326 research outputs found
Evolution of the solar irradiance during the Holocene
Aims. We present a physically consistent reconstruction of the total solar
irradiance for the Holocene. Methods. We extend the SATIRE models to estimate
the evolution of the total (and partly spectral) solar irradiance over the
Holocene. The basic assumption is that the variations of the solar irradiance
are due to the evolution of the dark and bright magnetic features on the solar
surface. The evolution of the decadally averaged magnetic flux is computed from
decadal values of cosmogenic isotope concentrations recorded in natural
archives employing a series of physics-based models connecting the processes
from the modulation of the cosmic ray flux in the heliosphere to their record
in natural archives. We then compute the total solar irradiance (TSI) as a
linear combination of the jth and jth + 1 decadal values of the open magnetic
flux. Results. Reconstructions of the TSI over the Holocene, each valid for a
di_erent paleomagnetic time series, are presented. Our analysis suggests that
major sources of uncertainty in the TSI in this model are the heritage of the
uncertainty of the TSI since 1610 reconstructed from sunspot data and the
uncertainty of the evolution of the Earth's magnetic dipole moment. The
analysis of the distribution functions of the reconstructed irradiance for the
last 3000 years indicates that the estimates based on the virtual axial dipole
moment are significantly lower at earlier times than the reconstructions based
on the virtual dipole moment. Conclusions. We present the first physics-based
reconstruction of the total solar irradiance over the Holocene, which will be
of interest for studies of climate change over the last 11500 years. The
reconstruction indicates that the decadally averaged total solar irradiance
ranges over approximately 1.5 W/m2 from grand maxima to grand minima
A new approach to long-term reconstruction of the solar irradiance leads to large historical solar forcing
The variable Sun is the most likely candidate for natural forcing of past
climate change on time scales of 50 to 1000 years. Evidence for this
understanding is that the terrestrial climate correlates positively with solar
activity. During the past 10,000 years, the Sun has experienced substantial
variations in activity and there have been numerous attempts to reconstruct
solar irradiance. While there is general agreement on how solar forcing varied
during the last several hundred years --- all reconstructions are proportional
to the solar activity --- there is scientific controversy on the magnitude of
solar forcing. We present a reconstruction of the Total and Spectral Solar
Irradiance covering 130 nm--10 m from 1610 to the present with annual
resolution and for the Holocene with 22-year resolution. We assume that the
minimum state of the quiet Sun in time corresponds to the observed quietest
area on the present Sun. Then we use available long-term proxies of the solar
activity, which are Be isotope concentrations in ice cores and 22-year
smoothed neutron monitor data, to interpolate between the present quiet Sun and
the minimum state of the quiet Sun. This determines the long-term trend in the
solar variability which is then superposed with the 11-year activity cycle
calculated from the sunspot number. The time-dependent solar spectral
irradiance from about 7000 BC to the present is then derived using a
state-of-the-art radiation code. We derive a total and spectral solar
irradiance that was substantially lower during the Maunder minimum than
observed today. The difference is remarkably larger than other estimations
published in the recent literature. The magnitude of the solar UV variability,
which indirectly affects climate is also found to exceed previous estimates. We
discuss in details the assumptions which leaded us to this conclusion.Comment: 9 pages, 5 figures, accepted for publication in
Astronomy&Astrophysic
First Measurement of Collectivity of Coexisting Shapes based on Type II Shell Evolution: The Case of Zr
Background: Type II shell evolution has recently been identified as a
microscopic cause for nuclear shape coexistence. Purpose: Establish a low-lying
rotational band in 96-Zr. Methods: High-resolution inelastic electron
scattering and a relative analysis of transition strengths are used. Results:
The B(E2; 0_1^+ -> 2_2^+) value is measured and electromagnetic decay strengths
of the secdond 2^+ state are deduced. Conclusions: Shape coexistence is
established for 96-Zr. Type II shell evolution provides a systematic and
quantitative mechanism to understand deformation at low excitation energies.Comment: 5 pages, 4 figure
Solar total irradiance in cycle 23
The apparently unusual behaviour of the TSI during the most recent minimum of
