248 research outputs found
Crisis? What crisis? Economic recovery and support for independence in Catalonia
Many political commentators and politicians claim that the effects of the Great Recession account for the surge in support for independence in Catalonia. However, available evidence does not point to a significant role having been played by the economic crisis in this political process. To enhance our understanding of the potential effects of changing economic conditions, we extend our analysis to the subsequent period, when economic recovery had taken place in Catalonia. Even in this very different economic scenario, the same results are found: that is, no evidence of a systematic relationship between changes in economic variables and variations in support for independence
Designing a regional cabinet: How the economic context, political fragmentation and polarization shape cabinet size
This article aims at studying the effect of the state of the economy and the characteristics of the party supply in Parliament on regional cabinet size. We complement previous literature on the characteristics of governments and analyse whether the magnitude of the cabinet varies as a function of the state of the economy, the number of opposition parties and the level of party polarization for the opposition parties. Results show that better economic conditions and a larger number of opposition political parties in parliament are associated with a larger number of portfolios. Ideological polarization of the parties in the legislature does not seem to have an influence when designing the cabinet structure. Findings also show that the effect of the economic conditions is not equal for all cabinets: cabinets with less political constraints (majority status or fewer opposition parties) will be more sensitive to economic vicissitudes. This article, therefore, highlights how the parliamentary scenario and the economic context significantly influence the decisions on how to form or reshuffle a cabinet
Star formation triggered by the Galactic HII region RCW 120: First results from the Herschel Space Observatory
By means of different physical mechanisms, the expansion of HII regions can
promote the formation of new stars of all masses. RCW 120 is a nearby Galactic
HII region where triggered star formation occurs. This region is well-studied -
there being a wealth of existing data - and is nearby. However, it is
surrounded by dense regions for which far infrared data is essential to obtain
an unbiased view of the star formation process and in particular to establish
whether very young protostars are present. We attempt to identify all Young
Stellar Objects (YSOs), especially those previously undetected at shorter
wavelengths, to derive their physical properties and obtain insight into the
star formation history in this region. We use Herschel-PACS and -SPIRE images
to determine the distribution of YSOs observed in the field. We use a spectral
energy distribution fitting tool to derive the YSOs physical properties.
Herschel-PACS and -SPIRE images confirm the existence of a young source and
allow us to determine its nature as a high-mass (8-10 MSun) Class 0 object
(whose emission is dominated by a massive envelope) towards the massive
condensation 1 observed at (sub)-millimeter wavelengths. This source was not
detected at 24 micron and only barely seen in the MISPGAL 70 micron data.
Several other red sources are detected at Herschel wavelengths and coincide
with the peaks of the millimeter condensations. SED fitting results for the
brightest Herschel sources indicate that, apart from the massive Class 0 that
forms in condensation 1, young low mass stars are forming around RCW 120. The
YSOs observed on the borders of RCW 120 are younger than its ionizing star,
which has an age of about 2.5 Myr.Comment: 5 pqges, 3 figures, accepted by A&A (Special issue on the Herschel
first results
Probing the Early Evolution of Young High-Mass Stars
Near-infrared imaging surveys of high-mass star-forming regions reveal an
amazingly complex interplay between star formation and the environment
(Churchwell et al. 2006; Alvarez et al. 2004). By means of near-IR spectroscopy
the embedded massive young stars can be characterized and placed in the context
of their birth site. However, so far spectroscopic surveys have been hopelessly
incomplete, hampering any systematic study of these very young massive stars.
New integral field instrumentation available at ESO has opened the possibility
to take a huge step forward by obtaining a full spectral inventory of the
youngest massive stellar populations in star-forming regions currently
accessible. Simultaneously, the analysis of the extended emission allows the
characterization of the environmental conditions. The Formation and Early
Evolution of Massive Stars (FEMS) collaboration aims at setting up a large
observing campaign to obtain a full census of the stellar content, ionized
material, outflows and PDR's over a sample of regions that covers a large
parameter space. Complementary radio, mm and infrared observations will be used
for the characterization of the deeply embedded population. For the first eight
regions we have obtained 40 hours of SINFONI observations. In this
contribution, we present the first results on three regions that illustrate the
potential of this strategy.Comment: To appear in ASP Conf. Proceedings of "Massive Star Formation:
Observations confront Theory", H. Beuther et al. (eds.), held in Heidelberg,
September 200
Linking pre- and proto-stellar objects in the intermediate-/high-mass star forming region IRAS 05345+3157
To better understand the initial conditions of the high-mass star formation
process, it is crucial to study at high-angular resolution the morphology, the
kinematics, and eventually the interactions of the coldest condensations
associated with intermediate-/high-mass star forming regions. The paper studies
the cold condensations in the intermediate-/high-mass proto-cluster IRAS
05345+3157, focusing the attention on the interaction with the other objects in
the cluster. We have performed millimeter high-angular resolution observations,
both in the continuum and several molecular lines, with the PdBI and the SMA.
