tinggi yang mempunyai tapak cadangan di sekitar kawasan persisir air

Knowledge, attitude and practice of safety measures among cooking gas refill attendants in Zaria Metropolis, Kaduna State, Nigeria

Cooking gas refill attendants play important role in the use of gas in Zaria. The aim of this study was to assess the knowledge, attitude and safety measure practices among cooking gas refill attendants in Zaria metropolis, Kaduna State, Nigeria. A cross sectional study was conducted in January, 2019 among cooking gas refill attendants using structured interviewer-administered questionnaire and checklist. It was a whole-population study of 121 participants. The data was collected using Open Data Kit (ODK) software version 1.21.1 installed in an android device and analyzed using SPSS version 25.0. The results were summarized and presented in tables and charts; p value was set at < 0.05 for statistical significance. Majority (79.6%) of the respondents were within the productive age group of 25 to 44 years with median age 36 years, married (57.9%) and more than half (52.1%) of the respondents had secondary education and all respondents were males. The overall scores for knowledge, attitudes and safety practices were 81.0%, 90.1% and 75.2% respectively but with various deficiencies. Those that attended training were 78.0%. Finding from the checklist showed that 5.8% of the inspected fire extinguishers were expired. The respondents’ knowledge, attitude and safety measures practices were associated with level of education, age and ethnicity. Majority of the gas refill attendants had good knowledge, attitude and safety measure practice, however, with some deficiencies. There is need for training and supervision to ensure use of personal protective equipment and replacement of the expired fire extinguishers

Ibn Khaldun’s theory, principles and concepts on urban planning

Ibn Khaldun was one of the most prominent Islamic scholars from Tunisia. He was very wise and futuristic and whose writings are still applicable to the current world. The objective of this article is to discuss the theories, principles and concepts formulated by Ibn Khaldun. His ideas gave rise to a new branch of science called social science today. Various theories were developed by Ibn Khaldun including urban planning. Other theories that he espoused were economic theory, development theory, concept of assabiyah, concept of urbanization, development of culture and civilization

Dengue virus is hyperendemic in Nigeria from 2009 to 2020: A contemporary systematic review

Backround: Data on Dengue virus (DENV) infection prevalence, geographic distribution and risk factors are necessary to direct appropriate utilization of existing and emerging control strategies. This study aimed to determine the pooled prevalence, risk factors of DENV infection and the circulating serotypes within Nigeria from January 1, 2009 to December 31, 2020. Materials and methods: Twenty-one studies out of 2,215 available articles were eligible and included for this systematic review. Relevant articles were searched, screened and included in this study according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The risk of bias in primary studies was assessed by Cochrane's method. Heterogeneity of pooled prevalence was calculated using the chi-square test on Cochrane's Q statistic, which was quantified by I-square values. The random-effects analyses of proportions were used to determine the pooled prevalence of DENV antibodies, antigen and RNA from eligible studies. Results: Of these, 3 studies reported co-circulation of all the 4 serotypes, while 2 separately reported co-circulation of DENV-1 &2 and DENV-1 to -3. All the antibody-based studies had significantly high heterogeneity (I2 >90%, P 0.05). The pooled prevalence of DENV IgM, IgG, RNA, NS1 and neutralizing antibodies were 16.8%, 34.7%, 7.7%, 7.7% and 0.7%, respectively. Southeast Nigeria had the highest pooled DENV-IgG seropositivity, 77.1%. Marital status, gender, educational level and occupation status, the proximity of residence to refuse dumpsite, frequent use of trousers and long sleeve shirts were significantly associated with DENV IgG seropositivity (P <0.05). Conclusion: Based on these findings, it can be inferred that Nigeria is hyperendemic for Dengue fever and needs concerted efforts to control its spread within and outside the country

Anemia prevalence in women of reproductive age in low- and middle-income countries between 2000 and 2018

Anemia is a globally widespread condition in women and is associated with reduced economic productivity and increased mortality worldwide. Here we map annual 2000–2018 geospatial estimates of anemia prevalence in women of reproductive age (15–49 years) across 82 low- and middle-income countries (LMICs), stratify anemia by severity and aggregate results to policy-relevant administrative and national levels. Additionally, we provide subnational disparity analyses to provide a comprehensive overview of anemia prevalence inequalities within these countries and predict progress toward the World Health Organization’s Global Nutrition Target (WHO GNT) to reduce anemia by half by 2030. Our results demonstrate widespread moderate improvements in overall anemia prevalence but identify only three LMICs with a high probability of achieving the WHO GNT by 2030 at a national scale, and no LMIC is expected to achieve the target in all their subnational administrative units. Our maps show where large within-country disparities occur, as well as areas likely to fall short of the WHO GNT, offering precision public health tools so that adequate resource allocation and subsequent interventions can be targeted to the most vulnerable populations.Peer reviewe

All-sky search for long-duration gravitational wave transients with initial LIGO

We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society