solar activity has been interpreted as evidence against solar surface magnetism
as the main driver of the secular change in the TSI. We test claims that the
evolution of the solar surface magnetic field does not reproduce the observed
TSI in cycle 23. We use sensitive, 60-minute averaged MDI magnetograms and
quasi-simultaneous continuum images as an input to our SATIRE-S model and
calculate the TSI variation over cycle 23, sampled roughly twice-monthly. The
computed TSI is then compared to the PMOD composite of TSI measurements and to
the data from two individual instruments, SORCE/TIM and UARS/ACRIM II, that
monitored the TSI during the declining phase of cycle 23 and over the previous
minimum in 1996, respectively. Excellent agreement is found between the trends
shown by the model and almost all sets of measurements. The only exception is
the early, i.e. 1996 to 1998, PMOD data. Whereas the agreement between the
model and the PMOD composite over the period 1999-2009 is almost perfect, the
modelled TSI shows a steeper increase between 1996 and 1999 than implied by the
PMOD composite. On the other hand, the steeper trend in the model agrees
remarkably well with the ACRIM II data. A closer look at the VIRGO data, that
make the basis of the PMOD composite after 1996, reveals that only one of the
two VIRGO instruments, the PMO6V, shows the shallower trend present in the
composite, whereas the DIARAD measurements indicate a steeper trend. We
conclude that (1) the sensitivity changes of the PMO6V radiometers within VIRGO
during the first two years have very likely not been correctly evaluated, and
that (2) the TSI variations over cycle 23 and the change in the TSI levels
between the minima in 1996 and 2008 are consistent with the solar surface
magnetism mechanism
CD69 is a TGF-β/1α,25-dihydroxyvitamin D3 target gene in monocytes
CD69 is a transmembrane lectin that can be expressed on most hematopoietic cells. In monocytes, it has been functionally linked to the 5-lipoxygenase pathway in which the leukotrienes, a class of highly potent inflammatory mediators, are produced. However, regarding CD69 gene expression and its regulatory mechanisms in monocytes, only scarce data are available. Here, we report that CD69 mRNA expression, analogous to that of 5-lipoxygenase, is induced by the physiologic stimuli transforming growth factor-β (TGF-β) and 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) in monocytic cells. Comparison with T- and B-cell lines showed that the effect was specific for monocytes. CD69 expression levels were increased in a concentration-dependent manner, and kinetic analysis revealed a rapid onset of mRNA expression, indicating that CD69 is a primary TGF-β/1α,25(OH)2D3 target gene. PCR analysis of different regions of the CD69 mRNA revealed that de novo transcription was initiated and proximal and distal parts were induced concomitantly. In common with 5-lipoxygenase, no activation of 0.7 kb or ~2.3 kb promoter fragments by TGF-β and 1α,25(OH)2D3 could be observed in transient reporter assays for CD69. Analysis of mRNA stability using a transcription inhibitor and a 3′UTR reporter construct showed that TGF-β and 1α,25(OH)2D3 do not influence CD69 mRNA stability. Functional knockdown of Smad3 clearly demonstrated that upregulation of CD69 mRNA, in contrast to 5-LO, depends on Smad3. Comparative studies with different inhibitors for mitogen activated protein kinases (MAPKs) revealed that MAPK signalling is involved in CD69 gene regulation, whereas 5-lipoxygenase gene expression was only partly affected. Mechanistically, we found evidence that CD69 gene upregulation depends on TAK1-mediated p38 activation. In summary, our data indicate that CD69 gene expression, conforming with 5-lipoxygenase, is regulated monocyte-specifically by the physiologic stimuli TGF-β and 1α,25(OH)2D3 on mRNA level, although different mechanisms account for the upregulation of each gene
Iron-dependent trafficking of 5-lipoxygenase and impact on human macrophage activation
5-lipoxygenase (5-LOX) is a non-heme iron-containing dioxygenase expressed in immune cells that catalyzes the two initial steps in the biosynthesis of leukotrienes. It is well known that 5-LOX activation in innate immunity cells is related to different iron-associated proinflammatory disorders, including cancer, neurodegenerative diseases, and atherosclerosis. However, the molecular and cellular mechanism(s) underlying the interplay between iron and 5-LOX activation are largely unexplored. In this study, we investigated whether iron (in the form of Fe3+ and hemin) might modulate 5-LOX influencing its membrane binding, subcellular distribution, and functional activity. We proved by fluorescence resonance energy transfer approach that metal removal from the recombinant human 5-LOX, not only altered the catalytic