2,178 research outputs found
Small-polaron hopping conductivity in bilayer manganite LaSrMnO
We report anisotropic resistivity measurements on a
LaSrMnO single crystal over a temperature range
from 2 to 400 K and in magnetic fields up to 14 T. For K, the
temperature dependence of the zero-field in-plane resistivity
obeys the adiabatic small polaron hopping mechanism, while the out-of-plane
resistivity can be ascribed by an Arrhenius law with the same
activation energy. Considering the magnetic character of the polarons and the
close correlation between the resistivity and magnetization, we developed a
model which allows the determination of . The excellent
agreement of the calculations with the measurements indicates that small
polarons play an essential role in the electrical transport properties in the
paramagnetic phase of bilayer manganites.Comment: 4 pages, 3 figures, to appear in Physical Review
The in-plane paraconductivity in La_{2-x}Sr_xCuO_4 thin film superconductors at high reduced-temperatures: Independence of the normal-state pseudogap
The in-plane resistivity has been measured in (LSxCO)
superconducting thin films of underdoped (), optimally-doped
() and overdoped () compositions. These films were grown
on (100)SrTiO substrates, and have about 150 nm thickness. The in-plane
conductivity induced by superconducting fluctuations above the superconducting
transition (the so-called in-plane paraconductivity, ) was
extracted from these data in the reduced-temperature range
10^{-2}\lsim\epsilon\equiv\ln(T/\Tc)\lsim1. Such a
was then analyzed in terms of the
mean-field--like Gaussian-Ginzburg-Landau (GGL) approach extended to the
high- region by means of the introduction of a total-energy cutoff,
which takes into account both the kinetic energy and the quantum localization
energy of each fluctuating mode. Our results strongly suggest that at all
temperatures above Tc, including the high reduced-temperature region, the
doping mainly affects in LSxCO thin films the normal-state properties and that
its influence on the superconducting fluctuations is relatively moderate: Even
in the high- region, the in-plane paraconductivity is found to be
independent of the opening of a pseudogap in the normal state of the underdoped
films.Comment: 35 pages including 10 figures and 1 tabl
Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype
Neutrophil dysregulation, particularly of a low-density subset, is associated with systemic lupus erythematosus (SLE); however, the exact role of normal-density neutrophils in SLE remains unknown. This study compares activation and functional phenotypes of neutrophils from SLE patients and healthy controls to determine potential contributions to SLE pathogenesis. Surface activation markers and release of neutrophil extracellular traps (NETs), granule proteins, and cytokines/chemokines were measured in resting and stimulated neutrophils from SLE patients (n=19) and healthy controls (n=10). Select miRNA and mRNA involved in neutrophil development and function were also measured. Resting SLE neutrophils exhibited fewer activation markers compared to control neutrophils, and activation markers were associated with different plasma cytokines/chemokines in SLE patients compared to healthy controls. However, activation markers increased similarly in SLE and control neutrophils following stimulation with a TLR7/8 agonist, neutrophil growth factors, and bacterial mimic. At the resting state, SLE neutrophils produced significantly more CXCL10 (IP-10), with trends toward other increased cytokines/chemokines. Following stimulation, SLE neutrophils produced fewer NETs and proinflammatory cytokines compared to control neutrophils but more MMP-8. In addition, SLE neutrophils expressed less miR130a, miR132, miR27a, and miR223. In conclusion, SLE neutrophils exhibit distinct functional responses compared to control neutrophils. These functional differences may result from differential gene expression via miRNAs. Furthermore, the differences in functional phenotype of SLE neutrophils suggest that they may contribute to SLE differently dependent on the inflammatory milieu
Suppression of charge-ordering and appearance of magnetoresistance in a spin-cluster glass manganite La0.3Ca0.7Mn0.8Cr0.2O3
The magnetic properties of electron-doped manganite La0.3Ca0.7MnO3 and
La0.3Ca0.7Mn0.8Cr0.2O3 polycrystalline samples prepared by sol-gel technique
have been investigated between 5 and 300 K in magnetic fields ranging from 0 to
5 T. The transition at 260 K, attributed to charge ordering in La0.3Ca0.7MnO3,
is completely suppressed in the Cr-substituted sample while the onset of a
magnetic remanence followed by the appearance of a magnetic irreversibility at
lower temperatures is observed in both samples. These features indicate that
ferromagnetic clusters coexist with either an antiferromagnetic phase for
La0.3Ca0.7MnO3 or a spin-cluster glass phase for La0.3Ca0.7Mn0.8Cr0.2O3 at the
lowest temperatures. The exponential temperature dependence of the resistivity
