DSL-Lab: a Low-power Lightweight Platform to Experiment on Domestic Broadband Internet

International audienceThis article presents the design and building of DSL-Lab, a platform to experiment on distributed computing over broadband domestic Internet. Experimental platforms such as PlanetLab and Grid'5000 are promising methodological approaches to study distributed systems. However, both platforms focus on high-end service and network deployments only available on a restricted part of the Internet, leaving aside the possibility for researchers to experiment in conditions close to what is usually available with domestic connection to the Internet. DSL-Lab is a complementary approach to PlanetLab and Grid'5000 to experiment with distributed computing in an environment closer to how Internet appears, when applications are run on end-user PCs. DSL-Lab is a set of 40 low-power and low-noise nodes, which are hosted by participants, using the participants' xDSL or cable access to the Internet. The objective is to provide a validation and experimentation platform for new protocols, services, simulators and emulators for these systems. In this paper, we report on the software design (security, resources allocation, power management) as well as on the first experiments achieved

DSL-Lab: a Platform to Experiment on Domestic Broadband Internet

This report presents the design and building of DSL-Lab, a platform for distributed computing and peer-to-peer experiments over the domestic broadband Internet. Experimental platforms such as PlanetLab and Grid'5000 are promising methodological approaches for studying distributed systems. However, both platforms focus on high-end services and network deployments on only a restricted part of the Internet, and as such, they do not provide experimental conditions of residential broadband networks. DSL-Lab is composed of 40 low-power and noiseless nodes, which are hosted by participants, using users' xDSL or cable access to the Internet. The objective is twofold: 1) to provide accurate and customized measures of availability, activity and performance in order to characterize and tune the models of such resources~; 2) to provide an experimental platform for new protocols, services and applications, as well as a validation tool for simulators and emulators targeting these systems. In this article, we report on the software infrastructure (security, resources allocation, power management) as well as on the first results and experiments achieved

The Stuttering Poet: A Deleuzian Reading of a Laforguian Poetics

This article explores the complex relationship between the yankee, the Impressionist and the minoritarian in Laforgue's work and suggests that Deleuze's notions of the minor and of stuttering, and his analysis of the characteristics of Anglo-American writing, are particularly pertinent to our understanding of Laforgue's poetics. There is a nineteenth-century context for the minor, but there is a danger that we capitulate to a ‘majoritarian’ criticism if we too quickly espouse lines of filiation. The article constructs an account of Laforgue's developing perception of, and relationship with, verse prosody by examining how he scumbles the outlines and activity of syllables, how he pushes line-structure into a terrain vague, how he re-orientates accent towards the qualitative and tunes the acoustic to Hartmann's Unconscious. His uses of the imperative and infinitive, and their associated punctuations, are related to his responses to Impressionism. The argument ends with reflections on Deleuzian becoming in Laforgue

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Laparoschisis (petite ouverture et grandes conséquences. Prise en charge périnatale de 69 cas)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Energy consumption side-channel attack at Virtual Machines in a Cloud

International audienceVirtualized data centers where several virtual machines (VMs) are hosted per server are becoming more popular due to Cloud Computing. As a consequence of energy efficiency concerns, the exact combination of VMs running on a specific server will most likely change over time. We present experimental results how to use the energy/power consumption logs of a power monitored server as a side-channel that allows us to recognize the exact combination of VMs it currently hosts to a high degree. For classification, we use a maximum log-likelihood approach, which works well for comparably small training and test set sizes. We also show to which degree a specific VM can be recognized, regardless of other VMs currently running on the same server, and show false negative/positive rates. To cross-validate our results, we have used a Kolmogorov-Smirnov test, resulting in comparable quality of recognition within shorter time. In order to clarify whether our approach is generalizable and yields reproducible results, we have set up a second experimental infrastructure in Lyon, using a different hardware platform and power measurement device. We have obtained similar results and have experimented with different CPU frequency scaling governors, yielding comparable quality of recognition. As a result, energy consumption data of servers must be protected carefully, as it is potentially valuable information for an attacker trying to track down a VM to mount further attack steps

Effect of bile acid supplementation on endogenous lipid synthesis in patients with short bowel syndrome: A pilot study

International audienceBackground & aims: Short bowel syndrome patients (SBS) receiving parenteral nutrition (PN) often have dyslipidaemia and can develop intestinal failure-associated liver disease (IFALD). These patients demonstrate increased cholesterol synthesis and hepatic lipogenesis. These lipid disturbances may be due to a decreased concentration of the bile acid pool or malabsorption. The aim of this pilot study was to evaluate the effect of bile acid administration on lipid synthesis in patients with SBS. Methods: The 24 h fractional synthesis rate (FSR) of cholesterol and triglycerides was measured by the isotopic method (deuterated water) before and after 4 months of ursodeoxycholic acid (UDCA) treatment (20 mg/kg/day). Five short bowel patients (age: 53.4 +/- 19.2 years) who had normal liver function and lipid plasmatic profiles received 1920 +/- 300 ml of PN for 151 +/- 74 days (mean PN energy intake was 27.0 +/- 6.0 kcal/kg body weight, composed with 3.87 +/- 1.38 g/kg of carbohydrate, 0.72 +/- 0.25 g/kg of fat and 1.10 +/- 0.23 g/kg of amino acids). Plasma metabolites, liver enzymes, 7-cc-OH-cholesterol and steatosis levels were also evaluated before and after treatment. Student's t-tests were performed, and the results were expressed in means (+/- SD). Results: After treatment, decreases in the absolute values of cholesterol synthesis (0.31 +/- 0.12 mmol L-1 to 0.24 +/- 0.11 mmol L-1; p < 0.05), FSR of cholesterol (31.6 +/- 4.7% to 26.4 +/- 4.7%; p = 0.06) and FSR of triglycerides (12.8 +/- 5.8% to 9.2 +/- 5.5%; p < 0.01) were observed. Cholesterol and alanine aminotrans-ferase concentrations also decreased (ALT) (p < 0.05). The absolute values of triglyceride synthesis and triglyceride concentrations remained unchanged. Conclusions: In SBS patients, UDCA decreases the hepatic synthesis of triglycerides and cholesterol. These results suggest that UDCA could prevent the onset of the IFALD. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

DSL-Lab: a Platform to Experiment on Domestic Broadband Internet

This report presents the design and building of DSL-Lab, a platform for distributed computing and peer-to-peer experiments over the domestic broadband Internet. Experimental platforms such as PlanetLab and Grid'5000 are promising methodological approaches for studying distributed systems. However, both platforms focus on high-end services and network deployments on only a restricted part of the Internet, and as such, they do not provide experimental conditions of residential broadband networks. DSL-Lab is composed of 40 low-power and noiseless nodes, which are hosted by participants, using users' xDSL or cable access to the Internet. The objective is twofold: 1) to provide accurate and customized measures of availability, activity and performance in order to characterize and tune the models of such resources~; 2) to provide an experimental platform for new protocols, services and applications, as well as a validation tool for simulators and emulators targeting these systems. In this article, we report on the software infrastructure (security, resources allocation, power management) as well as on the first results and experiments achieved