63 research outputs found
The disruption of proteostasis in neurodegenerative diseases
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
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- Smizanska M
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- Takahashi Y
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- Torchiani I
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- Tyrvainen H
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- Uhlenbrock M
- Uhrmacher M
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- Underwood DG
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- Vorobel V
- Vorobiev AP
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- Vos M
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- Vossebeld JH
- Vranjes N
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- Vuillermet R
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- Vukotic I
- Wagner P
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- Xie Y
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- Yagci KD
- Yamada M
- Yamaguchi H
- Yamamoto A
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- Yamamoto S
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- Yamanaka T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
- Yang H
- Yang UK
- Yang Y
- Yang Y
- Yang Z
- Yanush S
- Yao Y
- Yasu Y
- Ye J
- Ye S
- Yildizb HD
- Yilmaz M
- Yoosootiniya R
- Yorita K
- Yoshida R
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- Youssef S
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- Yu J
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- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zeitnitz C
- Zeller M
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang Q
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
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- Zhuravlov V
- Zieminska D
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- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
The Significance of Enzyme Immunoassay for the Assessment of Hepatitis B Virus Core-Related Antigen following Liver Transplantation
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- Angus PW McCaughan GW, Gane EJ, Cr
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- Charlton M
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- Hatakeyama T Noguchi C, Hiraga N,
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- Marzano A Salizzoni M, Debernardi-
- Mazet-Wagner AA Baclet MC, Loustau
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- TANAKA YASUHITO
- Tung BY Kowdley KV
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- Yuen MF Wong K, Sum SS, et al
- Zheng S Chen Y, Liang T, et al
- Publication venue
- 'Japanese Society of Internal Medicine'
- Publication date
- 01/01/2009
- Field of study
Purpose Recently, a new enzyme immunoassay for the detection of hepatitis B virus (HBV) core-related antigen (HBcrAg) has been reported. In this study, we proposed to account for feasibility of HBcrAg assay, and discuss the dynamics of HBV seen in patients following HBV-related living donor liver transplantation (LDLT). Methods and results This study involved 12 patients; 11 patients had positive serum HBcrAg, and 6 patients had negative HBV-DNA. In the post-operation period, all cases were negative for HBV-DNA and HBsAg in sera under prophylaxis therapy. At post-operation, 5 of the 12 had positive serum HBcrAg, and at stable state, 6 had positive serum HBcrAg postoperatively. The mean levels of HBcrAg following LDLT were significantly lower than those seen in the preoperative-operation stage. Conclusion This enzyme immunoassay is a readily utilizable marker of HBV replication in the post transplantation stage. Furthermore, the evaluation of HBV activity by HBcrAg assay must be studied to determine the appropriate prophylaxis for controlling replication of HBV following LDLT
Update of treatment for chronic hepatitis B using nucleos(t)ide analogues
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- Lee HS Chung YH, Lee KS, et al
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In Vivo Angiographic Detection of Vascular Lesions in Apolipoprotein E-Knockout Mice Using a Synchrotron Radiation Microangiography System
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- 01/01/2002
- Field of study
Molecular mechanisms of intestinal inflammation leading to colorectal cancer
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- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
Genomic-Glycosylation Aberrations in Tumor Initiation, Progression and Management
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- Abraham RT
- Ahmed M Rahman N
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- Cancer Genome Atlas N
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Search for diphoton events with large missing transverse momentum in 1 fb(-1) of 7 TeV proton-proton collision data with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Alimonti G
- Alison J
- Aliyev M
- Alley M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ami SB
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
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- Apolle R
- Arabidze G
- Aracena I
- Arai Y
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- Atoian G
- Aubert B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avolio G
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Backhaus M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker MD
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barajas CAC
- Barak L
- Baranov SP
- Barashkou A
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- Barberio EL
- Barberis D
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- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
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- Barnett RM
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- Barrillon P
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- Publication venue
- Publication date
- 01/01/2012
- Field of study
A search for diphoton events with large missing transverse momentum has been performed using 1.07 fb -1 of proton-proton collision data at s=7 TeV recorded with the ATLAS detector. No excess of events was observed above the Standard Model prediction and 95% Confidence Level (CL) upper limits are set on the production cross section for new physics. The limits depend on each model parameter space and vary as follows: Λ<(22-129) fb in the context of a generalised model of gauge-mediated supersymmetry breaking (GGM) with a bino-like lightest neutralino, σ<(27-91) fb in the context of a minimal model of gauge-mediated supersymmetry breaking (SPS8), and σ<(15-27) fb in the context of a specific model with one universal extra dimension (UED). A 95% CL lower limit of 805 GeV, for bino masses above 50 GeV, is set on the GGM gluino mass. Lower limits of 145 TeV and 1.23 TeV are set on the SPS8 breaking scale Λ and on the UED compactification scale 1/R, respectively. These limits provide the most stringent tests of these models to date. © 2012 CERN