for the Cr-substituted sample is consistent with the small polaron hopping
model for 120 K < T < 300 K, while the data are better described by Mott's
hopping mechanism for T < 120 K. Whereas the parent compound La0.3Ca0.7MnO3 is
known to show no magnetoresistance, a large negative magnetoresistance is
observed in the La0.3Ca0.7Mn0.8Cr0.2O3 sample below 120 K. The appearance of
the CMR is attributed to spin dependent hopping between spin clusters and/or
between ferromagnetic domains
Spintronics: Fundamentals and applications
Spintronics, or spin electronics, involves the study of active control and
manipulation of spin degrees of freedom in solid-state systems. This article
reviews the current status of this subject, including both recent advances and
well-established results. The primary focus is on the basic physical principles
underlying the generation of carrier spin polarization, spin dynamics, and
spin-polarized transport in semiconductors and metals. Spin transport differs
from charge transport in that spin is a nonconserved quantity in solids due to
spin-orbit and hyperfine coupling. The authors discuss in detail spin
decoherence mechanisms in metals and semiconductors. Various theories of spin
injection and spin-polarized transport are applied to hybrid structures
relevant to spin-based devices and fundamental studies of materials properties.
Experimental work is reviewed with the emphasis on projected applications, in
which external electric and magnetic fields and illumination by light will be
used to control spin and charge dynamics to create new functionalities not
feasible or ineffective with conventional electronics.Comment: invited review, 36 figures, 900+ references; minor stylistic changes
from the published versio
The state of the Martian climate
60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function (HOMA-B) and insulin resistance (HOMA-IR) in up to 46,186 nondiabetic participants. Follow-up of 25 loci in up to 76,558 additional subjects identified 16 loci associated with fasting glucose and HOMA-B and two loci associated with fasting insulin and HOMA-IR. These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1). We also demonstrated association of ADCY5, PROX1, GCK, GCKR and DGKB-TMEM195 with type 2 diabetes. Within these loci, likely biological candidate genes influence signal transduction, cell proliferation, development, glucose-sensing and circadian regulation. Our results demonstrate that genetic studies of glycemic traits can identify type 2 diabetes risk loci, as well as loci containing gene variants that are associated with a modest elevation in glucose levels but are not associated with overt diabetes
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality. Studies of rare human disorders of puberty and animal models point to a complex hypothalamic-pituitary-hormonal regulation, but the mechanisms that determine pubertal timing and underlie its links to disease risk remain unclear. Here, using genome-wide and custom-genotyping arrays in up to 182,416 women of European descent from 57 studies, we found robust evidence (P < 5 × 10(-8)) for 123 signals at 106 genomic loci associated with age at menarche. Many loci were associated with other pubertal traits in both sexes, and there was substantial overlap with genes implicated in body mass index and various diseases, including rare disorders of puberty. Menarche signals were enriched in imprinted regions, with three loci (DLK1-WDR25, MKRN3-MAGEL2 and KCNK9) demonstrating parent-of-origin-specific associations concordant with known parental expression patterns. Pathway analyses implicated nuclear hormone receptors, particularly retinoic acid and γ-aminobutyric acid-B2 receptor signalling, among novel mechanisms that regulate pubertal timing in humans. Our findings suggest a genetic architecture involving at least hundreds of common variants in the coordinated timing of the pubertal transition
Multiple Chronic Conditions: Prevalence, Health Consequences, and Implications for Quality, Care Management, and Costs
Persons with multiple chronic conditions are a large and growing segment of the US population. However, little is known about how chronic conditions cluster, and the ramifications of having specific combinations of chronic conditions. Clinical guidelines and disease management programs focus on single conditions, and clinical research often excludes persons with multiple chronic conditions. Understanding how conditions in combination impact the burden of disease and the costs and quality of care received is critical to improving care for the 1 in 5 Americans with multiple chronic conditions. This Medline review of publications examining somatic chronic conditions co-occurring with 1 or more additional specific chronic illness between January 2000 and March 2007 summarizes the state of our understanding of the prevalence and health challenges of multiple chronic conditions and the implications for quality, care management, and costs
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