Left atrial trajectory impairment in hypertrophic cardiomyopathy disclosed by geometric morphometrics and parallel transport

The analysis of full Left Atrium (LA) deformation and whole LA deformational trajectory in time has been poorly investigated and, to the best of our knowledge, seldom discussed in patients with Hypertrophic Cardiomyopathy. Therefore, we considered 22 patients with Hypertrophic Cardiomyopathy (HCM) and 46 healthy subjects, investigated them by three-dimensional Speckle Tracking Echocardiography, and studied the derived landmark clouds via Geometric Morphometrics with Parallel Transport. Trajectory shape and trajectory size were different in Controls versus HCM and their classification powers had high AUC (Area Under the Receiving Operator Characteristic Curve) and accuracy. The two trajectories were much different at the transition between LA conduit and booster pump functions. Full shape and deformation analyses with trajectory analysis enabled a straightforward perception of pathophysiological consequences of HCM condition on LA functioning. It might be worthwhile to apply these techniques to look for novel pathophysiological approaches that may better define atrio-ventricular interaction

Acute atrial ischemia associates with early but not late new-onset atrial fibrillation in STEMI patients treated with primary PCI: relationship with in-hospital outcomes

Abstract Funding Acknowledgements Type of funding sources: None. OnBehalf N/A Background. New-onset atrial fibrillation (NOAF) is known to be a common complication in STEMI patients undergoing primary percutaneous coronary intervention (PCI), which is associated with a negative short- and long-term prognosis. Recently, two distinct phenotypes of NOAF have been described, namely early (EAF) and late NOAF (LAF). However, whether EAF and LAF recognize different pathogenetic mechanisms is unknown. Purpose. To investigate atrial branches occlusion and EAF or LAF onset in STEMI patients undergoing primary PCI. Methods. Retrospective cohort study including 155 STEMI patients. Patients were divided into 3 groups: sinus rhythm (SR), EAF or LAF. Clinical characteristics, angiographic features including occlusion of atrial branches, namely ramus ostia cavae superioris (ROCS), atrio-ventricular node artery (AVNA), right intermediate atrial artery (RIAA) and left intermediate atrial artery (LIAA), were assessed. We also investigated in-hospital complications, death, and a composite of major post-NOAF adverse events (AEs) including cardiogenic shock, acute pulmonary edema, sustained ventricular tachycardia and ventricular fibrillation. Results. Mean age was 63.8 ± 11.9 years; 78.7% of men. NOAF was detected in 22 (14.2%) patients: 10 (6.4%) EAF and 12 LAF (7.7%). Compared to EAF, LAF patients were older (p = 0.013), with higher GRACE risk score (p = 0.014) and Killip class (p = 0.015), depressed ejection fraction (p = 0.007), elevated filling pressures (p = 0.029), higher c-reactive protein (p = 0.014) and more TIMI flow <3 (p = 0.015). As shown in Figure 1, EAF was associated with higher prevalence of occluded ROCS (p = 0.010), AVNA (p = 0.005) and RIAA (p < 0.001), compared to SR. Moreover, EAF patients had more frequently ≥2 diseased atrial branches than SR (19.5%, p < 0.001) and LAF (25%, p < 0.030) patients. In LAF patients, a higher incidence of pre-PCI cardiogenic shock, post-PCI AEs (p = 0.019 vs SR; p = 0.029 vs EAF) and death (p = 0.004 vs SR) was found. Conclusions. The occlusion of atrial branches is associated with early but not late NOAF following STEMI. LAF patients had worse in-hospital AEs and mortality. Abstract Figure

A multi-channel trigger and acquisition board for TDC-based readout: Application to the cosmic rays detector of the PolarQuEEEst 2018 project

In the summer of 2018, the PolarQuEEEst experiment accomplished a measurement of cosmic rays flux in the Arctic. The detector, installed on a sailboat, was based on scintillation tiles read by a total of 16 SiPM. A multi-channel board (called TRB) has been designed to process the discriminated SiPM signals providing both self-trigger capability and time-to-digital conversion; it was based on a Cyclone-V Intel FPGA. Time-to-digital conversion has been implemented both into FPGA and with the HPTDC chip (as a backup). In this document the board will be described, enlightening the main features and the achieved performance. Lastly, the PolarQuEEEst measurement campaigns will be briefly described, showing how the TRB board has proved to be effective for experiments which require low power consumption, integration with position and environmental sensors and great portability as well. Final thoughts on future improvements will be also discussed

Performance of scintillating tiles with direct silicon-photomultiplier (SiPM) readout for application to large area detectors

The light yield, the time resolution and the efficiency of different types of scintillating tiles with direct Silicon Photomultiplier readout and instrumented with a customised front-end electronics have been measured at the Beam Test Facility of Laboratori Nazionali di Frascati and several test stands. The results obtained on minimum ionising particles with different detector configurations are presented. A time resolution of the order of 300 ps, a light yield of more than 230 photo-electrons, and an efficiency better than 99.8% are obtained with ∼ 225 cm2 large area tiles. This technology is suitable for a wide range of applications in high-energy physics, in particular for large area muon and timing detectors

Protons in near earth orbit

The proton spectrum in the kinetic energy range 0.1 to 200 GeV was measured by the Alpha Magnetic Spectrometer (AMS) during space shuttle flight STS-91 at an altitude of 380 km. Above the geomagnetic cutoff the observed spectrum is parameterized by a power law. Below the geomagnetic cutoff a substantial second spectrum was observed concentrated at equatorial latitudes with a flux ~ 70 m^-2 sec^-1 sr^-1. Most of these second spectrum protons follow a complicated trajectory and originate from a restricted geographic region.Comment: 19 pages, Latex, 7 .eps figure

Search for antihelium in cosmic rays

The Alpha Magnetic Spectrometer (AMS) was flown on the space shuttle Discovery during flight STS-91 in a 51.7 degree orbit at altitudes between 320 and 390 km. A total of 2.86 * 10^6 helium nuclei were observed in the rigidity range 1 to 140 GV. No antihelium nuclei were detected at any rigidity. An upper limit on the flux ratio of antihelium to helium of < 1.1 * 10^-6 is obtained.Comment: 18 pages, Latex, 9 .eps figure

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

New high precision measurements of the cosmic charged particle rate beyond the Arctic Circle with the PolarquEEEst experiment

The goal of the PolarquEEEst experiment was to measure the cosmic charged particle rate at latitudes greater than 66° N, where no systematic and accurate measurements at sea level have ever been performed. A latitude range well above the Arctic Circle was explored on board of a sailboat, up to the unprecedented northernmost value of 82° 07' N. In this paper a description of the experimental set-up is reported, then the procedures for calibration and ata analysis are described in detail. The results show that the rate measured in this latitude range stays constant within a novel accuracy of ±1%

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented

Multiple identities in decentralized Spain: The case of Catalonia

Publicado en Regional and Federal Studies, vol. 8, nº 3, 1998, pp. 65-88.The persistence of a dual self-identification expressed by citizens in the Spanish Comunidades Autónomas (nationalities and regions) is one of the main features of centre-periphery relations in democratic Spain. This 'dual identity' or 'compound nationality' incorporates -in variable proportions, individually or subjectively asserted- both state/national and ethnoterritorial identities with no apparent exclusion. It characterises the ambivalent and dynamic nature of spatial politics in decentralized Spain. A succinct review of the main developments in Spain's contemporary history is carried out in order to provide a background for the discussion of the various identities expressed by citizens in Catalonia. A segmentation analysis reviews the various forms of Catalan self-identification, among which ‘duality’ is to be underlined.Peer reviewe