Treatment of age-related macular degeneration: focus on ranibizumab

Ranibizumab, a humanized antigen-binding fragment (Fab) that binds all isoforms of VEGF-A, significantly slows down loss of vision and causes significant visual improvement in many patients with choroidal neovascularization (CNV) due to exudative age-related macular degeneration (AMD). These benefits of intravitreal ranibizumab apply to all angiographic subtypes of neovascular AMD and across all lesion sizes when the drug is injected at monthly intervals as shown in two pivotal phase III trials (ANCHOR and MARINA). The results from the PrONTO study suggest that less frequent treatment with ranibizumab through a variable dosing regimen dependent on optical coherence tomography (OCT) findings is a treatment option that results in comparably favorable visual outcomes. Currently, it is unclear whether combination therapy of ranibizumab with photodynamic therapy (PDT) provides any significant advantage over ranibizumab monotherapy (FOCUS trial); however, the combination of PDT and ranibizumab may decrease the need for frequent retreatment. This question will be addressed in the SUMMIT trial. Therapy with ranibizumab is generally very well tolerated with a low rate of seriously adverse ocular events or systemic side-effects. The advent of vascular endothelial growth factor (VEGF) inhibitors has revolutionized the therapy of neovascular AMD. Ranibizumab at the moment appears to be the most effective approved treatment for neovascular AMD

Neutral Gas Outflows and Inflows in Infrared-Faint Seyfert Galaxies

Previous studies of the Na I D interstellar absorption line doublet have shown that galactic winds occur in most galaxies with high infrared luminosities. However, in infrared-bright composite systems where a starburst coexists with an active galactic nucleus (AGN), it is unclear whether the starburst, the AGN, or both are driving the outflows. The present paper describes the results from a search for outflows in 35 infrared-faint Seyferts with 10^9.9 < L_IR/L_sun < 10^11, or, equivalently, star formation rates (SFR) of ~0.4 -- 9 solar masses per year, to attempt to isolate the source of the outflow. We find that the outflow detection rates for the infrared-faint Seyfert 1s (6%) and Seyfert 2s (18%) are lower than previously reported for infrared-luminous Seyfert 1s (50%) and Seyfert 2s (45%). The outflow kinematics of infrared-faint and infrared-bright Seyfert 2 galaxies resemble those of starburst galaxies, while the outflow velocities in Seyfert 1 galaxies are significantly larger. Taken together, these results suggest that the AGN does not play a significant role in driving the outflows in most infrared-faint and infrared-bright systems, except the high-velocity outflows seen in Seyfert 1 galaxies. Another striking result of this study is the high rate of detection of inflows in infrared-faint galaxies (39% of Seyfert 1s, 35% of Seyfert 2s), significantly larger than in infrared-luminous Seyferts (15%). This inflow may be contributing to the feeding of the AGN in these galaxies, and potentially provides more than enough material to power the observed nuclear activity over typical AGN lifetimes.Comment: 17 pages, 12 figures, published in ApJ (article updated 12/30/09

Near-field examination of perovskite-based superlenses and superlens-enhanced probe-object coupling

A planar slab of negative index material works as a superlens with sub-diffraction-limited imaging resolution, since propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here, we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infrared regime. The combination of near-field microscopy with a tunable free-electron laser allows us to address precisely the polariton modes, which are critical for super-resolution imaging. We spectrally study the lateral and vertical distributions of evanescent waves around the image plane of such a lens, and achieve imaging resolution of wavelength/14 at the superlensing wavelength. Interestingly, at certain distances between the probe and sample surface, we observe a maximum of these evanescent fields. Comparisons with numerical simulations indicate that this maximum originates from an enhanced coupling between probe and object, which might be applicable for multifunctional circuits, infrared spectroscopy, and thermal sensors.Comment: 20 pages, 6 figures, published as open access article in Nature Communications (see http://www.nature.com/ncomms/

HST-COS Observations of Hydrogen, Helium, Carbon and Nitrogen Emission from the SN 1987A Reverse Shock

We present the most sensitive ultraviolet observations of Supernova 1987A to date. Imaging spectroscopy from the Hubble Space Telescope-Cosmic Origins Spectrograph shows many narrow (dv \sim 300 km/s) emission lines from the circumstellar ring, broad (dv \sim 10 -- 20 x 10^3 km/s) emission lines from the reverse shock, and ultraviolet continuum emission. The high signal-to-noise (> 40 per resolution element) broad LyA emission is excited by soft X-ray and EUV heating of mostly neutral gas in the circumstellar ring and outer supernova debris. The ultraviolet continuum at \lambda > 1350A can be explained by HI 2-photon emission from the same region. We confirm our earlier, tentative detection of NV \lambda 1240 emission from the reverse shock and we present the first detections of broad HeII \lambda1640, CIV \lambda1550, and NIV] \lambda1486 emission lines from the reverse shock. The helium abundance in the high-velocity material is He/H = 0.14 +/- 0.06. The NV/H-alpha line ratio requires partial ion-electron equilibration (T_{e}/T_{p} \approx 0.14 - 0.35). We find that the N/C abundance ratio in the gas crossing the reverse shock is significantly higher than that in the circumstellar ring, a result that may be attributed to chemical stratification in the outer envelope of the supernova progenitor. The N/C abundance ratio may have been stratified prior to the ring expulsion, or this result may indicate continued CNO processing in the progenitor subsequent to the expulsion of the circumstellar ring.Comment: 12 pages, 8 figures. ApJ - accepte