In a recent paper, we have already published part of these data. The main
finding of that work was the detection of two cold and dense gaseous
condensations, called N and S (masses ~2 and ~9 M_sun), characterised by high
values of the deuterium fractionation (~0.1 in both cores). In this paper, we
present a full report of the observations, and a complete analysis of the data
obtained. The millimeter maps reveal the presence of 3 cores inside the
interferometers primary beam, called C1-a, C1-b and C2. None of them are
associated with cores N and S. C1-b is very likely associated with a newly
formed early-B ZAMS star embedded inside a hot-core, while C1-a is more likely
associated with a class 0 intermediate-mass protostar. The nature of C2 is
unclear. Both C1-a and C1-b are good candidates as driving sources of a
powerful CO outflow, which strongly interacts with N and S, as demonstrated by
the velocity gradient across both condensations. Our major conclusion is that
the chemical properties of these pre-stellar cores are similar to those
observed in low-mass isolated ones, while the kinematics is dominated by the
turbulence triggered by the CO outflow and can influece their evolution.Comment: 16 pages, 13 figures, accepted for publication in Astronomy &
Astrophysic
ALMA Observations of Asteroid 3 Juno at 60 Kilometer Resolution
We present Atacama Large Millimeter/submillimeter Array (ALMA) 1.3 mm
continuum images of the asteroid 3 Juno obtained with an angular resolution of
0.042 arcseconds (60 km at 1.97 AU). The data were obtained over a single 4.4
hr interval, which covers 60% of the 7.2 hr rotation period, approximately
centered on local transit. A sequence of ten consecutive images reveals
continuous changes in the asteroid's profile and apparent shape, in good
agreement with the sky projection of the three-dimensional model of the
Database of Asteroid Models from Inversion Techniques. We measure a geometric
mean diameter of 259pm4 km, in good agreement with past estimates from a
variety of techniques and wavelengths. Due to the viewing angle and inclination
of the rotational pole, the southern hemisphere dominates all of the images.
The median peak brightness temperature is 215pm13 K, while the median over the
whole surface is 197pm15 K. With the unprecedented resolution of ALMA, we find
that the brightness temperature varies across the surface with higher values
correlated to the subsolar point and afternoon areas, and lower values beyond
the evening terminator. The dominance of the subsolar point is accentuated in
the final four images, suggesting a reduction in the thermal inertia of the
regolith at the corresponding longitudes, which are possibly correlated to the
location of the putative large impact crater. These results demonstrate ALMA's
potential to resolve thermal emission from the surface of main belt asteroids,
and to measure accurately their position, geometric shape, rotational period,
and soil characteristics.Comment: 8 pages, 3 figures, 2 tables, accepted for publication in the
Astrophysical Journal Letter
Phase 1b/2a study of galunisertib, a small molecule inhibitor of transforming growth factor-beta receptor I, in combination with standard temozolomide-based radiochemotherapy in patients with newly diagnosed malignant glioma
Altres ajuts: This trial was funded by Eli Lilly and Company.The online version of this article contains supplementary material, which is available to authorized users
First Results from High Angular Resolution ALMA Observations Toward the HL Tau Region
We present Atacama Large Millimeter/submillimeter Array (ALMA) observations
from the 2014 Long Baseline Campaign in dust continuum and spectral line
emission from the HL Tau region. The continuum images at wavelengths of 2.9,
1.3, and 0.87 mm have unprecedented angular resolutions of 0.075 arcseconds (10
AU) to 0.025 arcseconds (3.5 AU), revealing an astonishing level of detail in
the circumstellar disk surrounding the young solar analogue HL Tau, with a
pattern of bright and dark rings observed at all wavelengths. By fitting
ellipses to the most distinct rings, we measure precise values for the disk
inclination (46.72pm0.05 degrees) and position angle (+138.02pm0.07 degrees).
We obtain a high-fidelity image of the 1.0 mm spectral index (), which
ranges from in the optically-thick central peak and two
brightest rings, increasing to 2.3-3.0 in the dark rings. The dark rings are
not devoid of emission, we estimate a grain emissivity index of 0.8 for the
innermost dark ring and lower for subsequent dark rings, consistent with some
degree of grain growth and evolution. Additional clues that the rings arise
from planet formation include an increase in their central offsets with radius
and the presence of numerous orbital resonances. At a resolution of 35 AU, we
resolve the molecular component of the disk in HCO+ (1-0) which exhibits a
pattern over LSR velocities from 2-12 km/s consistent with Keplerian motion
around a ~1.3 solar mass star, although complicated by absorption at low
blue-shifted velocities. We also serendipitously detect and resolve the nearby
protostars XZ Tau (A/B) and LkHa358 at 2.9 mm.Comment: 11 pages, 5 figures, 2 tables, accepted for publication in the
Astrophysical Journal Letter
Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.
The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic intervention. Here, we show that Hedgehog pathway mutations predict chemotherapy resistance in human T-ALL, and drive oncogenic transformation in a zebrafish model of the disease. We found Hedgehog pathway mutations in 16% of 109 childhood T-ALL cases, most commonly affecting its negative regulator PTCH1. Hedgehog mutations were associated with resistance to induction chemotherapy (P = 0.009). Transduction of wild-type PTCH1 into PTCH1-mutant T-ALL cells induced apoptosis (P = 0.005), a phenotype that was reversed by downstream Hedgehog pathway activation (P = 0.007). Transduction of most mutant PTCH1, SUFU, and GLI alleles into mammalian cells induced aberrant regulation of Hedgehog signaling, indicating that these mutations are pathogenic. Using a CRISPR/Cas9 system for lineage-restricted gene disruption in transgenic zebrafish, we found that ptch1 mutations accelerated the onset of notch1-induced T-ALL (P = 0.0001), and pharmacologic Hedgehog pathway inhibition had therapeutic activity. Thus, Hedgehog-activating mutations are driver oncogenic alterations in high-risk T-ALL, providing a molecular rationale for targeted therapy in this disease
- …