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    Hasami ceramic from the view point of historical document - Focusing on “Kurawanka” in the 18th and 19th century -

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    Hasami-cho is located in the middle of Nagasaki Prefecture, northern part of Higashisonogi-gun, and is the only town in Nagasaki that does not have a coastline. Hasamicho,which belonged to the Omura-han has been mass-produced as a pottery production area since the early Edo period. Hasami-yaki has been developed as a ceramic industry along with Arita-yaki and Mikawachi-yaki through 400 years. Hasami has 36 series of climbing kilns and had not only made great achievements in spreading porcelain widely among the common people, but also been a great influence on Japanese pottery culture, especially “Kurawanka”. Kurawanka is one type of popular ceramics that have been used for a long time as decorations and tableware, and is one of the things that can be boasted as a traditional Japanese culture. Until the Edo period, ceramics were still out of reach for the common people, but Kurawanka was produced and sold in large quantities by Imari merchants in Edo and Osaka. Kurawanka had succeeded in inspiring a feeling of warmth and familiarity among the common people and played an important role in the traditional cuisine of Japan at that time


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    School of Global Humanities and Social Sciences, Nagasaki University

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    Japanese Immigration Control Regime established in 1990 necessitated multiplication of diverse side doors. New law of 2018 admits legal immigrant workers on the basis of their specified skills. This article will examine the ambiguity of the concept of “skills” and will show the contradictory aspects of newly established “specified skills” visa


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    長崎大学学位論文 [学位記番号]共博(医歯薬)甲第4号 [学位授与年月日]令和2年3月19

    Distribution and pyrethroid resistance status of Aedes aegypti and Aedes albopictus populations and possible phylogenetic reasons for the recent invasion of Aedes aegypti in Nepal

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    Background: When the first systematic list of mosquitoes in Nepal was reported in 1990, there was no description of Aedes aegypti (L.), while Aedes albopictus (Skuse) has been included in the Stegomyia subgroup since the 1950s. The first record of Ae. aegypti in Nepal was reported in 2009, suggesting some coincidence between the invasion of this species and the first record of dengue fever in Nepal in 2006. Results: We performed a field survey of the distribution and insecticide susceptibility of Ae. aegypti and Ae. albopictus in Nepal in 2017 and 2018. Mosquito larvae were collected from used tires located along the streets of Kathmandu, Bharatpur and Pokhara, and a simplified bioassay was used to assess the susceptibility of the larvae to pyrethroid insecticides using d-allethrin. The presence or absence of point mutations in the voltage-gated sodium channel was also detected by direct sequencing. V1016G was detected at a high frequency and a strong correlation was observed between the frequencies of V1016G and susceptibility indices in Ae. aegypti populations. F1534C was also detected at a relatively low frequency. In Ae. albopictus populations, susceptibilities to d-allethrin were high and no point mutations were detected. Analysis of the cytochrome c oxidase subunit 1 (cox1) gene was performed for assessing genetic diversity and the existence of two strains were identified in Ae. aegypti populations. One consisted of 9 globally-distributed haplotypes while the other was derived from an African haplotype. Conclusions: The high pyrethroid resistance, high V1016G frequency, and relatively low quantity of insecticides used to control dengue vectors in Nepal may have resulted in only weak selection pressure favoring insecticide resistance and could support the hypothesis that this species has recently been introduced from neighboring Asian countries where pyrethroid resistance is relatively widespread.[Figure not available: see fulltext.

    Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency

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    PolyADP-ribosylation is a post-translational modification of proteins, and poly(ADP-ribose) (PAR) polymerase (PARP) family proteins synthesize PAR using NAD as a substrate. Poly(ADP-ribose) glycohydrolase (PARG) functions as the main enzyme for the degradation of PAR. In this study, we investigated the effects of Parg deficiency on tumorigenesis and therapeutic efficacy of DNA damaging agents, using mouse ES cell-derived tumor models. To examine the effects of Parg deficiency on tumorigenesis, Parg+/+ and Parg−/− ES cells were subcutaneously injected into nude mice. The results showed that Parg deficiency delays early onset of tumorigenesis from ES cells. All the tumors were phenotypically similar to teratocarcinoma and microscopic findings indicated that differentiation spectrum was similar between the Parg genotypes. The augmented anti-tumor therapeutic effects of X-irradiation were observed under Parg deficiency. These results suggest that Parg deficiency suppresses early stages of tumorigenesis and that Parg inhibition, in combination with DNA damaging agents, may efficiently control tumor growth in particular types of germ cell tumor

    The view of nature and human view in Chinese literature by Japanese modern Chinese scholars

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    長崎大学学位論文 学位記番号:博(水・環)甲第61号 学位授与年月日:令和2年3月19


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    長崎大学学位論文 学位記番号:博(水・環)甲第63号 学位授与年月日:令和2年2月19

    Royal ordinance on discipline, subordination and serviceof Maréchaussées, promulgated on 19th April 1760.

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    An open-label continuation trial of tocilizumab for familial Mediterranean fever with colchicine ineffective or intolerance

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    Background:Colchicine is the first-line treatment for familial Mediterranean fever (FMF), but secondary amyloidosis resulting from persistent inflammation is a concern in patients with colchicine-resistant or colchicine-intolerant FMF. Although tocilizumab (TCZ), which is a recombinant, humanized, anti-human interleukin 6 receptor monoclonal antibody, has been reported to prevent FMF attacks, the long-term safety and efficacy of TCZ on individuals with colchicine-resistant or colchicine-intolerant FMF have not been evaluated.Methods/design:In this investigator-initiated, multicenter, open-label trial, the long-term safety of TCZ will be evaluated in patients participating in a placebo-controlled, randomized, double-blind, parallel-group trial on colchicine-resistant or colchicine-intolerant FMF. The study will be conducted in 9 centers in Japan. After the evaluation and examination for 24 weeks in the preceding study, this trial will be started promptly. The trial will be completed by the time the drug is approved for FMF treatment in Japan. The primary endpoint is the incidence of adverse events, and the secondary endpoints include the number of FMF attacks, number of occurrences of accompanying symptoms during attacks, serum C-reactive protein and amyloid A levels, general evaluation by a physician (100mm visual analog scale [VAS]), general evaluation by a patient (100mm VAS), and body temperature.Discussion:The study is expected to obtain evidence regarding the long-term safety of TCZ as a potential new therapeutic agent for patients with colchicine-resistant or colchicine-intolerant FMF.Trial registration:This study was registered with the University Hospital Medical Information Network Clinical Trials Registry (https://upload.umin.ac.jp/cgi-open-bin/ctr-e/ctr-view.cgi?recptno=R000037116) as UMIN000032557 on May 30 2018


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