第4級アンモニウムと無機ナノシートを用いたエンテロバクター・クロアカに対する抗菌効果の増強

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1134号 [学位授与年月日]平成31年3月20

Type A Behavior Pattern and Obesity in Japanese Workers: A Cross-Sectional Study

Obesity is associated with personality. The Type A behavior pattern (TABP), which is characterized by hostility and competitive behavior, is related to psychological stress. However, the relationship between obesity and the TABP has not been examined. This study aimed to examine the relationship between obesity and the Type A behavior pattern in 3,099 Japanese workers. The Type A behavior pattern was measured via the Maeda Type A Behavior Checklist. Data were analyzed using multivariate logistic regression adjusted for age, being current smokers, heavy drinker, lack of exercise, occupation, and rapid eating. The multivariate odds ratio (95% confidence interval) for obesity associated with TABP was 1.55 (1.13 to 2.13) in men. Regarding other variables, age, lack of exercise, and rapid eating were associated with obesity in men. The multivariate odds ratio (95% confidence interval) for obesity associated with TABP was 1.27 (0.81 to 2.02) in women. Regarding other variables, age and rapid eating were associated with obesity in women. The findings suggest that the Type A behavior pattern was associated with increased obesity prevalence in Japanese men. People with TABP tend to eat larger portions during mealtimes repeatedly by rapid eating; it is possible that eating large portions may lead to an increase weight in men with TABP

Establishment of potent and specific synthetic substrate for dipeptidyl-peptidase 7

Bacterial dipeptidyl-peptidase (DPP) 7 liberates a dipeptide with a preference for aliphatic and aromatic penultimate residues from the N-terminus. Although synthetic substrates are useful for activity measurements, those currently used are problematic, because they are more efficiently degraded by DPP5. We here aimed to develop a potent and specific substrate and found that the kcat/Km value for Phe-Met-methylcoumaryl-7-amide (MCA) (41.40 ± 0.83 μM−1 s−1) was highest compared to Met-Leu-, Leu-Leu-, and Phe-Leu-MCA (1.06–3.77 μM−1 s−1). Its hydrolyzing activity was abrogated in a Porphyromonas gingivalis dpp7-knockout strain. Conclusively, we propose Phe-Met-MCA as an ideal synthetic substrate for DPP7

胎盤由来間葉系幹細胞の胎盤機能検査法としての役割に関する研究

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1006号 [学位授与年月日]平成30年3月20

表面プラズモン共鳴 (SPR) イメージングを用いたβ遮断薬アルプレノロール塩酸塩の抗プリオン活性の同定

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1056号 [学位授与年月日]平成30年3月20

Fcγ受容体発現細胞を用いたデング熱流行期前の健康人血清中におけるデングウイルス感染増強抗体の解析

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1058号 [学位授与年月日]平成30年3月20

乳幼児突然死に対する網羅的遺伝子解析 新生児スクリーニングを行うことで如何ほどの突然死が事前に指摘し得るか

長崎大学学位論文 [学位記番号]博（医歯薬）甲第1072号 [学位授与年月日]平成30年3月31

Social Experiment Learning for Fostering Children Assume Social System Reform －From Analysis of Children’s Understanding of Social System and Their Proposes for its Reform －

長崎大学教育学部紀要:教科教育学 通巻 第58号（Bulletin of Faculty of Education, Nagasaki University:Curriculum and Teaching, Vol.58)　赤﨑眞弓教授 退職記念