Time-Expanded F-OTDR based on binary sequences

In this paper, the capabilities of time-expanded phase-sensitive optical time-domain reflectometry (TE F-OTDR) using binary sequences are demonstrated. We present a highly flexible and integrable TE F-OTDR approach that allows a customized distributed optical fiber sensor (range, spatial resolution, and acoustic sampling) by simply changing the length of the binary sequence and the reference clock frequencies of the binary sequence generators. The here presented architecture eliminates the need for the cumbersome arbitrary signal generators used to date to create the dual-comb spectra for interrogating the fiber. In this approach, the use of large binary sequences allows us to obtain dual combs in a simple and cost-effective way. Spatial resolution of ~1 cm is achieved, attaining ~15, 000 independent measurements points along the interrogated fiber, with a capability of sensing ~30, 000 measurements points

Preliminary numerical and experimental tests for the study of vibration signals in dry granular flows

Debris flows are one of the most important hazards in mountainous areas because of their paroxysmal nature, the high velocities, and energy carried by the transported material. The monitoring of these phenomena plays a relevant role in the prevention of the effects of these events. Among different possibilities, fiber optical sensors appear well-suited for this purpose thanks to their fair cheapness (with the exception of the interrogator), the robustness to electromagnetic interferences, the adaptability in extreme harsh conditions (no power supply is required), the possibility of locating the interrogator many kilometers far away from the monitored site, and the unique feature to provide very-dense multipoint distributed measurements along long distances. In this work, the vibro-acoustics signal produced by these phenomena has been focused as a possible source of information for the prediction of incipient movement, and the tracking of their path, velocity and thickness. Few literature works investigate these aspects, and for this reason, a preliminary laboratory and numerical campaign have been carried out with dry granular flume tests on an inclined chute. The discrete element method has been used to simulate the tests and to synthesize the signal measured on an instrumented mat along the channel. The grain shapes of the granular material used in simulations have been obtained by a photogrammetric tridimensional reconstruction. The force-time signal has been also analyzed in time-frequency domain in order to infer the features of the flow. The numerical activity has been preparatory for the experiments carried out by instrumenting the flume with an optical fiber distributed vibration sensing system

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Performance enhancement of an ultrafast all-fiber laser based on an InN saturable absorber using GRIN coupling

International audienceIndium nitride (InN)-based semiconductor saturable absorbers have previously shown advantages for application in near-IR fiber lasers due to their broad modulation depth, ultrafast nonlinear response and thermal stability. However, up to now all demonstrated saturable absorber elements based on InN (either transmissive or reflective) have shown limited performance due to poor coupling and insertion losses. We present here a simple mode-locking device based on a GRIN-rod lens in conjunction with an InN semiconductor saturable absorber mirror (SESAM) for its use in a passively mode-locked all-fiber laser system operating at telecom wavelengths. Our results demonstrate that this coupling element ensures not only a compact, turnkey and alignment-free design but also a highly-stable optical femtosecond pulse train. The reduction of insertion losses (3.5 dB) enables the generation of 90-fs ultrafast pulses with an average power of 40 mW and up to 7 nJ of pulse energy without the need for additional amplification

Common-Path Dual-Comb Spectroscopy Using a Single Electro-Optic Modulator

9 pags., 7 figs.Dual frequency comb (DFC) spectroscopy using electro-optic comb generators stands out for its flexibility, easy implementation, and low cost. Typically, two combs with different line spacing are generated from a common laser using independent electro-optic comb generators. This approach minimizes the impact of laser phase noise; however, the distinct paths followed by the two combs ultimately limit the attainable signal-to-noise ratio and long-term stability of the system. In this work, a common-path DFC is generated using a single modulator driven by an arbitrary waveform generator, thus enabling a remarkable increase of the system stability (up to 0.8 s of integration time) while maintaining high flexibility. The proposed technique is experimentally validated by implementing a dual frequency comb with 3000 lines, covering an optical bandwidth of 4.5 GHz, and demonstrating an optical-to-radiofrequency compression factor of 7500. Our system is able to measure extremely narrowband optical features (in the MHz range) with an accuracy only limited by the master laser stability.MAS acknowledges AC3E Basal Project FB0008 and thanks “Becas Iberoamérica Santander Universidades Convocatoria 2018” for supporting his research stay at Universidad de Alcalá, Spai

High-resolution chirped-pulse \u3c6-otdr by means of sub-bands processing

Conventional chirped-pulse (CP) phase-sensitive optical time-domain reflectometry (CP \u3c6-OTDR) allows the interrogation of tens of kilometers of optical fiber with high accuracies of millikelvin or nanostrain. With respect to standard coherent-detection \u3c6-OTDR, it shows increased robustness to coherent fading and allows a linear and quantitative monitoring of the perturbations acting on the fiber. Its spatial resolution, however, remains a critical parameter and new techniques allowing its improvement without reducing significantly other performances (or increasing the setup complexity) are constantly being researched. In this paper, we propose a method to improve the spatial resolution of CP \u3c6-OTDR without reducing the input pulse width, by means of sub-bands processing. The method is based on adding an optical carrier to the input pulse. Using digital filtering, the spectrum of the fiber backscatter can be split into multiple sub-bands. Each of these sub-bands corresponds to the fiber response generated by a short optical pulse, chirped over a smaller frequency range. This way each sub-band results in \u3c6-OTDR measurements with high spatial resolution, but with a reduced SNR. A dedicated post-processing methodology is proposed to mitigate the SNR reduction obtained from each sub-band, while securing high-resolution measurements of the perturbations acting on the fiber. Experimental results demonstrate the possibility of achieving CP \u3c6-OTDR measurements with a 15-fold spatial resolution improvement over the conventional CP analysis, at the expense of an SNR reduction lower than a factor 2