Renormalized field theory and particle density profile in driven diffusive systems with open boundaries

We investigate the density profile in a driven diffusive system caused by a plane particle source perpendicular to the driving force. Focussing on the case of critical bulk density $\bar{c}$ we use a field theoretic renormalization group approach to calculate the density $c(z)$ as a function of the distance from the particle source at first order in $\epsilon=2-d$ ($d$: spatial dimension). For $d=1$ we find reasonable agreement with the exact solution recently obtained for the asymmetric exclusion model. Logarithmic corrections to the mean field profile are computed for $d=2$ with the result $c(z)-\bar{c} \sim z^{-1} (\ln(z))^{2/3}$ for $z \rightarrow \infty$.Comment: 32 pages, RevTex, 4 Postscript figures, to appear in Phys. Rev.

From Galaxy Clusters to Ultra-Faint Dwarf Spheroidals: A Fundamental Curve Connecting Dispersion-supported Galaxies to Their Dark Matter Halos

We examine scaling relations of dispersion-supported galaxies over more than eight orders of magnitude in luminosity by transforming standard fundamental plane parameters into a space of mass (M1/2), radius (r1/2), and luminosity (L1/2). We find that from ultra-faint dwarf spheroidals to giant cluster spheroids, dispersion-supported galaxies scatter about a one-dimensional "fundamental curve" through this MRL space. The weakness of the M1/2-L1/2 slope on the faint end may imply that potential well depth limits galaxy formation in small galaxies, while the stronger dependence on L1/2 on the bright end suggests that baryonic physics limits galaxy formation in massive galaxies. The mass-radius projection of this curve can be compared to median dark matter halo mass profiles of LCDM halos in order to construct a virial mass-luminosity relationship (Mvir-L) for galaxies that spans seven orders of magnitude in Mvir. Independent of any global abundance or clustering information, we find that (spheroidal) galaxy formation needs to be most efficient in halos of Mvir ~ 10^12 Msun and to become inefficient above and below this scale. Moreover, this profile matching technique is most accurate at the high and low luminosity extremes (where dark matter fractions are highest) and is therefore quite complementary to statistical approaches that rely on having a well-sampled luminosity function. We also consider the significance and utility of the scatter about this relation, and find that in the dSph regime observational errors are almost at the point where we can explore the intrinsic scatter in the luminosity-virial mass relation. Finally, we note that purely stellar systems like Globular Clusters and Ultra Compact Dwarfs do not follow the fundamental curve relation. This allows them to be easily distinguished from dark-matter dominated dSph galaxies in MRL space. (abridged)Comment: 27 pages, 18 figures, ApJ accepted. High-res movies of 3D figures are available at http://www.physics.uci.edu/~bullock/fcurve/movies.htm

Galaxy Zoo: dust and molecular gas in early-type galaxies with prominent dust lanes

We study dust and associated molecular gas in 352 nearby early-type galaxies (ETGs) with prominent dust lanes. 65% of these `dusty ETGs' (D-ETGs) are morphologically disturbed, suggesting a merger origin. This is consistent with the D-ETGs residing in lower density environments compared to the controls drawn from the general ETG population. 80% of D-ETGs inhabit the field (compared to 60% of the controls) and <2% inhabit clusters (compared to 10% of the controls). Compared to the controls, D-ETGs exhibit bluer UV-optical colours (indicating enhanced star formation) and an AGN fraction that is more than an order of magnitude greater (indicating higher incidence of nuclear activity). The clumpy dust mass residing in large-scale features is estimated, using the SDSS r-band images, to be 10^{4.5}-10^{6.5} MSun. A comparison to the total (clumpy + diffuse) dust masses- calculated using the far-IR fluxes of 15% of the D-ETGs that are detected by the IRAS- indicates that only ~20% of the dust resides in these large-scale features. The dust masses are several times larger than the maximum value expected from stellar mass loss, ruling out an internal origin. The dust content shows no correlation with the blue luminosity, indicating that it is not related to a galactic scale cooling flow. No correlation is found with the age of the recent starburst, suggesting that the dust is accreted directly in the merger rather than being produced in situ by the triggered star formation. Using molecular gas-to-dust ratios of ETGs in the literature we estimate that the median current and initial molecular gas fraction are ~1.3% and ~4%, respectively. Recent work suggests that the merger activity in nearby ETGs largely involves minor mergers (mass ratios between 1:10 and 1:4). If the IRAS-detected D-ETGs form via this channel, then the original gas fractions of the accreted satellites are 20%-44%. [Abridged]Comment: 11 pages, 18 figures, 1 table, MNRAS (Accepted for publication- 2012 March 19