Search for heavy long-lived charged particles with the ATLAS detector in pp collisions at root s=7 TeV
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- Yilmaz M
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- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
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- Zeitnitz C
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- Zemla A
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- Zhang X
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- Zhao L
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- Zhemchugov A
- Zheng S
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- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
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- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Search for New Phenomena in tt̅ Events with Large Missing Transverse Momentum in Proton-Proton Collisions at √s=7 TeV with the ATLAS Detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
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- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
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- Andari N
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- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux ML
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
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- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Aranda CP
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin JF
- Arik E
- Arik M
- Armbruster AJ
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
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- Asfandiyarov R
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
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- Atoian G
- Atoian G
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- Auge E
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- Augsten K
- Aurousseau M
- Aurousseau M
- Austin N
- Austin N
- Avolio G
- Avramidou R
- Avramidou R
- Axen D
- Axen D
- Ay C
- Ay C
- Azuelos G
- Azuelos G
- Azuma Y
- Azuma Y
- Baak MA
- Baak MA
- Baccaglioni G
- Baccaglioni G
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- Bach AM
- Bach AM
- Bachacou H
- Bachacou H
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- Badescu E
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- Bahinipati S
- Bahinipati S
- Bai Y
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- Bailey DC
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- Bain T
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- Baker OK
- Baker OK
- Baker S
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- Banerjee S
- Banfi D
- Banfi D
- Bangert A
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- Bansal V
- Bansal V
- Bansil HS
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- Bar
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- Barak L
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- Barashkou A
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- Baroncelli A
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- Barrera CO
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- Battaglia A
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- Beauchemin PH
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- Tic T
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- Tikhonov YA
- Timmermans CJWP
- Tipton P
- Tisserant S
- Tobias J
- Toczek B
- Todorov T
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- Toggerson B
- Tojo J
- Tokar S
- Tokunaga K
- Tokushuku K
- Tollefson K
- Tomoto M
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- Toms K
- Tong G
- Tonoyan A
- Topfel C
- Topilin ND
- Torchiani I
- Toro RC
- Torregrosa EF
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- Torres H
- Toth J
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- Tovey DR
- Traynor D
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- Tremblet L
- Tricoli A
- Trigger IM
- Trincaz-Duvoid S
- Trinh TN
- Tripiana MF
- Trischuk W
- Trivedi A
- Trocme B
- Troncon C
- Trottier-McDonald M
- Trzupek A
- Tsarouchas C
- Tseng JCL
- Tsiakiris M
- Tsiareshka PV
- Tsionou D
- Tsipolitis G
- Tsiskaridze V
- Tskhadadze EG
- Tsukerman II
- Tsulaia V
- Tsung JW
- Tsuno S
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- Tua A
- Tudorache A
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- Tuggle JM
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- Ueda I
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- Uhlenbrock M
- Uhrmacher M
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- Vaniachine A
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- Vazeille F
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- Yildiz HD
- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zeitnitz C
- Zeller M
- Zeman M
- Zemla A
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- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
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- Zhemchugov A
- Zheng S
- Zhong J
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- Zhu CG
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- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
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- Zsenei A
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- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2011
- Field of study
A search for new phenomena in t <span style="text-decoration: overline">t</span> events with large missing transverse momentum in proton-proton collisions at a center-of-mass energy of 7 TeV is presented. The measurement is based on 1.04 fb<sup>-1</sup> of data collected with the ATLAS detector at the LHC. Contributions to this final state may arise from a number of standard model extensions. The results are interpreted in terms of a model where new top-quark partners are pair produced and each decay to an on-shell top (or antitop) quark and a long-lived undetected neutral particle. The data are found to be consistent with standard model expectations. A limit at 95% confidence level is set excluding a cross section times branching ratio of 1.1 pb for a top-partner mass of 420 GeV and a neutral particle mass less than 10 GeV. In a model of exotic fourth generation quarks, top-partner masses are excluded up to 420 GeV and neutral particle masses up to 140 GeV
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