27 research outputs found

    Recommendations for Your Data Visualization Bookshelf

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    Over the years that I’ve been involved in data visualization, I have collected a number of books on the topic. Not every book in my library is great, but a few stand out as particularly useful for businesspeople who wish to become experts in using visualizations to analyze and communicate quantitative data. I have intentionally not included most of the books that focus on the visualization needs of scientists and statisticians. A few books that venture in this direction have been included, however, because they provide a great deal of general content that is extremely worthwhile, such as those by Edward Tufte and William Cleveland. Fundamentals of Graph Design I will begin the list with those books that cover the fundamentals of graph design for the communication of quantitative business information. Even though it will appear self-promoting, I unapologetically recommend my own book, Show Me the Numbers: Designing Tables and Graphs to Enlighten, as the best available resource on the design of graphs (and tables) for communicating quantitative business information. As someone who has been involved in the business intelligence industry for many years, I am intimately aware of the needs of businesspeople who must make sense of quantitativ

    Solution NMR structure of the Ca2+-bound N-terminal domain of CaBP7 : a regulator of golgi trafficking

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    Calcium-binding protein 7 (CaBP7) is a member of the calmodulin (CaM) superfamily that harbors two high affinity EF-hand motifs and a C-terminal transmembrane domain. CaBP7 has been previously shown to interact with and modulate phosphatidylinositol 4-kinase III-β (PI4KIIIβ) activity in in vitro assays and affects vesicle transport in neurons when overexpressed. Here we show that the N-terminal domain (NTD) of CaBP7 is sufficient to mediate the interaction of CaBP7 with PI4KIIIβ. CaBP7 NTD encompasses the two high affinity Ca(2+) binding sites, and structural characterization through multiangle light scattering, circular dichroism, and NMR reveals unique properties for this domain. CaBP7 NTD binds specifically to Ca(2+) but not Mg(2+) and undergoes significant conformational changes in both secondary and tertiary structure upon Ca(2+) binding. The Ca(2+)-bound form of CaBP7 NTD is monomeric and exhibits an open conformation similar to that of CaM. Ca(2+)-bound CaBP7 NTD has a solvent-exposed hydrophobic surface that is more expansive than observed in CaM or CaBP1. Within this hydrophobic pocket, there is a significant reduction in the number of methionine residues that are conserved in CaM and CaBP1 and shown to be important for target recognition. In CaBP7 NTD, these residues are replaced with isoleucine and leucine residues with branched side chains that are intrinsically more rigid than the flexible methionine side chain. We propose that these differences in surface hydrophobicity, charge, and methionine content may be important in determining highly specific interactions of CaBP7 with target proteins, such as PI4KIIIβ.Peer reviewedFinal Published versio

    The 2MASS Redshift Survey - Description and Data Release

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    We present the results of the 2MASS Redshift Survey (2MRS), a ten-year project to map the full three-dimensional distribution of galaxies in the nearby Universe. The 2 Micron All-Sky Survey (2MASS) was completed in 2003 and its final data products, including an extended source catalog (XSC), are available on-line. The 2MASS XSC contains nearly a million galaxies with Ks <= 13.5 mag and is essentially complete and mostly unaffected by interstellar extinction and stellar confusion down to a galactic latitude of |b|=5 deg for bright galaxies. Near-infrared wavelengths are sensitive to the old stellar populations that dominate galaxy masses, making 2MASS an excellent starting point to study the distribution of matter in the nearby Universe. We selected a sample of 44,599 2MASS galaxies with Ks =5 deg (>= 8 deg towards the Galactic bulge) as the input catalog for our survey. We obtained spectroscopic observations for 11,000 galaxies and used previously-obtained velocities for the remainder of the sample to generate a redshift catalog that is 97.6% complete to well-defined limits and covers 91% of the sky. This provides an unprecedented census of galaxy (baryonic mass) concentrations within 300 Mpc. Earlier versions of our survey have been used in a number of publications that have studied the bulk motion of the Local Group, mapped the density and peculiar velocity fields out to 50 Mpc, detected galaxy groups, and estimated the values of several cosmological parameters. Additionally, we present morphological types for a nearly-complete sub-sample of 20,860 galaxies with Ks = 10 deg.Comment: Accepted for publication in The Astrophysical Journal Supplement Series. The 2MRS catalogs and a version of the paper with higher-resolution figures can be found at http://tdc-www.harvard.edu/2mrs

    Information dashboard design: Displaying data for at-a-glance monitoring. Second edition

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    Burlingame, CAxii, 246 p.: fig., index; 28 c

    Now you see it: simple visualization techniques for quantitative analysis

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    Oaklandxi, 327 p.: Ilus.; 28 cm

    Information dashboard design : The effective visual communication of data

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    Beijingviii, 211 p : Illus.; 26 cm
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