The Hot Galactic Corona and the Soft X-ray Background

I characterize the global distribution of the 3/4 keV band background with a simple model of the hot Galactic corona, plus an isotropic extragalactic background. The corona is assumed to be approximately polytropic (index = 5/3) and hydrostatic in the gravitational potential of the Galaxy. The model accounts for X-ray absorption, and is constrained iteratively with the ROSAT all-sky X-ray survey data. Regions where the data deviate significantly from the model represent predominantly the Galactic disk and individual nearby hot superbubbles. The global distribution of the background, outside these regions, is well characterized by the model; the 1 sigma relative dispersion of the data from the model is about 15%. The electron density and temperature of the corona near the Sun are about 1.1 x 10^{-3} cm^{-3} and about 1.7 x 10^6 K. The same model also explains well the 1.5 keV band background. The model prediction in the 1/4 keV band, though largely uncertain, qualitatively shows large intensity and spectral variations of the corona contribution across the sky.Comment: An invited talk at IAU Colloquium No. 166: The Local Bubble and Beyond. 10 pages (including b/w figures). Color versions of Figs. 1 and 4 are provided separately and may also be found at www.astro.nwu.edu/astro/wqd/paper/hal

Ubiquitous outflows in DEEP2 spectra of star-forming galaxies at z=1.4

Galactic winds are a prime suspect for the metal enrichment of the intergalactic medium and may have a strong influence on the chemical evolution of galaxies and the nature of QSO absorption line systems. We use a sample of 1406 galaxy spectra at z~1.4 from the DEEP2 redshift survey to show that blueshifted Mg II 2796, 2803 A absorption is ubiquitous in starforming galaxies at this epoch. This is the first detection of frequent outflowing galactic winds at z~1. The presence and depth of absorption are independent of AGN spectral signatures or galaxy morphology; major mergers are not a prerequisite for driving a galactic wind from massive galaxies. Outflows are found in coadded spectra of galaxies spanning a range of 30x in stellar mass and 10x in star formation rate (SFR), calibrated from K-band and from MIPS IR fluxes. The outflows have column densities of order N_H ~ 10^20 cm^-2 and characteristic velocities of ~ 300-500 km/sec, with absorption seen out to 1000 km/sec in the most massive, highest SFR galaxies. The velocities suggest that the outflowing gas can escape into the IGM and that massive galaxies can produce cosmologically and chemically significant outflows. Both the Mg II equivalent width and the outflow velocity are larger for galaxies of higher stellar mass and SFR, with V_wind ~ SFR^0.3, similar to the scaling in low redshift IR-luminous galaxies. The high frequency of outflows in the star-forming galaxy population at z~1 indicates that galactic winds occur in the progenitors of massive spirals as well as those of ellipticals. The increase of outflow velocity with mass and SFR constrains theoretical models of galaxy evolution that include feedback from galactic winds, and may favor momentum-driven models for the wind physics.Comment: Accepted by ApJ. 25 pages, 17 figures. Revised to add discussions of intervening absorbers and AGN-driven outflows; conclusions unchange

The Extended Environment of M17: A Star Formation History

M17 is one of the youngest and most massive nearby star-formation regions in the Galaxy. It features a bright H II region erupting as a blister from the side of a giant molecular cloud (GMC). Combining photometry from the Spitzer GLIMPSE survey with complementary infrared (IR) surveys, we identify candidate young stellar objects (YSOs) throughout a 1.5 deg x 1 deg field that includes the M17 complex. The long sightline through the Galaxy behind M17 creates significant contamination in our YSO sample from unassociated sources with similar IR colors. Removing contaminants, we produce a highly-reliable catalog of 96 candidate YSOs with a high probability of association with the M17 complex. We fit model spectral energy distributions to these sources and constrain their physical properties. Extrapolating the mass function of 62 intermediate-mass YSOs (M >3 Msun), we estimate that >1000 stars are in the process of forming in the extended outer regions of M17. From IR survey images from IRAS and GLIMPSE, we find that M17 lies on the rim of a large shell structure ~0.5 deg in diameter (~20 pc at 2.1 kpc). We present new maps of CO and 13CO (J=2-1) emission, which show that the shell is a coherent, kinematic structure associated with M17 at v = 19 km/s. The shell is an extended bubble outlining the photodissociation region of a faint, diffuse H II region several Myr old. We provide evidence that massive star formation has been triggered by the expansion of the bubble. The formation of the massive cluster ionizing the M17 H II region itself may have been similarly triggered. We conclude that the star formation history in the extended environment of M17 has been punctuated by successive waves of massive star formation propagating through a GMC complex.Comment: 31 pages, 15 figures, accepted for publication in ApJ. For a version with higher-quality figures, see http://www.astro.wisc.edu/glimpse/Povich2009_M17.pd