activity of the enzyme, but also impaired its membrane-binding. To ascertain whether iron can modulate the subcellular distribution of 5-LOX in immune cells, we exposed THP-1 macrophages and human primary macrophages to exogenous iron. Cells exposed to increasing amounts of Fe3+ showed a redistribution (ranging from ~45 to 75%) of the cytosolic 5-LOX to the nuclear fraction. Accordingly, confocal microscopy revealed that acute exposure to extracellular Fe3+, as well as hemin, caused an overt increase in the nuclear fluorescence of 5-LOX, accompanied by a co-localization with the 5-LOX activating protein (FLAP) both in THP-1 macrophages and human macrophages. The functional relevance of iron overloading was demonstrated by a marked induction of the expression of interleukin-6 in iron-treated macrophages. Importantly, pre-treatment of cells with the iron-chelating agent deferoxamine completely abolished the hemin-dependent translocation of 5-LOX to the nuclear fraction, and significantly reverted its effect on interleukin-6 overexpression. These results suggest that exogenous iron modulates the biological activity of 5-LOX in macrophages by increasing its ability to bind to nuclear membranes, further supporting a role for iron in inflammation-based diseases where its homeostasis is altered and suggesting further evidence of risks related to iron overload
Evolution of the dipole polarizability in the stable tin isotope chain
The dipole polarizability of stable even-mass tin isotopes
112,114,116,118,120,124 was extracted from inelastic proton scattering
experiments at 295 MeV under very forward angles performed at RCNP. Predictions
from energy density functionals cannot account for the present data and the
polarizability of 208Pb simultaneously. The evolution of the polarizabilities
in neighboring isotopes indicates a kink at 120Sn while all model results show
a nearly linear increase with mass number after inclusion of pairing
corrections.Comment: 10 pages, 6 figures, submitted to Phys. Lett.
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology
Multitarget design offers access to bioactive small molecules with potentially superior efficacy and safety. Particularly multifactorial chronic inflammatory diseases demand multiple pharmacological interventions for stable treatment. By minor structural changes, we have developed a close analogue of the cysteinyl-leukotriene receptor antagonist zafirlukast that simultaneously inhibits soluble epoxide hydrolase and activates peroxisome proliferator-activated receptor \u3b3. The triple modulator exhibits robust anti-inflammatory activity in vivo and highlights the therapeutic potential of designed multitarget agents
Estimating the frequency of extremely energetic solar events, based on solar, stellar, lunar, and terrestrial records
The most powerful explosions on the Sun [...] drive the most severe
space-weather storms. Proxy records of flare energies based on SEPs in
principle may offer the longest time base to study infrequent large events. We
conclude that one suggested proxy, nitrate concentrations in polar ice cores,
does not map reliably to SEP events. Concentrations of select radionuclides
measured in natural archives may prove useful in extending the time interval of
direct observations up to ten millennia, but as their calibration to solar
flare fluences depends on multiple poorly known properties and processes, these
proxies cannot presently be used to help determine the flare energy frequency
distribution. Being thus limited to the use of direct flare observations, we
evaluate the probabilities of large-energy solar explosions by combining solar
flare observations with an ensemble of stellar flare observations. We conclude
that solar flare energies form a relatively smooth distribution from small
events to large flares, while flares on magnetically-active, young Sun-like
stars have energies and frequencies markedly in excess of strong solar flares,
even after an empirical scaling with the mean activity level of these stars. In
order to empirically quantify the frequency of uncommonly large solar flares
extensive surveys of stars of near-solar age need to be obtained, such as is
feasible with the Kepler satellite. Because the likelihood of flares larger
than approximately X30 remains empirically unconstrained, we present indirect
arguments, based on records of sunspots and on statistical arguments, that
solar flares in the past four centuries have likely not substantially exceeded
the level of the largest flares observed in the space era, and that there is at
most about a 10% chance of a flare larger than about X30 in the next 30 years.Comment: 14 pages, 3 figures (in press as of 2012/06/18); Journal of
Geophysical Research (Space Physics), 201
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