In-silico structural modelling of cytochrome complex proteins of white turmeric (Curcuma zedoaria)

Curcuma zedoaria (Christm.) Roscoe (white turmeric) is a perennial herbaceous plant of family Zingiberaceae and mainly found in the wild areas of tropical and subtropical regions worldwide. The cytochrome proteins in plants play important roles in promoting their growth and development, as well as protecting them from stresses and diseases. Cytochrome proteins like psbF, psbE, petB, petD, petN, petG, and ccsA play important roles in degradation of mis-folded proteins, ATP formation, cyclic electron flow and biogenesis of c-type cytochrome of C. zedoaria. However, due to lack of structural availability of these C. zedoaria cytochrome proteins in structural databases, the physiochemical parameters of sequences were estimated using Expasy ProtParam web tool. Self-Optimized Prediction Method with Alignment (SOPMA) server and MODELLER version 9.23 were used for modelling along with Qualitative Model Energy Analysis (QMEAN) and Protein Structure Analysis (ProSA) servers were implemented for validating the secondary and tertiary structures of these proteins. The obtained QMEAN4 values of the modelled cytochrome proteins were -2.04, -1.20, -3.01, -1.57, -2.11, -1.74 and -12.87. The Z-scores obtained from ProSA server were 0.5, -0.83, -1.5, -0.58, -0.02, 0.14 and -3.73. All seven modelled structures have been submitted to protein model database (PMDB). The derived results will be helpful in further investigations towards determining the crystal structure of the hypothetical proteins, structural motifs, physiochemical properties, and also protein-protein interaction studies of various cytochrome proteins

The global burden of adolescent and young adult cancer in 2019 : a systematic analysis for the Global Burden of Disease Study 2019

Background In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. Methods Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. Findings There were 1.19 million (95% UI 1.11-1.28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59.6 [54.5-65.7] per 100 000 person-years) and high-middle SDI countries (53.2 [48.8-57.9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14.2 [12.9-15.6] per 100 000 person-years) and middle SDI (13.6 [12.6-14.8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23.5 million (21.9-25.2) DALYs to the global burden of disease, of which 2.7% (1.9-3.6) came from YLDs and 97.3% (96.4-98.1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. Interpretation Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.Peer reviewe

Beneficiary satisfaction with mental health care services: A cross sectional study at district mental health programme OPD of Ganjam District

contact drop outs. Active participation of people with mental illness (PWMI) & their caregivers is of utmost important to achieve the objectives of DMHP and reduce the longstanding mental & neurological disorder (MND) cases. Aim: To describe the beneficiary satisfaction with mental health care services under DMHP Ganjam. Materials & Methods: Descriptive theoretical framework & cross-sectional study design. Beneficiaries were selected by probability sampling. Beneficiary satisfaction was measured by using questionnaire in a Likert scale. Results: Communication skills of doctor, waiting time for consultation, availability of drugs at drug distribution centre were in the 4th quartile, cleanliness of OPD and Drug distribution centre functioning were in 3rd quartile. Adequacy of information available at hospital and waiting time at registration were in 2nd quartile. The functioning of NIDAN diagnostic centre and behaviour of hospital staff other than doctor got lowest score and were in 1st quartile. Conclusion: The distribution score in quartiles gave a preliminary evidence on components of beneficiary satisfaction on mental health care services at DMHP OPD. Recommendation: Counselling on service availability at NIDAN, training on communication skill for hospital staff, steps to reduce waiting time & need assessment of beneficiaries. Participatory research to explore the beneficiary perception needs to be carried out. Keywords: Mental Health, PWMI, MN

DNA barcoding adjudicate two different morphs of Bascanichthys deraniyagalai (Anguilliformes: Ophichthidae): re-description and first record from Chilika lagoon, India

Morphological characters and distribution pattern of the snake eel, Bascanichthys deraniyagalai is debatable during the past half-century. Thus, the species is re-described herewith by morphometry, vertebrae, and molecular data. In recent Chilika expedition in India, we have collected 10 specimens and observed a vertebral count dimorphism. The present study distinctly detected two vertebral groups of B. deraniyagalai: first group with 5 predorsal vertebrae, 81–83 preanal vertebrae, 190–196 total vertebrae in females; however, the sex of the second group with 5 predorsal vertebrae, 72–74 preanal vertebrae, 176–178 total vertebrae was not able to confirm. Further, the molecular data of morphologically identified two distinct groups of B. deraniyagalai shows negligible Kimura 2 parameter genetic divergence and cohesive clustering in Neighbor-Joining phylogeny proved to be the two different morphs of the same species. Hence, the present study indicated there might be vertebral count or sexual dimorphism in B. deraniyagalai, which need further sampling and taxonomic revision to unwrap the fact

Not Available

Not AvailablePsoriasis is a skin disease. It is rare growing disease around the world. Here in this investigation we have targeted a protein namely TRPV3 (Transient receptor potential cation channel, subfamily III) ion channel for the study of psoriasis, which is important factor of psoriasis. The medicinal plant namely Cassia fistula is selected for the in silico investigation. 39 phyto compounds as reported in various research papers are taken for study. Out of 39 phytochemicals, Chrysophanol compound showed highest binding affinity of -7.58kcal/mol having 3 conventional Hydrogen bonds with TRPV3 protein and is found to be a better natural compound as compared to other reported drugs generally used to for the psoriasis. This investigation will lead to more and better findings leading to drug discovery & use as functional food.Not Availabl

Abstracts of National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020

This book presents the abstracts of the papers presented to the Online National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020 (RDMPMC-2020) held on 26th and 27th August 2020 organized by the Department of Metallurgical and Materials Science in Association with the Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, India. Conference Title: National Conference on Research and Developments in Material Processing, Modelling and Characterization 2020Conference Acronym: RDMPMC-2020Conference Date: 26–27 August 2020Conference Location: Online (Virtual Mode)Conference Organizer: Department of Metallurgical and Materials Engineering, National Institute of Technology JamshedpurCo-organizer: Department of Production and Industrial Engineering, National Institute of Technology Jamshedpur, Jharkhand, IndiaConference Sponsor: TEQIP-