Synchrotron flaring behaviour of CygnusX-3 during the February-March 1994 and September 2001 outbursts

Aims: In this paper we study whether the shock-in-jet model, widely used to explain the outbursting behaviour of quasars, can be used to explain the radio flaring behaviour of the microquasar Cygnus X-3. Method: We have used a method developed to model the synchrotron outbursts of quasar jets, which decomposes multifrequency lightcurves into a series of outbursts. The method is based on the Marscher & Gear (1985) shock model, but we have implemented the modifications to the model suggested by Bjornsson & Aslaksen (2000), which make the flux density increase in the initial phase less abrupt. We study the average outburst evolution as well as specific characteristics of individual outbursts and physical jet properties of Cyg X-3. Results: We find that the lightcurves of the February-March 1994 and September 2001 outbursts can be described with the modified shock model. The average evolution shows that instead of the expected synchrotron plateau, the flux density is still increasing during the synchrotron stage. We also find that high frequency peaking outbursts are shorter in duration than the ones peaking at lower frequencies. Finally, we show that the method can be used, complementary to radio interferometric jet imaging, for deriving the physical parameters such as the magnetic field strength and the energy density of relativistic electrons in the jet of Cyg X-3.Comment: 8 pages, 3 figures, accepted for publication in Astronomy and Astrophysic

HAS-1 genetic polymorphism in sporadic abdominal aortic aneurysm

The hyaluronan synthase 1 (HAS-1) gene encodes a plasma membrane protein that synthesizes hyaluronan (HA), an extracellular matrix molecule. Accumulating evidence emphasizes the relevance of HA metabolism in an increasing number of processes of clinical interest, including abdominal aortic aneurysm (AAA). The existence of aberrant splicing variants of the HAS-1 gene could partly explain the altered extracellular matrix architecture and influence various biological functions, resulting in progressive arterial wall failure in the development of AAA. In the present study, we assessed the hypothesis that HAS-1 genetic 833A/G polymorphism could be associated with the risk of AAA by performing a case-control association study, involving AAA patients and healthy matched donors

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

Background: Dietary restriction (DR) increases life span and delays age-associated disease in many organisms. The mechanism by which DR enhances longevity is not well understood. Results: Using bacterial food deprivation as a means of DR in C. elegans, we show that transient DR confers long-term benefits including stress resistance and increased longevity. Consistent with studies in the fruit fly and in mice, we demonstrate that DR also enhances survival when initiated late in life. DR by bacterial food deprivation significantly increases life span in worms when initiated as late as 24 days of adulthood, an age at which greater than 50% of the cohort have died. These survival benefits are, at least partially, independent of food consumption, as control fed animals are no longer consuming bacterial food at this advanced age. Animals separated from the bacterial lawn by a barrier of solid agar have a life span intermediate between control fed and food restricted animals. Thus, we find that life span extension from bacterial deprivation can be partially suppressed by a diffusible component of the bacterial food source, suggesting a calorie-independent mechanism for life span extension by dietary restriction. Conclusion: Based on these findings, we propose that dietary restriction by bacterial deprivation increases longevity in C. elegans by a combination of reduced food consumption and decreased food sensing

The Origin and Evolution of Mutations in Acute Myeloid Leukemia

SummaryMost mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolution in AML, we sequenced the genomes of M3-AML samples with a known initiating event (PML-RARA) versus the genomes of normal karyotype M1-AML samples and the exomes of hematopoietic stem/progenitor cells (HSPCs) from healthy people. Collectively, the data suggest that most of the mutations found in AML genomes are actually random events that occurred in HSPCs before they acquired the initiating mutation; the mutational history of that cell is “captured” as the clone expands. In many cases, only one or two additional, cooperating mutations are needed to generate the malignant founding clone. Cells from the founding clone can acquire additional cooperating mutations, yielding subclones that can contribute to disease progression and/or relapse

Hyaluronan‐Based Nanohydrogels for Targeting Intracellular S. Aureus in Human Keratinocytes

Staphylococcus aureus is one of the most significant human pathogens that is frequently isolated in a wide range of superficial and systemic infections. The ability of S. aureus to invade and survive within host cells such as keratinocytes and host immune cells has been increasingly recognized as a potential factor in persistent infections and treatment failures. The incorporation of antibiotics into hyaluronan‐cholesterol nanohydrogels represents a novel paradigm in the delivery of therapeutic agents against intracellular bacteria. The work presented herein shows that NHs quickly enter human keratinocytes and accumulate into lysosomes. When used for targeting intracellular S. aureus the antimicrobial activity of loaded levofloxacin is enhanced, possibly changing the antibiotic intracellular fate from cytosol to lysosome. Indeed, gentamicin, an antibiotic that predominantly accumulates in lysosomes, shows significant and equal antibacterial activity when entrapped into NHs. These results strongly suggest that lysosomal formulations may display preferential activity toward intracellular S. aureus, opening new avenues for the use of HA‐based NHs for treatment of such skin infections

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

AGILE detection of Cygnus X-3γ-ray active states during the period mid-2009/mid-2010

Context. Cygnus X-3 (Cyg X-3) is a well-known microquasar producing variable emission at all wavelengths. Cyg X-3 is a prominent X-ray binary producing relativistic jets, and studying its high energy emission is crucial for the understanding of the fundamental acceleration processes in accreting compact objects. Aims. Our goal is to study extreme particle acceleration and γ-ray production above 100 MeV during special spectral states of Cyg X-3 usually characterized by a low hard X-ray flux and enhanced soft X-ray states. Methods. We observed Cyg X-3 with the AGILE satellite in extended time intervals from 2009 Jun.–Jul., and 2009 Nov.–2010 Jul. We report here the results of the AGILE γ-ray monitoring of Cyg X-3 as well as the results from extensive multiwavelength campaigns involving radio (RATAN-600, AMI-LA and Metsähovi Radio Observatories) and X-ray monitoring data (XTE and Swift). Results. We detect a series of repeated γ-ray flaring activity from Cyg X-3 that correlate with the soft X-ray states and episodes of decreasing or non-detectable hard X-ray emission. Furthermore, we detect γ-ray enhanced emission that tends to be associated with radio flares greater than 1 Jy at 15 GHz, confirming a trend already detected in previous observations. The source remained active above 100 MeV for an extended period of time (almost 1.5 months in 2009 Jun.–Jul. and 1 month in 2010 May). We study in detail the short timescale γ-ray flares that occurred before or near the radio peaks. Conclusions. Our results confirm the transient nature of the extreme particle acceleration from the microquasar Cyg X-3. A series of repeated γ-ray flares shows correlations with radio and X-ray emission confirming a well established trend of emission. We compare our results with Fermi-LAT and MAGIC TeV observations of Cyg X-3